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1 constitutive low signaling by titrating out Costal.
3 uding the role of the kinesin-family protein Costal 2 (Cos2), which directs Ci processing in Drosophi
5 -threonine kinase Fused (Fu) and the kinesin Costal 2 (Cos2, also known as Cos), yet Fu does not have
6 Fused (Fu), Suppressor of fused (Sufu), and Costal-2 (Cos2) or the vertebrate homologs Kif27/Kif7.
7 plex containing Ci, the kinesin-like protein Costal-2 (Cos2), the serine-threonine kinase Fused (Fu),
9 Further our data show that loss of PKA or Costal-2 activity does not fully mimic Hh signaling, dem
10 erary border cells, was found to disrupt the costal-2 locus, indicating a role for Hedgehog signaling
11 es now show that the kinesin-related protein Costal-2 provides a physical link between the transmembr
14 mponents, including the kinesin-like protein Costal-2, the serine-threonine kinase Fused, and Suppres
17 rating Smoothened cytoplasmic tails activate Costal and Fused, driving the regulatory complex to its
18 be found in other tetrapods that breathe by costal aspiration and locomote with a lateral undulatory
20 29), prominent convexity of anterior rib or costal cartilage (n = 19), prominent asymmetric costal c
21 tal cartilage (n = 19), prominent asymmetric costal cartilage (n = 20), well-defined paracostal subcu
22 n addition, embryos with paternal UPD12 have costal cartilage defects and hypo-ossification of mesode
25 tilted" sternum in six; prominent asymmetric costal cartilage in four; bifid rib in one; and well-def
34 linically relevant cell sources by comparing costal chondrocytes, dermal fibroblasts, a mixture of th
36 consist of highly disorganised vertebrae and costal defects, are similar to those associated with the
37 ol I, fifteen normal subjects maintained the costal diaphragm at inferior/superior positions by full
38 fiber type proportions and FEV1, we obtained costal diaphragm biopsies on 40 subjects whose FEV1 rang
40 n microvascular PO2 (PO2m) within the medial costal diaphragm of control (C, n = 10) and emphysematou
44 odel where low signaling is initiated when a Costal inhibitory site on the Smoothened cytoplasmic tai
46 esence of splenomegaly > or = 5 cm below the costal margin (BCM) or thrombocytosis > or = 700 x 10(9)
47 s underestimated the distance from the right costal margin to the liver edge by only about 2.4 centim
48 alpable splenomegaly (>/=5 cm below the left costal margin), Eastern Cooperative Oncology Group perfo
49 f the ribs into the turtle shell negates the costal movements that effect lung ventilation in other a
50 Depiction of the undersurface of the long costal muscle slips of the diaphragm on supine plain rad
54 muscle were obtained from the anterolateral costal regions of the stimulated and inactive hemidiaphr
55 ce a regulatory complex that includes Fused, Costal, Suppressor of Fused and Cubitus interruptus.
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