ライフサイエンスコーパス: cortical

1 A novel study shows that increasing cortical acetylcholine (ACh) levels alter specific aspec

2 tential mechanism through which CTLs control cortical actin density.

3 In thrombin-stimulated HUVECs, Kindlin-2 and cortical actin dissociated from stable AJs and redistrib

4 n PIP2 at the immunological synapse regulate cortical actin in CTLs, providing a potential mechanism

5 l behavior of stress fibers, actin arcs, and cortical actin-based structures.

6 -derived models proposing PMS as specialized cortical actin.

7 glutamatergic PPT neurons induced prolonged cortical activation and behavioral wakefulness, whereas

8 Significant increase in cortical activation lasting at least 3 years after GT wa

9 close to an instability leading to unbounded cortical activation.

10 n may include reduced working memory-related cortical activity associated with the downslope of the "

11 Optogenetic disruption of cortical activity before and during tone presentation sh

12 Here, we investigated how motor cortical activity changed in the presence of an object i

13 ently, insights into the network dynamics of cortical activity during sleep were obtained by investig

14 Targeted reduction of auditory cortical activity during training diminished perceptual

15 Cortical activity evoked by bilateral stimuli with varyi

16 monstrate a dissociation between FFR-related cortical activity from that related to the latency of th

17 thought to be involved in the regulation of cortical activity levels.

18 using measurement and perturbation of motor cortical activity together with electromyography in mice

19 ), EEG event-related potentials (nociceptive cortical activity), and facial expression (behavior) wer

20 ed subtype, driven by MAML3 and CSDE1, and a cortical admixture subtype.

21 nucleus (ACo) is a chemosensory area of the cortical amygdala that receives afferent projections fro

22 The anterior cortical amygdaloid nucleus (ACo) is a chemosensory area

23 e association between hippocampal volume and cortical amyloid uptake.

24 13), and neurologically normal elderly with cortical amyloid-beta accumulation (pathological ageing,

25 dynamic reconfiguration of multiple cortico-cortical and cortico-subcortical FC networks.

26 nterplay of three partly overlapping cortico-cortical and cortico-subcortical functional connectivity

27 w that FC between interhemispheric homotopic cortical and hippocampal areas, as well as in cortico-st

28 sults illuminate the dynamically interacting cortical and subcortical processes underlying spatial at

29 amygdala (BLA) integrates sensory input from cortical and subcortical regions, a function that requir

30 neurons were also found within transitional cortical areas (insular, cingulate, and piriform cortice

31 idly and alternately activate and deactivate cortical areas advantageous or obtrusive to function dir

32 ting theta phase coupling of distant frontal cortical areas and can contribute to the development of

33 iGluRs are differentially expressed in the cortical areas and in the species, and all have a unique

34 l signature of sporadic ALS is restricted to cortical areas as well as to subcortical nuclei that are

35 Higher and lower cortical areas in the visual hierarchy are reciprocally

36 al sub-cortical mechanism that regulates the cortical areas size in mice.

37 he primary motor (M1) and somatosensory (S1) cortical areas via the projections from reward-sensitive

38 ion encoding in high-gamma activity (HGA) in cortical areas where neurons are heterogeneous in select

39 send profuse axonal projections to olfactory cortical areas, but not to the OB.

40 Among cortical areas, the anterior cingulate cortex (ACC, area

41 ogeneous, even in layers 3b/4 of the primary cortical areas, where the thalamic input is dominated by

42 that propagate across the surface of visual cortical areas.

43 as it integrates information across multiple cortical areas.

44 ations for learned associations stabilize in cortical association areas or continue to change followi

45 ns NL1, NL2, and NL3, which are expressed by cortical astrocytes, control astrocyte morphogenesis thr

46 filled the diagnostic criteria for posterior cortical atrophy and eight for logopenic variant primary

47 ease and 3 with atypical variants (posterior cortical atrophy, logopenic variant primary progressive

48 views stimulation and patient studies of the cortical basis of conscious volition down to the single-

49 We find that cortical blebbing is tightly coupled to MRTF nuclear shu

50 was conducted to identify the role of Scx in cortical bone development and fracture healing.

51 ported evidence of a saliency map in various cortical brain areas, determining the contribution of ph

52 the intracellular potential of postsynaptic cortical cells in input layers of primary visual cortex.

53 both acting specifically in elongation zone cortical cells.

54 Localizing ESRRA binding sites in cortical chromatin, we show that this nuclear receptor b

55 lular levels, yet how these phenomena affect cortical circuit activity remains unclear.

56 excitatory and inhibitory inputs in healthy cortical circuits and discuss how shifts in excitation/i

57 How cortical circuits are altered and contribute to the inte

58 ce points to a disruption of cortico-thalamo-cortical circuits in schizophrenia (SZ) and bipolar diso

59 ate cortical layer, and became integrated in cortical circuits.

60 erceptual sensitivity mediated by the intact cortical circuits.

61 mature cortical responses, adult patterns in cortical coding of binaural timing cues were measured.

62 Cortical cognitive processing involves gamma oscillation

63 olateral plasma membrane exosomes from mouse cortical collecting duct cells.

64 odies of the same neurons and throughout the cortical column.

65 ed whether M-P streams exist in extrastriate cortical columns, in 8 human subjects (4 female).

66 ved Galpha-GPR-1/2(Pins/LGN)-LIN-5(Mud/NuMA) cortical complex interacts with dynein and is required f

67 thalamocortical inputs indexed by the early cortical component of somatosensory evoked potentials.

68 ent cell types possess distinct functions in cortical computations [5-7] and likely distinct capaciti

69 o dendrites could play a significant role in cortical computations, but how synapses of functionally

70 In addition to intra-cortical connectivity, prefrontal projection neurons inn

71 sin II that result in progressively stronger cortical contractions during ingression.

72 rovide humeral abduction and adduction under cortical control.

73 ons are more vulnerable to injury than their cortical counterparts, but the mechanisms that underlie

74 Previous work has identified cortical cues that regulate spindle orientation and the

75 of ASYN resulted in neuronal atrophy in DIV7 cortical cultures of either from E18 transgenic mouse mo

76 Human MSN modules recapitulate known cortical cytoarchitectonic divisions, and greater inter-

77 migration requires the reorganization of the cortical cytoskeleton at the leading edge of cells and e

78 , a major component of the outer hair cells' cortical cytoskeleton.

79 ical dysfunction after stroke can arise from cortical damage or from white matter disconnection.

80 FOXP1 may be an important mediator of early cortical development and neuronal network formation in t

81 anglioglioma) in 23.6%, and malformations of cortical development in 19.8% (focal cortical dysplasia

82 ential component in the mechanisms of visual cortical development or experience-dependent synaptic pl

83 precursors, a cell population essential for cortical development, but the cause of this neurotropism

84 ositive mild cognitive impairment cases, its cortical distribution overlapping that of amyloid deposi

85 nistration, although consistent increases in cortical dopamine levels (from 88 to 180%) were reported

86 nd in animal models has been shown to reduce cortical dopamine release, which is critically involved

87 The role of actin cross-linking proteins in cortical dynamics is still incompletely understood.

88 attern analysis to whole-brain slow (< 5 Hz) cortical dynamics recorded by magnetoencephalography (ME

89 ctome-lesion symptom mapping approach, since cortical dysfunction after stroke can arise from cortica

90 ions of cortical development in 19.8% (focal cortical dysplasia was the most common type, 52.7% of ca

91 When stimulating at 2 mA, cortical electric fields reach 0.8 V/m, the lower limit

92 epilepsy who were implanted with entorhinal cortical electrodes performing virtual navigation tasks

93 These results demonstrate that flexible cortical entrainment to language does not depend on neur

94 We find significant cortical entrainment to visual oscillations in sign lang

95 a PVS closure in connection with an abnormal cortical event that underlies a neurological disorder.

96 pha-band oscillations are thought to reflect cortical excitability and are therefore ascribed an impo

97 sity for contagious yawning is determined by cortical excitability and physiological inhibition in th

98 ggests that distinct frequencies may reflect cortical excitability in occipital versus posterior pari

99 trains inserted at different phases to probe cortical excitability.

100 alpha rhythm may serve as a general index of cortical excitability.SIGNIFICANCE STATEMENT Alpha-band

101 us (STN) has the ability to prolong incoming cortical excitation.

102 trol of Rok and Pkn is important for unequal cortical expansion, ensuring correct cleavage furrow pos

103 y associated with the degree of evolutionary cortical expansion.

104 Biochemical analysis of cortical extracts from behaviorally tested mice revealed

105 tion of the initiator caspase dronc triggers cortical F-actin dismantling, enabling the glands to str

106 among 50%/50% cortico-cancellous FDBA, 100% cortical FDBA, and 100% cancellous FDBA when used in rid

107 egression was used to evaluate how levels of cortical FDG metabolism were predictive of subsequent co

108 Motor cortical fibrin(ogen) deposition was significantly over-

109 ly couple protein diffusion and transport by cortical flow to control kinase activity gradients and p

110 encies combine to determine overall rates of cortical flow.

111 ility and movement variability, we find that cortical fMRI variability in parietal cortex of individu

112 , it remains unclear how large-scale cortico-cortical functional connectivity systematically reconfig

113 an inter-hemispheric asymmetry and olfactory cortical functional separation that may allow multiple,

114 Here, we estimated visual cortical GABA levels and Glx (combined estimate of gluta

115 n subjects of all ages were combined, visual cortical GABA levels but not Glx levels correlated with

116 intrinsic corticospinal excitability, local cortical GABA levels, and reaction time (RT) in a group

117 This modulation requires CB1 receptors on cortical glutamatergic afferents.

118 the dorsal or ventral forebrain and contain cortical glutamatergic or GABAergic neurons.

119 es transient synaptic potentiation (t-SP) of cortical glutamatergic synapses on nucleus accumbens cor

120 d was negatively associated with global mean cortical gray-matter thickness in the methamphetamine gr

121 In the methamphetamine group, mean cortical gray-matter thickness was negatively associated

122 poxia caused an expected increase in frontal cortical grey matter perfusion but unexpected perfusion

123 show that infection with Zika virus impairs cortical growth and folding.

124 Cortical gyrification of the brain represents the foldin

125 the evolution of genital cortex we flattened cortical hemispheres and assembled 104 complete body map

126 cessing right from the earliest stage of the cortical hierarchy.

127 iences and has also been linked to a typical cortical hyper-excitability.

128 eased intracortical facilitation, indicating cortical hyperexcitability.

129 contrast, during nontask listening sessions, cortical improvements were weak and uncorrelated with pe

130 tral striatum, given its ability to modulate cortical information flow, contributes to conscious perc

131 wo types of impulse is central to cerebellar cortical information processing.

132 In the DLPFC, cortical inhibition was significantly decreased in patie

133 whereas in rodents following photothrombotic cortical injury, transient middle cerebral artery occlus

134 m and spinal locomotor centers from abnormal cortical input after stroke, thus allowing for compensat

135 dback, and occur with behaviourally relevant cortical input.

136 Finally, cortico-cortical interhemispheric coordination among bilateral s

137 hat provide insights into the development of cortical interneurons and that shed light on when their

138 cribed to disturbances in the development of cortical interneurons.

139 vements that differ in their requirement for cortical involvement.

140 measured by multielectrodes covering several cortical lamina and averaged on spontaneous spikes of th

141 or CBSH3+ DNAs, migrated to the appropriate cortical layer, and became integrated in cortical circui

142 GF-1 receptor failed to migrate to the upper cortical layers and accumulated at the ventricular/subve

143 seek to assign FP/LFP recordings to specific cortical layers.

144 s mediated by diffusion of potassium to deep cortical layers.

145 In these experiments, the cortical LFP is measured by multielectrodes covering sev

146 Areas of cortical lobar hypo (hyper)-metabolism in the cerebrum t

147 uired and together sufficient for the robust cortical localization of the ActBD during cytokinesis.

148 ha-tubulin isotype TUBA1A is associated with cortical malformations in humans.

149 This plasticity occurs at the level of cortical maps and individual neurons in the auditory cor

150 Our results reveal that an innate cortical mechanism contributes to the emergence of broad

151 demonstrate the existence of a prenatal sub-cortical mechanism that regulates the cortical areas siz

152 ance of influence exerted by the two eyes on cortical mechanisms underlying binocular vision [1, 2],

153 ogic disruption of a striatopallidal-thalamo-cortical mesocircuit induced by cardiac arrest and pave

154 However, the cortical microtubule alignment along growth-derived maxi

155 pansion of individual cells is played by the cortical microtubule array.

156 owth of fixed handedness, the orientation of cortical microtubule arrays is unaltered in rhm1 mutants

157 ting of short, twisted roots with disordered cortical microtubule arrays that are hypersensitive to a

158 rexpression of NEK6 reduced and disorganized cortical microtubules and suppressed cell elongation.

159 ver learning, the sequential activity across cortical modules became temporally more compressed, and

160 These changes are associated with altered cortical myo-inositol and glycine levels, suggesting sle

161 itory of one-handers becomes utilized by its cortical neighbor (residual arm representation), dependi

162 ison, 1-hydroxymidazolam did not depress the cortical network activity at low nanomolar concentration

163 It relies on a widespread cortical network, including auditory sensory, but also f

164 ns, but how synapses of functionally defined cortical networks are arranged within the dendrites of i

165 Both the striatal and cortical networks encoded time, but the striatal network

166 consequence on the structure and function of cortical networks is unknown.

167 ing functional specialization of hippocampal-cortical networks.

168 hat disruptions of temporal parietal and sub-cortical neurogenesis during infancy are critical to the

169 ranscriptional coordination during mammalian cortical neurogenesis.

170 lays are consistent with the distribution of cortical neuron latencies and that temporal motion integ

171 Finally, in a cortical neuron primary culture, both Nanobodies were ab

172 spike-field coherence of a rat primary motor cortical neuron to the LFP theta rhythm.

173 By providing two-photon imaging access to cortical neuronal populations at single-cell or single d

174 this, we first developed a system combining cortical neurons and astrocytes from closely related spe

175 Here we demonstrate that cortical neurons directly innervate the brainstem to dri

176 We generated iPSC-derived cortical neurons from myoclonus-dystonia patients with m

177 how that betaIII spectrin in hippocampal and cortical neurons from rodent embryos of both sexes is di

178 a mammalian expression system, and protected cortical neurons from slow excitotoxic injury in vitro,

179 c branching and spine density are reduced in cortical neurons of Ube3A 2X ASD mice.

180 mutant does not have an inverted cortex, but cortical neurons overmigrate and invade the marginal zon

181 citability in both excitatory and inhibitory cortical neurons show that selective dysfunction of neur

182 first mechanistic description of how visual cortical neurons signal depth from MP.SIGNIFICANCE STATE

183 We previously reported that embryonic motor cortical neurons transplanted immediately after lesions

184 the rapid kinetics of miR-132 activation in cortical neurons under physiological conditions.

185 The embryonic precursors of these cortical neurons were in utero electroporated with CBSH3

186 Treatment of cultured cortical neurons with E2 reduced the accumulation of GAB

187 n highlights the suitability of iPSC-derived cortical neurons with SGCE mutations for myoclonus-dysto

188 n of the reticular system, which projects to cortical neurons, and projects to spinal motoneurons con

189 ome of which were not seen in hippocampal or cortical neurons, and resulting in neuronal hyperexcitab

190 ed in both infected and uninfected bystander cortical neurons, suggesting a role for paracrine factor

191 nd 1-hydroxymidazolam on network activity of cortical neurons.

192 itinerary for key synaptic molecules in rat cortical neurons.

193 tACS acts on both excitatory and inhibitory cortical neurons.

194 ed pluripotent stem cells, or in primary rat cortical neurons.

195 cts of TDP-43 dysfunction in hippocampal and cortical neurons.

196 d the receptive fields (RFs) of postsynaptic cortical neurons.

197 It scales to large volumes of cortical neuropil, plausibly even whole-brain datasets.

198 e asymmetric establishment and regulation of cortical NuMA-dynein complexes that position the mitotic

199 Decoding analyses indicate that cortical odor representations are not sparse.

200 n for testing hypotheses about the nature of cortical organization, because it is known to develop on

201 ay spiking activity, whereas delta-frequency cortical oscillations entrain spiking activity throughou

202 inhibitory neurons in orchestrating specific cortical oscillations.

203 Simultaneously, changes in cortical oxygenated hemoglobin and deoxygenated hemoglob

204 The maturation of cortical parvalbumin-positive (PV) interneurons depends

205 anillin assemble into dynamic rho-dependent cortical patches that rapidly disassemble in wild-type e

206 In addition, cortical pathways that mediate the precise coordination

207 he adult mouse motor cortex restored damaged cortical pathways.

208 lective findings suggest chimpanzees exhibit cortical plasticity in regions of the brain that were ce

209 To test this hypothesis, visual cortical plasticity was assessed in Ts65Dn mice that har

210 The findings provide a clearer picture of cortical processes for analysis of sound features.

211 Cortical processing depends on a fine balance between ex

212 l, subthreshold, electric fields to modulate cortical processing.

213 ptoTag, followed by 3D reconstruction of the cortical projections, we performed a comprehensive study

214 They also suggest that effective cortical proprioceptive processing operates at <3 Hz fre

215 scale cortical reorganization, regardless of cortical proximity to the hand territory.

216 ad orientation selectivity emerges in visual cortical PV interneurons.

217 the principal site of communication between cortical pyramidal neurons and their targets, a key locu

218 ted background potassium current observed in cortical pyramidal neurons from wild type mice was consp

219 subtype, ACh exerts two opposing actions in cortical pyramidal neurons: transient inhibition and lon

220 ce, the evaluation being limited to a single cortical region for epigenetic and transcriptomic data,

221 allowed induction of ischemia in a specific cortical region of conscious mice of any postnatal age,

222 in the human middle temporal gyrus (MTG), a cortical region supporting the semantic representation o

223 ed the circuit anatomy of zebra finch HVC, a cortical region that generates sequences underlying the

224 The fMRI activity in visual cortical regions contralateral to the cued direction of

225 Canonical IN types conserved across distinct cortical regions have been defined by their morphologica

226 responses within distributed subcortical and cortical regions including the striatum, insula, lateral

227 ns beyond relaying information to or between cortical regions is unknown.

228 patial extent, region, and laterality of the cortical regions most responsive to variations in pitch

229 amma-band EEG, consistent with activation of cortical regions representing attended locations in spac

230 tion or whether the GABA levels of different cortical regions selectively influence perception of dif

231 Six cortical regions were quantified using a standardized re

232 lamus is globally connected with distributed cortical regions, yet the functional significance of thi

233 ectivity between the right DLPFC and several cortical regions.

234 tern here described is not observed in other cortical regions; it is proposed to rely on the peculiar

235 roduce AG sounds resulted in region-specific cortical reorganization within the inferior portion of t

236 tory profile was associated with large-scale cortical reorganization, regardless of cortical proximit

237 cision-making behavior and identify a global cortical representation of task engagement encoded in th

238 ubjects demonstrate that attentional gain of cortical responses can sufficiently account for attentio

239 hanges in the way attention alters the early cortical responses that support selective information pr

240 , temporal, and amplitude characteristics of cortical responses to light touch that differentiate the

241 This encoding approach not only predicts cortical responses to time-varying stimuli from millisec

242 ld children with normal hearing had immature cortical responses, adult patterns in cortical coding of

243 Thus, impaired adaptation in cortical sensory circuits is a potential cause of tactil

244 eater improvement in second/third interdigit cortical separation distance following verum acupuncture

245 Two neighboring patches embedded in a cortical sheet, mimicking the two digit regions, were co

246 red rat hippocampal neurons or ex vivo human cortical slices to AbetaOs transiently decreased intrace

247 tical spindles, hippocampal ripples, and the cortical slow oscillations-is thought to be critical for

248 ng two brain states, respectively defined by cortical slow-wave activity (SWA) and activation.

249 We decomposed the posterior AR in the cortical source space with a 3-way PARAFAC technique, ta

250 -rapid-eye-movement (NREM) sleep-the thalamo-cortical spindles, hippocampal ripples, and the cortical

251 Cortical spreading depression (CSD) is likely the underl

252 e-dynamic range trigeminovascular neurons by cortical spreading depression (CSD).

253 However, in the post-subiculum, the main cortical stage of HD signal processing, HD neurons conve

254 all, the data show that slow fluctuations in cortical state are selectively linked to K pathway spiki

255 Both locomotion and the change in cortical state are thought to be initiated by projection

256 Locomotion causes a change in cortical state that leaves their selectivity unchanged b

257 phenotype, animal models of HD show aberrant cortical-striatal glutamate signaling.

258 principles apply with equal validity to any cortical structure.

259 Among different sub-cortical structures, the basal ganglia (BG) has been inv

260 rotubule depolymerase Kif2 is localized to a cortical subdomain of the ER that is involved in asymmet

261 RBCs entering the capillary bed close to the cortical surface (< 400 mum) the largest pressure drop t

262 a specific topographical organization on the cortical surface analogously to the category-specific or

263 Neuron numbers under a unit of cortical surface area are low toward the frontal cortex

264 if the needle path was parallel to the renal cortical surface, at a depth closer to the renal capsule

265 calculated from PET scans and a mean global cortical SUVR was calculated.

266 y reproduces known architectural features of cortical synapse distributions.

267 activation of NF-kappaB signaling decreased cortical synaptic plasticity via HDAC2.

268 rict the rate of exocytosis from a subset of cortical synaptic terminals within the EC and in this wa

269 A biopsy followed a cortical tangential approach if the needle path was para

270 al connectivity between an individual's rTMS cortical target and the subgenual cingulate predicts ant

271 ults are consistent with the hypothesis that cortical tau is associated with cognitive impairment.

272 ombination of the marginal band rigidity and cortical tension increases the ability of the cell to wi

273 aptive response to pain that de-synchronizes cortical theta and decreases sensory salience.

274 similar interaction effects on temporal lobe cortical thickness (whole-brain voxelwise analysis: fami

275 Cortical thickness did not differ significantly between

276 The epigenetic effect on cortical thickness was replicated in a sample comprising

277 PG activity, leading to steeper decreases in cortical thickness with age.

278 , roughness (i.e., the standard deviation of cortical thickness) of the right inferior parietal and r

279 uration, indexed by age-related decreases in cortical thickness, in adolescents living in neighborhoo

280 Tau burden, amyloid burden, and cortical thickness.

281 so in a manner partially mediated by rate of cortical thinning (point estimate=0.078 (95% CIs: 0.003,

282 Our cortical thinning classifier included nine microRNAs, p=

283 ural brain networks that undergo coordinated cortical thinning during adolescence, which is in part g

284 reduced higher visual function at baseline, cortical thinning in parietal, occipital and frontal cor

285 n changes might precede diffuse atrophy with cortical thinning.

286 on the surface of B cells, dendritic cells, cortical thymic epithelial cells, and medullary thymic e

287 The findings suggest that cortical tissue normally operates as a type I excitable

288 Similarly, cortical TSPO binding increased to a maximum at 14.5 mo

289 euronal assemblies.Slow oscillations between cortical Up and Down states are a defining feature of de

290 ore, when examining the relationship between cortical variability and movement variability, we find t

291 iddle cerebral artery stroke with absence of cortical vein opacification in the affected hemisphere (

292 clerotic glomeruli decreased by 48%, whereas cortical volume decreased by only 16% and the proportion

293 witz Social Anxiety Scale) and reductions in cortical volume in bilateral dorsomedial prefrontal cort

294 erebellar ratio above 1.5 within a composite cortical volume of interest.

295 ace-based morphometry revealed a significant cortical volume reduction (pre- to post-treatment) in th

296 Further, the dominant contributor to cortical volume reductions during adolescence was thinni

297 ebrain, hippocampus, striatum, amygdala, and cortical volume were also observed.

298 total number of glomeruli was estimated from cortical volumexglomerular density.

299 sembly provides the earliest spatial cue for cortical waves and sets the direction of propagation.

300 a repeating spatial progression in multiple cortical zones, suggesting that they are embedded within