ライフサイエンスコーパス: coronavirus

1 rus with its counterpart from a heterologous coronavirus.

2 ected with severe acute respiratory syndrome coronavirus.

3 such as Marburg virus, Nipah virus, and SARS coronavirus.

4 so inhibits infection by an alphavirus and a coronavirus.

5 demonstrated in mice infected with a murine coronavirus.

6 que to the severe acute respiratory syndrome coronavirus.

7 to animal samples containing flavivirus and coronavirus.

8 ral nervous system-specific strain of murine coronavirus.

9 and functional links between roniviruses and coronaviruses.

10 d unique features in comparison with that of coronaviruses.

11 icit broadly neutralizing antibodies against coronaviruses.

12 of approved drugs for treatment of emerging coronaviruses.

13 torovirus, which is more closely related to coronaviruses.

14 omyxoviruses, flaviviruses, filoviruses, and coronaviruses.

15 tural domain and is also conserved among all coronaviruses.

16 s, henipaviruses, lyssaviruses, and zoonotic coronaviruses.

17 prevent epidemics from this and other human coronaviruses.

18 ng served as a model system for the study of coronaviruses.

19 o vaccines or effective antivirals for human coronaviruses.

20 Like the coronavirus 2'-O-MTase, the roniviral 2'-O-MTase harbors

21 e of many other viruses, including the human coronavirus 229E (hCoV-229E), and the genomes of many of

22 e respiratory syndrome coronavirus and human coronavirus 229E), Togaviridae (Venezuelan equine enceph

23 l virus, rhinoviruses, other picornaviruses, coronaviruses 229E and OC43, parainfluenza viruses 1-3,

24 naviridae (severe acute respiratory syndrome coronavirus and human coronavirus 229E), Togaviridae (Ve

25 illness in Saudi Arabia," and "novel (beta) coronavirus and human coronavirus Erasmus Medical Center

26 This research focuses on coronavirus and influenza A virus cell entry and identif

27 targets in patients infected with pathogenic coronavirus and perhaps other respiratory viruses.

28 influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia.

29 onavirus (MERS-CoV) belongs to beta group of coronavirus and was first discovered in 2012.

30 y transduce Middle-East respiratory syndrome coronavirus and Zaire Ebolavirus templates into glucose

31 nidovirus RNA capping and methylation beyond coronaviruses and also strengthen the evolutionary and f

32 ccines or effective antivirals against human coronaviruses and few against those infecting animals, i

33 ging disease preparedness, because non-human coronaviruses and paramyxoviruses have been listed as pr

34 ost protein synthesis is a common feature of coronaviruses and primarily serves to inhibit the antivi

35 s a glycosylated loop that is variable among coronaviruses and they define four conformational states

36 nza virus, severe acute respiratory syndrome coronavirus, and Middle East respiratory syndrome corona

37 onstrates the zoonotic potential of emerging coronaviruses, and there are currently no vaccines or ef

38 Middle East respiratory syndrome-associated coronavirus antagonize the oligoadenylate-RNase L (OAS-R

39 Hence, human coronaviruses antagonize the viral inhibitor p53 via sta

40 While coronavirus antigens that induce protective neutralizing

41 Coronaviruses are an important cause of human and veteri

42 SARS-CoV and MERS-CoV provides evidence that coronaviruses are currently spreading from zoonotic sour

43 To date, it is not clear why these avian coronaviruses are enteropathogenic, whereas other closel

44 s, respiratory syncytial viruses (RSVs), and coronaviruses are highly prevalent respiratory pathogens

45 Human coronaviruses are important zoonotic pathogens.

46 Coronaviruses are positive-sense RNA viruses that genera

47 Highly pathogenic coronaviruses are rare and appear to emerge and disappea

48 nation between distantly related African bat coronaviruses associated with Triaenops afer and Hipposi

49 ificant step forward in the understanding of coronavirus biology and closes a gap in the understandin

50 Highly pathogenic human respiratory coronaviruses cause acute lethal disease characterized b

51 The Middle East respiratory syndrome (MERS) coronavirus causes isolated cases and outbreaks of sever

52 diarrhea virus (PEDV) is an enteropathogenic coronavirus causing lethal watery diarrhea in piglets.

53 viruses, the results indicate that the WIV1-coronavirus (CoV) cluster has the ability to directly in

54 Human coronavirus (CoV) HKU1 is a pathogen causing acute respi

55 The Middle East respiratory syndrome (MERS) coronavirus (CoV) is an emerging CoV with a known zoonot

56 The coronavirus (CoV) nonstructural protein 14 (nsp14) is a

57 The coronavirus (CoV) S protein requires cleavage by host ce

58 n 2012, caused by a zoonotically transmitted coronavirus (CoV).

59 in the spike (S) glycoproteins of different coronaviruses (CoV) have not yet been determined.

60 Coronaviruses (CoVs) and low-pathogenicity influenza A v

61 Coronaviruses (CoVs) are a major infectious disease thre

62 Coronaviruses (CoVs) are positive-sense RNA viruses that

63 Coronaviruses (CoVs) are the only known RNA viruses to e

64 Coronaviruses (CoVs) assemble by budding into the lumen

65 Coronaviruses (CoVs) can cause highly prevalent diseases

66 of the papain-like protease (PLP) domains of coronaviruses (CoVs) revealed an adjacent Ubl domain in

67 Coronaviruses (CoVs) stand out among RNA viruses because

68 the ultimate reservoir hosts for a number of coronaviruses (CoVs), including ancestors of severe acut

69 exception of the large nidoviruses, such as coronaviruses (CoVs), RNA viruses lack proofreading and

70 Bats harbor a large diversity of coronaviruses (CoVs), several of which are related to zo

71 Pathogenic human coronaviruses (CoVs), such as the severe acute respirato

72 Two zoonotic coronaviruses (CoVs)-SARS-CoV and MERS-CoV-have crossed

73 Because coronaviruses depend on host protease-mediated cleavage

74 evaluated two independent nsp15 mutant mouse coronaviruses, designated N15m1 and N15m3, and found tha

75 ork showed that in addition to the conserved coronavirus double membrane vesicles (DMVs), Beau-R, an

76 ), human enteric coronavirus (HECoV), equine coronavirus (ECoV), and equine torovirus Berne (BEV) are

77 A new coronavirus emerged in 2012 on the Arabian Peninsula wit

78 V and highlight the likelihood of future bat coronavirus emergence in humans.

79 Coronaviruses encode 16 nonstructural proteins (nsps), t

80 Coronaviruses encode proofreading machinery, unique in t

81 tifunctional molecular machine that mediates coronavirus entry into host cells.

82 two protease sites known to be important for coronavirus entry, provide a structural basis to support

83 ave biologically active peptides and aide in coronavirus entry.

84 ia," and "novel (beta) coronavirus and human coronavirus Erasmus Medical Center".

85 o approved therapeutic for highly pathogenic coronaviruses, even as MERS-CoV is spreading throughout

86 RNA cap formation and methylation beyond the coronavirus family.

87 studied 37 adult patients infected with MERS coronavirus for viral load in the lower and upper respir

88 Coronaviruses from both the Alphacoronavirus and Betacor

89 Coronaviruses from the genera Alphacoronavirus and Betac

90 must be considered potential contributors to coronavirus fusion.IMPORTANCE The family Coronaviridae i

91 Replication of the coronavirus genome requires continuous RNA synthesis, wh

92 avirus, and Middle East respiratory syndrome coronavirus has drawn attention to the current debate on

93 In turkey, guineafowl, and quail, coronaviruses have been reported to be the major causati

94 Coronaviruses have frequently expanded their host range

95 tion remains unclear as does the reason that coronaviruses have maintained this enzymatic activity th

96 e found that 2',5'-PDEs encoded by the human coronavirus HCoV-OC43 (OC43; an agent of the common cold

97 Human coronavirus (hCoV) HKU1 is one of six hCoVs identified t

98 Recent data suggest that human coronavirus (HCoV) pneumonia is associated with signific

99 -D68; influenza virus H3N2; RSV-B; and human coronavirus (HCoV)-OC43.

100 Human coronaviruses (hCoV) are important human respiratory pat

101 The four human coronaviruses (HCoVs) are globally endemic respiratory p

102 Human coronaviruses (HCoVs) were first described in the 1960s

103 an agent of the common cold), human enteric coronavirus (HECoV), equine coronavirus (ECoV), and equi

104 uding severe acute respiratory syndrome-like coronaviruses, henipaviruses, and Ebola virus.

105 surface spikes of MERS-CoV and a related bat coronavirus, HKU4.

106 al significance of human rhinoviruses, human coronaviruses, human metapneumovirus, and human bocaviru

107 Coronaviruses, human metapneumovirus, and influenza A de

108 Such vaccines present major challenges: coronavirus immunity often wanes rapidly, individuals ne

109 ming the natural tendency for rapidly waning coronavirus immunity.

110 been shown for any other nidoviruses beyond coronaviruses in the order Nidovirales In this study, we

111 Coronaviruses induce double-membrane vesicles (DMVs), bu

112 that Myd88 protects from lethal neurotropic coronavirus-induced encephalomyelitis by accelerating bu

113 Coronavirus-induced membrane changes include double-memb

114 somal acidification and various proteases to coronavirus infection and identifies an unexpected class

115 on the efficacy of 3CLpro inhibitors against coronavirus infection in experimental animals.

116 framework for studying the effects of prior coronavirus infection on neuron function.IMPORTANCE We d

117 ibitors was evaluated using a mouse model of coronavirus infection.

118 are not available for the treatment of human coronavirus infections, it is essential to understand th

119 tanding PLpro deubiquitinating activities in coronavirus infections.

120 mal species susceptible, and not, to certain coronavirus infections.

121 Zoonotic viruses, such as HIV, Ebola virus, coronaviruses, influenza A viruses, hantaviruses, or hen

122 Entry of coronaviruses into cells is mediated by the transmembran

123 the potential cross-reactivity among porcine coronaviruses is a major concern for the development of

124 iddle East respiratory syndrome, caused by a coronavirus, is highly lethal, with a case fatality rate

125 2 different Middle East respiratory syndrome coronavirus isolates have been assessed in this study.

126 During neurotropic coronavirus JHMV infection, infiltration of protective A

127 hogenic, whereas other closely related avian coronaviruses like IBV cause respiratory disease.

128 vaccines may exacerbate rather than prevent coronavirus lung immunopathology.

129 understanding of the interaction between the coronavirus M protein and the nucleocapsid protein.

130 The coronavirus macrodomain has ADP-ribose-1"-phosphatase ac

131 The coronavirus membrane (M) protein is the central actor in

132 tly emerged Middle East Respiratory Syndrome coronavirus (MERS-CoV) and development of a humanized mo

133 wly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory synd

134 mergence of Middle East respiratory syndrome coronavirus (MERS-CoV) as a cause of severe respiratory

135 Middle East respiratory syndrome coronavirus (MERS-CoV) belongs to beta group of coronavi

136 Middle East respiratory syndrome coronavirus (MERS-CoV) binds to cellular receptor dipept

137 Middle East respiratory syndrome-associated coronavirus (MERS-CoV) cause high case fatality rates an

138 RS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) cause significant morbidity and m

139 Middle East respiratory syndrome coronavirus (MERS-CoV) causes life-threatening disease.

140 Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness

141 fected with Middle East respiratory syndrome coronavirus (MERS-CoV) develop severe symptoms, which li

142 effects of Middle East respiratory syndrome coronavirus (MERS-CoV) during pregnancy.

143 Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and is a highly p

144 The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as the causative

145 RS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) encode multifunctional papain-lik

146 ly emerging Middle East respiratory syndrome coronavirus (MERS-CoV) encodes the conserved macro domai

147 smission of Middle East respiratory syndrome coronavirus (MERS-CoV) has been attributed to overcrowdi

148 Middle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both hum

149 Middle East Respiratory Syndrome coronavirus (MERS-CoV) has repeatedly caused outbreaks i

150 mergence of Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the zoonotic potential

151 Middle East respiratory syndrome coronavirus (MERS-CoV) infection causes an acute respira

152 41 cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection have been reported worl

153 Middle East respiratory syndrome coronavirus (MERS-CoV) infection is associated with a hi

154 of cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection occurred in Jeddah, Sau

155 or zoonotic Middle East respiratory syndrome coronavirus (MERS-CoV) infections are still unknown.

156 of notified Middle East respiratory syndrome coronavirus (MERS-CoV) infections occurred across Saudi

157 persisting Middle East respiratory syndrome-coronavirus (MERS-CoV) infections.

158 Middle East respiratory syndrome coronavirus (MERS-CoV) infects humans from zoonotic sour

159 RS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) into human populations demonstrat

160 Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic human CoV

161 RTANCE: The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic respirator

162 in vivo The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic respirator

163 Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus th

164 Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel virus that emerged in

165 Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging human pathogen tha

166 Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging pathogen, first re

167 Middle East respiratory syndrome coronavirus (MERS-CoV) is an important emerging pathogen

168 The 2012 Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak represents another prime

169 infections, Middle East respiratory syndrome coronavirus (MERS-CoV) remains a significant threat for

170 Middle East respiratory syndrome coronavirus (MERS-CoV) targets the epithelial cells of t

171 erstand how Middle East respiratory syndrome coronavirus (MERS-CoV) transmitted from bats to humans,

172 Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (

173 Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (

174 Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified in a human w

175 (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and human CoV 229E (HCoV-229E).

176 es, such as Middle East respiratory syndrome coronavirus (MERS-CoV), encode a papain-like protease (P

177 a, cases of Middle East respiratory syndrome coronavirus (MERS-CoV), including travel-associated case

178 f synthetic Middle East respiratory syndrome coronavirus (MERS-CoV), Mycobacterium tuberculosis (MTB)

179 for the Middle Eastern respiratory syndrome coronavirus (MERS-CoV).

180 sed of the receptor-binding domain from MERS coronavirus (MERS-CoV).

181 ost for the Middle East respiratory syndrome coronavirus (MERS-CoV).

182 Middle East respiratory syndrome-associated coronavirus (MERS-CoV).

183 East respiratory syndrome and was named MERS coronavirus (MERS-CoV).

184 es, such as Middle East respiratory syndrome coronavirus (MERS-CoV).

185 Human coronaviruses, most notably severe acute respiratory syn

186 Infection with the murine coronavirus mouse hepatitis virus (MHV) activates the pa

187 Many strains of the murine coronavirus mouse hepatitis virus (MHV) have distinct, S

188 actions, we constructed mutants of the model coronavirus mouse hepatitis virus (MHV) in which all or

189 RNA synthesis by the prototype coronavirus mouse hepatitis virus (MHV) is carried out b

190 placed the membrane (M) protein of the model coronavirus mouse hepatitis virus with its counterpart f

191 ectivity of alphavirus chikungunya virus and coronavirus mouse hepatitis virus.

192 Activation of RNase L during murine coronavirus (mouse hepatitis virus [MHV]) infection of m

193 Murine coronavirus (mouse hepatitis virus [MHV]) nonstructural

194 RNA binding for IFIT1 restriction of a human coronavirus mutant lacking viral N1 methylation.

195 identified in The Netherlands in 2004, human coronavirus NL63 (HCoV-NL63) was found to cause worldwid

196 s SARS-CoV as well as of replicons and human coronavirus NL63.

197 Here we report that coronavirus nonstructural protein 15 (nsp15), an endorib

198 expression of the RNase L antagonist, murine coronavirus NS2 accessory protein.

199 It is known that coronavirus nsp14 acts as an N7-(guanine)-methyltransfer

200 wever, the structures of the PRRSV nsp11 and coronavirus nsp15 catalytic domains were perfectly super

201 aken together, our findings demonstrate that coronavirus nsp15 is critical for evasion of host dsRNA

202 ly different from the hexameric structure of coronavirus nsp15.

203 protein cofactor for MTase activity, whereas coronavirus nsp16 needs the stimulating factor nsp10 for

204 and bovine viral diarrhea virus) and a human coronavirus (OC43), and this ability invariably depends

205 tics for these diseases and potential future coronavirus outbreaks.

206 The severe acute respiratory syndrome (SARS) coronavirus papain-like protease (PLpro) is a DUB that c

207 nd the virus-host interaction that regulates coronavirus pathogenesis.

208 nic cross-reactivity between porcine enteric coronaviruses, PEDV and TGEV, in CCIF assays supports th

209 r coronaviral 3CL(pro)'s from the same alpha-coronavirus phylogeny shows that the overall structures

210 in these studies is the first insight into a coronavirus PLP's interface with ISG15 via SARS-CoV PLpr

211 ce divergence to the recognition of ISG15 by coronavirus PLPs at a structural and biochemical level a

212 standing of the distinct specificities among coronavirus PLPs observed and addresses a critical gap o

213 -and-mouth disease virus leader protease and coronavirus PLPs, which act as deubiquitinating and deIS

214 f the papain-like protease (PLpro) domain in coronavirus polyproteins, and it may play a critical rol

215 oenteritis virus (TGEV), porcine respiratory coronavirus (PRCV), or porcine deltacoronavirus (PDCoV)

216 However, in contrast with the coronavirus protein, roniviral 2'-O-MTase does not requi

217 We found that very small changes in coronavirus proteins can profoundly affect tropism and v

218 ucidated many of the puzzles associated with coronavirus-receptor interactions.

219 Two domains in S1 from different coronaviruses recognize a variety of host receptors, lea

220 demic was controlled by nonvaccine measures, coronaviruses remain a major threat to human health.

221 The largest component of the coronavirus replicase-transcriptase complex, nsp3, conta

222 rary of FDA-approved drugs for inhibitors of coronavirus replication in which we identified Abelson (

223 used to identify host proteins required for coronavirus replication.

224 However, coronavirus replicative apparatus clearly has the plasti

225 e terms "Middle East respiratory syndrome," "coronavirus respiratory illness in Saudi Arabia," and "n

226 h murine hepatitis virus A59, a hepatotropic coronavirus, resulted in significant reductions in virus

227 tory syncytial virus, parainfluenza viruses, coronavirus, rhinovirus, and human metapneumovirus, repr

228 c role, whereas detections of parainfluenza, coronaviruses, rhinovirus, and adenovirus, especially in

229 80% of the ILI events with influenza virus, coronaviruses, rhinoviruses, human metapneumovirus, resp

230 Our data support the idea that coronavirus RNA capping could be targeted for developmen

231 Coronavirus RNA synthesis is connected with the formatio

232 Coronavirus RNA synthesis is performed by a replication-

233 The observed similarity between postfusion coronavirus S and paramyxovirus F structures demonstrate

234 comparison with crystal structures of human coronavirus S domains allows rationalization of the mole

235 Here we report the cryoEM structure of a coronavirus S glycoprotein in the postfusion state, show

236 velop a generalizable strategy for retaining coronavirus S proteins in the antigenically optimal pref

237 Here we present the structure of a mouse coronavirus S trimer ectodomain determined at 4.0 A reso

238 Moreover, coronavirus S1-NTDs can recognize either protein or suga

239 hibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL(pro), (R)-16, to have inhibit

240 om that of severe acute respiratory syndrome coronavirus (SARS-CoV) 3Cpro and revealed a greater flex

241 pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndr

242 severe acute respiratory syndrome-associated coronavirus (SARS-CoV) and Middle East respiratory syndr

243 ergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndr

244 spread of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndr

245 Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndr

246 beta-CoVs, severe acute respiratory syndrome coronavirus (SARS-CoV) and mouse hepatitis virus (MHV).

247 Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease with

248 Severe acute respiratory syndrome coronavirus (SARS-CoV) causes lethal disease in humans,

249 fection by severe acute respiratory syndrome coronavirus (SARS-CoV) causes severe respiratory distres

250 Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2003 in Southeast Asia

251 severe acute respiratory syndrome-associated coronavirus (SARS-CoV) epidemic was controlled by nonvac

252 pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) has developed strategies to inhib

253 ser to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others p

254 Severe acute respiratory syndrome coronavirus (SARS-CoV) is a highly pathogenic respirator

255 es such as severe acute respiratory syndrome coronavirus (SARS-CoV) to modulate the host immune respo

256 s, such as severe acute respiratory syndrome coronavirus (SARS-CoV), establish host shutoff via their

257 cestors of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome

258 rpart from severe acute respiratory syndrome coronavirus (SARS-CoV).

259 ronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV).

260 e agent of SARS was identified to be a novel coronavirus, severe acute respiratory syndrome coronavir

261 evere acute respiratory syndrome (SARS)-like coronaviruses (SL-CoVs) from which the causative agent o

262 Bats harbor genetically diverse SARS-like coronaviruses (SL-CoVs), and some of them have the poten

263 The coronavirus spike (S) glycoprotein initiates infection b

264 Coronavirus spike (S) glycoproteins mediate receptor bin

265 and host range is determined in part by the coronavirus spike (S) protein, which binds cellular rece

266 The coronavirus spike protein is a multifunctional molecular

267 The receptor-binding S1 subunit of coronavirus spike proteins contains two distinctive doma

268 wledge about the structures and functions of coronavirus spike proteins, illustrating how the two S1

269 evolution of these two critical functions of coronavirus spike proteins, receptor recognition and mem

270 Coronaviruses such as SARS-CoV and Middle East respirato

271 ty within MERS-CoV and other CoVs.IMPORTANCE Coronaviruses, such as Middle East respiratory syndrome

272 es, including filoviruses, arenaviruses, and coronaviruses, suggests the potential for wider medical

273 s are furthermore conserved among additional coronavirus superfamily members, including lineage A bet

274 Here we report that additional coronavirus superfamily members, including lineage A bet

275 sialic acids (9-O-Ac-Sias), but one group of coronaviruses switched to using 4-O-Ac-Sias instead (typ

276 rrhea virus (PEDV) is a highly transmissible coronavirus that causes a severe enteric disease particu

277 f mouse hepatitis virus (MHV), a neurotropic coronavirus that causes acute encephalitis in susceptibl

278 Porcine epidemic diarrhea virus (PEDV) is a coronavirus that infects pigs and can have mortality rat

279 Coronaviruses, the largest RNA viruses, have a complex p

280 -reactivity with other closely related swine coronaviruses, the N protein sequences of PEDV were anal

281 As in other coronaviruses, the spike (S) glycoprotein of MERS-CoV me

282 actions that occlude surfaces known in other coronaviruses to bind protein receptors.

283 e macrodomain is critical for the ability of coronaviruses to evade the immune system and promote vir

284 Coronavirus transcription is regulated by multiple facto

285 ity to the severe acute respiratory syndrome coronavirus unique domain C (SUD-C), suggesting that thi

286 rtance for development of effective and safe coronavirus vaccines of selection of adjuvants based on

287 eutralizing antibodies have been identified, coronavirus vaccines present a unique problem in that im

288 The design of optimal coronavirus vaccines therefore remains a priority.

289 V is a potential strategy for developing pan-coronavirus vaccines.

290 ability to develop safer and more effective coronavirus vaccines.

291 foundation for the structure-based design of coronavirus vaccines.

292 The assembly of coronavirus virions entails concerted interactions among

293 In 2012, a zoonotic coronavirus was identified as the causative agent of Mid

294 The tremendous pandemic potential of coronaviruses was demonstrated twice in the past few dec

295 The tremendous pandemic potential of coronaviruses was demonstrated twice in the past few dec

296 30 cases of Middle East respiratory syndrome coronavirus were identified during a large hospital outb

297 Parainfluenza and coronaviruses were also more common among patients with

298 solation and characterization of a novel bat coronavirus which is much closer to the severe acute res

299 CNS infection by neurotropic coronavirus with replication confined to the brain and s

300 oteins of orthomyxoviruses, toroviruses, and coronaviruses with a carbohydrate-binding "lectin" domai

301 n and methylation have been best studied for coronaviruses, with emphasis on the identification and c