ライフサイエンスコーパス: cortisone

1 at interconvert active cortisol and inactive cortisone.

2 nished ability to convert [11-3H]cortisol to cortisone.

3 verts hormonally active cortisol to inactive cortisone.

4 at interconvert active cortisol and inactive cortisone.

5 pe 1 (11beta-HSD1) regenerates cortisol from cortisone.

6 by converting active cortisol into inactive cortisone.

7 and the binding selectivity of cortisol over cortisone.

8 interconversion of active cortisol and inert cortisone.

9 ts as a dehydrogenase converting cortisol to cortisone.

10 eta2 showed only inactivation of cortisol to cortisone.

11 r synthesis of active cortisol from inactive cortisone.

12 tive glucocorticoid, cortisol, with inactive cortisone.

13 f biologically inactive 11 keto derivatives (cortisone, 11-dehydrocorticosterone) to active glucocort

14 terone) and their inert 11-keto derivatives (cortisone, 11-dehydrocorticosterone).

15 d3-cortisol 5.9 +/- 1.8 pmol/100 mL/min, and cortisone 15.2 +/- 5.8 pmol/100 mL/min) and splanchnic (

16 /min, d3-cortisol 12.9 +/- 2.1 nmol/min, and cortisone 19.5 +/- 2.8 nmol/min) circulations.

17 After oral cortisone (25 mg), cortisol concentrations within adipos

18 teady state and after oral administration of cortisone (5 mg) to estimate whole-body and liver 11beta

19 simultaneous adipose microdialysis and oral cortisone acetate administration.

20 ropenic mice that were immunosuppressed with cortisone acetate and infected with the Deltaace2 mutant

21 ceptible to oral infection by injection with cortisone acetate and then inoculated by placing a swab

22 Cortisone acetate gave results similar to dexamethasone,

23 The effect of GM-CSF on cortisone acetate suppression lasted at least 7 days.

24 e gave results similar to dexamethasone, but cortisone acetate suppression of BAM responses lasted 7

25 Either cyclophosphamide or cortisone acetate treatment could cause reactivation, bu

26 everely immunosuppressed by cyclophosphamide-cortisone acetate treatment.

27 ivo administration of saline, dexamethasone, cortisone acetate, granulocyte-macrophage colony-stimula

28 emotherapeutic antiangiogenic agents tested: cortisone acetate, vincristine, bleomycin, Adriamycin, 5

29 of the A. fumigatus protein Asp f3 protected cortisone acetate-immunosuppressed mice from experimenta

30 ailed monkeys treated orally for 1 year with cortisone acetate.

31 Conversion of cortisone (administered as 25 mg orally) to cortisol in

32 corticosterone) and their inactive versions (cortisone and 11-dehydrocorticosterone) were measured by

33 d2-Cortisone and 9,11,12,12-[(2)H](4)-cortisol (d4-cortisol

34 rotein that catalyzes the interconversion of cortisone and cortisol.

35 rast, ROS 17/2.8beta1 were sensitive to both cortisone and cortisol.

36 nistically distinct anti-inflammatory drugs, cortisone and ibuprofen, significantly inhibited angioge

37 on of hormonally active cortisol to inactive cortisone and is vital for dictating specificity for the

38 Complexes with cortisone and progesterone reveal productive substrate b

39 oacyl-tRNA biosynthesis; and in CSF involved cortisone and prostaglandin 2 biosynthesis and metabolis

40 y steroidal drugs (such as dexamethasone and cortisone) and nonsteroidal anti-inflammatory drugs (suc

41 rtisone to cortisol greater than cortisol to cortisone) and was higher in omental than subcutaneous f

42 -HSD1), which generates active cortisol from cortisone, and 5alpha-reductase (5alphaR), which inactiv

43 analysis using stable isotope-labeled (SIL) cortisone as a substrate was developed.

44 HEPES bound in the active site), NADP(+) and cortisone at 1.90-A resolution, NADP(+) and progesterone

45 culating glucocorticoid, and its metabolite, cortisone, both equally stimulate the growth of these Ca

46 duced cortisol production by 85% following a cortisone challenge.

47 ocytes after inhibition of the intracellular cortisone-cortisol shuttle 11beta-hydroxysteroid dehydro

48 to enantioselective versions, including (1) cortisone/cortisol (Merck/Sarett), (2) dendrobine (Kende

49 lites, a process commonly referred to as the cortisone/cortisol shuttle.

50 1,2-[(2)H](2)-Cortisone (d2-cortisone) was validated as a tracer for 1

51 deuterium during conversion to [9,12,12-2H3] cortisone (D3-cortisone), which in turn generates [9,12,

52 -HSD) interconvert cortisol (F) and inactive cortisone (E), and are thus able to modulate GC action a

53 ies supplemented with physiologic amounts of cortisone, however, display normal SC ultrastructure on

54 longer tested positive by xenodiagnosis, and cortisone immunosuppression did not alter this result.

55 yses reductase regeneration of cortisol from cortisone in adipose and liver.

56 humans) and inert 11-dehydrocorticosterone (cortisone in humans).

57 al concentrations of free cortisol and total cortisone in men greatly exceed the binding affinity of

58 Active recycling between cortisol and cortisone in metabolic tissues in vivo may facilitate dy

59 1) enzyme regenerates cortisol from inactive cortisone in tissues such as liver and adipose.

60 of clobetasol propionate (CLO), cortisol and cortisone in zebrafish embryos as single compounds and b

61 ted by production of SIL-cortisol during SIL-cortisone infusion.

62 dehydrogenase (HSD) type 1 converts inactive cortisone into active cortisol in cells, thereby raising

63 rogenase type-1 (11beta-HSD1) converts inert cortisone into active cortisol, amplifying intracellular

64 th cell types were able not only to activate cortisone into the active form cortisol, but also to syn

65 nase type 1 (11beta-HSD-1) converts inactive cortisone into the active glucocorticoid cortisol and th

66 In contrast, the viscera releases cortisone into the portal vein, thereby providing substr

67 Inactive cortisone is converted to active cortisol by the reducta

68 In contrast, cortisone led to down-regulation of vitellogenin.

69 t revealed a moderately elevated cortisol to cortisone metabolite ratio.

70 videnced by an abnormal ratio of cortisol to cortisone metabolites and by an exceedingly diminished a

71 ry tuberculosis (PTB), the ratio of cortisol/cortisone metabolites in 24-h urine showed a shift towar

72 d with A. fumigatus, suggesting an effect of cortisone on bronchial spore clearance.

73 17/2.8beta1 decreased further with exogenous cortisone or cortisol whereas ROS 17/2.8beta2 were resis

74 P-9 into the HT-1080 onplants engrafted into cortisone- or ibuprofen-treated embryos reversed the ant

75 ry low in visceral fat, the viscera released cortisone (P < 0.001) and D3 cortisone (P < 0.01) into t

76 iscera released cortisone (P < 0.001) and D3 cortisone (P < 0.01) into the portal vein.

77 Cortisol/cortisone ratio was increased in bronchoalveolar lavage

78 ed AR functioned as a high-affinity cortisol/cortisone receptor (ARccr).

79 In cortisone reductase deficiency (CRD), activation of cort

80 Apparent cortisone reductase deficiency is characterized by andro

81 se was more readily detected than reductase (cortisone release 38.7 +/- 5.8 pmol/100 g/min).

82 performance test mix-composed of aspartame, cortisone, reserpine, and dioctyl phthalate has been dev

83 ly, donor lymphocyte infusion induced severe cortisone-resistant gastrointestinal graft-versus-host d

84 tine during their postnatal development, and cortisone selectively regulates ileal but not kidney TC

85 CLO and cortisol, but not cortisone showed a concentration-dependent decrease in m

86 iltrating T cells, and modulate the cortisol-cortisone shuttle so that the inflammatory site becomes

87 ursors 11-dehydrocorticosterone (11-DHC) and cortisone suppress voltage-dependent Ca(2+) channel func

88 , can generate active cortisol from inactive cortisone through the expression of 11 beta-HSD1.

89 ne reductase deficiency (CRD), activation of cortisone to cortisol does not occur, resulting in adren

90 nt activity was oxo-reductase (conversion of cortisone to cortisol greater than cortisol to cortisone

91 ts active form corticosterone in rodents (or cortisone to cortisol in humans).

92 talyzed conversion of stable-isotope-labeled cortisone to cortisol in liver microsomes from dog, monk

93 The reduction of cortisone to cortisol is catalyzed by 11beta-hydroxyster

94 The ratio of urinary free cortisone to cortisol measured by using a radioimmunoass

95 oximating extraadrenal tissues by converting cortisone to cortisol via the 11beta-hydroxysteroid dehy

96 vivo, 11beta-HSD1 catalyzes the reduction of cortisone to cortisol whereas purified enzyme acts as a

97 ROS 17/2.8beta1 showed net conversion of cortisone to cortisol whereas ROS 17/2.8beta2 showed onl

98 demonstrate that 11beta-HSD1, which converts cortisone to cortisol, is expressed only upon differenti

99 was higher in omental than subcutaneous fat (cortisone to cortisol, median 57.6 pmol mg-1 h-1 [95% CI

100 1 (11beta-HSD1) is the enzyme that converts cortisone to cortisol.

101 1 (11beta-HSD1) is the enzyme that converts cortisone to cortisol.

102 protein and an elevated capacity to convert cortisone to cortisol.

103 s, evidenced by the restricted conversion of cortisone to cortisol.

104 in the ability of the adipocytes to convert cortisone to cortisol.

105 a-HSD1) catalyzes the conversion of inactive cortisone to its active form, cortisol.

106 The interconversion from M+4 cortisone to M+4 cortisol was detected in dog, human, an

107 The conversion of SIL-cortisone to SIL-cortisol in rhesus monkey adipose tissu

108 tained using a microdialysis infusion of M+4 cortisone to the microsomes coincubated with a proprieta

109 deficient A. nidulans was highly virulent in cortisone-treated BALB/c mice.

110 -encoding genes was observed in the lungs of cortisone-treated mice during early invasive aspergillos

111 pidly to baseline levels in cyclophosphamide/cortisone-treated mice.

112 Splenectomy or high-dose cortisone treatment had no effect on the shorter surviva

113 Cortisone treatment reversed these changes noted in the

114 ly in adrenalectomized rats before and after cortisone treatment.

115 re, Asian or Hispanic heritage, smoking, and cortisone use were associated with significantly increas

116 The conversion of cortisol to cortisone was 58% compared with 0-6% in typical patients

117 glucocorticoid marker in ovary extracts, and cortisone was abundant in extracts of both testes and ov

118 ol appearance in the hepatic vein after oral cortisone was unchanged.

119 1,2-[(2)H](2)-Cortisone (d2-cortisone) was validated as a tracer for 11beta-dehydrog

120 yme, 11beta-HSD2, which converts cortisol to cortisone, was not detectable in either monocytes or cul

121 ctive rodent dehydrocorticosterone and human cortisone were able to substitute for the synthetic gluc

122 1.0 and 0.5 microL/min, E(d) values for SIL-cortisone were between 58.7+/-5.6% (n=4) and 72.7+/-1.3%

123 ions containing 100, 500, and 1000 ng/mL SIL-cortisone were locally delivered through an implanted 30

124 ng conversion to [9,12,12-2H3] cortisone (D3-cortisone), which in turn generates [9,12,12(2)H3] corti