ライフサイエンスコーパス: corneocyte

1 hat promote the adherence of S. aureus to AD corneocytes.

2 ganelles and convert into anucleate cells or corneocytes.

3 ells lose their nuclei and become desiccated corneocytes.

4 at a specific depth below the surface of the corneocytes.

5 ocalized to the extracellular spaces between corneocytes.

6 ls that can exceed the size of water-swollen corneocytes.

7 corneum showed premature loss of cohesion of corneocytes.

8 ix is largely compartmentalized within fetal corneocytes.

9 lular envelopes indicative of differentiated corneocytes.

10 in compound envelopes of mammalian epidermal corneocytes.

11 phi) and cellular replacement rates are 52.9 corneocytes/69.3 keratinocytes per mm2 per h approximate

12 ter 6 h, and nearly complete dissociation of corneocytes after 24 h.

13 This dysadhesion of corneocytes and its contribution to increased transepide

14 ule for the interaction of S. aureus with AD corneocytes and represents a target for intervention.

15 characterized by dysmorphic and pleomorphic corneocytes and the absence of vesicular bodies in trans

16 s embryos, enlarged granular layer cells and corneocytes, and a morphologically abnormal cornified la

17 of a live mouse, including sebaceous glands, corneocytes, and adipocytes, with unprecedented contrast

18 neal and intraepithelial pustules, nucleated corneocytes, and dilated superficial dermal blood vessel

19 corneocytes in adult stratum corneum, vernix corneocytes appeared swollen, the density of the keratin

20 Because corneocytes are also required for barrier function, we h

21 hodology, the number of VPs per investigated corneocyte area was assessed and expressed as the Dermal

22 n that is important for the formation of the corneocyte, as well as the generation of its intracellul

23 portunity to detect biomechanical changes in corneocytes because of, e.g., environmental factors, agi

24 e, PNPLA1-deficient mice lacked a functional corneocyte-bound lipid envelope leading to a severe skin

25 npla1-mutant mice promoted rebuilding of the corneocyte-bound lipid envelope, indicating that supplem

26 xyceramide, and the appearance of prominent, corneocyte-bound lipid envelopes, whereas cornified enve

27 Whereas the structure responsible for corneocyte cohesion has been visualized at the microscop

28 ogenic ClfB-deficient mutant to adhere to AD corneocytes compared to that of its parent clonal comple

29 tial role of vibrational imaging to evaluate corneocyte composition and molecular structure in the tr

30 We applied atomic force microscopy to study corneocyte conformation in patients with AD stratified b

31 These corneocyte conformational changes shed further insight i

32 are used to determine whether the lipids or corneocytes constitute the main permeation barrier.

33 Anucleate corneocytes contain keratin filaments bound to a periphe

34 Stratum corneum comprises corneocytes, derived from outer stratum granulosum durin

35 re was no evidence of tracer accumulation in corneocytes, despite the fragility of nucleated keratino

36 Corneocyte desquamation has been ascribed to the followi

37 pth, but are not affected by depth-dependent corneocyte diffusivity; and the follicular contribution

38 (many of which failed to be secreted); i.e., corneocytes displayed retained cytosolic lamellar bodies

39 idermal permeability barrier is comprised of corneocytes embedded in a lipid enriched matrix.

40 atum corneum is composed of protein-enriched corneocytes embedded in an intercellular matrix of nonpo

41 1/desmocollin 1 redistribute uniformly into corneocyte envelopes (CEs) in the outer SC (shown by pro

42 d for barrier function, we hypothesized that corneocyte formation could also be regulated by barrier

43 ause cornification was blocked by occlusion, corneocytes formed specifically in response to barrier,

44 Our studies revealed abnormal corneocyte fragility and basal permeability barrier func

45 rmal lamellar body secretion, rather than to corneocyte fragility or an abnormal cornified envelope/c

46 keratosis of the ear and the tail epidermis, corneocyte fragility, increased transepidermal water los

47 Adherence of single S. aureus bacteria to corneocytes from AD patients ex vivo was studied using a

48 Corneocytes from AD skin are structurally different from

49 t variations in the mechanical properties of corneocytes from different volunteers.

50 from AD skin are structurally different from corneocytes from normal healthy skin.

51 In both tissues, corneocytes have normal-looking cell envelopes, despite

52 Compared with mature corneocytes in adult stratum corneum, vernix corneocytes

53 neum, whereas the intracellular space of the corneocytes in mid-stratum corneum (25 microm diameter)

54 lease of proinflammatory IL-1 cytokines from corneocytes in patients with atopic dermatitis (AD) with

55 terial adhesion to the cornified envelope of corneocytes in the outer layer, the stratum corneum.

56 c force microscopy showed that it shrunk the corneocytes in the stratum corneum (p<0.001) and the ima

57 er cells were all stained uniformly, but not corneocytes in the stratum corneum.

58 nd the transformation of granular cells into corneocytes, in an SP- and Casp-14-dependent manner, sig

59 iven these empirical data: (1) the number of corneocytes is a mean proportional between the sum of th

60 yer and the more rigid internal structure of corneocytes is apparent, which is consistent with the cu

61 e intracellular mechanical behavior of human corneocytes is determined using "nanoneedle" AFM probes.

62 t measures the relative NMF concentration in corneocytes is introduced.

63 the ratio of nucleated epidermal cells over corneocytes is phi proportional, 75,346/17,778 approxima

64 The maturation of corneocytes isolated from different depths in healthy hu

65 in the concentration of NMF was observed for corneocytes isolated from superficial compared to deeper

66 ption of the outermost and inner two to four corneocyte layers, which swell less.

67 tein-bound omega-hydroxyceramides and of the corneocyte lipid envelope and die shortly after birth fr

68 ion, and suggest further that acylCer and/or corneocyte lipid envelope are required elements in perme

69 hed lipids, showed numerous foci with absent corneocyte lipid envelope in ABT- versus vehicle-treated

70 er) are the predominant lipid species of the corneocyte lipid envelope in the epidermis.

71 ke a defect in the formation of a functional corneocyte lipid envelope linked to impaired omega-O-acy

72 ovalent binding to protein, thus forming the corneocyte lipid envelope, a key component of the epider

73 omega-hydroxyl of the ceramide, forming the corneocyte lipid envelope, a scaffold between lipid and

74 nces the concept that the oxidations disrupt corneocyte membrane lipids, promoting release of free om

75 Abnormalities in corneocyte morphology have been observed in patients wit

76 cts (natural moisturizing factor [NMF]), and corneocyte morphology in patients with AD.

77 NMF levels are highly correlated with corneocyte morphology in patients with AD.

78 Extensive dissociation of corneocytes occurs after 24 h of water exposure.

79 900-microm2 corneocyte surface area, 17,778 corneocytes per mm2, 14-d (SC) turnover time, and 93,124

80 hydrophobic lipid matrix with embedded fetal corneocytes possessing unique biomechanical and water-bi

81 (SC) and Malpighian epidermis, the number of corneocytes results from subtraction of a cellular fract

82 e SC interstices in RXLI could contribute to corneocyte retention, by increasing CD and interlamellar

83 iciently to delay CD degradation, leading to corneocyte retention.

84 ikely facilitating exfoliation by increasing corneocyte rigidity.

85 cent cornified-bound lipid envelope, i.e., a corneocyte scaffold abnormality does not explain the bar

86 ipped, yielding the characteristic polygonal corneocytes shown by scanning electron microscopy as wel

87 information on fixed human epithelial cells, corneocyte skin flakes, and polymers used for bioimplant

88 nocytes per mm2, 16 (SC) layers, 900-microm2 corneocyte surface area, 17,778 corneocytes per mm2, 14-

89 cognized ligands distributed over the entire corneocyte surface.

90 Corneocytes swell uniformly with the exception of the ou

91 yer is a compacted lattice of lipid-embedded corneocytes that provides an organism's barrier to the e

92 comparable with the thickness of a layer of corneocytes, this technique can be used to follow the di

93 enhancing its partitioning into keratin-rich corneocytes through concurrent binding of SPP with kerat

94 er, although increased fragility of isolated corneocytes was demonstrated.

95 IR and Raman spectral quality of individual corneocytes was high and revealed depth-dependent variat

96 Corneocytes were also labeled with an anti-corneodesmosi

97 hibitor Z-VAD-FMK delayed cornification, and corneocytes were structurally aberrant in Casp14(-/-) mi

98 e lipid multilamellae region surrounding the corneocytes within the stratum corneum.