ライフサイエンスコーパス: cornify

1 In Mode 3A, keratinocytes cornified and flaked off to free skin appendages (feathe

2 The eye surface, lacking the cornified barrier of skin, provides an excellent model.

3 fragility or an abnormal cornified envelope/cornified-bound lipid envelope scaffold, a defect that c

4 ither the cornified envelope or the adjacent cornified-bound lipid envelope, i.e., a corneocyte scaff

5 The epidermal cornified cell envelope (CE) is a complex protein-lipid

6 The cornified cell envelope (CE) is a specialized structure

7 ied as a likely constituent of the insoluble cornified cell envelope (CE) of stratified squamous epit

8 ester linkages to undefined proteins of the cornified cell envelope (CE).

9 al compelling lines of evidence point to the cornified cell envelope and structural components of the

10 inocytes, where they serve as a scaffold for cornified cell envelope assembly.

11 The major protein component of the cornified cell envelope barrier structure of the epiderm

12 l involucrin biotinylation and the increased cornified cell envelope formation provided evidence that

13 isclose novel insights into perturbations of cornified cell envelope formation.

14 keratinocyte transglutaminase activities and cornified cell envelope formation.

15 akin may not relate to the physiology of the cornified cell envelope in epidermal keratinocytes but m

16 1) enzyme is involved in the formation of a cornified cell envelope in terminally differentiating ep

17 e, which is critical for the assembly of the cornified cell envelope in terminally differentiating ke

18 periplakin have been shown to be part of the cornified cell envelope in terminally differentiating st

19 a previously characterized component of the cornified cell envelope of stratified epithelia, where i

20 R) proteins are structural components of the cornified cell envelope of stratified squamous epithelia

21 ne-rich (SPR) proteins are components of the cornified cell envelope of stratified squamous epithelia

22 cross-bridging reinforcement protein of the cornified cell envelope of the inner root sheath cells b

23 Mutations in the cornified cell envelope protein loricrin have been repor

24 Loricrin is a major component of the cornified cell envelope, a highly insoluble structure co

25 The cornified cell envelope, a lipoprotein layer that assemb

26 ing keratin filaments, as a component of the cornified cell envelope, and as a source of natural mois

27 uctural proteins and in the formation of the cornified cell envelope, thereby contributing to rigid s

28 plakin, which is known as a precursor of the cornified cell envelope.

29 ns become sequentially incorporated into the cornified cell envelope.

30 cytes, but did not detect the protein in the cornified cell envelope.

31 l differentiation and incorporation into the cornified cell envelope.

32 ified as a putative precursor protein of the cornified cell envelope.

33 tin filaments, intercellular lipids, and the cornified cell envelope.

34 ross-linked to form a major component of the cornified cell envelope.

35 fferentiation of keratinocytes that form the cornified cell layer.

36 well-developed basal, spinous, granular, and cornified cell layers providing an excellent model to st

37 nsults by creating an impermeable barrier of cornified cell layers, the stratum corneum.

38 suggest a mechanism for the coordination of cornified cell structure by permanent covalent attachmen

39 optotic biochemical machinery to produce the cornified cell.

40 sitive cells in stratum granulosum and newly cornified cells by electron microscopy.

41 We determined the citrulline contents in the cornified cells of the epidermis of newborn rats, as wel

42 hly ordered macrofibrils that crisscross the cornified cells of the stratum corneum imparting structu

43 tal hyperkeratosis (abnormal accumulation of cornified cells) resulting from impaired desquamation.

44 When PAI-2, purified from human cornified cells, was added to synchronized keratinocytes

45 to the cell envelope and in the shape of the cornified cells.

46 ere surrounded by a thick, compact sheath of cornified cells.

47 t of mucin contents in the remaining ones by cornifying cells that block the egress of mucin contents

48 h loricrin is the predominant protein of the cornified envelope (CE) in keratinocytes, loss or gain o

49 The cornified envelope (CE) is an insoluble sheath of epsilo

50 Cornified envelope (CE) precursor protein expression and

51 Real-time PCR evaluated the expression of cornified envelope (CE) precursor proteins (involucrin a

52 t S100A11 is a component of the keratinocyte cornified envelope (CE) suggests that S100A11 is a trans

53 cross-linked in an orderly fashion to form a cornified envelope (CE).

54 epidermis, disturbed cornification, fragile cornified envelope (CE, a skin barrier structure), and i

55 The late cornified envelope (LCE) gene cluster within the epiderm

56 Deletion of late cornified envelope (LCE) genes LCE3B and LCE3C (LCE3B/C-

57 Late cornified envelope (LCE) genes, located in the epidermal

58 in knockout mouse skin and confirm that late cornified envelope 1 genes are transcriptional targets o

59 We also demonstrate that late cornified envelope 1 genes are upregulated at the transc

60 we present evidence suggesting that the late cornified envelope 1 proteins are also compensatory comp

61 cross-linked keratin filaments enclosed in a cornified envelope [1].

62 ly during fetal days E15.5 to E16.5, and the cornified envelope and desmosomes in the newborn mice we

63 eability assays to show that final stages of cornified envelope assembly are coordinated with initial

64 tain keratin filaments bound to a peripheral cornified envelope composed of cross-linked proteins.

65 This directly affects cornified envelope cross-linking rather than corneodesmo

66 al proteins involved in the formation of the cornified envelope during squamous cell differentiation.

67 responsible for assembly of the keratinocyte cornified envelope during terminal keratinocyte differen

68 Ca2+-induced differentiation, as assessed by cornified envelope formation or transglutaminase activit

69 f the TIG3-positive cells and the effects on cornified envelope formation suggest that TIG3 is an act

70 The rate of cornified envelope formation was increased 3-fold in ker

71 t, corneocyte-bound lipid envelopes, whereas cornified envelope formation was unchanged.

72 Rates of cornified envelope formation, a marker of keratinocyte t

73 Rates of cornified envelope formation, an indicator of terminal d

74 and mRNA levels of two proteins required for cornified envelope formation, involucrin (INV) and trans

75 ression of structural proteins necessary for cornified envelope formation, involucrin, loricrin, and

76 ed in SCC 12F cells, including inhibition of cornified envelope formation, reduction of involucrin mR

77 ikely to have a similar functional effect on cornified envelope formation, with disturbance of transg

78 possible link between connexin function and cornified envelope formation.

79 cessation of cell proliferation and enhanced cornified envelope formation.

80 nced transglutaminase activity and excessive cornified envelope formation.

81 mal skin barrier requires the formation of a cornified envelope from terminally differentiating kerat

82 The cornified envelope is a layer of transglutaminase cross-

83 The cornified envelope is assembled from transglutaminase cr

84 ins may provide a scaffolding onto which the cornified envelope is assembled.

85 art of the scaffold onto which the epidermal cornified envelope is assembled.

86 tase/MT-SP1 perturbs lipid matrix formation, cornified envelope morphogenesis, and stratum corneum de

87 n and infection is bacterial adhesion to the cornified envelope of corneocytes in the outer layer, th

88 proteins that becomes incorporated into the cornified envelope of cultured epidermal keratinocytes,

89 of periplakin, and is incorporated into the cornified envelope of cultured keratinocytes.

90 Involucrin is a protein that makes up the cornified envelope of keratinocytes and is expressed in

91 Involucrin is a major protein of the cornified envelope of keratinocytes that provides much o

92 Involucrin is a major protein of the cornified envelope of keratinocytes that provides much o

93 Sciellin is a precursor of the cornified envelope of mammalian stratified epithelia cha

94 on microscopy showed no defect in either the cornified envelope or the adjacent cornified-bound lipid

95 hornerin [hrn] and filaggrin 2 [flg-2]); the cornified envelope precursor (ie, SPRR3); mattrin, which

96 kers K1 and K10 and the cross-linking of the cornified envelope precursor protein involucrin.

97 xamine the intracellular distribution of the cornified envelope precursor S100A11 (S100C) and the eff

98 affinity column made with an antibody to the cornified envelope precursor sciellin.

99 Involucrin, a cornified envelope precursor, and the cross-linking enzy

100 ), functions as a transglutaminase substrate/cornified envelope precursor, signal transduction protei

101 imulates ocular surface epithelia to produce cornified envelope precursors and the tissue transglutam

102 ne repeat organization is unique among other cornified envelope precursors characterized by homologou

103 Several cytoplasmic cornified envelope precursors have been described.

104 to evaluate the presence and distribution of cornified envelope precursors in human corneal epitheliu

105 cal epithelia expressing increased levels of cornified envelope precursors.

106 Desquamation of and cornified envelope protein (involucrin and small proline

107 ing insertional mutants of Loricrin, a major cornified envelope protein of the epidermis, suggest a p

108 The cornified envelope protein small proline-rich protein 1B

109 pidermal keratins was unchanged, whereas the cornified envelope proteins involucrin and loricrin were

110 Levels of cornified envelope proteins mRNA were measured by real-t

111 Thus, combined loss of the cornified envelope proteins not only impairs the epiderm

112 on, we identified three transcripts encoding cornified envelope proteins with altered expression in t

113 eramides covalently linked by ester bonds to cornified envelope proteins, most abundantly to involucr

114 uman SPRR1 gene and other genes encoding for cornified envelope proteins.

115 cal desquamation and increased expression of cornified envelope proteins.

116 ant structural component of the keratinocyte cornified envelope that is expressed early in the kerati

117 in (hINV) is a precursor of the keratinocyte cornified envelope that is specifically expressed in the

118 diate filaments and is cross-linked into the cornified envelope to form the epidermal barrier.

119 Involucrin is an integral component of the cornified envelope which is a characteristic feature of

120 y being structural protein precursors of the cornified envelope) and the other 13 belong to the S100

121 ggested that SerpinB2 (cross-linked into the cornified envelope) is present in the stratum corneum an

122 n barrier, which is normally imparted by the cornified envelope, a composite of protein and lipid tha

123 res are selectively perturbed, including the cornified envelope, a likely scaffold for lipid organiza

124 oteins are cross-linked together to form the cornified envelope, an essential and discrete unit of th

125 The third wave contains components of the cornified envelope, as keratinocytes enhance the epiderm

126 Sciellin, a precursor of the cornified envelope, contains a LIM domain that is known

127 e loss of loricrin, a major component of the cornified envelope, results in a delay of epidermal barr

128 gulating the expression of genes of the late cornified envelope-1 (Lce1) family involved in epidermal

129 uclear shrinkage, and increased formation of cornified envelope-like structures.

130 he late marker, loricrin, a component of the cornified envelope.

131 tuents of both keratohyalin granules and the cornified envelope.

132 that TGX contributes to the formation of the cornified envelope.

133 responsible for assembly of the keratinocyte cornified envelope.

134 and that FATP4 functions in establishing the cornified envelope.

135 ier structure on their periphery, termed the cornified envelope.

136 nocyte and critical for the formation of the cornified envelope.

137 ent proteins leading to the formation of the cornified envelope.

138 than to corneocyte fragility or an abnormal cornified envelope/cornified-bound lipid envelope scaffo

139 Comparative proteomics of cornified envelopes (CEs) from prenatal KtyI(-/-) and Kt

140 NIKS keratinocytes produce similar levels of cornified envelopes and nucleosomal fragmentation in res

141 rkedly increased the number of cells forming cornified envelopes and the number of cells staining wit

142 d in CNBr extracts of purified keratinocytes cornified envelopes by western blot.

143 Cornified envelopes form but are ultrastructurally abnor

144 bstrates, the small proline-rich proteins of cornified envelopes found in stratified squamous epithel

145 e-rich (Sprr2) protein, a major component of cornified envelopes in keratinized epidermis, were subst

146 own that cyanogen bromide (CNBr) cleavage of cornified envelopes isolated from cultured foreskin kera

147 Sciellin is a precursor of the cornified envelopes of mammalian keratinizing tissues.

148 s peptide from recombinant hINV and from the cornified envelopes yields the sequence G-Q-L-K-H-L-E-Q-

149 (LBs) and LB secretion, thinner lipid-bound cornified envelopes, and a defective permeability barrie

150 ation of the epidermis and the production of cornified envelopes, structures essential for barrier ac

151 junctions and terminally differentiate into cornified envelopes.

152 erentiation, as measured by the formation of cornified envelopes.

153 ced lower levels of cross-linked protein and cornified envelopes.

154 ycle, stratification, and even production of cornified envelopes.

155 reduced mechanical strength detected in the cornified envelopes.

156 inal differentiation markers and assembly of cornified envelopes.

157 dermal differentiation, leading to thickened cornified envelopes; and (ii) enhanced epidermal lipid s

158 lieved necessary for normal formation of the cornified epidermal barrier.

159 d with the cell envelope at the periphery of cornified epidermal cells.

160 is confined to differentiating granular and cornified epidermal cells.

161 comes a part of the keratinized cells of the cornified epidermal layer.

162 organics represent condensed remains of the cornified epidermis and, likely also, deeper anatomical

163 cells undergo squamous differentiation into cornified (i.e., 1% SDS insoluble) envelopes and death i

164 nuclease Trex2 are expressed specifically in cornifying keratinocytes.

165 of epidermis (acanthosis), thickening of the cornified layer (hyperkeratosis), and increased vascular

166 e, due to a combination of thickening of the cornified layer and an increase in the production of non

167 The cornified layer is a compacted lattice of lipid-embedded

168 , in a patient's skin, its expression in the cornified layer was significantly decreased.

169 nd involucrin (EPI-/- mice)-have a defective cornified layer, reduced epidermal gammadelta T cells, a

170 nd involucrin-(EPI-/- mice) have a defective cornified layer, reduced epidermal gammadelta T cells, i

171 thout a reduction in non-polar lipids in the cornified layer, which has the potential to reduce scali

172 epidermis, and a mild hyperkeratosis in the cornified layer.

173 turation undergo enucleation to generate the cornified layer.

174 active state in the keratinized cells of the cornified layer.

175 comes a part of the keratinized cells of the cornified layer.

176 tinocyte transition from the granular to the cornified layer.

177 corneocytes, and a morphologically abnormal cornified layer.

178 sal region and a pronounced but disorganized cornified layer.

179 py showed marked thickening of the epidermal cornified layers and increased epidermal TUNEL staining,

180 loricrin staining is markedly reduced in the cornified layers and increased in the nucleus.

181 filaggrin, and filaggrin was absent from the cornified layers of ft/ft epidermis.

182 9C7 was abundantly expressed in granular and cornified layers of the epidermis.

183 accumulation of DNA fragments throughout the cornified layers of the tongue epithelium.

184 lated cultures also had reduced granular and cornified layers, and produced lower levels of cross-lin

185 exhibit nuclear staining of granular and/or cornified layers.

186 composed of the basal, spinous, granular and cornified layers.

187 ng multiple steps within both suprabasal and cornified layers.

188 ulation of DNA fragments in the cytoplasm of cornifying lingual keratinocytes and co-deletion of DNas

189 The shafts emerge from the follicle with cornified material still attached.

190 his essential epidermal barrier, composed of cornified proteins encased in lipids, prevents both wate

191 is expressed in the suprabasal layers of non-cornified stratified epithelia.

192 pole epidermis that functions in lieu of the cornified, stratified epithelium of the adult epidermis.

193 n an approximately 0.1-mm-thick layer in the cornified tips of the filiform (but not fungiform) papil