ライフサイエンスコーパス: corpus callosum

1 nd white matter of cerebrum, cerebellum, and corpus callosum).

2 white matter tracts (forceps minor, anterior corpus callosum).

3 ter tracts of interest (fornix, cingulum and corpus callosum).

4 ct orientation within white matter, e.g. the corpus callosum.

5 cross-hemispheric communication through the corpus callosum.

6 cerebellar vermis and lobules V and VI, and corpus callosum.

7 ith cuprizone, and OPCs were sorted from the corpus callosum.

8 trics (FA, MD, RD, and AD), primarily in the corpus callosum.

9 ls of PEDF was capable of infiltration along corpus callosum.

10 f genes related to myelination and increased corpus callosum.

11 rrhages predominantly in the splenium of the corpus callosum.

12 m aberrant axonal bundles within the rostral corpus callosum.

13 decreased numbers of myelinated axons in the corpus callosum.

14 tal retardation (MR) and malformation of the corpus callosum.

15 he interhemispheric connecting fibers of the corpus callosum.

16 evere mental retardation and agenesis of the corpus callosum.

17 asciculus, as well as in the splenium of the corpus callosum.

18 which appeared progressive, and a prominent corpus callosum.

19 ossibly associated with the evolution of the corpus callosum.

20 wing demyelinating injury to the adult mouse corpus callosum.

21 ivo pathology of the sensorimotor cortex and corpus callosum.

22 orks as well as in the frontal aspect of the corpus callosum.

23 inflammatory microglia only (p=0.01) in the corpus callosum.

24 Brain MRI of the patient showed a thin corpus callosum.

25 tion of the main neocortical commissure, the corpus callosum.

26 ion of adult-onset spastic ataxia and a thin corpus callosum.

27 odendroglial progenitors in the hypoperfused corpus callosum.

28 ut mice, the number of OLs is reduced in the corpus callosum.

29 uch as the fornix and the cingulum bundle or corpus callosum.

30 diameters from four different sectors of the corpus callosum.

31 ontine tracts), and the anterior body of the corpus callosum.

32 OL production in adulthood in the cortex and corpus callosum.

33 ene is required for development of the human corpus callosum.

34 al pathways and the splenium and genu of the corpus callosum.

35 zone, the hippocampal dentate gyrus, and the corpus callosum.

36 en the bilateral prefrontal cortexes via the corpus callosum.

37 impaired myelination of the optic nerve and corpus callosum.

38 d neural progenitors toward the demyelinated corpus callosum.

39 ndex in the anterior part of the genu of the corpus callosum.

40 weeks or greater advanced maturation of the corpus callosum.

41 d cells from the ventricular region into the corpus callosum.

42 the inferior premotor cortex and body of the corpus callosum.

43 tructural connectivity in anterior/posterior corpus callosum.

44 mispheric commissural bridges traversing the corpus callosum.

45 as frontal white matter and the genu of the corpus callosum.

46 also failed to cross the midline to form the corpus callosum.

47 rected P < .05) in posterior portions of the corpus callosum.

48 ng an increase in unmyelinated fibers in the corpus callosum.

49 ased in the superior cerebellar peduncle and corpus callosum.

50 ite matter organization, particularly in the corpus callosum.

51 myelination of the axonal projections in the corpus callosum.

52 as achieved with FA index measurement of the corpus callosum (51%).

53 lities included intracranial calcifications, corpus callosum abnormalities, abnormal cortical formati

54 ic individuals with isolated agenesis of the corpus callosum (ACC) without intellectual disability.

55 bility in the structural organization of the corpus callosum accounts for these differences.

56 nly consistently observed in the genu of the corpus callosum across both samples.

57 precursor protein aggregates in axons of the corpus callosum after traumatic brain injury as compared

58 tion in 25 participants with agenesis of the corpus callosum (AgCC) and 21 matched neurotypical indiv

59 c dominance in patients with agenesis of the corpus callosum (AgCC) and found reduced laterality (i.e

60 e investigated the effect of agenesis of the corpus callosum (AgCC), one of the most common brain mal

61 e also characterized by a high prevalence of corpus callosum agenesis (32/80; 40%), and mild to sever

62 isorders, such as autism spectrum disorders, corpus callosum agenesis, Joubert syndrome, Kallmann syn

63 ctrum disorder, intellectual disability, and corpus callosum agenesis.

64 and all cases exhibited partial or complete corpus callosum agenesis.

65 re present in frontal and temporal lobes and corpus callosum (all p values <0.01).

66 However, it is unclear whether corpus callosum alterations are related to the underlyin

67 Except for the genu of the corpus callosum, an increase in AD values was also found

68 From these, sections of the corpus callosum and adjacent parasaggital cortex were ex

69 diffusion anisotropy of the splenium of the corpus callosum and adjacent parietal white matter (P <

70 he FEF, in one hemisphere and transected the corpus callosum and anterior commissure in two macaques.

71 Neuroimaging reveals a thin corpus callosum and anterior commissure, and hypoplastic

72 osomal recessive inheritance pattern of thin corpus callosum and axonal Charcot-Marie-Tooth disease i

73 sive hereditary spastic paraplegia with thin corpus callosum and axonal peripheral neuropathy (SPG7/P

74 RD, and MD in more extended portions of the corpus callosum and beyond (eg, corona radiata and infer

75 nction leads to insufficient angiogenesis in corpus callosum and catastrophic axon loss.

76 For macrostructural comparison, we measured corpus callosum and centrum semiovale volumes on MRI.

77 ice revealed strong microglial activation in corpus callosum and cingulum along with severe astroglio

78 thin major clinically relevant white matter (corpus callosum and corticospinal tract) and deep grey m

79 e mouse model for focal demyelination of the corpus callosum and in multiple sclerosis lesions in hum

80 -superior temporal atrophy and reduced FA in corpus callosum and inferior frontal-occipital fasciculu

81 ng, white matter injury was prominent in the corpus callosum and internal capsule on day 3 and then p

82 We examined the corpus callosum and its subregion volumes and their rela

83 degeneration spread into the splenium of the corpus callosum and motor cortex white matter.

84 signs of anxiety and hypomyelination in the corpus callosum and optic nerve, providing in vivo evide

85 a reduced number of myelinated axons in the corpus callosum and optic nerves.

86 cific damage to the genu and splenium of the corpus callosum and parahippocampal tract bilaterally (P

87 sive hereditary spastic paraplegia with thin corpus callosum and peripheral axonal neuropathy, and ac

88 es and attenuated white matter growth of the corpus callosum and pons relative to nondrinkers.

89 n vitro and also increased cell death in the corpus callosum and reduced cell division in the mouse s

90 In addition, the measurements from the corpus callosum and superior cerebellar peduncles reveal

91 Although both the corpus callosum and superior cerebellar peduncles were o

92 vity in the posterior midbody/isthmus of the corpus callosum and that fractional anisotropy in this r

93 ad lower mean diffusivity in the genu of the corpus callosum and the anterior thalamic tracts.

94 rmed neuroblasts in the subventricular zone, corpus callosum and the peri-infarct area 7 days after s

95 of proteins regulating the formation of the corpus callosum and their respective developmental funct

96 godendroglial progenitor cells in the normal corpus callosum, and accelerated oligodendroglial regene

97 ions in the hippocampus, degeneration of the corpus callosum, and ataxia and seizures.

98 /- but not Nova1-/- mice had agenesis of the corpus callosum, and axonal outgrowth defects specific t

99 tly present with spastic paraparesis, a thin corpus callosum, and cognitive impairment.

100 plegia, developmental delay, agenesis of the corpus callosum, and enlargement of the third cerebral v

101 late gyrus, cortex of the temporal lobes and corpus callosum, and fractional anisotropy (FA) index me

102 encephalic commissures (anterior commissure, corpus callosum, and hippocampal commissure) along with

103 Small telencephalic commissures (anterior, corpus callosum, and hippocampal), an enlarged posterior

104 fewer YFP+ cells were evident in the cortex, corpus callosum, and hippocampus.

105 nifest stage around the striatum, within the corpus callosum, and in posterior white matter tracts.

106 ficantly higher in the medial cortex, in the corpus callosum, and in the thalamus than in the corresp

107 interconnect auditory and motor structures, corpus callosum, and in tracts interconnecting cortical

108 otonia, developmental delay, thinning of the corpus callosum, and seizures.

109 rain malformation (microcephaly, agenesis of corpus callosum, and simplified gyration), and severe en

110 ith the nodes of Ranvier in the optic nerve, corpus callosum, and spinal cord of young adult mice or

111 small normally proportioned cerebellum, and corpus callosum anomalies.

112 regions included genu, body and splenium of corpus callosum, anterior and superior corona radiata, s

113 neurons in the neocortex results in lack of corpus callosum, anterior commissure, and corticospinal

114 ntral WM tracts, including internal capsule, corpus callosum, anterior commissure, and fimbria hippoc

115 aining and MPF in all anatomical structures (corpus callosum, anterior commissure, internal capsule,

116 ntry of new astrocytes from the SVZ into the corpus callosum appears to be balanced by astroglial apo

117 ncephaly, developmental abnormalities of the corpus callosum, arachnoid cyst, abnormalities of the se

118 Brain malformations involving the corpus callosum are common in children with developmenta

119 We found significantly increased corpus callosum area and thickness in children with auti

120 white matter tracts, including the anterior corpus callosum as well as bilateral internal and extern

121 e., fractional anisotropy alterations in the corpus callosum) as a shared feature of ASD, ADHD, and O

122 uding hippocampus hypoplasia and agenesis of corpus callosum, as well as neuromuscular and behavioral

123 enetic fate-mapping, we demonstrate that new corpus callosum astrocytes are continuously generated fr

124 These nestin fate-mapped corpus callosum astrocytes are uniformly postmitotic, ex

125 oglial apoptosis, because overall numbers of corpus callosum astrocytes remain constant during normal

126 ces were particularly robust in the anterior corpus callosum at the 6 and 12 month time points.

127 re available in 7 of the patients, revealing corpus callosum atrophy (7/7 [100%]) and periventricular

128 , measurements of brain biparietal diameter, corpus callosum, basal ganglia and thalami, and cerebell

129 le, p=4.90x10(-5)) and posterior part of the corpus callosum (beta=-15.3 muL per risk allele, p=1.23x

130 )/stria terminalis, genu and splenium of the corpus callosum, bilateral anterior and posterior limbs

131 , as did white matter areas (splenium of the corpus callosum, bilateral superior-parietal lobe, bilat

132 Corpus callosum bisections demonstrated that premotor co

133 ed to greater amounts of white matter in the corpus callosum, but did not control for length of train

134 Lesions in the corpus callosum (CC) are important radiological clues to

135 The corpus callosum (CC) connects the left and right cerebra

136 The corpus callosum (cc) contains nitric oxide (NO)-producin

137 anual responses to these unseen stimuli, the corpus callosum (CC) dynamically recruited areas in the

138 While microstructural alterations in corpus callosum (CC) have been identified as a consisten

139 The corpus callosum (CC) is one of the most commonly reporte

140 The corpus callosum (CC) is the largest fiber tract in the m

141 The authors examined the relationship of corpus callosum (CC) morphology and organization to hand

142 1 controls the formation of the layer II/III corpus callosum (CC) projections through the development

143 m have been often reported to have a smaller corpus callosum (CC) than control subjects.

144 the widths of the frontal horn (FH) and the corpus callosum (CC) were not significantly different be

145 vity (MD) and radial diffusivity (RD) in the corpus callosum (CC), superior longitudinal fasciculus (

146 hite matter (WM) damage, particularly to the corpus callosum (CC).

147 connect the two cerebral hemispheres via the corpus callosum (CC).

148 with affected males showing ID, agenesis of corpus callosum, cerebellar hypoplasia, microcephaly and

149 entilation, brain atrophy, dysgenesis of the corpus callosum, cerebellar vermis hypoplasia, and facia

150 decreased volume and abnormal signal), thin corpus callosum, cerebellar vermis hypoplasia, optic ner

151 features of the brain, such as the amygdala, corpus callosum, cerebellum, and gyrnecephalic index, al

152 ignificant decrease in FA in the genu of the corpus callosum characterized both conditions.

153 Apart from alterations in white matter (in corpus callosum, cingulum bundle, corona radiata, and su

154 nt and control groups in subdivisions of the corpus callosum, cingulum, and fornix were measured as i

155 tensor imaging abnormalities observed in the corpus callosum, cingulum, and temporal lobe likely cons

156 n a number of WM tracts, particularly in the corpus callosum, cingulum, bilateral superior and inferi

157 microglia (2 x 10(5) cells transplanted into corpus callosum) compared with WT microglia toward micro

158 also evident in the anterior portions of the corpus callosum connecting left and right frontal lobes.

159 the increased white matter integrity in the corpus callosum connecting these regions, suggesting an

160 The corpus callosum connects cerebral hemispheres and is the

161 l and macrostructural variability within the corpus callosum, consistent with differential effects on

162 hypothesis that congenital disruption of the corpus callosum constitutes a major risk factor for deve

163 lue than those without along the body of the corpus callosum (corrected for multiple testing).

164 e in several brain structures, including the corpus callosum, cortex, and striatum, and the corpus ca

165 d the psALS group, encompassing parts of the corpus callosum, corticospinal tracts and superior longi

166 The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39)

167 Remarkably, all seven genes showed corpus callosum defects, including thicker (Atg16l1, Cor

168 ial-temporal lobe epilepsy, microcephaly and corpus callosum deficiency, and by postnatal Day 21, mic

169 roglial regeneration in lysolecithin-induced corpus callosum demyelinative lesions.

170 e crossing of an axonal subpopulation of the corpus callosum derived from the anterior cingulate cort

171 Our findings define a new stage in corpus callosum development and demonstrate that neocort

172 The role that corpus callosum development has on the hemispheric speci

173 rce for identifying new proteins integral to corpus callosum development that will provide new insigh

174 previously-identified proteins in aspects of corpus callosum development, and identifies new candidat

175 econdary hypomyelination, microcephaly, thin corpus callosum, developmental delay, intellectual disab

176 r evidence that the presence of any residual corpus callosum differentiated those who exhibited curre

177 However, postnatal lesions of the corpus callosum do not precipitate social behavioral pro

178 elination in the hippocampal fimbria and the corpus callosum during development, and that this is thr

179 ffecting directional axonal growth, triggers corpus callosum enlargement due to the errant CB1 cannab

180 e weeks or greater delayed maturation of the corpus callosum; every additional 10 days of human milk

181 microstructural integrity of the body of the corpus callosum (FA, beta = 0.01 [P = .01]; RD, beta = -

182 losum is a congenital condition in which the corpus callosum fails to develop; such individuals exhib

183 ffusivity in the forceps minor, the anterior corpus callosum, fascicles in the temporal lobe, and the

184 bilateral atrophy of the dorsal cingulum and corpus callosum fibers, which we interpret as a conseque

185 of the developmental mechanisms involved in corpus callosum formation have provided insights into th

186 interhemispheric connectivity by controlling corpus callosum formation remains unclear.

187 n of WM damage that involved the body of the corpus callosum, fornix, and main anterior-posterior pat

188 In slices of corpus callosum from mice subjected to a demyelination p

189 ces and corticospinal tracts, to include the corpus callosum; frontal, sensory, and premotor cortices

190 findings suggest novel dual mechanism of the corpus callosum function in spatial attention and have b

191 First, whereas FA in anterior corpus callosum (genu) correlated with word-matching BPA

192 The corpus callosum has been implicated in the pathogenesis

193 he module (dorsomedial) lying closest to the corpus callosum has the most complete set of commissural

194 These findings suggest that the corpus callosum helps to drive language lateralization.

195 nd dermal abnormalities and the absence of a corpus callosum; his immune deficit was fully corrected

196 n 25 families in which members affected with corpus callosum hypoplasia (CCH) lacked syndromic featur

197 aging showed subtle abnormalities, including corpus callosum hypoplasia and ventriculomegaly.

198 Affected individuals have cerebellar and corpus callosum hypoplasia, abnormal myelination of the

199 onia, movement disorders, behavior problems, corpus callosum hypoplasia, and epilepsy.

200 ced the size of the anterior branches of the corpus callosum, i.e., forceps minor (CCFM), and this ne

201 fections, respectively; abnormalities of the corpus callosum in 16 of 17 (94%) and 22 of 28 (78%) inf

202 ity before and after surgical section of the corpus callosum in 22 patients with medically refractory

203 but inattention scores were related to AD in corpus callosum in a cluster sized 716 voxels.

204 the inferior frontal gyrus white matter and corpus callosum in addition to the corticospinal tracts

205 evealed significantly lower integrity in the corpus callosum in bipolar subjects.

206 Finally, we observed hypoplasia of the corpus callosum in both mouse mutants and a marked decre

207 ructural organization of the splenium of the corpus callosum in low-risk infants, but this associatio

208 hese findings suggest a notable role for the corpus callosum in maintaining stable functional communi

209 allosal structure, supporting a role for the corpus callosum in mediating functional asymmetry.

210 a semiquantitative proteomic analysis of the corpus callosum in mice mutant for Dcx.

211 against brain injury in the hippocampus and corpus callosum in rats with vascular dementia.

212 raumatic axonal injury in the cerebellum and corpus callosum in those soldiers with pituitary dysfunc

213 PN) connect the cerebral hemispheres via the corpus callosum, integrating cortical information and pl

214 g abnormalities of the cerebellum, cingulum, corpus callosum, internal capsule, thalamus, basal foreb

215 e fine myelinated fibers projecting from the corpus callosum into the cortex were lost.

216 abnormalities with sparing of the U fibers, corpus callosum involvement with sparing of the outer bl

217 Agenesis of the corpus callosum is a common brain malformation that can

218 Agenesis of the corpus callosum is a congenital condition in which the c

219 The number of oligodendrocytes in the corpus callosum is established in childhood and remains

220 rous brain imaging studies indicate that the corpus callosum is smaller in older children and adults

221 The corpus callosum is the largest fibre tract in the brain,

222 The corpus callosum is the principal cerebral commissure con

223 The development of the corpus callosum is under tight genetic control, as demon

224 Fourth, white matter such as corpus callosum, known to contain negligible numbers of

225 NFIX) results in abnormal development of the corpus callosum, lateral ventricles, and hippocampus.

226 d radial diffusivity in all divisions of the corpus callosum, left fornix, and subgenual cingulum com

227 not in FA values, including the splenium of corpus callosum, left posterior corona radiate/posterior

228 Section of the corpus callosum markedly reduced interhemispheric functi

229 en and adults, our findings suggest that the corpus callosum may be larger in infants who go on to de

230 Together, our findings suggest that the corpus callosum may have a dual inhibitory and excitator

231 ctroscopy data from the anterior body of the corpus callosum of 13 patients with systemic lupus eryth

232 High focal uptake was found in the posterior corpus callosum of a TBI subject.

233 G-ratio of myelin, were also detected in the corpus callosum of adult HdhQ250 mice.

234 demyelination induced by lysolecithin in the corpus callosum of adult mice.

235 he remyelination phase of the CPZ model, the corpus callosum of Cav1.2(KO) animals presented a signif

236 rpus callosum, cortex, and striatum, and the corpus callosum of Cav1.2(KO) animals showed an importan

237 he dentate nucleus, subthalamic nucleus, and corpus callosum of multiple system atrophy, and in all r

238 with lower microstructural integrity in the corpus callosum of non-demented elderly individuals, and

239 drocyte differentiation were impaired in the corpus callosum of Olig1-null mice, resulting in hypomye

240 neuropathy, cognitive impairment and a thin corpus callosum on brain MRI.

241 ons surrounding the anterior crossing of the corpus callosum on E18 as well as the persistence of lar

242 m healthy 101LL mice with PrP plaques in the corpus callosum or (ii) brain extracts from mice overexp

243 on, relevant to limited brain areas like the corpus callosum, or multiple orientations but without th

244 arietal regions, and lower FA in the body of corpus callosum, posterior superior longitudinal fascicu

245 in their siblings, mainly restricted to the corpus callosum, posterior thalamic radiations, and left

246 ivity, we found that increased volume of the corpus callosum predicted good receptive language outcom

247 c functional connectivity in relation to the corpus callosum presents a case in point.

248 Evoked action potentials in the myelinated corpus callosum projections of Msh2-null mice were small

249 The volumetric assessment of the corpus callosum proved to be a useful tool in discrimina

250 d in some subcortical regions, including the corpus callosum, putamen, and cerebellum.

251 volume and microstructural integrity of the corpus callosum, represented the most promising candidat

252 d by 67.4% and 203.0% in the hippocampus and corpus callosum, respectively.

253 iculi (IFOF), genu (GCC) and splenium of the corpus callosum (SCC), posterior limbs of the internal c

254 ric functional connectivity before and after corpus callosum section in rhesus monkeys.

255 l neuropathy with or without agenesis of the corpus callosum (SLC12A6).

256 in a priori regions of interest: splenium of corpus callosum (SPCC) and posterior limb of internal ca

257 ated with word-matching BPA, FA in posterior corpus callosum (splenium-occipital) correlated with fac

258 corona radiata, right tapetum, and bilateral corpus callosum, statistically moderates whether sleep s

259 insula, and a large cluster that covered the corpus callosum, superior and medial frontal gyrii, as w

260 esent in the subcortical gray matter nuclei, corpus callosum, superior temporal gyrus, and pre- and p

261 Astrogliosis significantly increased in corpus callosum (TBI = 6.7 +/- 0.69, Sham = 2.5 +/- 0.38

262 es in white matter tracts of the genu of the corpus callosum that connect the two hemispheres of the

263 r microstructure (FA) within a region of the corpus callosum that projects to the SMA within each hem

264 onal connectivity in individuals in whom the corpus callosum (the major commissure between the hemisp

265 ieved with the volumetric measurement of the corpus callosum - the values were 73% and 71%, respectiv

266 ismatch repair deficiency is agenesis of the corpus callosum, the cause of which has not been establi

267 alues along the body and the splenium of the corpus callosum, the left cingulum, and the anterior par

268 Why do humans born without the corpus callosum, the major interhemispheric commissure,

269 e fewer axons than in wild-type mice and, in corpus callosum, the myelin is thinner than in controls.

270 ivity in the genu, body, and splenium of the corpus callosum, the right posterior limb of the interna

271 capsule (RLIC), the body and splenium of the corpus callosum, the superior and posterior corona radia

272 nal ventricular zone-subventricular zone and corpus callosum there is reduced OPC production from RGC

273 Reduced corpus callosum thickness confirmed trend-level observat

274 Moreover, there was a 25% reduction in the corpus callosum thickness with survival >1 year post-inj

275 ia, interhemispheric lipoma, agenesis of the corpus callosum, tibial hemimelia, preaxial polydactyly

276 The corpus callosum, two projection tracts, and five associa

277 nal anisotropy (FA) index measurement of the corpus callosum using diffusion tensor imaging.

278 Surprisingly, intercortical tracts-corpus callosum, ventral hippocampal, and anterior commi

279 pus, on average, but lower right caudate and corpus callosum volume, relative to 22q-del carriers.

280 tional anisotropy within the splenium of the corpus callosum was found in each NDD group, compared wi

281 silesional corticospinal tract and bilateral corpus callosum was increased but sensorimotor CBF was d

282 Interestingly, the corpus callosum was markedly thinner, a characteristic w

283 on anisotropy in the body and isthmus of the corpus callosum was negatively correlated with the compo

284 Absence of the corpus callosum was noted at screening prenatal head ult

285 White matter integrity in corpus callosum was reduced in BD1 patients only.

286 on anisotropy in the body and isthmus of the corpus callosum was shown to mediate this association.

287 Luxol fast blue staining of the corpus callosum was significantly greater in the BCCAO r

288 erc1), thinner (Kif21b and Wdr89), or absent corpus callosum (Wdr47), revealing a common role for WDR

289 distribution volume (VT), determined in the corpus callosum, we calculated the binding potential (re

290 necting ipsilateral cortical regions and the corpus callosum were significantly heritable, ranging fr

291 Schizencephaly and abnormalities of the corpus callosum were the most often developmental disord

292 ected), mainly in the uncinate, cingulum and corpus callosum, whereas responders were indistinguishab

293 Dissociations were found in the genu of corpus callosum which accounted for short-term memory bi

294 nterior parts of cingulum bundle and body of corpus callosum), which showed both increased WMV and de

295 udate nucleus, and cerebellum but not in the corpus callosum, which served as reference region for no

296 particularly significant with regard to the corpus callosum, whose development undergoes several dyn

297 In WT mice, microglia expanded in the corpus callosum with age, whereas aged Trem2(-/-) mice h

298 ite matter with sparing of the U fibers, the corpus callosum with sparing of the outer blades, the ba

299 ight frontal cortex to 0.46 mL cm(-3) in the corpus callosum, with intermediate VT values in subcorti

300 The corpus callosum, with its approximately 200 million axon