ライフサイエンスコーパス: corneal graft

1 ents for orthotopic syngeneic and allogeneic corneal grafts.

2 estigated whether CHIKV is transmittable via corneal grafts.

3 onors of combined MHC and minor H-mismatched corneal grafts.

4 ecessary for the rejection of MHC-mismatched corneal grafts.

5 o play in determining the fate of orthotopic corneal grafts.

6 gene expression in syngeneic and allogeneic corneal grafts.

7 les in these mice induced acute rejection of corneal grafts.

8 nition have the ability to reject allogeneic corneal grafts.

9 ossed corneal surface wounds, and orthotopic corneal grafting.

10 (11.8% vs 0%, P = .03), previous history of corneal graft (20.6% vs 0%, P = .0012), and prior topica

11 e led to the improved success rate for clear corneal grafts after penetrating keratoplasty.

12 e hydrops, and have improved the survival of corneal grafts after transplantation for resolved hydrop

13 eal grafts had swift rejection of subsequent corneal grafts and exhibited strong donor-specific DTH.

14 In addition, minor Ag-mismatched corneal grafts are more readily rejected than their MHC-

15 presenting passenger Langerhans cells in the corneal graft; (b) expression of Fas ligand on the epith

16 l keratoplasty procedure or cut from a whole corneal graft button unsuitable for keratoplasty.

17 o receive a B-KPro using a frozen or a fresh corneal graft carrier on the basis of tissue availabilit

18 erm clinical outcomes of fresh versus frozen corneal graft carriers for the Boston Keratoprosthesis t

19 In the latter type of corneal grafts, CD95L expression on the endothelium play

20 significantly increased opacity of C57BL/6J corneal grafts, compared with the relatively clear graft

21 low-risk eyes of mice, most of the composite corneal grafts composed of syngeneic epithelium layered

22 Recipients of composite corneal grafts containing syngeneic epithelial layers ac

23 at at least three additional features of the corneal graft contribute to its immune privileged status

24 mph nodes (LNs), we tracked the migration of corneal graft-derived transgenic green fluorescent prote

25 is promotes systemic Th2 immune responses to corneal graft donor alloantigens; 2) corneal allografts

26 iver exogenous gene(s) to the endothelium of corneal grafts during hypothermic organ preservation.

27 The most common indication for surgery was corneal graft failure (n = 50; 44%) followed by chemical

28 PKP has significant implications leading to corneal graft failure and irreversible vision loss from

29 Corneal graft failure arising after trabeculectomy was s

30 Corneal graft failure was defined as persistent corneal

31 favorable outcomes of KPro surgery for donor corneal graft failure with a greater likelihood of maint

32 diated rejection is the most common cause of corneal graft failure.

33 interfering with chemokine action to prevent corneal graft failure.

34 has been identified as a predictor of future corneal graft failure.

35 of MHC-matched, multiple minor H-mismatched corneal grafts fell from 80% in untreated controls to 36

36 t rejection is frequent in the 2 years after corneal graft for KC.

37 Most penetrating corneal grafts for Fuchs dystrophy or PACE remain clear

38 Twelve corneal grafts from 12 patients (7 men and 5 women) aged

39 allografts were no different than those for corneal grafts from Fas-bearing C57BL/6 donors.

40 - and wild-type C57BL/6 (ICAM-1+/+) received corneal grafts from the following strains of mice: BALB/

41 nstituted with CLNs from hosts with rejected corneal grafts had swift rejection of subsequent corneal

42 Partial thickness corneal grafts have favorable long-term outcome as a pat

43 rneal graft, prevented rejection of a second corneal graft in the same strain combination.

44 s results in the permanent acceptance of NZB corneal grafts in 60% and 90% of the CB6F1 hosts, respec

45 orneal grafts showed rejection of subsequent corneal grafts in a manner that was indistinguishable fr

46 transplantation of fully allogeneic skin and corneal grafts in mice.

47 each of the three cell layers of orthotopic corneal grafts in mice.

48 rence in survival of fully-mismatched BALB/c corneal grafts in p55-/- (n=12; P=0.76) or in double-kno

49 rvival of minor alloantigen-disparate BALB.b corneal grafts in p75-/- (n=13; P=0.95) or in combined p

50 In corneal grafts, in vivo relative thickening of the En/DM

51 Corneal grafting is by far the most common form of trans

52 To examine the widely accepted dogmas that corneal grafts lack passenger leukocytes or cells capabl

53 The partial thickness corneal grafts maintained clarity throughout follow-up w

54 ute can alleviate this reliance on cadaveric corneal graft material.

55 Corneal graft melting occurred in 3 (6.7%) eyes.

56 on were activated directly in both skin- and corneal-grafted mice, only CD8+ T cells from skin-transp

57 unized hosts rejected their fully allogeneic corneal grafts (MST = 43 days) compared with 100% reject

58 Rejection of TNFRII KO corneal grafts occurred even though suppressor cells dev

59 In addition to multiple failed corneal grafts, other ocular conditions for which the Bo

60 The total number of corneal grafts performed annually is increasing steadily

61 n to determine the fate of similar composite corneal grafts placed in high-risk mouse eyes.

62 These studies have been extended to include corneal grafts placed in neovascularized high-risk eyes

63 One hundred thirty-nine eyes (96 corneal grafts post penetrating keratoplasty or Descemet

64 ce who had already been primed by a previous corneal graft, prevented rejection of a second corneal g

65 of mice, removal of the DLN before a second corneal graft procedure was performed.

66 les, saline, or DSP in solution demonstrated corneal graft rejection accompanied by severe corneal ed

67 that CD8(+) CTLs are essential in promoting corneal graft rejection and instead further implicates d

68 tion of allospecific effector macrophages in corneal graft rejection and the role of CD4(+) T cells a

69 tained release of corticosteroids to prevent corneal graft rejection following subconjunctival inject

70 unct to prevent graft neovascularization and corneal graft rejection in high-risk corneal transplants

71 Corneal graft rejection in IFN-gamma-deficient hosts was

72 ed further the role of the DLN and spleen in corneal graft rejection in mice.

73 Thus, MHC matching may reduce the risk of corneal graft rejection in patients with atopic keratoco

74 study is to develop a pre-clinical model of corneal graft rejection in the semi-inbred NIH minipig a

75 Thus, allergy-induced exacerbation of corneal graft rejection is due to the production of IL-4

76 eye, so the required frequency of dosing for corneal graft rejection management can be as high as onc

77 The B6 corneal graft rejection rate in BALB/c vs Jalpha281 knoc

78 HC matching dramatically reduces the risk of corneal graft rejection when IFN-gamma is depressed or a

79 ., the SM node, is the major DLN involved in corneal graft rejection whereas its nearest neighbor, th

80 uggested a role for Fas-induced apoptosis in corneal graft rejection, additional experiments indicate

81 Alloantibody, although not necessary for corneal graft rejection, can produce extensive injury to

82 se of corticosteroids may reduce the rate of corneal graft rejection, perhaps especially in the days

83 or is administered after surgery, to prevent corneal graft rejection.

84 othesis that CTLs are essential in promoting corneal graft rejection.

85 associated with CD8(+) T cells, in promoting corneal graft rejection.

86 e as effective as viable cells in preventing corneal graft rejection.

87 r postoperative management and prevention of corneal graft rejection.

88 ng IL-17A at this time significantly reduced corneal graft rejection.

89 s demonstrated to be markedly upregulated in corneal graft rejection.

90 omplex (En/DM) characteristics in diagnosing corneal graft rejection.

91 esis is associated with an increased rate of corneal graft rejection.

92 mmune responses and reduces the incidence of corneal graft rejection.

93 contribution of donor-specific antibodies to corneal graft rejection.

94 s into the cornea with the aim of preventing corneal graft rejection.

95 nstituted with CLNs from hosts with accepted corneal grafts showed rejection of subsequent corneal gr

96 At 4 degrees C (corneal graft storage temperature), significant amounts

97 ic epithelium protects orthotopic allogeneic corneal grafts (stroma plus endothelium) placed in high-

98 ed elevated intraocular pressure (IOP) after corneal graft surgery were included.

99 mplications related to trabeculectomy and/or corneal graft surgery.

100 BAT glare responses identified that the hazy corneal graft surrounding the KPro is the main source of

101 cells is an effective strategy for enhancing corneal graft survival and preventing graft rejection in

102 munization with donor corneal cells enhanced corneal graft survival in all three high-risk settings.

103 Results showed a significant increase in corneal graft survival in alpha-MSH-treated recipients c

104 Corneal graft survival in the 3 groups was calculated us

105 Because anti-CD1d mAb abrogated the corneal graft survival in the wild-type mice we conclude

106 c cells to induce oral tolerance and enhance corneal graft survival indicates that oral tolerance to

107 Corneal graft survival was calculated using Kaplan-Meier

108 B), was examined for its capacity to enhance corneal graft survival when given separately or conjugat

109 t with normal hamster serum had no effect on corneal graft survival, infusion of anti-gamma delta Ab

110 fixed cells retain their capacity to enhance corneal graft survival, it may be possible to store dono

111 the subconjunctival treatment group, 33% of corneal grafts survived (P < 0.01).

112 Epithelium-deprived corneal grafts survived in syngeneic recipients but were

113 Rag(-/-) mice, both allogeneic and syngeneic corneal grafts survived; endostatin remained high throug

114 as covered by a 300-micron partial thickness corneal graft taken either from a previous Descemet stri

115 Surprisingly, when corneal grafts that are undergoing this later phase of r

116 ing induction vs effector of alloimmunity in corneal grafts, the most common form of tissue transplan

117 ally quantified the considerable shortage of corneal graft tissue, with only 1 cornea available for 7

118 the long-term outcomes of partial thickness corneal grafts to cover the tube and prevent its exposur

119 Many corneal grafts undergo immune rejection, and current the

120 Corneal grafting was eventually performed in 7 of the 11

121 In vivo expression of GFP in syngeneic corneal grafts was demonstrated for up to 12 weeks.

122 Corneal grafts were evaluated by ophthalmic slit-lamp bi

123 Moreover, all 31 of the TNFRII KO corneal grafts were rejected by naive BALB/c hosts.

124 CCR7(-/-) or wild-type (WT) allogeneic corneal grafts were transplanted onto the neovascularize

125 Corneal grafts were until recently considered entirely d

126 he posterior surface of accepted or rejected corneal grafts, whereas bone marrow-derived cells of rec

127 ss than 10% of the uncomplicated, first-time corneal grafts will undergo immune rejection even though

128 st deficiency in ICAM-1 promotes survival of corneal grafts with different degrees of allodisparity.