ライフサイエンスコーパス: cortisol

1 lly elevated levels of the catabolic hormone cortisol.

2 se of the stress response-regulating hormone cortisol.

3 gene, to respond to the host stress hormone cortisol.

4 onic, autonomous, and excessive secretion of cortisol.

5 atic skin leading to localized deficiency of cortisol.

6 highly-sensitive quantification of salivary cortisol.

7 variation in blood pressure, heart rate, and cortisol.

8 of 20beta-dihydrocortisol (20beta-DHF) from cortisol.

9 tor (GR), the nuclear receptor of endogenous cortisol.

10 cific to the physiological relevant range of cortisol (8.16 to 141.7 ng/mL) in perspired human sweat.

11 Cortisol affects maternal and fetal metabolism, but whet

12 High selectivity was observed to salivary cortisol against a background of closely related steroid

13 Ab binds the capture Ab, an IgG specific for cortisol, allowing its correct orientation.

14 The stress hormone, cortisol, alters metabolism in the adult and fetus but i

15 orrelated with serum hormone concentrations (cortisol and aldosterone), hepatobiliary enzyme levels,

16 al stress measures via the salivary analytes cortisol and alpha-amylase with self-assessments of psyc

17 he previously reported metabolites as DHEAS, cortisol and androstenedione and extending that to a lar

18 in activation, increasing bioavailability of cortisol and catecholamine.

19 cognitive functions, beyond the influence of cortisol and clinical symptoms.

20 Binary mixtures of cortisol and CLO mostly showed a similar activity as CLO

21 that ozone exposure markedly increased serum cortisol and corticosterone together with increases in m

22 Cortisol and corticosterone were significantly higher in

23 Glucocorticoids (cortisol and corticosterone) and their inactive versions

24 onal effects of clobetasol propionate (CLO), cortisol and cortisone in zebrafish embryos as single co

25 nal prenatal distress, and elevated maternal cortisol and epigenetic regulation of placental glucocor

26 The relationship between cortisol and epileptiform discharges was positively asso

27 battery, overnight hourly blood sampling for cortisol and genetic assessment.

28 HIIT suppressed cortisol and growth hormone responses, but not catechola

29 a unique endocrine milieu comprising minimum cortisol and high aldosterone, growth hormone (GH), and

30 aracterizing SWS (mainly by further reducing cortisol and increasing aldosterone levels) and reduces

31 fluence of two major stress neuromodulators, cortisol and noradrenaline, on loss aversion during fina

32 rmed women in the stress task and had higher cortisol and testosterone levels than women after stress

33 rn of effects was observed across endocrine (cortisol and testosterone), psychological (feeling in co

34 We show that corticosterone and cortisol and their less active precursors 11-dehydrocort

35 he conventional body mass index, followed by cortisol and, lastly, perceived health.

36 e explored the joint impact of testosterone, cortisol, and brain reactivity to anger expressions on w

37 ostsurgery reductions in levels of glucagon, cortisol, and catecholamine and the sympathetic nerve re

38 lasma epinephrine, norepinephrine, glucagon, cortisol, and growth hormone responses were similarly re

39 growth factor I, triglycerides, cholesterol, cortisol, and leptin, were measured after an overnight f

40 rmance was negatively correlated with higher cortisol, and PMD patients had higher cortisol than did

41 with the prepartum increase in fetal plasma cortisol, and treatment of the preterm fetus with clinic

42 nanosheets were surface functionalized with cortisol antibodies towards developing an affinity biose

43 although delta cortisol (change in baseline cortisol at 60 min of < 9 mug/dL) after cosyntropin (250

44 ectrical biosensor chip to quantify salivary cortisol at a point-of-care (POC) level.

45 to populate the magnetic nanoparticle bound cortisol at the sensing electrode area.

46 d no relationship between job strain and the cortisol awakening response.

47 xysteroid dehydrogenase type 2 to inactivate cortisol before it reaches the fetus, leading to higher

48 uicide attempters also showed lower baseline cortisol before the TSST (beta=-0.45, 95% CI (-0.74, -0.

49 measuring impedance changes associated with cortisol binding along the MoS2 nanosheet interface usin

50 A non-faradaic label-free cortisol biosensor was demonstrated using MoS2 nanosheet

51 1beta-hydroxylase (CYP11B1), which catalyzes cortisol biosynthesis and is highly homologous to CYP11B

52 teroidogenesis pathway that lead to impaired cortisol biosynthesis.

53 The HRP-labelled cortisol, bonded to the capture Ab, is measured through

54 CLO and cortisol, but not cortisone showed a concentration-depen

55 the ability to enhance the surface area for cortisol capture, this assay shows signal linearity over

56 talyst ink that can electrochemically reduce cortisol, captured by aptamer functionalized magnetic na

57 can reliably diagnose CIRCI, although delta cortisol (change in baseline cortisol at 60 min of < 9 m

58 existing psychological factors and treatment cortisol changes.

59 e low (or insufficiently high in the case of cortisol) circulating levels of the target-organ hormone

60 Cortisol, clinical symptoms and variation in genes, NR3C

61 Hair cortisol concentration (HCC) is a promising measure of l

62 sensor was able to discriminate between four cortisol concentration ranges (0.5, 5, 50, 500 ng/mL) fo

63 However, when maternal cortisol concentrations are raised chronically, prolonge

64 The results show that maternal cortisol concentrations regulate uteroplacental glycolyt

65 rwise inactivates cortisol, sustaining tumor cortisol concentrations to stimulate GR and enzalutamide

66 Cortisol concentrations were determined in fetal plasma

67 Here, cortisol concentrations were measured in the plasma and,

68 Plasma cortisol concentrations were positively correlated with

69 In this study, when cortisol concentrations were raised in pregnant sheep by

70 In contrast, blubber cortisol concentrations were shown not to be significant

71 l and fetal metabolism, but whether maternal cortisol concentrations within the physiological range r

72 no effect of MCH on fetal plasma/lung tissue cortisol concentrations, nor genes regulating glucocorti

73 or salivary cortisol level over plasma total cortisol (conditional, very low quality of evidence).

74 Salivary cortisol confirmed that our stressor elicited changes in

75 , suggesting a shared evolutionary origin of cortisol coregulation in vertebrates.

76 Whether cortisol coregulation is unique to humans or can also be

77 From an adaptive perspective, cortisol coregulation may serve to reduce risk in challe

78 Research into moderating effects on cortisol coregulation suggests stronger covariation amon

79 Cortisol coregulation, which is the up- or down-regulati

80 is the major receptor for the stress hormone cortisol (corticosterone in rodents) and is widely expre

81 maternal BMI associated with lower maternal cortisol, corticosterone and 11-dehydrocorticosterone.

82 elationship between job strain and the whole cortisol curve, accounting for sources of cortisol varia

83 In contrast, stress levels of cortisol decreased CLDN1 in late differentiation stage b

84 th excess mortality, a key risk factor being cortisol deficiency due to adrenocorticotropic hormone (

85 If onset is acute, cortisol deficiency should be replaced first.

86 Beyond the effects of cortisol, demographics and clinical symptoms, NR3C1 vari

87 During stress, cortisol-dependent regulation of uteroplacental glycolys

88 hological adverse effects may be a result of cortisol depletion of the cerebral mineralocorticoid rec

89 m norepinephrine and concomitant increase in cortisol, despite suppressed adrenocorticotropic hormone

90 f-care sensing platform specific to salivary cortisol detection.

91 nd-held device successfully exhibited a wide cortisol-detection range from 3 pg/mL to 10 mug/mL, with

92 ), neuroendocrine function (diurnal salivary cortisol, dexamethasone suppression), cognition (neurops

93 (DHEA) concentration and a reduction in the cortisol/DHEA-ratio in hair.

94 Changes in serum cortisol during the intervention were associated with ch

95 that synergistic action of noradrenaline and cortisol enables emotional stimuli to gain privileged ac

96 e, norepinephrine, glucagon, growth hormone, cortisol, endogenous glucose production, and lipolytic a

97 upled with reduced stress-axis activity (low cortisol) engage in profit-maximizing decision-making.

98 , such that the cotwin with higher childhood cortisol evinced relatively lower rs-FC and poorer amygd

99 Prompt treatment of cortisol excess and specific treatments of comorbidities

100 e characterized by high testosterone and low cortisol exhibited the highest performance.

101 or increased Salmonella proliferation inside cortisol exposed macrophages.

102 Higher levels of cortisol exposure are also hypothesized to underlie the

103 FKBP5 expression is upregulated by cortisol exposure during stressful episodes, with greate

104 aches the fetus, leading to higher levels of cortisol exposure.

105 ltiple sources of variability) in estimating cortisol features.

106 nd physiology, such as freezing and elevated cortisol, followed by a return to the baseline state whe

107 expected, intrapair differences in childhood cortisol forecast amygdala-perigenual PFC rs-FC (R(2) =

108 A detailed comparison of sodium, lactate and cortisol from saliva is reported, demonstrating the pote

109 onitoring the periodic diurnal variations in cortisol from small volume samples of serum or saliva is

110 ection of analytes, Interleukin-6 (IL-6) and Cortisol, from human sweat in RTILs.

111 In previous work, childhood basal cortisol function predicted adolescent resting-state fun

112 significant variation in telomere length and cortisol functioning was observed at the neighborhood le

113 biological outcomes were telomere length and cortisol functioning.

114 ring KET, serum tumor necrosis factor-alpha, cortisol, glucagon, and growth hormone levels increased,

115 Adrenocorticotropic hormone (ACTH), cortisol, glucagon, and nonesterified fatty acid (NEFA)

116 ala (BLA) reactivity to angry faces, whereas cortisol had no effect.

117 Cortisol has been identified as a biomarker in saliva to

118 Testosterone and cortisol have been proposed to influence aggressive beha

119 Salivary cortisol (hypothalamic pituitary axis), heart rate varia

120 The advantages of the newly developed cortisol immune biosensor over previously reported chips

121 ZnO-NSs based cortisol immunosensors were tested on human saliva sampl

122 We also show experimentally that cortisol implants increase the expression of agouti sign

123 actor in HCC, so we investigated the role of cortisol in gender discrepancy in a zebrafish model of H

124 ry functions on binding of a single natural (cortisol in human and corticosterone in mice) and synthe

125 hermore, combinatorial detection of IL-6 and Cortisol in human sweat was established with minimal cro

126 ycosylation regulates the bioavailability of cortisol in inflamed environments by fine-tuning the RCL

127 hors examined maternal distress and salivary cortisol in relation to fetal movement and heart rate ("

128 nd chronic stress, as measured by changes in cortisol in response to an acute stress manipulation and

129 adult and fetus but it is not known whether cortisol in the pregnant mother affects metabolism of th

130 belled cortisol is added to compete with the cortisol in the sample, for the capture Ab binding sites

131 incorporation rates and dynamic circulating cortisol in vertebrates.

132 ifferentially correlated with stress-induced cortisol increases between the groups, enriched for gene

133 Through this mechanism, cortisol increases Salmonella proliferation inside macro

134 nsecticides, bifenthrin, and 3-PBA decreased cortisol-induced PEPCK gene expression, while o,p'-DDT a

135 Cypermethrin and tolyfluanid attenuated cortisol-induced TAT expression.

136 so net fetal glucose uptake was 29% lower in cortisol-infused than control ewes (P < 0.05).

137 This study determined the effect of maternal cortisol infusion (1.2 mg kg(-1) day(-1) i.v. for 5 days

138 Cortisol infusion also raised maternal insulin, glucose

139 Compared to saline infusion (n = 21), cortisol infusion increased maternal, but not fetal, pla

140 oup-level concentrations of testosterone and cortisol interact to predict a group's standing across g

141 ucocorticoid metabolism by converting active cortisol into inactive cortisone.

142 Horseradish peroxidase (HRP)-labelled cortisol is added to compete with the cortisol in the sa

143 We previously showed that cortisol is lower in obese pregnancy.

144 s have demonstrated that plasma clearance of cortisol is markedly reduced during critical illness, ex

145 Cortisol is one of the main glucocorticoid hormones invo

146 x metalloproteinases mmp-9 and mmp-13, while cortisol led to stronger upregulation of the gluconeogen

147 cortisol signaling in males, or increase of cortisol level in females, decreased or increased the nu

148 bound with electro-active triamcinolone, the cortisol level is detected based on its competitive bind

149 Measurement of a late-night salivary cortisol level is the best screening test but petrosal s

150 ainst using plasma-free cortisol or salivary cortisol level over plasma total cortisol (conditional,

151 Higher "normal" postdexamethasone cortisol levels (</=50 nmol/L) were associated with larg

152 ntranasal insulin also increased circulating cortisol levels (F=12.78, P0.001).

153 ome were significantly less likely to reduce cortisol levels after a reactivity test (beta, 0.029; P

154 transformations of the correlations between cortisol levels and HCVs were calculated using random ef

155 The relationship between cortisol levels and incidence of interictal epileptiform

156 ob strain was associated with lower salivary cortisol levels and lower total area under the curve.

157 We investigated the relationship between cortisol levels and the epileptiform discharges distingu

158 We tested the relation between cortisol levels and the incidence of epileptiform abnorm

159 inically relevant as maternal and cord blood cortisol levels are correlated and offspring of obese ar

160 Moreover, we measured cortisol levels by ELISA and found that mevastatin inhib

161 uiring continuous monitoring of the salivary cortisol levels during a circadian cycle.

162 Despite the elevated cortisol levels during critical illness, tissue resistan

163 their home had a steeper diurnal decline in cortisol levels during the day (beta [SE], -0.002 [0.001

164 or waking cortisol levels, and 5.5% for peak cortisol levels following a stressor.

165 Evidence of the link between job strain and cortisol levels has been inconsistent.

166 pt studies were performed to detect salivary cortisol levels in human subjects with high and low risk

167 A combination of apolipoprotein A-II and cortisol levels in plasma and fibroblast growth factor 4

168 sh (Gasterosteus aculeatus) coregulate their cortisol levels in shared environments.

169 ty in the adrenal cortex and an elevation of cortisol levels in the blood.

170 intrapair differences in childhood afternoon cortisol levels predicted cotwin differences in adolesce

171 cortisol levels were predicted by partner's cortisol levels prior to the shared experience.

172 , women with lower dispositional anxiety and cortisol levels showed the largest vasopressin-induced m

173 Most importantly, blood cortisol levels strongly indicate that grass-fed animals

174 stradiol, thyroid hormones, and urinary free cortisol levels were assessed.

175 No differences in cortisol levels were found.

176 Cortisol levels were increased and activity levels decre

177 Morning cortisol levels were measured in saliva samples obtained

178 thyroid-stimulating hormone (TSH), and 8 am cortisol levels were normal.

179 Structural MRI scans and cortisol levels were obtained following each medication

180 Thyroxine levels and urinary free cortisol levels were positively associated with thigh SA

181 ag analysis further revealed that open field cortisol levels were predicted by partner's cortisol lev

182 Dyadic cortisol levels were unrelated when cohabiting (home tan

183 show altered crh levels, fail to upregulate cortisol levels when under stress and do not modulate sh

184 e (HCV) and total brain volume (TBV), and of cortisol levels with HCV, including subgroup analyses of

185 ing a more stressful (as indicated by higher cortisol levels) environment (open field).

186 s of 6% for telomere length, 3.4% for waking cortisol levels, and 5.5% for peak cortisol levels follo

187 's disease, characterized by elevated plasma cortisol levels, can be controlled by inhibition of 11be

188 ee bins examined was associated with wake-up cortisol levels, indicating functional relevance of the

189 ividuals, as well as alterations in salivary cortisol levels.

190 inhibitors farnesyl pyrophosphate (FPP) and cortisol, ligands for the glucocorticoid receptor (GR).

191 For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calcula

192 These results suggest that cortisol may play a key role in increased fat metabolism

193 ponse to CRF was assessed by serial salivary cortisol measurements.

194 ants genotyped for FKBP5 SNPs shown to alter cortisol metabolism (rs1360780, rs9470080, and rs9394309

195 CBR1 provides the major route of cortisol metabolism in horses and is up-regulated in adi

196 alamic-pituitary-adrenal (HPA) axis, altered cortisol metabolism, and tissue resistance to glucocorti

197 essed expression and activity of the primary cortisol-metabolizing enzymes in the liver and kidney.

198 ushing's disease who had a mean urinary free cortisol (mUFC) concentration (from three 24 h samples)

199 (250 mug) administration and a random plasma cortisol of < 10 mug/dL may be used by clinicians.

200 To examine the impact of stress-induced cortisol on attentional bias to threat, participants in

201 (HPA) axis is closed by negative feedback of cortisol on the hypothalamus and pituitary.

202 e due to effects of stress hormones, such as cortisol, on neuronal excitability.

203 We suggest against using plasma-free cortisol or salivary cortisol level over plasma total co

204 spring suicide attempters showed lower total cortisol output (beta=-0.47, 95% CI (-0.83, -0.11), p=0.

205 ng of reward is already related to increased cortisol output and depression severity in preschoolers.

206 as found to mediate the relationship between cortisol output and depression severity.

207 Higher total cortisol output following a stressor was associated with

208 s in placental lactate production induced by cortisol overexposure may contribute to the adverse effe

209 on increased maternal, but not fetal, plasma cortisol (P < 0.05).

210 es evaluated relationships between NFATs and cortisol physiology.

211 , master clock markers (plasma melatonin and cortisol), plasma triglycerides, or clock gene expressio

212 r the concentration range of 0-10(-6)g/ml of cortisol prepared in artificial saliva.

213 gh DNA methylation in hypercortisolemia with cortisol-producing adenoma (CPA), and to investigate a p

214 These results identify increased cortisol production and TAN/TAM infiltration as primary

215 in the regulation of CYP11B1 expression and cortisol production in CPA, and that somatic mutations a

216 f1alpha function, induced the HPA/I axis and cortisol production.

217 -loss decrements in alertness, melatonin and cortisol profile, skin temperature and wrist motor activ

218 thesis testing and for evaluation of morning cortisol profiles; and 5) identify measures that best di

219 The cortisol quantification is performed by colorimetric det

220 ignificant differences between the groups on cortisol reactivity to stress (beta=4.5, 95% CI (-12.9,

221 th lower sensitivity to sedative effects and cortisol reactivity, relative to light drinkers.

222 Cortisol, regardless of stress, is released in hourly pu

223 (lactate) management, (iii) stress hormone (cortisol) regulation; (iv) neurotransmitter (dopamine, n

224 ssments revealed stress-induced increases in cortisol release and negative affect that persisted 65 a

225 ted a significant stress-induced increase in cortisol release and negative affect, the hyper-response

226 d that high and low levels of stress-induced cortisol release correlated with reduced hippocampal gra

227 d that high and low levels of stress-induced cortisol release were associated with less hippocampal g

228 prolonged neuroendocrine response, marked by cortisol release, which can influence important forms of

229 al gray matter volume compared with moderate cortisol release.

230 d rat CBG crystal structures in complex with cortisol resemble each other, but their primary structur

231 he stress group (including both Low and High cortisol responders) showed reduced P300 amplitude to ta

232 e stress group were split into Low- and High cortisol responders.

233 mygdala volumes, yet a continuous measure of cortisol response (area under the curve) showed that hig

234 on also reduced risk perception and salivary cortisol response (P=.032; effect size 0.36).

235 examined the concurrent associations between cortisol response following a stressor, functional brain

236 reported child depression severity and child cortisol response following stress were also measured.

237 Moreover, a continuous measure of cortisol response showed that high and low levels of str

238 rception at 6 weeks and 1 year, and salivary cortisol response to a simulated anaphylaxis scenario at

239 esults suggest that distinct trajectories of cortisol response to prolonged acute stress among health

240 relations may better describe links between cortisol response to stress and affective responses, as

241 onse, groups characterized by hyper and mild cortisol response were both associated with more negativ

242 Relative to the group showing a moderate cortisol response, groups characterized by hyper and mil

243 we identified three distinct trajectories of cortisol response.

244 es identified three distinct trajectories of cortisol response: the hyper-response (n = 10), moderate

245 r mixed modeling on individuals' patterns of cortisol responses identified three distinct trajectorie

246 first evidence for coregulatory processes on cortisol responses in a non-human animal that lacks stro

247 r mixed modeling on individuals' patterns of cortisol responses to a prolonged acute stressor, we ide

248 In this study, we examined cortisol responses to an experimental stressor, the Trie

249 onses to stress, evidenced by lower ACTH and cortisol responses.

250 I/IV (HR, 1.80; 95% CI, 0.95-3.39; P = .07), cortisol-secreting tumor (HR, 2.38; 95% CI, 1.27-4.48; P

251 ts were given metyrapone (to inhibit adrenal cortisol secretion) + /- hydrocortisone (HC) in a random

252 hronotypes, which was associated with higher cortisol secretion.

253 ants suggests glucose involvement in blubber cortisol sensitivity.

254 The performance of the proposed cortisol sensor chip was validated using an enzyme-linke

255 A fiber optic salivary cortisol sensor using a contemporary approach of lossy m

256 Lossy mode resonance based salivary cortisol sensor using nanocomposite molecular imprinted

257 Finally, high concentrations of cortisol showed weak bacteriostatic effects toward virul

258 Inhibition of cortisol signaling in males, or increase of cortisol lev

259 ed cellular stress (HIF) and stress hormone (cortisol) signaling in TNBC, identifying the phospho-GR/

260 olerance, glycated haemoglobin A1c, salivary cortisol, sitting height, and head circumference.

261 n, while o,p'-DDT and methoxychlor inhibited cortisol-stimulated Arg and TAT gene expression.

262 -DDE, methoxychlor- and tolylfluanid-reduced cortisol-stimulated GILZ expression.

263 12205) showed the strongest association with cortisol stress reactivity (P=5.8 x 10(-6)).

264 ated whether SKA2 DNA methylation influences cortisol stress reactivity and is involved in the develo

265 tion was significantly associated with lower cortisol stress reactivity in 85 healthy individuals exp

266 he relationship between childhood trauma and cortisol stress reactivity in the discovery sample (32%

267 se data establish the importance of SKA2 for cortisol stress responsivity and the development of PTSD

268 ed by crowding stress or exposed to elevated cortisol stress, both of which activate glucocorticoid r

269 2 (11beta-HSD2), which otherwise inactivates cortisol, sustaining tumor cortisol concentrations to st

270 by ELISA and found that mevastatin inhibited cortisol synthesis in keratinocytes and biopsies from pa

271 The physiological control of cortisol synthesis in the adrenal cortex involves stimul

272 Higher levels of cortisol, TGFB1, and TAN/TAM infiltration in males were

273 higher cortisol, and PMD patients had higher cortisol than did NPMDs and HCs.

274 l lactate production was > 2-fold greater in cortisol- than saline-treated ewes (P < 0.05), although

275 ctate dehydrogenase activity were greater in cortisol- than saline-treated ewes (P < 0.05).

276 tive aptamer-based detection methodology for cortisol that does not require target labeling, capture

277 Whether they impact on plasma cortisol through inhibition of cholesterol synthesis is

278 ed by colorimetric detection of HRP-labelled cortisol, through optical absorption at 450nm, using a C

279 ng globulin (CBG) delivers anti-inflammatory cortisol to inflamed tissues upon elastase-based proteol

280 er 8) gene expression were also greater with cortisol treatment.

281 s often done by measuring 24-hour urine free cortisol (UFC) excretion.

282 This could be due to failure to account for cortisol variability leading to underestimated standard

283 le cortisol curve, accounting for sources of cortisol variability.

284 mL) and exhibits rapid binding kinetics with cortisol versus other glucocorticoids, as apparent from

285 control manipulation a week later; salivary cortisol was measured throughout to assay stress reactiv

286 Cortisol was positively related to incidence of epilepti

287 Interestingly, the adrenal hormone cortisol was predominantly produced in males to induce T

288 ved stress (Perceived Stress Scale), but not cortisol, was associated with altered CpG methylation in

289 Subjective sleepiness, melatonin and cortisol were assessed hourly.

290 Changes in serum cortisol were associated with changes in body fat and LB

291 Elevations in cortisol were associated with more negative ratings of s

292 Of the 12 studies included, higher levels of cortisol were associated with smaller HCV (correlation =

293 Mood questionnaires and salivary cortisol were collected from 61 women between 24-27 gest

294 circulating adrenocorticotropic hormone and cortisol were observed.

295 adults and controls were found for salivary cortisol, whereas lower serum docosahexaenoic acid (DHA)

296 on caused a significant increase in salivary cortisol, which lasted for 135 min.

297 stronger effects on immune system genes than cortisol, which was characterized by upregulation of fkb

298 igh specificity of the sensor chip to detect cortisol with a detection limit of 3 pg/mL was achieved

299 ts application towards routine monitoring of cortisol within bio-fluids.

300 reat interest, due to the regulatory role of cortisol within various physiological functions and stre