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1 rmal conductivity to avoid thermal loss, and cost effectiveness.
2 a longer stabilizing effect of CXL increases cost effectiveness.
3 e systems, priority setting, and the role of cost effectiveness.
4 imited evidence base, particularly regarding cost-effectiveness.
5 tery disease to assess clinical outcomes and cost-effectiveness.
6  health care resources, quality of life, and cost-effectiveness.
7 shold of $100000 per QALY was used to assess cost-effectiveness.
8 ictions, were used to evaluate the policies' cost-effectiveness.
9 among initial cases, and 10-year incremental cost-effectiveness.
10 reatment completion and discontinuation, and cost-effectiveness.
11 mpatibility, room temperature operation, and cost-effectiveness.
12 g the harms of overdiagnosis and maintaining cost-effectiveness.
13 in morbidity, mortality, quality of life, or cost-effectiveness.
14 e performed to maximize clinical utility and cost-effectiveness.
15 tion of progression to MDR-TB, and confirmed cost-effectiveness.
16 s well within the range of acceptability for cost-effectiveness.
17 ined the influence of input variation on the cost-effectiveness.
18 lue for money judged using US benchmarks for cost-effectiveness.
19      Rabbit ATG appears to achieve excellent cost-effectiveness acceptability curves (80% of the reci
20 y offer improved immunogenicity, simplicity, cost-effectiveness, acceptability, and safety.
21 CEA offers a standardized means of comparing cost-effectiveness among interventions.
22                                              Cost-effectiveness analyses (CEAs) of hepatitis C virus
23                                  Preliminary cost-effectiveness analyses of proprotein convertase sub
24 ocial sciences, public health, epidemiology, cost-effectiveness analyses, and operations research.
25                                  In Bayesian cost-effectiveness analyses, likelihood that CPG was the
26 hese competing concerns can be obtained from cost-effectiveness analyses.
27 bility-adjusted life-year metric and related cost-effectiveness analyses.
28 he proposed intervention and finally perform cost effectiveness analysis of the results.
29 tiveness ratio" OR "economic evaluation" OR "cost effectiveness analysis" OR "cost utility analysis"
30                                              Cost-effectiveness analysis (CEA) is a research method u
31 nd eliminated wait time (EWT), and perform a cost-effectiveness analysis comparing RWT and EWT with c
32                                     We did a cost-effectiveness analysis for these strategies, implem
33  to our knowledge there has been no previous cost-effectiveness analysis in pediatric IF including IR
34                                            A cost-effectiveness analysis of the study results demonst
35 m this review could be used to inform future cost-effectiveness analysis on the impact of LTBI screen
36                               We performed a cost-effectiveness analysis to assess diagnosis and trea
37                               We performed a cost-effectiveness analysis to determine optimal CRC scr
38                                            A cost-effectiveness analysis using a Markov model from th
39 nts with atrial fibrillation, we performed a cost-effectiveness analysis using patient-level data fro
40                        We did a within-trial cost-effectiveness analysis using person-level data and
41 lled trial with two open parallel arms and a cost-effectiveness analysis was performed in 12 tertiary
42                                           In cost-effectiveness analysis, choice for both age groups
43                                         In a cost-effectiveness analysis, the average cost of total-b
44                                       In the cost-effectiveness analysis, the care bundle was estimat
45                                      For the cost-effectiveness analysis, the primary outcome was the
46                                     For this cost-effectiveness analysis, we used a transmission mode
47                                  Model-based cost-effectiveness analysis.
48                         A wide availability, cost effectiveness and better tolerability of ultrasonog
49 ons, especially regarding clinical outcomes, cost effectiveness and contextual issues affecting succe
50  dedicated service for Barrett's oesophagus, cost-effectiveness and appropriateness of current survei
51  no economic evaluation has yet assessed its cost-effectiveness and budgetary impact.
52                                              Cost-effectiveness and cost-benefit analyses of pressure
53                                The projected cost-effectiveness and cost-benefit of preventive chemot
54                        Here, we evaluate the cost-effectiveness and cost-benefit of the preventive ch
55 f this clinical service requires evidence of cost-effectiveness and data addressing potential overtre
56 safety, patient and physician acceptability, cost-effectiveness and its compatibility with informatio
57                                 Owing to the cost-effectiveness and less-invasive nature of this proc
58 cess, we sought to assess the effectiveness, cost-effectiveness and safety of AIT in the management o
59 an be utilized to improve the efficiency and cost-effectiveness and, hence, the sustainability of bio
60 of patient preference, lower bleeding rates, cost effectiveness, and reduced risk of mortality in hig
61  because of their large specific capacities, cost effectiveness, and the abundance of organic precurs
62 ociated with these devices and their overall cost effectiveness, and we highlight important potential
63 alysis, an evaluation of the potential cost, cost-effectiveness, and government budgetary impact of a
64 se that will benefit patients and/or improve cost-effectiveness, and it requires the collaboration of
65 tive trial is needed to assess the efficacy, cost-effectiveness, and public health impact of this int
66 lines by accelerating efficiency, maximizing cost-effectiveness, and raising ultimate success rates.
67 obesity is becoming more common, but data on cost-effectiveness are limited.
68 plant DAA treatment strategy trended towards cost-effectiveness as HCV(+) donor liver availability de
69  research is needed to determine program and cost-effectiveness as part of the WIC program.
70                 We examined the survival and cost-effectiveness associated with sorafenib in elderly
71 ution, combined with its noninvasive nature, cost-effectiveness, availability, and portability.
72 No general conclusion could be reached about cost effectiveness, because of limitations in the eviden
73 -36 questionnaire, Von Korff pain score, and cost-effectiveness between both study groups.
74                   We sought to determine the cost-effectiveness (CE) of monthly ZA, ZA every 3 months
75                                 Furthermore, cost-effectiveness, cost-utility and budget impact analy
76 atment versus deferred DAA treatment using a cost-effectiveness decision analysis model to estimate i
77 he conventional microfluidic chips including cost-effectiveness, ease of fabrication, and ease of use
78 fe years (QALYs), costs in U.S. dollars, and cost-effectiveness expressed as an incremental cost-effe
79                                          The cost-effectiveness for skin cancer screening is higher i
80 cal utility (AII duration and survival), and cost-effectiveness from an institutional perspective wer
81 line expands recommended statin use, but its cost-effectiveness has not been compared with other guid
82  achieving reasonable efficiencies, and thus cost-effectiveness, have hampered significant research p
83 ietal perspective, we assessed the potential cost-effectiveness, health gains, and financial impacts
84 having a monogenic disorder and evaluate its cost-effectiveness if WES had been available at differen
85 gens and confirmation of its feasibility and cost-effectiveness in multiple settings.
86 ) on treatment effectiveness and incremental cost-effectiveness in the 2 years after a natural disast
87  existing risk group-based vaccine programme cost-effectiveness in the presence of the paediatric vac
88                                              Cost-effectiveness (incremental cost per quality-adjuste
89 ic conditions has high diagnostic yield, and cost-effectiveness is maximized by early application in
90 ith aripiprazole, further analysis including cost-effectiveness is needed to understand the net utili
91                                 However, its cost-effectiveness is seriously hampered by the relative
92 reventing further infections in MSM, but its cost-effectiveness is uncertain.
93  their uncontested advantages of simplicity, cost-effectiveness, limited necessity of laboratory infr
94 clinical psychology, epidemiology, genomics, cost-effectiveness modeling, pathology, bioethics, and p
95       These findings should be considered in cost-effectiveness models informing vaccine choice and m
96 model assumptions were varied, with lifetime cost-effectiveness most affected by the price of apixaba
97 al positive effect on patient outcome and to cost effectiveness of amyloid imaging.
98                              To evaluate the cost effectiveness of corneal collagen crosslinking (CXL
99 tant breeding traits, and (d) improvement in cost effectiveness of large-scale genotyping.
100 tic review aims to evaluate the clinical and cost effectiveness of nurse-led self-management for pati
101                                The projected cost effectiveness of PCSK9 inhibitors does not meet gen
102           Here, we estimate the system-level cost effectiveness of reducing CO2 emissions with flexib
103 on oF FactORs ImpacTing CLinical Outcome and Cost EffectiveneSS of the S-ICD) registry is collecting
104                                          The cost effectiveness of these approaches needs further eva
105                              We compared the cost-effectiveness of 12 weeks of HCV therapy before or
106                               To examine the cost-effectiveness of 2 population-based skin cancer scr
107 e compared the 96-week clinical outcomes and cost-effectiveness of 2 strategies: no IR testing vs IR
108 of pound22 000 per QALY and a probability of cost-effectiveness of 20%.
109 tudy calculated the public health impact and cost-effectiveness of 4 strategies: no choice, pediatric
110             We investigated the clinical and cost-effectiveness of a behavioural activation intervent
111            We assessed the effectiveness and cost-effectiveness of a brief psychological treatment (H
112                 To determine the incremental cost-effectiveness of a clinical practice guideline (CPG
113         This trial raises concerns about the cost-effectiveness of a fluoride-based intervention deli
114                              To evaluate the cost-effectiveness of a patient-centred pressure ulcer p
115    To use the trial results to determine the cost-effectiveness of a PCSK9i and statin treatment stra
116  vaccine uptake among girls and assessed the cost-effectiveness of a sex-neutral program.
117 e were unable to draw any conclusions on the cost-effectiveness of AIT for food allergy.
118  found no eligible studies investigating the cost-effectiveness of AIT for food allergy.
119 esizing data and gaps in the evidence on the cost-effectiveness of AIT for these conditions.
120 ss evidence on the effectiveness, safety and cost-effectiveness of AIT for these conditions.
121        Of these, 19 studies investigated the cost-effectiveness of AIT in allergic rhinitis, of which
122         Overall, the evidence to support the cost-effectiveness of AIT is limited and of low methodol
123 cal utility of a molecular diagnosis and the cost-effectiveness of alternative diagnostic trajectorie
124           We then compared effectiveness and cost-effectiveness of alternative policy options.
125            We assessed the effectiveness and cost-effectiveness of alternative public health response
126                       To assess the cost and cost-effectiveness of apixaban therapy compared with war
127                                To assess the cost-effectiveness of bariatric surgery for adolescents
128 the effects after treatment termination, the cost-effectiveness of CAP over 12 months, and the effect
129 oup randomized controlled trial measured the cost-effectiveness of caries prevention in caries-free c
130 reover there is very little evidence for the cost-effectiveness of changing care providers from docto
131  evaluate the additional benefit in terms of cost-effectiveness of colonoscopy surveillance in a scre
132  objective of this study was to estimate the cost-effectiveness of complying with HCC screening guide
133 ur objective was to determine the impact and cost-effectiveness of confirmatory HIV testing for EID p
134  studies evaluating the efficacy, safety and cost-effectiveness of continuing anticoagulant therapy b
135            We assessed the effectiveness and cost-effectiveness of Counselling for Alcohol Problems (
136  in lifetime health outcomes) to compare the cost-effectiveness of CXL versus conventional management
137 , parameter variations did not influence the cost-effectiveness of CXL.
138 ials are needed to compare effectiveness and cost-effectiveness of different low-vision (LV) programs
139 , we developed a Markov model to compare the cost-effectiveness of different strategies for sequencin
140 unded by the limited evidence base regarding cost-effectiveness of different treatment regimens for t
141                                          The cost-effectiveness of each moisturizer was determined by
142     Further, we did not model or compare the cost-effectiveness of each proposed policy.
143 imulation models to evaluate the comparative cost-effectiveness of early corneal cross-linking (CXL)
144 dy provides strong economic evidence for the cost-effectiveness of early CXL in keratoconus.
145 or a method that combines the simplicity and cost-effectiveness of ELISA with the sensitivity and spe
146                             To determine the cost-effectiveness of etanercept-methotrexate versus tri
147                              To evaluate the cost-effectiveness of evolocumab in patients with athero
148                We estimated the outcomes and cost-effectiveness of five alternative strategies: no ad
149 the effects after treatment termination, the cost-effectiveness of HAP over 12 months, and the effect
150 Y, thresholds generally used to evaluate the cost-effectiveness of health interventions in Canada and
151 nvestigated this trade-off by estimating the cost-effectiveness of HIV screening in primary care.
152  have provided evidence of effectiveness and cost-effectiveness of HIV treatment adherence interventi
153 ct of this on long term outcomes and related cost-effectiveness of home visiting has not been establi
154  addition, we also investigate the potential cost-effectiveness of hydrocele surgery.
155                              To estimate the cost-effectiveness of individualized control versus unif
156                                          The cost-effectiveness of integrated RTC strategies is furth
157                             We evaluated the cost-effectiveness of IR by comparing 1 scenario with IR
158                   We sought to determine the cost-effectiveness of IR in terms of costs and life-year
159                              To estimate the cost-effectiveness of liver resection followed by adjuva
160 Markov model was constructed to evaluate the cost-effectiveness of liver resection followed by postop
161                                      Data on cost-effectiveness of liver resection for advanced breas
162 am coastal marine ecosystem and contrast the cost-effectiveness of marine- and land-based conservatio
163                    This study calculates the cost-effectiveness of methicillin-resistant S aureus pre
164           Due to the short-term benefits and cost-effectiveness of minimally invasive techniques, hos
165                      Purpose To evaluate the cost-effectiveness of multiparametric diagnostic magneti
166 straints, when predicting and evaluating the cost-effectiveness of new tuberculosis diagnostics in So
167                             To determine the cost-effectiveness of OAT for all treatment recipients c
168 o evaluate the long-term clinical impact and cost-effectiveness of OCA as a second-line treatment for
169 We evaluated the potential health impact and cost-effectiveness of offering vaccination to MSM who vi
170                             To determine the cost-effectiveness of perioperative administration of pa
171  Further research is needed to determine the cost-effectiveness of personalized warfarin dosing.
172 mes, evidence supports the effectiveness and cost-effectiveness of policies that address affordabilit
173 views the evidence for the effectiveness and cost-effectiveness of policies to reduce alcohol-related
174 e objective of this study was to analyze the cost-effectiveness of pre-LT versus post-LT treatment wi
175                         METHOD AND Using the Cost-effectiveness of Preventing AIDS Complications (CEP
176     More studies are required to clarify the cost-effectiveness of robotic surgery.
177            This study sought to estimate the cost-effectiveness of routine administration of pasireot
178          Research is needed to establish the cost-effectiveness of routine M. genitalium testing in s
179 ancreatic fistula (POPF) and to evaluate the cost-effectiveness of routine pasireotide use.
180                              The incremental cost-effectiveness of SC compared with UC was $3428.71 t
181      If clinical benefit is proven, then the cost-effectiveness of screening for and the treatment of
182   This trial evaluated the effectiveness and cost-effectiveness of silk garments (in addition to stan
183                        Purpose To assess the cost-effectiveness of stereotactic body radiation therap
184 nts (strategy C) significantly decreased the cost-effectiveness of strategy B (conventional systemic
185 review by providing economic evidence on the cost-effectiveness of studies identified after 2012, and
186 linical trial of DAA use for PEP and the low cost-effectiveness of such an intervention is not suppor
187  our analysis assessed the effectiveness and cost-effectiveness of surgery to manage NASH.
188 ascular Disease Policy Model to estimate the cost-effectiveness of the ACC/AHA guideline relative to
189  We therefore examined the effectiveness and cost-effectiveness of the Adherence Improving self-Manag
190                       Purpose To analyze the cost-effectiveness of the American Society for Gastroint
191 was to assess the epidemiological effect and cost-effectiveness of the existing elderly and risk grou
192 igible for both RFA and SBRT to evaluate the cost-effectiveness of the following treatment strategies
193 th lifetime projections to evaluate lifetime cost-effectiveness of the Food and Drug Administration-a
194 ublic health implications for evaluating the cost-effectiveness of the intervention in the long term.
195 to reach firm conclusions on the clinical or cost-effectiveness of the interventions.
196                              We compared the cost-effectiveness of the personalized monitoring strate
197                                  We assessed cost-effectiveness of the RHIVA2 trial by fitting model
198  Acceptability was analysed and finally, the cost-effectiveness of the surveillance strategies was de
199 arm during the 6-month follow-up period; and cost-effectiveness of the VHS as measured by estimated i
200 , it would be useful to examine the relative cost-effectiveness of these 2 treatment modalities.
201 eeded to understand the clinical utility and cost-effectiveness of this approach to risk stratificati
202                    Little is known about the cost-effectiveness of this approach.
203 rch is needed to assess generalizability and cost-effectiveness of this intervention and to understan
204                  To our knowledge, long-term cost-effectiveness of this therapy has not been evaluate
205                        The authors evaluated cost-effectiveness of ticagrelor + low-dose ASA in patie
206 ut found no evidence that Xpert improved the cost-effectiveness of tuberculosis diagnosis.
207 ability that Xpert introduction improved the cost-effectiveness of tuberculosis diagnostics.
208                             We evaluated the cost-effectiveness of two alternative direct-acting anti
209 e aimed to compare the clinical outcomes and cost-effectiveness of two brief psychological treatments
210                           To investigate the cost-effectiveness of using a daily moisturizer as preve
211       The study demonstrates the utility and cost-effectiveness of utilizing existing big data source
212                                          The cost-effectiveness of VIT needs to be established.
213 No analyses have been performed modeling the cost-effectiveness of wait time reduction for IBI.
214 of the vaccines differed, will influence the cost-effectiveness of which vaccine to use in immunizati
215                          We investigated the cost-effectiveness of Xpert in the real world during nat
216  1 review) were also generally effective for cost-effectiveness outcomes.
217                                       From a cost-effectiveness perspective, individuals with more af
218 influenza cases by >100,000 with a favorable cost-effectiveness profile.
219                              The simplicity, cost-effectiveness, rapidity, robustness, selectivity an
220               Strategies with an incremental cost effectiveness ratio below $100,000 per quality-adju
221 litaxel chemotherapy produced an incremental cost effectiveness ratio of $198,867/QALY.
222 NIVO followed by IPI produced an incremental cost effectiveness ratio of $90,871/QALY, and first-line
223 ative costs, graft survival, and incremental cost-effectiveness ratio (ICER - cost per additional yea
224                       We used an incremental cost-effectiveness ratio (ICER = difference in lifetime
225      The primary outcome was the incremental cost-effectiveness ratio (ICER) between test and no-test
226 distribution strategy yielded an incremental cost-effectiveness ratio (ICER) of $323 per QALY, and na
227 tal costs of $7,435, yielding an incremental cost-effectiveness ratio (ICER) of $94,917/QALY gained.
228 s, may be cost-effective with an incremental cost-effectiveness ratio (ICER) of pound10 726 per QALY.
229                              The incremental cost-effectiveness ratio (ICER) of vaccinating boys was
230                               An incremental cost-effectiveness ratio (ICER) was calculated for a 10-
231                              The incremental cost-effectiveness ratio (ICER) was euro6840.75 (95% CI
232 ality-adjusted life-year (QALY), incremental cost-effectiveness ratio (ICER), and net value-based pri
233                                  Incremental cost-effectiveness ratio (ICER), defined as euros per QA
234                Over 2 years, the incremental cost-effectiveness ratio (ICER; compared with brief inte
235  cost of HCV recurrence) was the incremental cost-effectiveness ratio associated with HCV DAA treatme
236                              The incremental cost-effectiveness ratio for NHAS compared with Current
237                              The incremental cost-effectiveness ratio for PCI compared with MT was $1
238                 We evaluated the incremental cost-effectiveness ratio from a health system perspectiv
239 argeted therapies resulted in an incremental cost-effectiveness ratio of $189,000 per quality-adjuste
240 s perspective, and results in an incremental cost-effectiveness ratio of $35663 (95% CI, cost savings
241 00 and $633,900, resulting in an incremental cost-effectiveness ratio of $473,400/quality-adjusted li
242 tive in both populations with an incremental cost-effectiveness ratio of $74,255 (HCC) and $36,583 (D
243                              The incremental cost-effectiveness ratio of ECHO was $10,351 per QALY co
244 UI) 208-232] per vaccine, for an incremental cost-effectiveness ratio of pound20 000 per quality-adju
245 to be cost-effective with a mean incremental cost-effectiveness ratio of pound22 000 per QALY and a p
246        At the current price, the incremental cost-effectiveness ratio of statin plus PCSK9i therapy w
247 ith ticagrelor 60 mg + low-dose ASA yields a cost-effectiveness ratio suggesting intermediate value b
248 ought included a combination of "incremental cost-effectiveness ratio" OR "economic evaluation" OR "c
249 g, basing coverage decisions on a particular cost-effectiveness ratio).
250 ty-adjusted life months (QALMs), incremental cost-effectiveness ratio, and net health benefit (NHB).
251                                  Incremental cost-effectiveness ratio, net present value of lifetime
252 st-effectiveness expressed as an incremental cost-effectiveness ratio.
253  trial's outcomes in a series of incremental cost effectiveness ratios (ICERs).
254 ision analysis model to estimate incremental cost-effectiveness ratios (cost per quality-adjusted lif
255 y-adjusted life-years (QALY) and incremental cost-effectiveness ratios (ICER) of policy 1 versus poli
256      In an incremental analysis, incremental cost-effectiveness ratios (ICERs) for screening plus sur
257            Outcome measures were incremental cost-effectiveness ratios (ICERs) in 2015 U.S. dollars p
258 djusted life years [QALYs]), and incremental cost-effectiveness ratios (ICERs) of the four prevention
259                                  Incremental cost-effectiveness ratios (ICERs) were calculated for so
260                                  Incremental cost-effectiveness ratios (ICERs) were determined.
261 adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs).
262 g the Consumer Price Index), and incremental cost-effectiveness ratios (ICERs).
263               Main outcomes were incremental cost-effectiveness ratios and numbers needed to treat fo
264 ar clinical outcomes, costs, and incremental cost-effectiveness ratios for (1) Current Pace of detect
265 atment only for F3 patients; the incremental cost-effectiveness ratios for providing surgery or ILI o
266                                  Incremental cost-effectiveness ratios for surgery in all F0-F3 patie
267                      To evaluate incremental cost-effectiveness ratios of 0.5-mg ranibizumab therapy
268 ed a gain in QALYs, resulting in incremental cost-effectiveness ratios of euro33072 (US $35475) per Q
269                                  Incremental cost-effectiveness ratios of ranibizumab compared with P
270 seline vision-impairing DME, the incremental cost-effectiveness ratios of ranibizumab therapy compare
271 d life years (QALYs), costs, and incremental cost-effectiveness ratios were calculated.
272     Over a 40 year time horizon, incremental cost-effectiveness ratios were pound22 201 (95% credible
273 omic evaluation to calculate the incremental cost-effectiveness ratios, measured in cost per quality-
274 safety, clinical efficacy, best setting, and cost-effectiveness remain to be addressed in further stu
275 ugh patient engagement as part of methods in cost-effectiveness research in existing published studie
276 f randomized controlled trials demonstrating cost effectiveness, screening of asymptomatic men cannot
277                      While absolute risk and cost-effectiveness should be considered, additional CVD
278 roves health outcomes and is cost-effective; cost-effectiveness significantly increases when lowering
279  horizon of 50 years was used to analyze the cost-effectiveness (societal perspective) and budget eff
280 discounts are necessary to meet conventional cost-effectiveness standards.
281         Potential cost-effective barriers in cost-effectiveness studies mean that budgetary impact an
282   Jan Hontelez and colleagues argue that the cost-effectiveness studies of HIV treatment scale-up nee
283 eatment options with patients and to support cost-effectiveness studies.
284 The very limited evidence found on modelling cost-effectiveness suggested that VIT was likely to be c
285       We took a 20 year time horizon, used a cost effectiveness threshold of US$500 per DALY averted,
286 nal Institute for Health and Care Excellence cost-effectiveness threshold (about pound30 000 per QALY
287            Under base case assumptions and a cost-effectiveness threshold of pound15 000 per QALY, th
288 te for Health and Clinical Excellence (NICE) cost-effectiveness threshold of pound20 000/quality-adju
289 ains cost-effective, driven by the choice of cost-effectiveness threshold.
290  ART initiation, adherence behavior, and the cost-effectiveness threshold.
291 if less than $398 (based on the World Bank's cost-effectiveness thresholds for low income countries).
292 PRETATION: With the likely move to decreased cost-effectiveness thresholds, reassessment of existing
293 ovascular disease exceeds generally accepted cost-effectiveness thresholds.
294 atic literature reviews of effectiveness and cost-effectiveness to identify priority interventions.
295    The primary outcomes were the incremental cost-effectiveness values ($/QALY) for each moisturizer
296    Gains in health status were observed, and cost-effectiveness was better with closed tunnel EVH.
297                                              Cost-effectiveness was greatest using a fluoroquinolone/
298                                  Evidence on cost-effectiveness was inconclusive.
299 , morbidity, mortality, quality of life, and cost-effectiveness was measured after 1 year of follow-u
300 pt is at the core of initiatives for merging cost effectiveness with maximized clinical efficiency an

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