ライフサイエンスコーパス: cornified envelope

1 that TGX contributes to the formation of the cornified envelope.

2 responsible for assembly of the keratinocyte cornified envelope.

3 and that FATP4 functions in establishing the cornified envelope.

4 ier structure on their periphery, termed the cornified envelope.

5 nocyte and critical for the formation of the cornified envelope.

6 ent proteins leading to the formation of the cornified envelope.

7 he late marker, loricrin, a component of the cornified envelope.

8 tuents of both keratohyalin granules and the cornified envelope.

9 junctions and terminally differentiate into cornified envelopes.

10 erentiation, as measured by the formation of cornified envelopes.

11 ced lower levels of cross-linked protein and cornified envelopes.

12 ycle, stratification, and even production of cornified envelopes.

13 reduced mechanical strength detected in the cornified envelopes.

14 inal differentiation markers and assembly of cornified envelopes.

15 in knockout mouse skin and confirm that late cornified envelope 1 genes are transcriptional targets o

16 We also demonstrate that late cornified envelope 1 genes are upregulated at the transc

17 we present evidence suggesting that the late cornified envelope 1 proteins are also compensatory comp

18 cross-linked keratin filaments enclosed in a cornified envelope [1].

19 gulating the expression of genes of the late cornified envelope-1 (Lce1) family involved in epidermal

20 n barrier, which is normally imparted by the cornified envelope, a composite of protein and lipid tha

21 res are selectively perturbed, including the cornified envelope, a likely scaffold for lipid organiza

22 oteins are cross-linked together to form the cornified envelope, an essential and discrete unit of th

23 ly during fetal days E15.5 to E16.5, and the cornified envelope and desmosomes in the newborn mice we

24 NIKS keratinocytes produce similar levels of cornified envelopes and nucleosomal fragmentation in res

25 rkedly increased the number of cells forming cornified envelopes and the number of cells staining wit

26 y being structural protein precursors of the cornified envelope) and the other 13 belong to the S100

27 (LBs) and LB secretion, thinner lipid-bound cornified envelopes, and a defective permeability barrie

28 dermal differentiation, leading to thickened cornified envelopes; and (ii) enhanced epidermal lipid s

29 The third wave contains components of the cornified envelope, as keratinocytes enhance the epiderm

30 eability assays to show that final stages of cornified envelope assembly are coordinated with initial

31 d in CNBr extracts of purified keratinocytes cornified envelopes by western blot.

32 h loricrin is the predominant protein of the cornified envelope (CE) in keratinocytes, loss or gain o

33 The cornified envelope (CE) is an insoluble sheath of epsilo

34 Cornified envelope (CE) precursor protein expression and

35 Real-time PCR evaluated the expression of cornified envelope (CE) precursor proteins (involucrin a

36 t S100A11 is a component of the keratinocyte cornified envelope (CE) suggests that S100A11 is a trans

37 cross-linked in an orderly fashion to form a cornified envelope (CE).

38 epidermis, disturbed cornification, fragile cornified envelope (CE, a skin barrier structure), and i

39 Comparative proteomics of cornified envelopes (CEs) from prenatal KtyI(-/-) and Kt

40 tain keratin filaments bound to a peripheral cornified envelope composed of cross-linked proteins.

41 Sciellin, a precursor of the cornified envelope, contains a LIM domain that is known

42 than to corneocyte fragility or an abnormal cornified envelope/cornified-bound lipid envelope scaffo

43 This directly affects cornified envelope cross-linking rather than corneodesmo

44 al proteins involved in the formation of the cornified envelope during squamous cell differentiation.

45 responsible for assembly of the keratinocyte cornified envelope during terminal keratinocyte differen

46 Cornified envelopes form but are ultrastructurally abnor

47 Ca2+-induced differentiation, as assessed by cornified envelope formation or transglutaminase activit

48 f the TIG3-positive cells and the effects on cornified envelope formation suggest that TIG3 is an act

49 The rate of cornified envelope formation was increased 3-fold in ker

50 t, corneocyte-bound lipid envelopes, whereas cornified envelope formation was unchanged.

51 Rates of cornified envelope formation, a marker of keratinocyte t

52 Rates of cornified envelope formation, an indicator of terminal d

53 and mRNA levels of two proteins required for cornified envelope formation, involucrin (INV) and trans

54 ression of structural proteins necessary for cornified envelope formation, involucrin, loricrin, and

55 ed in SCC 12F cells, including inhibition of cornified envelope formation, reduction of involucrin mR

56 ikely to have a similar functional effect on cornified envelope formation, with disturbance of transg

57 nced transglutaminase activity and excessive cornified envelope formation.

58 possible link between connexin function and cornified envelope formation.

59 cessation of cell proliferation and enhanced cornified envelope formation.

60 bstrates, the small proline-rich proteins of cornified envelopes found in stratified squamous epithel

61 mal skin barrier requires the formation of a cornified envelope from terminally differentiating kerat

62 e-rich (Sprr2) protein, a major component of cornified envelopes in keratinized epidermis, were subst

63 The cornified envelope is a layer of transglutaminase cross-

64 The cornified envelope is assembled from transglutaminase cr

65 art of the scaffold onto which the epidermal cornified envelope is assembled.

66 ins may provide a scaffolding onto which the cornified envelope is assembled.

67 ggested that SerpinB2 (cross-linked into the cornified envelope) is present in the stratum corneum an

68 own that cyanogen bromide (CNBr) cleavage of cornified envelopes isolated from cultured foreskin kera

69 The late cornified envelope (LCE) gene cluster within the epiderm

70 Deletion of late cornified envelope (LCE) genes LCE3B and LCE3C (LCE3B/C-

71 Late cornified envelope (LCE) genes, located in the epidermal

72 uclear shrinkage, and increased formation of cornified envelope-like structures.

73 tase/MT-SP1 perturbs lipid matrix formation, cornified envelope morphogenesis, and stratum corneum de

74 n and infection is bacterial adhesion to the cornified envelope of corneocytes in the outer layer, th

75 proteins that becomes incorporated into the cornified envelope of cultured epidermal keratinocytes,

76 of periplakin, and is incorporated into the cornified envelope of cultured keratinocytes.

77 Involucrin is a protein that makes up the cornified envelope of keratinocytes and is expressed in

78 Involucrin is a major protein of the cornified envelope of keratinocytes that provides much o

79 Involucrin is a major protein of the cornified envelope of keratinocytes that provides much o

80 Sciellin is a precursor of the cornified envelope of mammalian stratified epithelia cha

81 Sciellin is a precursor of the cornified envelopes of mammalian keratinizing tissues.

82 on microscopy showed no defect in either the cornified envelope or the adjacent cornified-bound lipid

83 hornerin [hrn] and filaggrin 2 [flg-2]); the cornified envelope precursor (ie, SPRR3); mattrin, which

84 kers K1 and K10 and the cross-linking of the cornified envelope precursor protein involucrin.

85 xamine the intracellular distribution of the cornified envelope precursor S100A11 (S100C) and the eff

86 affinity column made with an antibody to the cornified envelope precursor sciellin.

87 Involucrin, a cornified envelope precursor, and the cross-linking enzy

88 ), functions as a transglutaminase substrate/cornified envelope precursor, signal transduction protei

89 imulates ocular surface epithelia to produce cornified envelope precursors and the tissue transglutam

90 ne repeat organization is unique among other cornified envelope precursors characterized by homologou

91 Several cytoplasmic cornified envelope precursors have been described.

92 to evaluate the presence and distribution of cornified envelope precursors in human corneal epitheliu

93 cal epithelia expressing increased levels of cornified envelope precursors.

94 Desquamation of and cornified envelope protein (involucrin and small proline

95 ing insertional mutants of Loricrin, a major cornified envelope protein of the epidermis, suggest a p

96 The cornified envelope protein small proline-rich protein 1B

97 pidermal keratins was unchanged, whereas the cornified envelope proteins involucrin and loricrin were

98 Levels of cornified envelope proteins mRNA were measured by real-t

99 Thus, combined loss of the cornified envelope proteins not only impairs the epiderm

100 on, we identified three transcripts encoding cornified envelope proteins with altered expression in t

101 eramides covalently linked by ester bonds to cornified envelope proteins, most abundantly to involucr

102 cal desquamation and increased expression of cornified envelope proteins.

103 uman SPRR1 gene and other genes encoding for cornified envelope proteins.

104 e loss of loricrin, a major component of the cornified envelope, results in a delay of epidermal barr

105 ation of the epidermis and the production of cornified envelopes, structures essential for barrier ac

106 ant structural component of the keratinocyte cornified envelope that is expressed early in the kerati

107 in (hINV) is a precursor of the keratinocyte cornified envelope that is specifically expressed in the

108 diate filaments and is cross-linked into the cornified envelope to form the epidermal barrier.

109 Involucrin is an integral component of the cornified envelope which is a characteristic feature of

110 s peptide from recombinant hINV and from the cornified envelopes yields the sequence G-Q-L-K-H-L-E-Q-