ライフサイエンスコーパス: correlation time

1 mobile core water (~25 ps average rotational correlation time).

2 erienced a complex environment with a finite correlation time.

3 es decay in good approximation with a single correlation time.

4 ecreases in S2 and an increase in the global correlation time.

5 time is not necessarily associated with each correlation time.

6 tein interface with a limited lengthening in correlation time.

7 nor CoASH altered overall I-FABP rotational correlation time.

8 ribed by an order parameter and an effective correlation time.

9 st internal motions, faster than the overall correlation time.

10 We define retroactivity by the change in the correlation time.

11 cur on timescales longer than the rotational correlation time.

12 coupled and tumble in solution with a faster correlation time.

13 me and [Formula: see text] is the turbulence-correlation time.

14 ort (<10 s) versus long (approximately 60 s) correlation times.

15 t the methyl end and isomerizes with shorter correlation times.

16 buffer or to differences in their rotational correlation times.

17 tended model-free analyses with two or three correlation times.

18 used to derive order parameters and internal correlation times.

19 ater moving with picosecond to subnanosecond correlation times.

20 e probabilities, greatly reducing structural correlation times.

21 tly dynamic, i.e., dependent on the motional correlation times.

22 n, the two domains have different rotational correlation times.

23 DNP) phase for sufficiently large rotational correlation times.

24 arlo sampling methods often suffer from long correlation times.

25 n function valid in the limit of small noise correlation times.

26 The domains exhibit different rotational correlation times (16.6(+/-0.1) ns and 12.6(+/-0.1) ns,

27 3 residue nuclease A inhibitor (2 degrees C, correlation time 17.5 ns) were obtained in 3 h, illustra

28 I-FABP Trp displayed two rotational correlation times, 6.6 and 0.4 ns, reflecting motion of

29 L-FABP motion but yielded longer rotational correlation times, 8.2 and 10.7 ns, than the respective

30 accharide relaxation kinetics and rotational correlation times agreed with the NMR data indicated tha

31 Judging from the C-N bond-rotation correlation times along with experimental and quantum-ch

32 oach commonly used for estimation of overall correlation time and identification of chemical exchange

33 is hundreds of times larger than the slowest correlation time and is much larger when the sites move

34 onstant value that is independent of overall correlation time and motional anisotropy.

35 shape are modulated by both changes in label correlation time and spin-spin interactions.

36 motion (spectrum-dependent on the rotational correlation time and the orientational distribution).

37 at thermal equilibrium usually has a finite correlation time and will eventually be randomized after

38 ent mixing times, assuming different overall correlation times and different starting structures.

39 temperature dependence of internal motional correlation times and order parameters is essentially th

40 requencies yielded values for the rotational correlation times and order parameters that were much mo

41 ling" motions are characterized by effective correlation times and squared-order parameters of approx

42 eneity, shorter average lifetime, rotational correlation time, and lower order parameter of the DPH m

43 ities for contrast agents, longer rotational correlation times, and increases in relaxivity (r(1)) up

44 nt chain upturns with longer reorientational correlation times, and relatively low order parameters.

45 were adequately described by two rotational correlation times, and these are compared with the theor

46 ved emission anisotropy detects a rotational correlation time appropriate for octameric but not dimer

47 d RNA tumbled with a subnanosecond isotropic correlation time (approximately 0.60 ns at room temperat

48 ns on time scales longer than the rotational correlation time are rare and hence do not perturb the o

49 ificant long-range order, and that the local correlation times are adequately described by a random c

50 a dynamic scattering medium having a speckle correlation time as short as 5.6 ms, typical of living t

51 ngly complex motions with long (nanoseconds) correlation times as the temperature increases, suggesti

52 , self-diffusion coefficient, and rotational correlation time) as well.

53 pecific, approach to predict protein subunit correlation times, as measured by NMR experiments of (1)

54 The rotational correlation times associated with the amide nitrogen ato

55 lent fluctuations have decreasing energy and correlation times at smaller scales, with nearly Gaussia

56 atively affect the actin filament rotational correlation time, but with opposite effects: muscle S1 d

57 bile, bulk-like aqueous environment having a correlation time ca. 1.3 ps at pH 6.2.

58 and a 33% decrease in the global rotational correlation time calculated from anisotropy decay data.

59 (1)H HSQC fingerprint region, and rotational correlation time calculated from NMR longitudinal (T(1))

60 are attributed to an increase in the overall correlation time, caused by the increased viscosity of t

61 tor is typically signalled by the rotational correlation time changes of the tracer.

62 the correlation amplitude and increases the correlation time compared to a point particle model.

63 bited approximately 3-fold slower rotational correlation times compared with active LHRs (59 +/- 4 an

64 le side chain, whereas the longer rotational-correlation-time component (1.37 +/- 0.15 ns), independe

65 tics exhibited two well-separated rotational-correlation-time components.

66 rasaccharide to FGF-2 was an increase in the correlation time consistent with the formation of an FGF

67 lower fields, R(1) increases further with a correlation time consistent with vesicle tumbling.

68 (sub-tau(c), where tau(c) is the rotational correlation time) consistent with S(2) obtained from spi

69 We resolve three rotational correlation times corresponding to (i) a large-amplitude

70 The subsequent increase in rotational correlation time corresponds to the formation of an on-p

71 , values that are smaller than the principal correlation times determined for the global rotation of

72 ion NMR methods were used to investigate the correlation time, distribution, and population of water

73 ectral density approach that yields motional correlation time distributions, and a new approach that

74 We did not observe the increased rotational correlation time expected for the G domain dimer.

75 The critical interplay among correlation time, fluorescence lifetime, and the observe

76 l-free analysis were used to extract tauc, a correlation time for each type of phospholipid molecule

77 quared order parameter (S(2)), the effective correlation time for fast internal motions (tau(e)), and

78 ralized order parameters (S2), the effective correlation time for internal motions (tau e), and the 1

79 eralized order parameter (S2), the effective correlation time for internal motions (tau(e)), 15N exch

80 The rotational correlation time for LacS did not vary significantly ove

81 id on the (2)H MAS NMR time scale (i.e., the correlation time for motion, tau(c), is >10(-3) s) at ro

82 le (for example, its assumption of a uniform correlation time for overall molecular tumbling can be p

83 The overall rotational correlation time for the CTSYM is 3.44 ns and the CTSYMT

84 In addition, the correlation time for the exchange of molecules between t

85 a 1H-15N correlation spectrum, the apparent correlation time for the free electron-proton vectors fo

86 We find that the rotational correlation time for the OD bond vector in D(2)(16)O var

87 to 0.86 ps at 350 K, and that the rotational correlation time for the out-of-plane vector of dilute D

88 This has permitted determination of the correlation time for URD and the width of the square-wel

89 Sensitivity to Delta depends on the correlation time for URD with higher sensitivity to larg

90 s a function of the microwave frequency, the correlation time for URD, and the orientation of the spi

91 substantial increases in sensitivity to the correlation time for URD, to small constraints in URD, a

92 T-EPR signals at 94, 140, and 250 GHz to the correlation time for URD, to the amplitude of constraine

93 s, bound and unbound, require two rotational correlation times for adequate fits.

94 In the myosin monomers the correlation times for both domains were the same (approx

95 have determined the order parameters and the correlation times for C-N bond rotation and reorientatio

96 traction of generalized order parameters and correlation times for internal and overall bond vector r

97 lation time, order parameters, and effective correlation times for internal motions.

98 he variable-temperature 17O NMR spectra, and correlation times for motion were estimated.

99 Rotational correlation times for probes located on the four-helix b

100 in binding causes less dramatic increases in correlation times for the 22-base oligonucleotide relati

101 Comparison of the rotational correlation times for the full-length alphaTS and the am

102 Correlation times for the protein-bound 17-base oligonuc

103 In general for these helices, the correlation times for their overall tumbling that best a

104 confirm a 10-fold increase in the rotational correlation time from 0.049 to 0.60 ns at 310 K.

105 en retroactivity is defined using the decay (correlation) times from the gene expression autocorrelat

106 t the approach should work for proteins with correlation times >50 ns.

107 rticular, internal motion with a 5- to 10-ns correlation time has been attributed to diffusion-in-a-c

108 on models possible for two lifetimes and two correlation times has been evaluated.

109 Statistical distributions of correlation times have been found specifically for the p

110 ergo rapid depolarizing motion with a 0.5 ns correlation time; however, the extent of fast motion at

111 of motions by a projection onto an array of correlation times (IMPACT), which focuses on an array of

112 are found to be in the range of the overall correlation time in solution, where internal motions cha

113 dyl NdeltaH indicates that the Mb rotational correlation time in the cell is only approximately 1.4 t

114 lly on protein overexpression levels and the correlation time in the cytoplasm.

115 nBPS179C-acrylodan showed a 13-ns rotational correlation time in the ligand-free state, whereas multi

116 e similar for both proteins, with the longer correlation time in the range of molecular tumbling of t

117 salt bridges) did not affect the rotational correlation time in the tandem further supporting indepe

118 backbone dynamics modes with characteristic correlation times in the nanosecond or faster time scale

119 The longer correlation time increases upon protein binding.

120 nal amplitude) and decreasing the rotational correlation times (increasing the rotational rates and t

121 The measured H-C internuclear correlation times indicated differences in dynamics of s

122 mains possess different effective rotational correlation times, indicating that the knuckles are not

123 depolarization measurements gave rotational correlation times indicative of a reversible change in t

124 The hemoglobin (Hb) rotational correlation time is 2.2 longer in the cell than in solut

125 out on human ubiquitin at 284.1 K, where the correlation time is 7.1 ns.

126 The extracted global correlation time is 9.94 ns.

127 the anions from the site, whereas the 30-ps correlation time is identified with relative motions of

128 er (S2 approximately 0.9) and from the local correlation time < 100 ps.

129 The correlation time map outputted in PCI informs on the dyn

130 for a time long compared with the rotational correlation time may be measured.

131 py decay displays a subnanosecond rotational correlation time much shorter than that expected for the

132 The anisotropy decayed with two correlation times near 5 and 370 ns, with the larger val

133 ntational eigenmodes, their eigenvalues, and correlation times, NMR relaxation data were calculated i

134 End-to-end distance distributions and correlation times obtained from Langevin molecular dynam

135 6MI in the PTRT duplex displays a rotational correlation time of >7 ns.

136 components: a fast component with rotational correlation time of 0.3-3 ns representing probe internal

137 thin a cone of semiangle 22-25 degrees and a correlation time of 0.5 ns, in addition to rotating toge

138 A correlation time of 0.65 +/- 0.35 ns was estimated for t

139 peptide undergoes slow reorientation with a correlation time of 0.7 +/- 0.2 s in POPC bilayers.

140 of a double-kinetic approach, the rotational correlation time of 1-anilino-8-naphthalene sulfonate bo

141 At a correlation time of 10 micros, the V'(2) signal is very

142 ns show that for a protein with a rotational correlation time of 10 ns or larger, the c-TROSY-HNCO ex

143 at 28 degrees C with an effective rotational correlation time of 11.5 ns.

144 y time-resolved anisotropy gave a rotational correlation time of 23.3 +/- 1 ns, similar to that of 20

145 utility is demonstrated on a protein with a correlation time of 28 ns ( approximately 60 kDa).

146 n states of the C403S PTPase reveal a single correlation time of 30-48 ns due to the rotational motio

147 A rapid rotational correlation time of 325 ps was also found for a small fl

148 A long rotational correlation time of 36 ns was observed for the excited s

149 n is accurately Lorentzian with an effective correlation time of 41 +/- 3 ns when measured at low pro

150 for a time long compared with the rotational correlation time of 42 ns.

151 tion parameters (at 25 degrees C) leads to a correlation time of 5 ns for gelator molecules within th

152 n order of magnitude slower than the overall correlation time of 5.2 ns, were required for only two r

153 ating together with the whole protein with a correlation time of 7-11 ns.

154 are typical of a well-ordered protein with a correlation time of 8.25 +/- 2.1 ns.

155 Relaxation measurements yield a rotational correlation time of 8.6 +/- 0.1 ns for wild-type MIP-1 b

156 PGAM tumbles isotropically with a rotational correlation time of 8.7 ns and displays a range of dynam

157 ular) = 1.20 +/- 0.02 with an overall global correlation time of 8.93 +/- 0.03 ns.

158 brane protein VDAC-1, which has a rotational correlation time of about 70 ns in detergent micelles, t

159 The correlation time of an MTSL derivative (I) attached to F

160 the fluorescence switched on and off with a correlation time of approximately 0.1 s.

161 a protein of molecular mass 18.6 kDa with a correlation time of approximately 10 ns at 30 degrees C.

162 evidence for a slow rotational motion with a correlation time of approximately 300 micros, which is n

163 he Mn-N coordinative bonds, occurring with a correlation time of approximately 70 ps.

164 RG-alpha EGF-like domain yields a rotational correlation time of approximately 8.4 ns, suggesting tha

165 In addition, the rotational correlation time of both PKCalpha and PKCdelta C1-domain

166 The correlation time of F99C in tears (13.5 ns) was the same

167 ic values of generalized order parameter and correlation time of nanosecond motions for the inner but

168 gs of lipids, and leading to reorientational correlation time of nearly 100 ns.

169 we observe fluorescence fluctuations with a correlation time of over 2 s that cannot be explained by

170 ylation significantly reduces the rotational correlation time of regulatable myosin preparations, whe

171 The rotational correlation time of spin-labeled caa3 (65 micros) in STE

172 D( perpendicular) = 1.15 +/- 0.02), a global correlation time of tau(m) = 7.80 +/- 0.03 ns, and a uni

173 sistent with an estimated overall rotational correlation time of tau(m)=(2D(||)+4D(perpendicular))(-1

174 d rotational tumbling to the total effective correlation time of the bound protein are modulated by n

175 this self-consistent analysis determined the correlation time of the bound species (tauB = 13.5 ns) a

176 The overall rotational correlation time of the fatty acid.protein complex was 2

177 as well as in orientation domains, with the correlation time of the fluctuations controlled by the N

178 ds to a significant change in the rotational correlation time of the fluorophore attached to the PNA.

179 The rotational correlation time of the four-alpha-helix bundle is 8.1 +

180 In addition, the analysis estimated the correlation time of the free species (tauF approximately

181 he individual spins, provided the rotational correlation time of the interspin vector is sufficiently

182 The 3.8 ns correlation time of the ligand-free enzyme is attributed

183 The rotational correlation time of the major fraction of band 3 molecul

184 surements for free suramin indicate that the correlation time of the molecule is approximately 3 ns a

185 of a 60-100-fold increase in the rotational correlation time of the molecule upon binding (tau(R) =

186 unneling process that we monitor through the correlation time of the nitrogen Fermi-contact interacti

187 ) values best represent changes in the local correlation time of the peptide epitope upon binding ant

188 The overall correlation time of the protein in micelles was found to

189 did not significantly affect the rotational correlation time of the regulatory domain (441 to 408 mi

190 e EPR spectral line shape and the rotational correlation time of the spin label when PsaC(WT) binds t

191 ydrochloride denaturation leads to a shorter correlation time of the spin-label, tau(c) < 1 ns, appro

192 monitored through changes in the rotational correlation time of the tetraloop and the attached nitro

193 The overall correlation time of this 169-residue flavodoxin (>19 kDa

194 n the final anisotropy and a decrease in the correlation time of transient phosphorescence anisotropy

195 cromolecular targets increase the rotational correlation time of xenon, increasing its relaxation rat

196 Changes in relaxation and correlation times of (1)H and (31)P signals and saturati

197 analyses of the results show peak rotational correlation times of 0.6 ns (zero Ca2+) and 1.2 ns (+Ca2

198 Average motional correlation times of 0.8 and 1.2 micros were extracted f

199 Rotational correlation times of 1-2 micros for purified spin-labele

200 rsion has inflection points corresponding to correlation times of 30 ps and 4 ns for both ions.

201 -free, wild-type PTPase is found to have two correlation times of 31 and 3.8 ns.

202 ating large-amplitude rotational motion with correlation times of 5-50 micros.

203 ed calmodulin monomer give global rotational correlation times of 7.9 ns (zero Ca2+) and 11.4 ns (+Ca

204 These relaxation times can yield rotational correlation times of appropriate molecule-fixed unit vec

205 ere used to determine the overall rotational correlation times of HSA and IgG.

206 g temperature most likely because of shorter correlation times of lipid and ethanol reorientation.

207 he NMR data, we estimate that the rotational correlation times of Mg2+ are independent of the overall

208 However, the rotational correlation times of probes located on the linker and th

209 his study we determine the range of possible correlation times of rocking motion, 0.1-100 mus.

210 are well reproduced after adjustment of the correlation times of the 10 largest eigenmodes.

211 By adjusting the correlation times of the 10 largest modes, a high degree

212 nts of fluorescence lifetimes and rotational correlation times of the conjugates supported the presen

213 d significantly by adjusting eigenvalues and correlation times of the dominant modes.

214 motions with moderately large amplitudes and correlation times of the order of a nanosecond or longer

215 ndergo rapid conformational transitions with correlation times of the order of nanoseconds at carbon

216 decay data were used to determine rotational correlation times of the proteins, which showed local pr

217 The rotational correlation times of these proteins are larger than pred

218 The correlation times of tumbling motion of the (13)C-(1)H i

219 e populations of water, whereas the measured correlation times of tumbling motion of water across the

220 indicates that the dominant slow relaxation (correlation) times of the dipolar and chemical shift ani

221 ow-order parameters with internal rotational correlation times on the order of 0.6 ns-1 ns.

222 vity to large values of Delta at the shorter correlation times, on the microwave frequency, and on th

223 cause a noticeable change in the rotational correlation time or angular amplitude of tryptophan in a

224 e dynamics were characterized by the overall correlation time, order parameters, and effective correl

225 d from these trajectories we then calculated correlation times, orientational distributions, and orde

226 solid-state NMR experiments can overcome the correlation time problem and extend the range of protein

227 Alexa fluorophore reports local motions with correlation times ranging from 1.0 to 1.8 ns.

228 n of three different motional processes with correlation times ranging from 10(2) to 10(6) s(-1) over

229 Correlation times reflective of the time scale of the in

230 tio of chemical shift anisotropy and dipolar correlation times reported here and the previous observa

231 these helices was modeled with an effective correlation time representing helix tumbling as well as

232 motions and a slow component with 50-100 ns correlation time representing overall tumbling of the pr

233 This correlation time represents an intrinsic timescale for t

234 A longer correlation time, resolved by anisotropy measurements, c

235 rescence decay lifetime (tau), or rotational correlation time (rho) of DHE versus PE composition plot

236 uorescence anisotropy (r) and the rotational correlation time (rho) of S1 reconstituted with LC1 labe

237 y decay, thereby increasing SCP-2 rotational correlation time, SCP-2 hydrodynamic radius, and SCP-2 T

238 of the environment, such as variability and correlation times, set optimal biochemical parameters, s

239 nal diffusion around the bilayer normal with correlation times shorter than 10(-4) s.

240 folds upon DNA binding by TBP, its increased correlation time shows that the overall structure of the

241 should allow other proteins with rotational correlation times significantly longer than HCA II (tau

242 s of wild-type nuclease to have a rotational correlation time similar to that of tryptophan-containin

243 This change in correlation time suggested a decrease in the axial ratio

244 This long correlation time suggests that in addition to aggregatio

245 ange with each other, and an extremely short correlation time tau(C) for the motion of these ions of

246 axation components characterized by a single correlation time tau(c), with a small contribution from

247 attering function and that the corresponding correlation time tau(Q) displays a dynamic cross-over fr

248 e combined with either measured or estimated correlation times tau(c), the r(-6)-weighted, time and e

249 on T(1)/T(2) measurements and the rotational correlation time (tau(c)) estimated from a (15)N-TRACT e

250 -6-alpha2]2 shows their effective rotational correlation time (tau(c)) is 7.3 +/- 0.5 ns, consistent

251 increase in the estimated overall rotational correlation time (tau(c)) was observed, consistent with

252 alized order parameters (Ss2 and Sf2), local correlation time (tau(e)), and exchange rate (R(ex)) wer

253 rder parameters (S(s)(2) and S(f)(2)), local correlation time (tau(e)), and exchange rate (R(ex)) wer

254 f the two domains was similar; the effective correlation time (tau(eff)) for ELC was 17 micros and th

255 The global rotational correlation time (tau(m)) for apo-K1(Pg) was 5.87(+/-0.0

256 a whole with an overall molecular rotational correlation time (tau(m)) of 12.9 ns at 25 degrees C.

257 motions (tau(e)), and the global rotational correlation time (tau(m)) were calculated for all TM2e b

258 ex) for each residue, as well as the overall correlation time (tau(m)).

259 R(ex)), and the overall molecular rotational correlation time (tau(m)).

260 The analysis provides a rotational correlation time (tau(r) = 4.1 +/- 0.3 ns) for the duple

261 e species was relatively rapid, defined by a correlation time (tau(R)) of less than 10 micros, wherea

262 The correlation times (tau = 1/kappa) were found to be in th

263 (T(1)) of (14)N to determine reorientational correlation times (tau(c)) of CH(3)CN-H(2)O solvent mixt

264 ermine the order parameters (S(2)) and local correlation times (tau(e)) of the N-H bond vectors withi

265 sor ratios (D( parallel)/D( perpendicular)), correlation times (tau(m)) for overall reorientations of

266 generalized order parameter, S(2), the local correlation time, tau(e), and the conformational exchang

267 axation due to internal motions, for which a correlation time, tau(hf), can be approximately extracte

268 avity-reservoir interactions, as well as the correlation time, tau, of the structured reservoir.

269 S(2) = 0.75 to 0.89), and effective internal correlation times, tau(e), distinct from global tumbling

270 ynthetic filaments, the effective rotational correlation times, tau(r), were 24 +/- 6 micros and 441

271 A-binding attenuator protein tumbling with a correlation time tauc of 120 ns.

272 The overall rotational correlation time tauc was found to be 8.1 ns.

273 rly, motions between the globular rotational correlation time (tauc ) and 40 mus (supra-tauc window),

274 dimer or multimer, vMIP-II has a rotational correlation time (tauc) of 4.7 +/- 0.3 ns, which is cons

275 The rotational correlation time (tauc) of hSTAT4(1-124) was estimated f

276 cycling 31P NMR methods to estimate internal correlation times (tauc) of phospholipid headgroup motio

277 The correlation time, tauc, for the Mn2+-205Tl+ interaction

278 r determination of the temperature-dependent correlation times tauf characterizing fast methyl motion

279 measurements indicate a molecular rotational correlation time taum of 4.88 +/- 0.04 ns and provide ev

280 The rotational correlation time (taum) for uncomplexed Hck SH2 was 6.8

281 ameter (S2) of 0.9 +/- 0.05 and a rotational correlation time (taum) of 7.0 +/- 0.5 ns.

282 was characterized by an effective rotational correlation time (tauR) between 24 and 48 micros.

283 s in rigor indicated an effective rotational correlation time (taureff) of 140 +/- 5 microseconds, si

284 spin-labeled ligand complexes have a shorter correlation time than the protein alone, indicating that

285 To each eigenmode belongs a correlation time that can be adjusted to optimally repro

286 nd to XPA-MBD the internal residues assume a correlation time that is characteristic of the molecular

287 Focusing on the fast rotational correlation time, the results indicate that most of the

288 ng motions, requiring multiple lifetimes and correlation times to define the fluorescence intensity a

289 low field (0.03-0.08 T), which reflects this correlation time, to explore the energy barriers associa

290 , and Val residues are clearly detectable at correlation times up to approximately 330 ns.

291 PYP is observed both within the 4-6-ps cross-correlation times used in this work, and with a 16-ps de

292 Insight into the motions leading to this correlation time was gained by a 28 ns molecular dynamic

293 -domain microfluorimetry, the GFP rotational correlation time was measured to be 39 +/- 8 ns, approxi

294 iscosities at which the protein's rotational correlation time was much longer than the fluorescence l

295 as substituted for the alkaliphile F1F0, the correlation time was unchanged (65-70 micros).

296 e in the ligand-free state, whereas multiple correlation times were assigned in the glutamine-bound c

297 ns of cardiac troponin C tumble with similar correlation times when bound to cardiac troponin I-(1-80

298 a significantly increased average rotational correlation time, which we interpret at least in part as

299 neralized order parameters and low effective correlation times, while residues in the loops connectin

300 s (IMPACT), which focuses on an array of six correlation times with intervals that are equidistant on