ライフサイエンスコーパス: corneum

1 he uppermost layer of the epidermis (stratum corneum).

2 ar to be free to act only within the stratum corneum.

3 se approximately 50% of the lipid in stratum corneum.

4 , an integral lipid component of the stratum corneum.

5 ound to a thiol-rich band within the stratum corneum.

6 lete absence of a granular layer and stratum corneum.

7 e 5-fold thickening of the Abca12-/- stratum corneum.

8 m granulosum, and a non-keratinizing stratum corneum.

9 corneocytes in the outer layer, the stratum corneum.

10 rupted, producing a poorly developed stratum corneum.

11 stages: spinous, granular layer, and stratum corneum.

12 ustain 0.6N that is enough to pierce stratum corneum.

13 se agents on the lipid matrix of the stratum corneum.

14 ch microabscesses formed beneath the stratum corneum.

15 nd in the intercellular space of the stratum corneum.

16 f abundant lipase activity in asebia stratum corneum.

17 that previously recorded from intact stratum corneum.

18 overy of the barrier function of the stratum corneum.

19 that can rival the volume of the dry stratum corneum.

20 arrier of cornified cell layers, the stratum corneum.

21 filaggrin-processing products in the stratum corneum.

22 corneum was 85% lower than in normal stratum corneum.

23 ly disrupt the lipid bilayers of the stratum corneum.

24 layers of the epidermis, beneath the stratum corneum.

25 acidic to neutral regions within the stratum corneum.

26 anulosum, and declining again in the stratum corneum.

27 t aggregate keratin filaments in the stratum corneum.

28 then over a few days migrated to the stratum corneum.

29 ccumulation of lipid droplets in the stratum corneum.

30 niformly, but not corneocytes in the stratum corneum.

31 er, by altering the structure of the stratum corneum.

32 tration efficacy of the nanogel into stratum corneum.

33 ter way to deliver siRNAs across the stratum corneum.

34 effectively permeate through intact stratum corneum.

35 tributed into, or on the top of, the stratum corneum.

36 lts in increased water loss from the stratum corneum.

37 the intracellular components of the stratum corneum.

38 y the heterogeneous structure of the stratum corneum.

39 uctures could be elucidated in human stratum corneum.

40 ular space of the corneocytes in mid-stratum corneum (25 microm diameter) approaches neutrality (aver

41 n grafting experiments confirmed the stratum corneum abnormalities and normal BrdU uptake.

42 The data definitively show that the stratum corneum acid mantle results from the presence of aqueous

43 ventions with partial removal of the stratum corneum after curettage and microdermabrasion and simila

44 imated saturation doses in the upper stratum corneum allows one to distinguish between diffusion-limi

45 Such barrier function of the stratum corneum also hampers the use of common adjuvants used to

46 After minimal injury to the stratum corneum alterations in the calcium concentration in the

47 ween a macroscopic sample of porcine stratum corneum and an adherent deformable elastomer substrate.

48 rome, which causes detachment of the stratum corneum and chronic inflammation.

49 effectively carry siRNA through the stratum corneum and deposit it at the lower epidermis/upper derm

50 The stratum corneum and DNA repair do not completely protect keratin

51 ow permeability of siRNA through the stratum corneum and epidermis has significantly limited its use

52 as been shown to efficiently disrupt stratum corneum and facilitate transcutaneous drug delivery, but

53 munostaining was associated with the stratum corneum and fluorescein isothiocyanate-labeled oligonucl

54 ubstitute was healed by day 3, and a stratum corneum and fully stratified epithelium were re-establis

55 pple-like pattern in the junction of stratum corneum and granular layers.

56 th SRB and RBHE penetrate beyond the stratum corneum and into the viable epidermis only in discrete r

57 Mutant mice exhibit fragile stratum corneum and perinatal death due to dehydration.

58 the physical barrier function of the stratum corneum and provide innate cutaneous host defense.

59 anionic molecules must penetrate the stratum corneum and reach the living epidermis and dermis.

60 ornified envelope) is present in the stratum corneum and retains the ability to form covalent inhibit

61 erved deficit in the adhesion of the stratum corneum and the severely compromised epidermal barrier f

62 oneedles, providing microporation of stratum corneum and therefore enhancement of topical drug delive

63 ies in both skin barrier structures (stratum corneum and tight junctions), a robust T(H)2 response to

64 system that can permeate through the stratum corneum and viable epidermis and efficiently deposit the

65 ccumulation of lipid droplets in the stratum corneum, and a water barrier defect.

66 intercellular lipid lamellae in the stratum corneum, and aberrant keratinocyte differentiation.

67 ("cisternae") present throughout the stratum corneum, and at 24 h these cisternae substantially incre

68 ssion, microjet penetration into the stratum corneum, and impact of microjet on the stratum corneum a

69 ctivity, prevented detachment of the stratum corneum, and improved the barrier function of the epider

70 mal changes, primarily involving the stratum corneum, and increased epidermal thickness were mainly p

71 gh the external barrier of the skin, stratum corneum, and secure exposure to the viable skin layers.

72 rneum, and impact of microjet on the stratum corneum are considered.

73 is in Drosophila (cuticle) and mice (stratum corneum) are structurally unrelated.

74 he polymer matrix, breach the skin's stratum corneum barrier and dissolve upon contact with skin inte

75 eolytic cascade that is required for stratum corneum barrier functionality.

76 o their ability to bypass the skin's stratum corneum barrier in a minimally-invasive fashion and achi

77 work, that deliver the precursors of stratum corneum barrier lipids to the extracellular compartment.

78 e and shown to penetrate through the stratum corneum barrier when topically applied to mouse skin.

79 w that on breakdown of the epidermal stratum corneum barrier, type 2 and type 17 inflammatory respons

80 differentiation to form an effective stratum corneum barrier.

81 mouse skin on breakdown of epidermal stratum corneum barrier.

82 nction is compromised because of the stratum corneum becoming spontaneously detached in the newborn m

83 rease in the free thiol layer in the stratum corneum, but not in the nucleated epidermis.

84 er and thinning of the epidermis and stratum corneum by 50%.

85 diffusivities of these compounds in stratum corneum by factors ranging from 250 to over 2000.

86 d to the extracellular spaces of the stratum corneum by the secretion of lamellar bodies.

87 Disruption of the stratum corneum, by acetone application on the skin of hairless

88 Physical disruption of the stratum corneum can improve the efficiency of delivery.

89 glands, since increased hydration in stratum corneum causes it to become softer.

90 tum corneum swelling, and identifies stratum corneum cell layers that swell less.

91 Both the number of stratum corneum cell layers was reduced and the processing of th

92 caused striking malformations of the stratum corneum, characterized by dysmorphic and pleomorphic cor

93 In the normal epidermis, the stratum corneum chymotryptic enzyme (SCCE) thought to play a cen

94 mes are potential substrates for the stratum corneum chymotryptic enzyme (SCCE), protein extracts fro

95 ptic enzyme (SCTE, kallikrein 5) and stratum corneum chymotryptic protease (SCCE, kallikrein 7) were

96 es permeability barrier homeostasis, stratum corneum cohesion, wound healing, and epidermal innate im

97 Ceramides in mammalian stratum corneum comprise a heterogeneous mixture of molecular sp

98 Stratum corneum comprises corneocytes, derived from outer stratu

99 t allergy, nickel sensitization, and stratum corneum defects.

100 d, following penetration through the stratum corneum, depleted thiols in the viable epidermis.

101 ornified envelope morphogenesis, and stratum corneum desquamation.

102 peptidases that are associated with stratum corneum detachment was either low or undetectable, but t

103 lays a physiologic role during fetal stratum corneum development.

104 ovides free amino acids in the outer stratum corneum, did not account for the relative humidity depen

105 ed that a well-tolerated regimen for stratum corneum disruption before vaccine patch application resu

106 d immunity and that the magnitude of stratum corneum disruption correlates with the immune response.

107 These rhythms persist during stratum corneum disruption with and without CS application.

108 -effects is related to the degree of stratum corneum disruption.

109 kin, moved through the extracellular stratum corneum domains.

110 uamation by cleaving proteins of the stratum corneum (e.g., corneodesmosin and plakoglobin).

111 Injury to the stratum corneum elicits an epidermal hyperproliferative response

112 d in culture media and extracts from stratum corneum, epidermis and dermis after 24h, and the results

113 Even though stratum corneum exhibits structural features across multiple len

114 oncept is probed using excised human stratum corneum exposed to aqueous solutions of radiolabeled sod

115 the in vivo swelling behavior of the stratum corneum: exposure to water for 4 or 24 h results in a 3-

116 The stratum corneum extracellular matrix (ECM) is enriched in lipids

117 epidermis, including defects of the stratum corneum, extracellular lipid composition and cell adhesi

118 that psoriasin, purified from human stratum corneum extracts, selectively kills Escherichia coli by

119 epidermal thickness, contributes to stratum corneum formation and may eliminate pre-malignant cells.

120 AR-alpha-/- mice we observed delayed stratum corneum formation between day 18.5 of gestation and birt

121 t both epidermal differentiation and stratum corneum formation in utero are stimulated by pharmacolog

122 ole in epidermal differentiation and stratum corneum formation in utero.

123 -specific polyprotein, profilaggrin, stratum corneum formation, and acquisition of epidermal barrier

124 is required for epidermal turnover, stratum corneum formation, and removal of ultraviolet-damaged pr

125 g filaggrin, a protein essential for stratum corneum formation, these data point to an innate epiderm

126 /-) mice with striking impairment of stratum corneum formation.

127 ferentiation protein expression, and stratum corneum formation.

128 Serum antibody reactive with human stratum corneum found in patients with psoriatic arthritis was s

129 rin were quantified in tape-stripped stratum corneum from 31 atopic dermatitis patients and urocanic

130 bers of bacteria which penetrate the stratum corneum from everyday activities.

131 nocyte SerpinB2 is protection of the stratum corneum from proteolysis via inhibition of urokinase, th

132 orneum neutralization alone provokes stratum corneum functional abnormalities, including aberrant per

133 ecretion of lamellar bodies into the stratum corneum, glucosylceramides are metabolized to ceramides,

134 n-like serine protease (TLSP) in the stratum corneum, have been implicated in the pathogenesis of ros

135 lar metabolites, which contribute to stratum corneum hydration and pH.

136 sessed here whether sebum influences stratum corneum hydration or permeability barrier function in as

137 riglycerides) did not restore normal stratum corneum hydration to asebia skin, topical glycerol, the

138 triglyceride in sebaceous glands for stratum corneum hydration was demonstrated further by (i) the ab

139 ysis in sebaceous glands, normalized stratum corneum hydration, and the glycerol content of asebia st

140 , inflammation, and decreased (>50%) stratum corneum hydration, associated with a reduction in sebace

141 lity barrier homeostasis and reduced stratum corneum hydration, we hypothesized here that epidermal d

142 d glycerol is a major contributor to stratum corneum hydration.

143 and uncharged, partition into human stratum corneum immersed in aqueous solutions to an extent compa

144 risscross the cornified cells of the stratum corneum imparting structural integrity, and defects in f

145 ed glycerol content in epidermis and stratum corneum in AQP3-knockout mice, and correction of the phe

146 water loss, increased overt loss of stratum corneum in inflammatory lesions, and impaired stratum co

147 have been shown to permeabilize the stratum corneum in vivo and facilitate the transport of macromol

148 The average pH of the stratum corneum increases with depth because of a decrease in th

149 ontrast to BMV, restores compromised stratum corneum integrity and barrier function.

150 ty barrier homeostasis and decreased stratum corneum integrity/cohesion, as well as the mechanisms re

151 us permeability barrier function and stratum corneum integrity/cohesion, as well as the responsible m

152 permeability barrier homeostasis and stratum corneum integrity/cohesion, but these approaches all int

153 ties in both barrier homeostasis and stratum corneum integrity/cohesion.

154 bitors with the superbase normalized stratum corneum integrity/cohesion.

155 Three modes of bubble-stratum corneum interactions including shock wave emission, micr

156 ure leads to extensive disruption of stratum corneum intercellular lipid lamellae.

157 ptive effect of overhydration on the stratum corneum intercellular space, identifies large and numero

158 ong signal at the stratum granulosum/stratum corneum interface.

159 content marker, acid lipase, to the stratum corneum interstices.

160 Keratinization of the stratum corneum involves a highly choreographed sequence of even

161 fter tape-stripping, indicating that stratum corneum is a major source of UVA-induced oxidative stres

162 The study suggests the stratum corneum is a more chaotic structure than previously envi

163 ding of the mechanical properties of stratum corneum is based on the assumption that its thickness an

164 pth of the evanescent field into the stratum corneum is comparable with the thickness of a layer of c

165 The stratum corneum is composed of protein-enriched corneocytes embe

166 een the follicle and the surrounding stratum corneum is involved.

167 pic brick-and-mortar geometry of the stratum corneum is obtained using the commercial finite element

168 The barrier function of the stratum corneum is provided by patterned lipid lamellae localize

169 The permeabilization of the stratum corneum is transient and its barrier function recovers.

170 The skin barrier (stratum corneum) is a major factor for determining the nature of

171 the viable epidermis, underlying the stratum corneum, is included as a potentially important contribu

172 e activity at the stratum granulosum-stratum corneum junction and a modest decrease in both involucri

173 expression at the stratum granulosum/stratum corneum junction.

174 of terminal differentiation markers (stratum corneum, K10, and loricrin).

175 The stratum corneum layer and Ki67 in keratinocytes of the epidermis

176 he lack of restoration of functional stratum corneum layers observed after BM treatment.

177 ion of the lacunar spaces within the stratum corneum leading to the formation of transient channels.

178 tural analyses demonstrated abnormal stratum corneum lipid architecture in AD and IV HEEs, independen

179 ion of the lacunar spaces within the stratum corneum lipid bilayers but no changes in the organizatio

180 tions of cavitation bubbles with the stratum corneum lipid bilayers.

181 ely drive both the generation of the stratum corneum lipid-enriched extracellular matrix and the tran

182 l dermal absorption models treat the stratum corneum lipids as a homogenous medium through which solu

183 lar distribution patterns within the stratum corneum lipids as observed in experimental data.

184 udies demonstrate unequivocally that stratum corneum neutralization alone provokes stratum corneum fu

185 To study the consequences of stratum corneum neutralization, independent of hydration, we app

186 es in skin properties and CCBAs from stratum corneum of healthy human subjects, providing a means to

187 ort and distribution of water of the stratum corneum of infants and compare it to those of adults.

188 he results suggest that although the stratum corneum of infants may appear intact shortly after birth

189 The stratum corneum of lesional but also clinically unaffected skin

190 both interfollicular and follicular stratum corneum of lesional KP, which correlated ultrastructural

191 tratum basale, stratum spinosum, and stratum corneum of lesions from the transgenic mice using PALM m

192 mised chelation of the metals in the stratum corneum of patients with atopic dermatitis.

193 phylococcus aureus spreads under the stratum corneum of skin by elaboration of exfoliative toxin, whi

194 notable topographical changes in the stratum corneum of skin permeated with CYnLIP that were absent i

195 is a major structural protein in the stratum corneum of the epidermis.

196 by their poor permeation across the stratum corneum of the skin and low penetration into the skin's

197 the transport barriers posed by the stratum corneum of the skin and the biofilm.

198 ions made between the keratin of the stratum corneum of the skin and the glass surface.

199 pact of the complex structure of the stratum corneum on transdermal penetration is not yet fully desc

200 hat it shrunk the corneocytes in the stratum corneum (p<0.001) and the imaging of the skin hair folli

201 ntegrity and barrier function of the stratum corneum, particularly during times of skin inflammation.

202 down, attributed to the elevation of stratum corneum pH.

203 H dependent over the pH range of the stratum corneum (pH 4.5 to pH 7.2).

204 vertical diffusion holder, with the stratum corneum placed between two electrode-containing chambers

205 The lipid matrix of the skin's stratum corneum plays a key role in the barrier function, which

206 or in the protein components of the stratum corneum produce scaly or ichthyotic skin with abnormal b

207 In the stratum corneum proteases degrade the inhibitor, freeing the RNa

208 correlated with the denaturation of stratum corneum proteins, making it feasible to use protein conf

209 ns multiple conserved genes encoding stratum-corneum proteins.

210 rs of these specialized cells in the stratum corneum provide a tough and resilient framework for the

211 The origin of the acidic pH of the stratum corneum remains conjectural, however.

212 The stratum corneum resistance was measured using a vertical diffusi

213 Since stratum corneum (SC) acidification in adults is required for nor

214 l endogenous pathway responsible for stratum corneum (SC) acidification.

215 ths) are linked instead to defective stratum corneum (SC) acidity.

216 Neutralization of stratum corneum (SC) adversely impacts key epidermal functions,

217 d by their low absorption across the stratum corneum (SC) and into viable cells of skin.

218 s often dependent upon breaching the stratum corneum (SC) and targeting cells within defined layers o

219 Stratum corneum (SC) and viable epidermal thickness measured wit

220 ts has been proposed on the basis of stratum corneum (SC) architecture, proliferation kinetics, melan

221 mality was associated with decreased stratum corneum (SC) ceramide content and impaired lamellar body

222 At birth, human stratum corneum (SC) displays a near-neutral surface pH, which d

223 we assessed epidermal structure and stratum corneum (SC) function in a previously genotyped human lo

224 ed the mechanisms by which PS alters stratum corneum (SC) function.

225 rter aquaporin-3 (AQP3) have reduced stratum corneum (SC) hydration and skin elasticity, and impaired

226 We studied the role of AQP3 in stratum corneum (SC) hydration by comparative measurements in wi

227 Although stratum corneum (SC) hydration has been primarily of concern to

228 imately 2-fold, suggesting defective stratum corneum (SC) hydration.

229 al permeability barrier function and stratum corneum (SC) integrity were abnormal, but barrier recove

230 nonlamellar phase separation in the stratum corneum (SC) interstices, explaining the barrier abnorma

231 The stratum corneum (SC) is an effective permeability barrier.

232 ty and spatial distribution of human stratum corneum (SC) lipids from samples collected in vivo.

233 in (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) component

234 The reduced pH of the stratum corneum (SC) of darkly pigmented skin could account for

235 ant lacunae of unprocessed lipids in stratum corneum (SC) of FAK(K5 KO) mice and delayed barrier reco

236 ecently that short-term increases in stratum corneum (SC) pH are accompanied by minor alterations in

237 At birth, neonatal stratum corneum (SC) pH is close to neutral but acidifies with m

238 es in epidermal function, we studied stratum corneum (SC) pH, permeability barrier homeostasis, and S

239 ive, but the barrier of skin's outer stratum corneum (SC) prevents delivery of most drugs.

240 rmalities were not evident, and both stratum corneum (SC) skin hydration and surface pH were normal.

241 We collected stratum corneum (SC) specimens from the volar forearms of 10 CSU

242 utermost layer of the epidermis, the stratum corneum (SC), are not understood.

243 l details of epidermis, specifically stratum corneum (SC), during sonophoresis are beyond the resolut

244 The outermost epidermal layer, the stratum corneum (SC), exhibits an acidic surface pH, whereas the

245 In neonatal rat stratum corneum (SC), pH declines from pH 6.8 at birth to adult

246 termost region of the epidermis, the stratum corneum (SC), provides an essential barrier to water los

247 s fifth stripping ("outer" vs. "mid"-stratum corneum (SC), respectively) from nine normal adult forea

248 Intercellular lipids of the stratum corneum (SC), the outer layer of the epidermis, form a b

249 on the outermost layer of skin, the stratum corneum (SC), using polarization transfer solid-state NM

250 f epidermal ontogenesis is to form a stratum corneum (SC), which is required for post-natal permeabil

251 0-5.5) over 5-6 days in neonatal rat stratum corneum (SC).

252 utermost layer of the epidermis, the stratum corneum (SC).

253 ng from serine proteases (SP) in the stratum corneum (SC).

254 eous functions largely reside in the stratum corneum (SC).

255 spanned the entire thickness of the stratum corneum (SC).

256 bnormally-compacted outer epidermis [stratum corneum (SC)], while electron microscopy revealed defici

257 ost skin barrier (referred to as the stratum corneum, SC) and subsequent catalytic generation of O2 b

258 rcellular lipid matrix of the skin's stratum corneum serves to protect the body against desiccation a

259 The stratum corneum showed parakeratotsis.

260 Ultrastructure of the stratum corneum showed premature loss of cohesion of corneocytes

261 the secreted lamellar bodies at the stratum corneum-stratum granulosum boundary.

262 nical effects of these events on the stratum corneum structure, the relationship between the number o

263 ng permeability barrier homeostasis, stratum corneum surface pH, and water-holding capacity, and resp

264 e acquired every 1.7 microm from the stratum corneum surface to the first viable layer (stratum granu

265 structures, defines the magnitude of stratum corneum swelling, and identifies stratum corneum cell la

266 oduce the protective, semi-permeable stratum corneum that permits terrestrial life.

267 ally reduced drug diffusivity in the stratum corneum (the outermost epidermal layer), dominant at sho

268 onding to a depth of 2-3 mum, of the stratum corneum (the outermost, 15-20 mum skin layer).

269 allow S. aureus to spread under the stratum corneum, the main barrier of the skin, explaining how, a

270 ffectively deliver siRNA through the stratum corneum, the major challenge is that this approach is pa

271 Stratum corneum, the outermost layer of skin, allows transport o

272 ction of the skin is mediated by the stratum corneum, the outermost layer of the skin, which is the e

273 We study the drying of stratum corneum, the skin's outermost layer and an essential bar

274 oids cause dyshesion and thinning of stratum corneum, thereby reducing hyperkeratosis that likely und

275 n inflammatory lesions, and impaired stratum corneum thickening after phorbol ester treatment.

276 (filaggrin and loricrin), increased stratum corneum thickness, and significantly reduced T-cell infi

277 s in a 3- or 4-fold expansion of the stratum corneum thickness, respectively.

278 arger values consistently for infant stratum corneum throughout the first year of life and showed gre

279 reacts with amino acids in the outer stratum corneum to form a mixture of high molecular weight pigme

280 Both exposure of stratum corneum to neutral pH buffers and blockade of acidificat

281 ality associated with an increase in stratum corneum tryptic enzyme (SCTE) in the epidermis.

282 lot, and siRNA, the serine proteases stratum corneum tryptic enzyme (SCTE, kallikrein 5) and stratum

283 Located in the stratum corneum, urocanic acid is a major epidermal chromophore

284 r effects to skin's barrier layer of stratum corneum using microneedles, thermal ablation, microderma

285 , and the glycerol content of asebia stratum corneum was 85% lower than in normal stratum corneum.

286 The interaction of water with the stratum corneum was assessed by measuring capacitance, transepid

287 e skin barrier was defective and the stratum corneum was detached through desmosomal cleavage.

288 In the current study, the stratum corneum was disrupted using an electrocardiogram prep pa

289 e content of both asebia and control stratum corneum was low, consistent with high rates of triglycer

290 indicating that the structure of the stratum corneum was not a major factor.

291 AQP3-knockout mice have reduced stratum corneum water content and elasticity compared with wild-

292 in the extracellular matrix of skin stratum corneum, were analyzed by X-ray diffraction methods.

293 limited solute diffusion through the stratum corneum, where the lipid structure is represented by a l

294 thin the extracellular matrix of the stratum corneum, whereas the intracellular space of the corneocy

295 al epithelium leading to a defective stratum corneum, which allows enhanced allergen penetration and

296 ation is the barrier function of the stratum corneum, which must be overcome either by abrasive metho

297 of ultra long-chain ceramides in the stratum corneum, which play a key role in maintaining the permea

298 aled hyperkeratosis and a disordered stratum corneum with an accumulation of neutral lipid droplets;

299 a pathogen that is restricted to the stratum corneum, with little or no tissue reaction.

300 kin barrier function and a defective stratum corneum, with SerpinB2(-/-) mice showing increased trans

301 n water, facilitate adherence to the stratum corneum without subsequent intra-epidermal or follicular