ライフサイエンスコーパス: corneal epithelium

1 cells (epidermis/limbus) or K3/K12(+) cells (corneal epithelium).

2 re localized in basal layer of entire murine corneal epithelium.

3 m development and daily renewal of the adult corneal epithelium.

4 face, acting to protect the integrity of the corneal epithelium.

5 red for P. aeruginosa traversal of the human corneal epithelium.

6 II (Tbr2) was conditionally ablated from the corneal epithelium.

7 fibrosis transmembrane regulator in diabetic corneal epithelium.

8 olarity, and separation of lens vesicle from corneal epithelium.

9 regulator-this time for nerves entering the corneal epithelium.

10 ves by increasing nerve branching within the corneal epithelium.

11 key protein in maintaining integrity of the corneal epithelium.

12 ce that express abundant syndecan-1 in their corneal epithelium.

13 egulated level of p68 RNA helicase in mutant corneal epithelium.

14 o the mouse corneal epithelium and the human corneal epithelium.

15 itating gammadelta T cell migration into the corneal epithelium.

16 in ex vivo tissues and in vitro cultures of corneal epithelium.

17 MBP, and MPZL1 mRNAs were expressed only in corneal epithelium.

18 RP1 is expressed at high levels in the mouse corneal epithelium.

19 itical for the proper differentiation of the corneal epithelium.

20 -/-) mice showed phosphorylated Stat3 in the corneal epithelium.

21 iform and round-shaped, were detected in the corneal epithelium.

22 e bundles form a subbasal plexus beneath the corneal epithelium.

23 Sey/Sey cells were absent from the lens and corneal epithelium.

24 tem cells (LSCs) that continuously renew the corneal epithelium.

25 r removal of a 2-mm diameter area of central corneal epithelium.

26 tion of soluble precursors in UVB-stimulated corneal epithelium.

27 characterized by conjunctivalization of the corneal epithelium.

28 differentiated (TD) cell populations of the corneal epithelium.

29 onditionally overexpresses reporter genes in corneal epithelium.

30 cell is an important area of interest in the corneal epithelium.

31 olecular mechanism(s) of PA infection in the corneal epithelium.

32 ucrin gene expression in the differentiating corneal epithelium.

33 d as a model to study gene expression in the corneal epithelium.

34 ble surface and result in desiccation of the corneal epithelium.

35 study to delineate their roles in the human corneal epithelium.

36 he recruitment of MHC class II(+) LCs to the corneal epithelium.

37 ert different molecular effects in the human corneal epithelium.

38 ately differentiate to form the multilayered corneal epithelium.

39 mobilization of MHC class II(+) LCs into the corneal epithelium.

40 main changes of these components occurred in corneal epithelium.

41 iate, and desquamate similar to normal human corneal epithelium.

42 tant roles in maintaining normal function of corneal epithelium.

43 e immunoreactivity in both RCE cells and rat corneal epithelium.

44 rneal epithelial cells and in the intact rat corneal epithelium.

45 eye, which is detected by the nerves in the corneal epithelium.

46 expression to the entire lens but not to the corneal epithelium.

47 e cells at producing progeny to populate the corneal epithelium.

48 ith fluorescein to assess the quality of the corneal epithelium.

49 th factor (OGF), [Met(5)]-enkephalin, in the corneal epithelium.

50 uble protein), which resembles the zebrafish corneal epithelium.

51 the normal homeostatic turnover rate of the corneal epithelium.

52 wing, but not in superficial, cells of human corneal epithelium.

53 l, as well as suprabasal, cells of adult rat corneal epithelium.

54 epithelium, and apoptosis in the basal layer corneal epithelium.

55 ed the cell proliferation rate in the rabbit corneal epithelium.

56 owed that destrin is highly expressed in the corneal epithelium.

57 eted products, and ability to desquamate the corneal epithelium.

58 Pseudomonas aeruginosa infection of healing corneal epithelium.

59 ng that hBD-2 is upregulated in regenerating corneal epithelium.

60 Pax6 in maintenance and repair of the adult corneal epithelium.

61 Bmal1, Per2, Cry1, and Rev-erbalpha) in the corneal epithelium.

62 the total water-soluble protein in the mouse corneal epithelium.

63 rformed by confocal microscopy on wholemount corneal epithelium.

64 aside from that in the PMNs occurred in the corneal epithelium.

65 results in precocious stratification of the corneal epithelium.

66 lacrimal gland and mitogenic activity at the corneal epithelium.

67 on between 4-HNE and oxidative stress in the corneal epithelium.

68 eripheral epithelium on wound healing of the corneal epithelium.

69 cause inflammation and keratinization of the corneal epithelium.

70 TLR4, a similar expression, occurred in the corneal epithelium.

71 x) induction to overexpress TGF-alpha in the corneal epithelium.

72 optimized to maximize the sensitivity of the corneal epithelium.

73 tion to differentiation in the epidermis and corneal epithelium.

74 on is up-regulated in diseased epidermis and corneal epithelium.

75 crog water-soluble protein) than the ventral corneal epithelium (5-7 cell layers; approximately 1.63

76 % reduction in internalized PA in the rabbit corneal epithelium after 24 hours (P = 0.03).

77 eta6 expression was upregulated in migrating corneal epithelium after a keratectomy.

78 expression increases at the leading edge of corneal epithelium after injury in an organ culture mode

79 transient amplifying cells makes the limbal/corneal epithelium an exceptionally suitable system for

80 Regular corneal epithelium and a quiet ocular surface were obtai

81 coherence tomography (UHR-OCT) can image the corneal epithelium and Bowman's layer and measurement th

82 he entire vertical thickness profiles of the corneal epithelium and Bowman's layer can provide valuab

83 power of vertical thickness profiles of the corneal epithelium and Bowman's layer imaged by UHR-OCT

84 Vertical thickness profiles of the corneal epithelium and Bowman's layer were measured by U

85 IL-6, and IL-1beta protein were observed in corneal epithelium and conjunctiva from dry eye mice.

86 mulated IL-33 mRNA and protein expression by corneal epithelium and conjunctiva in wild type, but not

87 ion of chemokines and their receptors by the corneal epithelium and conjunctiva of C57BL/6 and BALB/c

88 a, MIP-1beta, IP-10, and MIG proteins in the corneal epithelium and conjunctiva of C57BL/6 mice.

89 e protease that kills both human and hamster corneal epithelium and degrades collagen.

90 od vessels, optic nerve vascular structures, corneal epithelium and endothelium, and lens epithelium.

91 OPN was present in the trabecular meshwork, corneal epithelium and endothelium, iris, ciliary body,

92 man and mouse corneas showed staining in the corneal epithelium and endothelium.

93 rnea is the presence of Fas ligand (FasL) on corneal epithelium and endothelium.

94 degeneration developed, with thinning of the corneal epithelium and eventually perforation after 7 da

95 s play important roles in the homeostasis of corneal epithelium and hair follicles.

96 ptor that is constitutively expressed in the corneal epithelium and has been implicated in many homeo

97 tral amino acid transporter, LAT1, on rabbit corneal epithelium and human cornea.

98 s envelope precursors are expressed in human corneal epithelium and in HCECs, acute UVB stress differ

99 madelta T cells in the limbal and peripheral corneal epithelium and in the corneal stroma adjacent to

100 ium, is strongly constitutively expressed by corneal epithelium and is mechanistically responsible fo

101 TSLP was found to be expressed by human corneal epithelium and its cultures.

102 icroscopy provides objective measures of the corneal epithelium and may significantly improve the eva

103 epidermis, palpebral and bulbar conjunctiva, corneal epithelium and meibomian glands.

104 We investigated changes in the corneal epithelium and nerve morphology using three-dime

105 YRP1 is a novel antimicrobial protein of the corneal epithelium and protects the ocular surface from

106 reaks down, allowing bacteria to bind to the corneal epithelium and resulting in spontaneous keratiti

107 ase was constitutively expressed in both the corneal epithelium and several retinal layers before int

108 nous VEGF expression was up-regulated in the corneal epithelium and stroma after wounding.

109 t to the corneal stroma, was elevated in the corneal epithelium and stroma of control, but not MyD88(

110 Upregulated MMPs and TIMP-1 in the corneal epithelium and stroma of infected eyes correlate

111 The expression of TLR4 by the corneal epithelium and stroma was evaluated using real-t

112 Sema7a was expressed in the corneal epithelium and stromal keratocytes, but was more

113 ics of keratoconus, including visual acuity, corneal epithelium and stromal thickness changes, cornea

114 : anterior stromal scars, dystrophies of the corneal epithelium and the anterior stroma, and elevated

115 PGLYRP1 was localized to the mouse corneal epithelium and the human corneal epithelium.

116 for KLF6 protein was evident at E15.5 in the corneal epithelium and the stroma.

117 nclusion, 4-HNE plays an oxidant role in the corneal epithelium and this work provides a new strategy

118 replicated and spread normally in the mouse corneal epithelium and to the trigeminal ganglia.

119 e IVCM sections showed structures resembling corneal epithelium and vascular structures.

120 on, viral plaques could be visualized in the corneal epithelium and viral DNA copies were detected in

121 PRCE cells, loss of the superficial layer of corneal epithelium, and apoptosis in the basal layer cor

122 activation of NF-kappaB in the ciliary body, corneal epithelium, and retinal wall of the rat eye.

123 NOS, and COX-2 proteins in the ciliary body, corneal epithelium, and retinal wall was also significan

124 ssion was sporadically detected in the basal corneal epithelium, and the number of K12-positive basal

125 Pax6 is present in the adult corneal epithelium, and we showed that the amount of Pax

126 Ulcers and erosions of the corneal epithelium, as well as delays in resurfacing of

127 BrdU-labeled pairs of cells over the entire corneal epithelium at day 2 compared with the number in

128 ddition to the known Langerhans cells in the corneal epithelium, at least three BM-derived cell subse

129 he location of each BrdU-labeled cell in the corneal epithelium (basal or suprabasal) was determined.

130 nase protein expression was primarily in the corneal epithelium before corneal infection and was also

131 Key issues in corneal epithelium biology are the mechanism for corneal

132 was reduced at the leading edge of a healing corneal epithelium both in vivo and in vitro.

133 (NTR) was noted in the full-thickness of the corneal epithelium but was limited to the superficial la

134 P2X(7) was present in the WT corneal epithelium but was not detected in P2X(7)(-/-) m

135 d encoding S. pyogenes Cas9 and sgRNA to the corneal epithelium by intrastromal injection and acheive

136 After removal of the corneal epithelium by scraping, re-epithelialization was

137 Functionally, corneal epithelium can be regenerated in cultures from c

138 The increased beta-galactosidase activity in corneal epithelium caused by doxycycline returned to bas

139 minantly present on basal cells of the mouse corneal epithelium (CE) throughout development and in th

140 lium: cK12-positive and MUC1-positive cells; corneal epithelium: cK12-positive and MUC1-negative cell

141 y revealed successful regeneration of normal corneal epithelium (CK3(+)/12(+)) without admixture of c

142 This squamous metaplasia of Pnn mutant corneal epithelium closely correlated with significantly

143 Tear fluid and the corneal epithelium combine to make a formidable defense

144 After the last SRW challenge, the corneal epithelium, conjunctiva, and cervical lymph node

145 s of CD11c, TSLPR, and OX40L detected in the corneal epithelium, conjunctiva, and cervical lymph node

146 t intact, TGF-beta2 remained confined to the corneal epithelium, consistent with the absence of a fib

147 The corneal epithelium consists of stratified epithelial cel

148 RNA was purified from isolated corneal epithelium, corneal stroma, and primary cultures

149 inical relevance of promoting the healing of corneal epithelium debridement.

150 eneration of a functional and transplantable corneal epithelium derived from human induced pluripoten

151 and suggest the novel phenomenon that human corneal epithelium-derived TSLP may serve as a link betw

152 ferentiation, and plays an important role in corneal epithelium development and daily renewal of the

153 together to specify LSCs, and WNT7A controls corneal epithelium differentiation through PAX6.

154 14-3-3sigma is essential for corneal epithelium differentiation, and plays an importa

155 The corneal epithelium displayed histological features of th

156 Pnn mutant corneal epithelium displayed the loss of corneal epithel

157 In the mouse, the corneal epithelium does not become fully mature until 3

158 Injury to the corneal epithelium downregulates the expression of PTEN

159 no degenerative changes were observed in the corneal epithelium during cultivation using histology fo

160 on of the antimicrobial peptide LL-37 in the corneal epithelium during wound healing and to investiga

161 maging unstained cells within the stratified corneal epithelium during wound healing were made.

162 on was used to observe indentation of bovine corneal epithelium, endothelium, and stroma by a spheric

163 mal cells and scleral fibroblasts but not in corneal epithelium, endothelium, ciliary epithelium, cho

164 II collagen was immunolocalized to the mouse corneal epithelium, epithelial basement membrane, Descem

165 iffusion of RF across embryonic day 18 chick corneal epithelium ex vivo was monitored using confocal

166 sion in actively proliferating primary human corneal epithelium explant cultures, indicating that ALD

167 i were analyzed for their ability to bind to corneal epithelium, express MBP, and produce a cytopathi

168 Human corneal epithelium expresses hBD-1 and -3.

169 protease (MIP133) mediates apoptosis of the corneal epithelium, facilitates corneal invasion, and de

170 However, after removal of the corneal epithelium, fibroblasts are activated and had re

171 ient by n-heptanol debridement of the entire corneal epithelium followed by surgical removal of 360 d

172 he antioxidant and prooxidant enzymes in the corneal epithelium, followed by the imbalance between me

173 inguishing the mode of keratin expression in corneal epithelium from that of all other stratified epi

174 ive hemidesmosomes, leading to detachment of corneal epithelium from the underlying stroma, which in

175 a constitutively active form of STAT3 in the corneal epithelium had abnormal features, including corn

176 ogether, these findings demonstrate that the corneal epithelium has functional TLR2 and -9, and that

177 ression is upregulated in regenerating human corneal epithelium, has antibacterial activity against o

178 A wound in the corneal epithelium healed primarily by sliding of the wh

179 d eyes (90%), revealing the presence of just corneal epithelium in 7 cases, just conjunctival epithel

180 bsequent intracellular bacterial load in the corneal epithelium in a contact lens infection model in

181 oth the proliferation and differentiation of corneal epithelium in a novel Krt12-rtTA/tet-O-FGF-7 dou

182 promotes differentiation and recapitulates a corneal epithelium in a three-dimensional raft culture m

183 contributes to the inflammatory responses of corneal epithelium in a TLR5-NF-kappaB signaling pathway

184 ght microscopy revealed clear healing of the corneal epithelium in all groups except for some cases i

185 of MMP-1, -3, -9, and -10 transcripts in the corneal epithelium in C57BL/6 mice, but had no effect on

186 LSCs are maintained and differentiated into corneal epithelium in healthy individuals and which key

187 ted beyond the very superficial layer of the corneal epithelium in mice with intact corneas even afte

188 ICAM-1 expression by corneal epithelium in response to epithelial abrasion ap

189 ications for preventing cornification of the corneal epithelium in response to the hyperosmolar tear

190 copy showed that 46.2% of patients exhibited corneal epithelium in the central and peripheral cornea,

191 lts in a loss of hINV gene expression in the corneal epithelium in vivo and in cultured corneal epith

192 role of lipid rafts in PA internalization by corneal epithelium in vivo, in vitro, and after contact

193 lanted limbal cells' ability to reconstitute corneal epithelium in vivo.

194 vitro, but it does not penetrate the intact corneal epithelium in vivo.

195 retention, resembling characteristics of the corneal epithelium in vivo.

196 ion only happened in the limbal, but not the corneal, epithelium in airlift, but not submerged, cultu

197 expression profile of connexins in the human corneal epithelium (in vivo) and in cultured primary cor

198 es, but showed irregularities underneath the corneal epithelium, in Bruch's membrane and in the iris.

199 were highly restricted in spread within the corneal epithelium, in the case of mutant 277 to only 4

200 Overexpression of TGF-alpha in the corneal epithelium induces changes in anterior segment m

201 Abrasion of murine corneal epithelium induces neutrophil emigration through

202 Complete transformation of the corneal epithelium into a stratified epithelium that exp

203 y enhances the diffusion of RF across intact corneal epithelium into the stroma.

204 The detection of the MUC5AC transcript in corneal epithelium is a more sensitive method to diagnos

205 rom neuroectoderm via the optic vesicle, the corneal epithelium is descended from surface ectoderm, w

206 The normal corneal epithelium is endowed with CD11c(+) Langerin+ ce

207 The basal layer of limbal and central corneal epithelium is enriched in stem cells and transie

208 onship between nerve loss and effects on the corneal epithelium is limited.

209 Gap junction communication in the human corneal epithelium is mediated by Cx26, -30, -31.1, and

210 The corneal epithelium is one of the most highly innervated

211 The corneal epithelium is the outermost layer of the cornea

212 The Anableps dorsal corneal epithelium is thicker (>20 cell layers), flatter

213 The mucin-rich environment of the intact corneal epithelium is thought to contribute to the preve

214 membrane duplicating or insinuating into the corneal epithelium layer, or both, and the presence of h

215 Pnn depletion in developing mouse corneal epithelium led to disrupted alternative splicing

216 It is suggested that PAX6 involves corneal epithelium lineage-specific differentiation; how

217 In the central human corneal epithelium, loss of DeltaNp63 occurs in all surf

218 rix, relative to matrix secreted by normoxic corneal epithelium, may be responsible for increased bac

219 ative cells), and cell morphologic features (corneal epithelium: multilayered polygonal and flat cell

220 LL-37 peptide was present throughout the corneal epithelium (n=4).

221 show that conditional ablation of Srf in the corneal epithelium of a diseased Dstn(corn1) cornea resu

222 Corneal epithelium of adult GFP mice exhibits a pattern

223 o effect on levels of MMP transcripts in the corneal epithelium of BALB/c mice.

224 The corneal epithelium of BALB/c, C3H/HeJ, and C3H/HeN mice

225 a-galactosidase induction was limited to the corneal epithelium of bitransgenic mice fed doxycycline.

226 The central corneal epithelium of C57BL/6 and gene knockout mice was

227 Corneal epithelium of C57BL/6, TLR2(-/-), TLR9(-/-), and

228 role of TRIF in host inflammatory responses, corneal epithelium of C57BL/6, TLR3(-/-), TRIF(-/-), and

229 DNA synthesis in the corneal epithelium of diabetic rats was decreased up to

230 -mm diameter punch was placed on the abraded corneal epithelium of either untreated or cyclophosphami

231 ings demonstrate that nerve terminals in the corneal epithelium of mice and guinea pigs can be distin

232 and neurochemistry of nerve terminals in the corneal epithelium of mice and guinea pigs.

233 Tissue-specific deletion of Pbx1 in the corneal epithelium of mice resulted in corneal dystrophy

234 or cervical ganglion occurred throughout the corneal epithelium of mice, but only in the basal epithe

235 ate the role of the Pbx1 TALE protein in the corneal epithelium of mice.

236 marker of oxidative stress, in HCE cells and corneal epithelium of rats by immunofluorescent staining

237 Ca2+]i (Ca2+ transients) in PSNTs within the corneal epithelium of the rat.

238 ed by intracellular deposition of C3d in the corneal epithelium of vaccinated animals following chall

239 Similar to the corneal epithelium, only some of the conjunctival epithe

240 by any significant increase in thickness of corneal epithelium or contact lens, respectively.

241 not affect adherence of trophozoites to the corneal epithelium or protect corneal epithelial or stro

242 Corneal epithelium over the entire cornea was topographi

243 ecific to the structure and functions of the corneal epithelium, particularly keratin 3 (KRT3) and ke

244 To reveal their function in the corneal epithelium, PAX6 isoforms, along with reprogramm

245 FIH-1 and provides new insight into how the corneal epithelium regulates its energy requirements.

246 Corneal epithelium relies on abundant glycogen stores as

247 rile 1.0 microM latex beads into the central corneal epithelium renders Chinese hamsters resistant to

248 Toll-like receptors (TLRs) expressed by the corneal epithelium represent a first line of host defens

249 ing tear instability and to test whether the corneal epithelium responds to transient hyperosmolar st

250 AC amplicon was detected in 56 of 59 (94.9%) corneal epithelium samples.

251 Healthy corneal epithelium showing survival of limbal stem cells

252 nts that develop irregular thickening of the corneal epithelium, similar to that observed in human co

253 understanding of the molecular basis of the corneal epithelium specific phenotype.

254 acterize a Krt12-Cre knock-in mouse line for corneal epithelium-specific gene ablation and to analyze

255 eal epithelium biology are the mechanism for corneal epithelium stem cells to maintain the corneal ep

256 ear upregulates mannosylated proteins on the corneal epithelium, stimulates MIP133 secretion, and exa

257 Mouse corneal epithelium stratification is the consequence of

258 in-of-function mutant (Ctnnb1(cGOF)) retards corneal epithelium stratification.

259 ts reconstituted in vitro with normal BALB/c corneal epithelium survived indefinitely when placed in

260 In ethanol-exposed corneal epithelium Tbeta(4) treatment inhibited caspase-

261 erplay between bacteria, tear fluid, and the corneal epithelium that determines health as the usual o

262 r removal of a 2-mm diameter area of central corneal epithelium that did not directly injure the limb

263 can be sorted and expanded ex vivo to form a corneal epithelium that recovers function in an experime

264 role for ExsA in early interactions with the corneal epithelium that was not detectable with the conv

265 In corneal epithelium, the transgene expression causes decr

266 on of cornified envelope precursors in human corneal epithelium, their expression in human corneal ep

267 ean subbasal nerve density (P < 0.001), mean corneal epithelium thickness (P = 0.006), and mean corne

268 retinopexy was associated with a decrease in corneal epithelium thickness (r(2) = 0.42; P = 0.006) an

269 The authors used wound healing of mouse corneal epithelium to examine the role TGF-beta signalin

270 synthetic peptide, NC-1059, can modulate the corneal epithelium to increase the permeation of therape

271 er (K), preoperative anterior chamber depth (corneal epithelium to lens), and horizontal corneal diam

272 The exposure of corneal epithelium to S. aureus induced neutrophil recru

273 herpes simplex virus (HSV) travels from the corneal epithelium to sensory ganglia then returns to th

274 epth (ACD), defined as the distance from the corneal epithelium to the anterior lens surface; anterio

275 After a period of epithelial thinning, the corneal epithelium undergoes differentiation to an epide

276 Specific factors from the corneal epithelium underlying the stimulation of stromal

277 receptor, the expression of proteins in the corneal epithelium was altered and wound healing was com

278 f NC-1059 peptide on RF diffusion across the corneal epithelium was concentration and time dependent.

279 ine-rich protein [SPRR]-2) expression by the corneal epithelium was evaluated by laser scanning confo

280 uthanatized at different time points and the corneal epithelium was immunocytochemically stained for

281 measured by the duration for which a healthy corneal epithelium was maintained.

282 of this sensor, the permeability of a rabbit corneal epithelium was monitored by applying a solution

283 The GFP expression in the corneal epithelium was nearly ubiquitous up to about 1 w

284 The expression of MUC-1 and -4 mRNA by the corneal epithelium was reduced in NRTN(-/-) mice.

285 After stabilization, the corneal epithelium was removed with a rotating bristle b

286 The corneal epithelium was removed with the use of a corneal

287 invasion was noted when the limbal, but not corneal, epithelium was recombined with the limbal strom

288 RNA-Seq data from corneal epithelium were compared to epidermal hair folli

289 Goblet cells in the corneal epithelium were detected by light microscopy, an

290 d postoperative visual acuity and quality of corneal epithelium were evaluated.

291 y, Akt signaling and glycogen content of the corneal epithelium were significantly decreased in c-kit

292 or cells to contribute fully not only to the corneal epithelium, where Pax6 is expressed at high leve

293 ephrin signaling proteins are present in the corneal epithelium, where their function remains unknown

294 e suprabasal and/or superficial cells of the corneal epithelium, whereas the K14 expression was restr

295 wer gammadelta T cells resident in unwounded corneal epithelium, which failed to increase in response

296 in sensory neurons supplying the guinea pig corneal epithelium, which have well-defined modalities i

297 itor cells (LSCs), and deficiency in LSCs or corneal epithelium--which turns cornea into a non-transp

298 Histological analysis revealed a stratified corneal epithelium with at least three layers in all PF-

299 Success was defined as a stable corneal epithelium without conjunctivalization.

300 ration of transparent, avascular, and stable corneal epithelium without neovascularization in central