ライフサイエンスコーパス: corneal stroma

1 aracterized by leukocyte emigration into the corneal stroma.

2 EGFP inflammatory cells through the anterior corneal stroma.

3 otrusion of the anterior chamber with a thin corneal stroma.

4 cilitates corneal invasion, and degrades the corneal stroma.

5 ting inflammatory cell migration through the corneal stroma.

6 ) infiltration and neovascularization in the corneal stroma.

7 T revealed increased reflectivity within the corneal stroma.

8 ient way to deliver and express genes in the corneal stroma.

9 ellular architecture and distribution in the corneal stroma.

10 ed immunoinflammatory response to HSV in the corneal stroma.

11 nce of deposits as bright lesions within the corneal stroma.

12 ements on fibrils isolated from adult bovine corneal stroma.

13 tly higher relative to the RI in the younger corneal stroma.

14 This method can be used to engineer a new corneal stroma.

15 duced mononuclear cell infiltration into the corneal stroma.

16 ents of extracellular KSPG in the vertebrate corneal stroma.

17 BM-derived cell subsets reside in the normal corneal stroma.

18 eosinophils, but not of neutrophils, to the corneal stroma.

19 ncided with neutrophil infiltration into the corneal stroma.

20 al in the establishment of a properly formed corneal stroma.

21 rm Onchocerca volvulus are injected into the corneal stroma.

22 tan sulfate, a unique molecular component of corneal stroma.

23 nd stroma, and of MMP-3/stromelysin-1, in DR corneal stroma.

24 progressive disease that thins and scars the corneal stroma.

25 nflammatory cells from limbal vessels to the corneal stroma.

26 ogic lesions were confined to the peripheral corneal stroma.

27 aped granular opacities are deposited in the corneal stroma.

28 l opacity, and modest disorganization in the corneal stroma.

29 use it to drive a foreign gene expression in corneal stroma.

30 ite antigens were injected directly into the corneal stroma.

31 broblasts of all types, including those from corneal stroma.

32 mbrane, and the interfibrillar matrix of the corneal stroma.

33 fluences myofibroblast transformation in the corneal stroma.

34 l and mononuclear cell infiltration into the corneal stroma.

35 iniscent of the organization of normal fetal corneal stroma.

36 those seen in normal developing and healing corneal stroma.

37 ornea and are secreted by keratocytes in the corneal stroma.

38 and biochemically similar to that in healing corneal stroma.

39 ility properties necessary for replacing the corneal stroma.

40 ght fascicles, advancing straight toward the corneal stroma.

41 t also functions to restore integrity of the corneal stroma.

42 d vessel endothelial cells that occur in the corneal stroma.

43 th an intact cornea penetrates well into the corneal stroma.

44 owever, showed variable penetration into the corneal stroma.

45 scopy were used to assess HCEC attachment to corneal stroma.

46 model in which conidia are injected into the corneal stroma.

47 flammation in which LPS is injected into the corneal stroma.

48 ds and in the structural organization of the corneal stroma.

49 t with delayed neutrophil recruitment to the corneal stroma.

50 nce for a predominance of neutrophils in the corneal stroma.

51 erior banded layer, which is adhesive to the corneal stroma.

52 d haze due to neutrophil infiltration to the corneal stroma.

53 ulminating in dissolution of the collagenous corneal stroma.

54 oxylation of collagen that is present in the corneal stroma.

55 e significantly lower than in normal control corneal stromas.

56 in the pericentral and central region of the corneal stroma (200-300 cells/mm(2)).

57 l ocular morphogenesis characterized by thin corneal stroma, absence of corneal endothelium, fusion o

58 f AQP1 in active extrusion of fluid from the corneal stroma across the corneal endothelium.

59 and peripheral corneal epithelium and in the corneal stroma adjacent to the limbal blood vessels.

60 Neutrophil emigration into corneal stroma after epithelial abrasion occurs in two w

61 ns in neutrophil (PMN) migration through the corneal stroma after epithelial scrape injury.

62 before corneal infection and was also in the corneal stroma after infection.

63 However, they have a thinner corneal stroma and a narrower cornea-iris angle of the a

64 RB penetrated approximately 100 mum into the corneal stroma and absorbed >90% of the incident green l

65 ncontrolled growth of Fusarium hyphae in the corneal stroma and anterior chamber, and eventually resu

66 In the first wave, MCs migrated to the corneal stroma and became distributed throughout the cor

67 s (2.3%) showed focal adhesions of DM to the corneal stroma and developed isolated tears during strip

68 the tear film toward bacteria in the central corneal stroma and early neutrophil migration from the l

69 phil and F4/80(+) cell infiltration into the corneal stroma and elevated corneal haze, which is an in

70 ult heterozygotes had defects in the central corneal stroma and endothelium and anterior polar catara

71 the corneal epithelial cells, but not in the corneal stroma and endothelium nor in other ocular tissu

72 essed at high levels, but also to the to the corneal stroma and endothelium, where the protein is det

73 ient of the hydrogen-bicarbonate ion pair in corneal stroma and epithelium is calculated from the obs

74 emet membrane, allowing aqueous to enter the corneal stroma and epithelium.

75 a3 collagens were expressed in normal rabbit corneal stroma and in keratocytes cultured in serum-free

76 type XII collagen is present in the ECMs of corneal stroma and in the sclera, as well as in the corn

77 aureus induced neutrophil recruitment to the corneal stroma and increased corneal thickness and haze

78 e that induce neutrophil infiltration to the corneal stroma and loss of corneal clarity.

79 Ten cadaveric porcine eyes with exposed corneal stroma and plastic test spheres underwent unifor

80 Keratocytes isolated from rabbit corneal stroma and plated in a serum-free medium were tr

81 ratopathy with a fluid interface between the corneal stroma and previous laser-assisted in situ kerat

82 cterized by neutrophil infiltration into the corneal stroma and the development of corneal haze.

83 st for specification of corneal endothelium, corneal stroma and the sclera.

84 ed depositions of matrix proteins within the corneal stroma and the stroma-to-stroma interface, which

85 production and cellular infiltration to the corneal stroma and unimpaired bacterial growth.

86 anti-VEGF antibodies were implanted into the corneal stroma and were used to determine the requiremen

87 cules within mammalian collagen fibrils from corneal stromas and that this region becomes masked as c

88 ne production, neutrophil recruitment to the corneal stroma, and bacterial clearance than C57BL/6 mic

89 al epithelium, nerve axons were evaluated in corneal stroma, and capacity of manipulated eyes to supp

90 , leukocytes and platelets rapidly enter the corneal stroma, and CCR6(+) IL-17(+) gammadelta T cells

91 Keratocytes, isolated from rabbit corneal stroma, and cultured in a serum-free medium, pre

92 escens induced neutrophil recruitment to the corneal stroma, and increased corneal thickness and haze

93 ness of corneal neovessels, loss of axons in corneal stroma, and loss of ability of I/CB after kerato

94 s purified from isolated corneal epithelium, corneal stroma, and primary cultures of both epithelial

95 hemokines, recruitment of neutrophils to the corneal stroma, and subsequent bacterial killing and tis

96 es, leading to neutrophil recruitment to the corneal stroma, and that TLR2 mediates O. volvulus/Wolba

97 he demarcation between treated and untreated corneal stroma appeared as a region where normal keratoc

98 Keratan sulfate proteoglycans (KSPGs) in the corneal stroma are believed to influence collagen fibril

99 ective tissues of other organs and embryonic corneal stroma as a glycoprotein.

100 up there was a reduced number of PMNs in the corneal stroma at 3 and 7 days of follow-up.

101 corneal epithelial layer and portions of the corneal stroma at 9 hours PI, and polymorphonuclear (PMN

102 vulus) induces eosinophil recruitment to the corneal stroma at the time of maximum corneal opacificat

103 Apoptosis was detected in the corneal stroma at various time points using an in situ t

104 Neovascularization of the corneal stroma began on day 3 and was sustained through

105 h as androgen, luteotropin, and estrogen, on corneal stroma bioenergetics.

106 ased cross-linking reactions dominate in the corneal stroma, but other possible reaction schemes are

107 Keratocytes isolated from rabbit corneal stroma by collagenase digestion were plated in s

108 rs to regulate neutrophil recruitment to the corneal stroma by enhancing TLR2 expression and OvAg-ind

109 ion through the dense collagenous ECM of the corneal stroma by generating chemotactic PGP during infl

110 Invasion of the corneal stroma by neutrophils and eosinophils and subseq

111 all time points tested, infiltration of the corneal stroma by P. aeruginosa revealed a high degree o

112 t of EGFP-positive inflammatory cells in the corneal stroma can be detected in vivo by 6 hours after

113 study sought identification of cells in the corneal stroma capable of assuming a keratocyte phenotyp

114 Cultured human corneal stroma cells and whole human corneas received UV

115 After corneal wounding, the remaining corneal stroma cells are phenotypically fibroblasts and

116 Corneal stroma cells cultured at 500 cells/mm2 were trea

117 noviral construct could be used to transfect corneal stroma cells effectively in vivo and to determin

118 Collagenase-isolated corneal stroma cells obtained from newborn and adult mic

119 allowed visualization of EGFP expression in corneal stroma cells, to accurately assess cellular arch

120 of IL-1, IL-6, IL-8, and TNF alpha in human corneal stroma cells.

121 n average, throughout the whole depth of the corneal stroma, collagen fibrils in mimecan-null mice, u

122 produced significantly less CXCL1/KC in the corneal stroma compared with C57BL/6 mice consistent wit

123 Fibroblasts in the corneal stroma, conjunctiva, and sclera labeled similarl

124 n sulfate-containing proteoglycans of bovine corneal stroma contain three unique core proteins design

125 xyproline content indicated that the central corneal stroma contained significantly more collagen per

126 The normal murine corneal stroma contains a significant number of CD45(+)

127 Corneal stroma contains an extracellular matrix of ortho

128 Normal murine corneal stroma contains heterogeneous cell populations i

129 and ciliary body) and cranial neural crest (corneal stroma, corneal endothelium and anterior iris).

130 y of 1 microm to cut a spiral pattern in the corneal stroma creating precise lamellar flaps for LASIK

131 sed the entry of topical riboflavin into the corneal stroma despite the presence of a previously inta

132 During normal corneal stroma development and healing, changes in mRNA

133 pectively, and neutrophil recruitment to the corneal stroma, development of corneal haze, and chemoki

134 sion function of preparations indicated that corneal stromas dialysed against 154 mM NaCl had usable

135 njection of air or collagenase into the deep corneal stroma did not result in a reproducible separati

136 acellular matrix in vitro resembling primary corneal stroma during embryonic development.

137 e the inflammatory cells that migrate to the corneal stroma during endotoxin-induced keratitis and to

138 sive corneal isolate of P. aeruginosa in the corneal stroma during infection of ex vivo and in vivo r

139 tion of collagen reorganization in the avian corneal stroma during the latter stages of embryogenesis

140 stallins are lost from resident cells of the corneal stroma during wound repair, and this is associat

141 erful tool for enhanced visualization of the corneal stroma environment and cellular biology.

142 Keratocytes in the corneal stroma express keratan sulfate-containing proteo

143 Corneal stroma extracellular matrix (ECM) glycosaminogly

144 human foreskin fibroblasts (HFFs), and human corneal stroma fibroblasts (HCFs).

145 blasts (RAB9) and primary cultures of rabbit corneal stroma fibroblasts (NRCF) were grown to confluen

146 g tissue-specific promoter constructs to the corneal stroma for gene expression.

147 Wholemounts of paraformaldehyde-fixed corneal stroma from normal mice at 5 to 16 weeks of age

148 Collagen fibrils in the corneal stroma have been recognised to have a high degre

149 ages and polarization anisotropy profiles of corneal stroma heated in the 35-80 degrees C range are a

150 dure that delivers radio-frequency energy to corneal stroma in a circular fashion to steepen the corn

151 D11b monocyte-specific antigen appear in the corneal stroma in high numbers by 24 hours after epithel

152 nvestigate the fibrillar architecture of the corneal stroma in mice homozygous for a null mutation in

153 The corneal stroma in persons undergoing penetrating keratop

154 eovascularization process that occurs in the corneal stroma in response to HSV infection.

155 s facilitated the attachment of HCECs to the corneal stroma in the human anterior segment model with

156 the influx of monocytes-macrophages into the corneal stroma in the rabbit.

157 anscripts were also detected in the anterior corneal stroma, in the ciliary muscle, beneath the anter

158 or T-cells and NK cells were absent from the corneal stroma, indicating that all the cells identified

159 156S and recombinant murine VEGF-D) into the corneal stroma induce not only LA but also robust HA cha

160 ryonic day (E)9, then penetrate the anterior corneal stroma, invade the epithelium, and branch over t

161 ithelial scrape injury, PMN migration in the corneal stroma involves close contact between keratocyte

162 No recognizable corneal endothelium, corneal stroma, iris stroma, or anterior chamber was fou

163 of extracellular matrix architecture in the corneal stroma is associated with abundant type VI colla

164 The transparency of the corneal stroma is critically dependent on the hydration

165 such as neutrophils and eosinophils into the corneal stroma is initiated from peripheral (limbal) ves

166 In addition, the layering of the corneal stroma is poorly formed or absent.

167 Incisional or ablation injury to the corneal stroma is repaired by deposition of a fibrotic t

168 The RI in the older corneal stroma is slightly higher relative to the RI in

169 one marrow-derived fibroblastic cells of the corneal stroma is strongly correlated with the failure o

170 Within the corneal stroma, keratocytes communicate through gap junc

171 ssion patterns of adult and postnatal day-10 corneal stroma, keratocytes, fibroblasts, and myofibrobl

172 atitis is an immunopathologic disease in the corneal stroma leading to scarring, opacity, and blindne

173 a large number of macrophages infiltrate the corneal stroma, limbus, and lacrimal glands of diseased

174 We propose that loss of beta-actin in the corneal stroma might be a triggering factor in the devel

175 the ability of FIB to bind noncovalently to corneal stroma molecules, Coll-I, decorin, dermatan sulf

176 ession of ANGPTL7 protein was located in the corneal stroma, near the limbus, and throughout the scle

177 Furthermore, corneal stroma neovascularization and meibomian gland de

178 -9 stimulated neutrophil recruitment to the corneal stroma of C57BL/6 mice, but not TLR2(-/-) or -9(

179 ogenous cytokines, we injected OvAg into the corneal stroma of C57BL/6, IL-1 receptor 1(-/-) (IL-1R1(

180 e to impaired KC and MIP-2 production in the corneal stroma of CXCR2(-/-) mice, which was similar to

181 lus adult worms (OvAg) was injected into the corneal stroma of each animal.

182 on of a lumican expression minigene into the corneal stroma of Lum-/- mice.

183 marked contrast, neutrophil migration to the corneal stroma of MyD88(-/-) mice challenged with Pam(3)

184 adult stem cell recellularization within the corneal stroma of patients with advanced keratoconus.

185 show that beta-actin is downregulated in the corneal stroma of patients with KC, which may be related

186 SP present in the corneal stroma of the eyes with severe HSK lesions coloc

187 In the present study, the corneal stroma of the mouse was examined to provide some

188 No staining was observed in the corneal stroma or in the choroid.

189 lassic NK cells migrated into the limbus and corneal stroma, peaking at 24 hours with an eightfold in

190 on through limbal vessels into the avascular corneal stroma, peaking within 12 to 18 hours after woun

191 cellular and molecular effects on the human corneal stroma post CXL, and promises to establish optim

192 fferentiation, such as the thickening of the corneal stroma, proceed relatively slowly.

193 Keratocytes of the corneal stroma produce a specialized extracellular matri

194 Keratocytes of the corneal stroma produce a transparent extracellular matri

195 Keratocytes of the corneal stroma produce transparent extracellular matrix

196 iform scanning excimer laser ablation of the corneal stroma produces a significant central steepening

197 the direction favoring stemness, whereas the corneal stroma promotes differentiation.

198 and vascularized, immature APCs in the donor corneal stroma quickly mature and migrate to lymphoid ti

199 -2, KC, and MIP-1 alpha was localized to the corneal stroma, rather than to the epithelium, which was

200 implex virus type 1 (HSV-1) infection of the corneal stroma remains a major cause of blindness.

201 e response to infection, and in the infected corneal stroma represents an elementary defense mechanis

202 Keratocytes of the corneal stroma secrete a unique population of proteoglyc

203 broblasts or other cell types present in the corneal stroma show no significant expression of VEGF mR

204 gth ultraviolet light (UVA; RFUVA) increases corneal stroma tensile strength significantly.

205 ly less (P < 0.0001) GAG accumulation in the corneal stroma than dogs with a later onset of treatment

206 Regions within the corneal stroma that lack collagen autofluorescence coinc

207 d population of PAX6-positive cells in adult corneal stroma that maintain the potential to assume a k

208 that it is the basis for the formation of a corneal stroma that must be transparent to visible light

209 ort variant form of type XII collagen, human corneal stroma, the BM zone, and the sclera contain the

210 orm of type XII collagen was detected in the corneal stroma, the sclera, and the stroma in the rudime

211 r viral persistence and dissemination to the corneal stroma, the site of inflammation.

212 event attachment of the lens and iris to the corneal stroma, therefore permitting the normal formatio

213 ied cholesterol and cholesterol ester in the corneal stroma; this is believed to be due to an imbalan

214 on resident bone marrow-derived cells in the corneal stroma to produce CXC chemokines, leading to neu

215 Progression of the virus from the corneal stroma to the retina during acute infection was

216 During wound healing, keratocytes in the corneal stroma transdifferentiate into fibroblasts and m

217 In the corneal stroma, type XII collagen may be organized along

218 Slit2 in preventing nerves from entering the corneal stroma until the proper time (i.e., they serve a

219 e ablation threshold for the collagen in the corneal stroma was determined to be 30 mJ/cm2.

220 in vitro three-dimensional (3-D) model of a corneal stroma was developed by using primary human corn

221 scent signal from the collagen fibers of the corneal stroma was evident in the TPAF channel.

222 al microscopy, neutrophil recruitment to the corneal stroma was quantified by immunohistochemistry, a

223 itment of neutrophils and eosinophils to the corneal stroma was significantly impaired in FcgammaR(-/

224 Prolonged virus expression in the corneal stroma was suggested to cause bystander activati

225 which mediate neutrophil recruitment to the corneal stroma, was elevated in the corneal epithelium a

226 of filarial nematodes were injected into the corneal stroma, we demonstrated that the predominant inf

227 mediators of granulocyte recruitment to the corneal stroma, we determined the relative contribution

228 ation of leukocyte migration into and out of corneal stroma, we showed reentry of extravasated leukoc

229 crophage inflammatory protein (MIP)-2 in the corneal stroma were also significantly elevated after ex

230 The depth distributions of RF in the corneal stroma were calculated using a group of linear e

231 es of 84 patients with disorders of anterior corneal stroma were correlated to clinical outcome param

232 ages, PMN and fibroblasts) and mBD3 (PMN) in corneal stroma were identified by dual label immunostain

233 After corneal stromas were digested with proteinase K, aliquot

234 microscopy showed patches along the denuded corneal stroma where there was a partial or complete los

235 ce scar was significantly higher than normal corneal stroma, whereas concentrations of DeltaUA-beta-1

236 eas can lead to blinding inflammation in the corneal stroma, which is referred to clinically as herpe

237 a pronounced cellular infiltration into the corneal stroma, which was TLR3- and TRIF-dependent.

238 15 mm/s), phase gratings were created in the corneal stroma, which were shown to be pure RI changes r

239 ce were immunized s.c. and injected into the corneal stroma with Ags from the parasitic helminth Onch

240 g spatial expression patterns throughout the corneal stroma with differential temporal expression.

241 development, particularly the formation of a corneal stroma with the appropriate number of fibroblast

242 epithelialised and de-endothelialised bovine corneal stromas with a hydration of 3.2 equilibrated at

243 1 hours after injection of adeno-EGFP in the corneal stroma, with a duration of approximately 3 weeks

244 with peak accumulation of neutrophils in the corneal stroma within 12 hours.

245 gnetic source and attachment of cells to the corneal stroma without affecting cell viability or light

246 n frozen sections of 5- to 6-month-old mouse corneal stromas without the need for any unmasking techn