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1 from Catalog of Somatic Mutations in Cancer (COSMIC), a large-scale database curated by the Wellcome
2 t is difficult to reconcile the low observed cosmic abundance of 3He with the predictions of both ste
3 , silicon, iron, and calcium) are present in cosmic abundances, with only small grain-to-grain variat
6 at a redshift of z = 9.6 +/- 0.2 (that is, a cosmic age of 490 +/- 15 million years, or 3.6 per cent
7 tribution of the first stars at redshift 20 (cosmic age of around 180 million years), incorporating a
8 laxies (where the bulk of stars formed) at a cosmic age of less than about 500 million years (z less,
9 galaxies seem to be abundant at such a young cosmic age, suggesting that they may be the dominant sou
13 e occupationally exposed to higher levels of cosmic and UV radiation than the general population, but
14 ns in human cancer has now been curated into COSMIC and while this is continually updated, a greater
15 he Catalogue of Somatic Mutations in Cancer (COSMIC) and the spatial information in the Protein Data
17 ol regions, as well as links to Entrez Gene, COSMIC, and iHOP gene pages and the UCSC and Ensembl gen
18 sphere; they are inconsistent with volcanic, cosmic, anthropogenic, lightning, or authigenic sources.
19 of the cosmic microwave background with the Cosmic Background Imager from September 2002 to May 2004
20 on today, will demonstrate the presence of a cosmic background of hard X-rays at that early time.
21 t grains); this energy now forms part of the cosmic background radiation at wavelengths near 1 mm.
25 ely 470 million years ago one of the largest cosmic catastrophes occurred in our solar system since t
26 om the Cancer Cell Line Encyclopedia and the COSMIC Cell Lines Project to three renal cancer subtypes
28 tifies 15% redundant indels in dbSNP, 29% in COSMIC coding, and 13% in COSMIC noncoding datasets acro
29 ore redundant indels in dbSNP; 2,118 more in COSMIC coding, and 553 more in COSMIC noncoding indel da
32 ble for ionization of the Universe after the cosmic 'Dark Ages', when the baryonic matter was neutral
35 on for approximately 10 000 mutations in the COSMIC database, the method does well in assigning highe
39 ination, provide a direct measurement of the cosmic density of ionized baryons in the intergalactic m
42 This review discusses the magnitude of the cosmic dust input into the earth's atmosphere, and the r
45 esolution, glacial-to-interglacial record of cosmic dust using helium isotope analysis of the Europea
46 , soil erosion, eolian dust, sea-salt spray, cosmic dust, volcanic emissions, and for helium, hydrody
48 c, and cosmic materials, yet consistent with cosmic ejecta, supporting the hypothesis of extraterrest
49 in agreement with the accumulation rates of cosmic-enriched elements (Ir, Pt, Os and super-paramagne
50 d Strelka obtained the largest proportion of COSMIC entries as well as the lowest rate of dbSNP prese
51 cured to unobscured quasars as a function of cosmic epoch up to z congruent with 3 and show that a si
53 scovered hundreds of galaxies at these early cosmic epochs, but their star-formation rates are more t
57 wed range of the Hubble constant, unless the cosmic equation of state is dominated by a component tha
59 emanates from a variety of sources, such as cosmic events, particle accelerators, nuclear reactors a
60 e constraint on the primordial abundance and cosmic evolution of lithium that is not susceptible to t
61 the Big Bang, and traces 13 billion years of cosmic evolution with 12 billion resolution elements in
62 city is the line-of-sight departure from the cosmic expansion and arises from gravitational perturbat
64 ervational programs can trace the history of cosmic expansion more precisely and over a larger span o
65 d arrivals of the supernova images probe the cosmic expansion rate, as well as the distribution of ma
66 rnovae good 'standard candles' for measuring cosmic expansion, but a correction must be applied to ac
67 be derived from the subtraction of the mean cosmic expansion, the product of distance times the Hubb
69 sion that arrives with the gamma-rays from a cosmic gamma-ray burst (GRB) is a signature of the engin
72 tion gamma-ray bursts are intense flashes of cosmic gamma-rays, lasting less than about two seconds,
73 pha emission, discovered during a survey for cosmic gas fluorescently illuminated by bright quasars a
74 This is based on the assumption that the cosmic gas was heated by stellar remnants-particularly X
75 tations such as the 1000 Genomes project and COSMIC give an opportunity to investigate general princi
76 he Catalogue of Somatic Mutations in Cancer (COSMIC), GraphPAC identifies new mutational clusters in
77 mic features has become a significant focus; COSMIC has begun curating full-genome resequencing exper
78 C risk prediction after exposure to high-LET cosmic heavy ion radiation exposure is hindered due to s
79 ions in the total production of photons over cosmic history and may contain faint, extended component
80 based and space-borne telescopes have probed cosmic history from the present day to a time when the U
82 their centres, are the relics of a period in cosmic history when galaxies formed stars at remarkable
83 h in the young Universe and that, throughout cosmic history, black-hole growth occurs in the dusty, g
85 ast 20 years have revolutionized our view of cosmic history, transforming our understanding of how th
87 y galaxies probably induced a major event in cosmic history: the reionization of intergalactic hydrog
88 YDB objects with melt products from a known cosmic impact (Meteor Crater, Arizona) and from the 1945
89 ounger Dryas impact hypothesis posits that a cosmic impact across much of the Northern Hemisphere dep
90 en invigorated by a hypothesis implicating a cosmic impact at the Allerod-Younger Dryas boundary or Y
91 raters, and its presence strongly supports a cosmic impact event, further strengthened by its co-occu
93 mpelling evidence to accept the claim that a cosmic impact occurred approximately 12,800 y ago and ca
94 episode known as the Younger Dryas (YD) is a cosmic impact or airburst at the YD boundary (YDB) that
95 egafaunal extinction possibly triggered by a cosmic impact over North America at approximately 12,900
98 scopes, they would have produced significant cosmic infrared background radiation in the near-infrare
99 omic information recently updated to GRCh37, COSMIC integrates many diverse types of mutation informa
100 0(6) non-synonymous mutations extracted from COSMIC, involving ~8000 genome-wide screened samples acr
101 as well as in the thermalization of both the cosmic IR and microwave background and in galactic cente
102 e of mutations in cancer, the information in COSMIC is curated by expert scientists, primarily by scr
103 bers of genomic rearrangements in cancer and COSMIC is now displaying details of these analyses also.
104 he catalogue of Somatic Mutations in Cancer (COSMIC) is the largest public resource for information o
106 ticle formation experiments performed at the Cosmics Leaving Outdoor Droplets chamber at the European
107 ow, in experiments performed with the CLOUD (Cosmics Leaving Outdoor Droplets) chamber at CERN, that
109 we study nano-particle growth in the CLOUD (Cosmics Leaving OUtdoors Droplets) chamber, starting fro
111 The microspherules were explained as either cosmic material ablation or terrestrial ejecta from a hy
112 ith anthropogenic, volcanic, authigenic, and cosmic materials, yet consistent with cosmic ejecta, sup
113 ich are expected to be representative of the cosmic matter content of the universe (baryons and dark
114 The apparent baryon fraction exceeds the cosmic mean at larger radii, suggesting a clumpy distrib
115 an a millikelvin) that marks the rise of the cosmic mean gas temperature above the microwave backgrou
117 stant supernovae and the fluctuations in the cosmic microwave background (CMB) indicate that the expa
120 ons, which manifest in the anisotropy of the cosmic microwave background and the large-scale correlat
121 -ray binaries-to temperatures well above the cosmic microwave background at that time (about 30 kelvi
124 a vital role across a range of systems: from cosmic microwave background polarization to superconduct
125 With recent precise measurements of the cosmic microwave background radiation, large galaxy reds
126 Age is the period between the time when the cosmic microwave background was emitted and the time whe
128 teristic imprints in the polarization of the cosmic microwave background, or later with direct space-
133 s in dbSNP, 29% in COSMIC coding, and 13% in COSMIC noncoding datasets across all human chromosomes,
134 2,118 more in COSMIC coding, and 553 more in COSMIC noncoding indel dataset in addition to the ones r
138 vey of the outskirts of 42 galaxies with the Cosmic Origins Spectrograph onboard the Hubble Space Tel
140 before being driven more than 2 hours to the Cosmic Physics Laboratory at Chacaltaya (5200 m) where t
142 he Catalogue of Somatic Mutations in Cancer (COSMIC), QuartPAC is able to identify clusters which are
144 Because messages require protection from cosmic radiation and small messages could be difficult t
146 ue opportunity to reconstruct the history of cosmic radiation and solar activity over many millennia.
148 Of particular concern is the potential for cosmic radiation exposure to compromise critical decisio
151 ion will result in an inevitable exposure to cosmic radiation that has been shown to cause cognitive
153 enous thromboembolism and long-haul flights, cosmic-radiation exposure, jet lag, and cabin-air qualit
155 ang nucleosynthesis (BBN) depend only on the cosmic ratio of baryons to photons, a quantity inferred
156 many predictions, the intensity of anomalous cosmic ray (ACR) helium did not peak at the shock, indic
158 er risk is an important concern for galactic cosmic ray (GCR) exposures, which consist of a wide-ener
160 er began making detailed measurements of the cosmic ray and energetic particle radiation environment
161 gh a variety of processes (such as solar and cosmic ray bombardment, micro-meteorite bombardment, and
166 The small intensity gradient of Galactic cosmic ray helium indicates that either the gradient is
167 hat for the processes studied, variations in cosmic ray intensity do not appreciably affect climate t
170 rs in the interstellar medium in response to cosmic ray ionization is summarized, and a review of the
171 here was a simultaneous increase in Galactic cosmic ray ions and electrons, anomalous cosmic rays and
172 ned inside the heliosphere, the intensity of cosmic ray nuclei from outside the heliosphere abruptly
175 For data pretreatment, we developed a unique cosmic ray removal method and used an automated baseline
181 The Pierre Auger Observatory is the largest cosmic-ray detector on Earth, and as such is beginning t
182 volts per nucleon and an increasing galactic cosmic-ray electron intensity down to ~10 x 10(6) electr
187 paper we review the observables generated by cosmic-ray interactions with the interstellar medium, fo
191 anisotropy maps of ground-based high-energy cosmic-ray observatories (Milagro, Asgamma, and IceCube)
198 nyl alcohol (C2H3OH) act as key tracers of a cosmic-ray-driven nonequilibrium chemistry leading to co
200 700 years ago), based on new measurements of cosmic-ray-produced beryllium and aluminium isotopes ((1
201 s are not the only source of pulsed heating; cosmic rays also can heat interstellar grains in a pulse
202 iving interstellar chemistry via ionization, cosmic rays also interact with the interstellar medium i
203 on of high-energy (tera-electron volts, TeV) cosmic rays and diffusive propagation from supernova sou
205 rays', as well as to re-accelerate Galactic cosmic rays and low-energy particles from the inner Sola
206 ssess the damage caused to such materials by cosmic rays and neutrons, which pose a variety of hazard
207 nsoon connection is dominated most likely by cosmic rays and oceanic circulation (both associated to
209 orbed dose and dose equivalent from galactic cosmic rays and solar energetic particles on the martian
210 cts of meteorites and micrometeorites and of cosmic rays and solar-wind particles are major causes of
213 rse, demands a mechanism for ionization, and cosmic rays are the ideal candidate as they can operate
214 at hundreds to thousands of eV and galactic cosmic rays at tens of TeV has wide-ranging implications
216 yager 2 did not find the source of anomalous cosmic rays at the shock, suggesting that the source is
219 istance does not greatly exceed the distance cosmic rays can diffuse over this time, 1 kiloparsec.
220 expectations, the extragalactic component of cosmic rays contributes substantially to the total flux
223 aelectron volt electrons, ACRs, and galactic cosmic rays have steadily increased since late 2004 as t
224 he detection of supernova-produced (60)Fe in cosmic rays implies that the time required for accelerat
225 It provides an example to study the youth of cosmic rays in a superbubble environment before they mer
230 y support the idea that the bulk of galactic cosmic rays is accelerated in such remnants by a Fermi m
231 We argue that the radial anisotropy of the cosmic rays is expected to be small in the foreshock reg
233 50-parsec-wide cocoon of freshly accelerated cosmic rays that flood the cavities carved by the stella
235 Iron-60 ((60)Fe) is a radioactive isotope in cosmic rays that serves as a clock to infer an upper lim
236 va remnants (SNRs) hint that they accelerate cosmic rays to energies close to ~10(15) electron volts.
237 nets, astronauts will be exposed to galactic cosmic rays which are composed of heavy particles (such
238 uare centimetre for air showers initiated by cosmic rays with energies of 10(17)-10(17.5) electronvol
239 Measurements of the mass composition of cosmic rays with energies of 10(17)-10(18) electronvolts
240 g nucleosynthesis, interactions of energetic cosmic rays with interstellar matter, evolved low-mass s
241 s shock is expected to accelerate 'anomalous cosmic rays', as well as to re-accelerate Galactic cosmi
245 pectral energy distribution of the anomalous cosmic rays, however, indicates that Voyager 1 still has
246 the most energetic particles ever observed, cosmic rays, will begin to be revealed in the next few y
247 i's classic result on the energy spectrum of cosmic rays, with the universal exponent -2, which is in
252 les us to determine the mass spectrum of the cosmic rays: we find a mixed composition, with a light-m
253 s have had an important role in the epoch of cosmic reionization and the chemical evolution of early
254 f the interstellar medium in galaxies during cosmic reionization are important for understanding the
255 approximately 2), galaxies vigorously fed by cosmic reservoirs are dominated by gas and contain massi
259 we show that the FeNi metal in the resulting cosmic spherules was oxidized while molten, and quench-c
262 tation in galaxies during this peak epoch of cosmic star formation indicates that gas accretion is li
265 According to the current understanding of cosmic structure formation, the precursors of the most m
266 has been remarkably successful in explaining cosmic structure over an enormous span of redshift, but
268 count the milestones in our understanding of cosmic structure; summarize its impact on astronomy, cos
271 the dynamo excitation of magnetic fields in cosmic systems; (ii) its bearing on the existence of Eul
274 xies during the first three billion years of cosmic time (redshift z > 4) indicate a rapid evolution
276 rise and fall of star formation over 95% of cosmic time, back to the current observational frontier
279 ion of extragalactic magnetic fields through cosmic times (up to microgauss levels reported in nearby
280 observations find metal-enriched galaxies at cosmic times when the Universe was less than 1 Gyr old.
281 rophysical conditions and remain stable over cosmic timescales, giving unique insights on their exist
283 lly on highly characterized drugs and genes, COSMIC v78 contains wide resistance mutation profiles ac
284 We find that the baryon fraction reaches the cosmic value near the virial radius for all groups and c
286 alyses of YDB spherules suggest they are not cosmic, volcanic, authigenic, or anthropogenic in origin
287 , but reside throughout the filaments of the cosmic web (where matter density is larger than average)
288 a and constrain the net magnetization of the cosmic web along this sightline to <21 nanogauss, parall
293 smic structures have broadly reproduced the 'cosmic web' of galaxies that we see in the Universe, but
294 rse predict that galaxies are embedded in a 'cosmic web', where most baryons reside as rarefied and h
295 forming a "cosmic web." The discovery of the cosmic web, especially through its signature of absorpti
298 s, sheets, and knots collectively forming a "cosmic web." The discovery of the cosmic web, especially
300 ed emission from these quasars generates the cosmic X-ray background, the spectrum of which has been
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