ライフサイエンスコーパス: costamere

1 hing a mechanism by which Mef2A controls the costamere.

2 l proteins and pathways that link Z-disk and costamere.

3 ocalized at the muscle adhesion sites termed costameres.

4 se bodies, structures analogous to mammalian costameres.

5 h beta2 spectrin recruitment of ankyrin-B to costameres.

6 uired to align sarcolemmal microtubules with costameres.

7 rt and is enriched at intercalated discs and costameres.

8 PM-sarcomere attachment sites also known as costameres.

9 s involvement in the establishment of mature costameres.

10 ocal adhesion-like cell-matrix contacts into costameres.

11 l adhesion kinase (FAK), are associated with costameres.

12 ation of dystrophin and beta-dystroglycan at costameres.

13 ate filament protein of muscle in organizing costameres.

14 or the peripheral layer of myofibrils to the costameres.

15 tting sites, the myotendinous junctions, and costameres.

16 omes the main Tln isoform, localizing to the costameres.

17 d we present the initial description for the costamere, a key muscle stability complex, in Drosophila

18 ctrin is normally found at the sarcolemma in costameres, a rectilinear array of longitudinal strands

19 ibited disruptions of intercalated disks and costameres accompanied by fibrosis.

20 collaborates with dystrophin in coordinating costamere-aligned microtubules.

21 The relationship between costamere and myofibril formation was tested further by

22 ts of a 66-/68-kDa protein that localized to costameres and focal adhesions.

23 of integrin-containing adhesion complexes at costameres and MTJs advance normally in the mutants.

24 -glycoprotein complex (DGC) are localized at costameres and neuromuscular junctions in the sarcolemma

25 cur within the sarcomere, intercalated disc, costamere, and extracellular matrix.

26 microtubules, localization of dystrophin at costameres, and maintenance of sarcolemmal integrity.

27 age complexes, including intercalated discs, costameres, and myotendinous junctions.

28 cal interactions between desmin and Z-disks, costameres, and nuclei were measured during passive defo

29 by severe disruption of desmosome as well as costamere architecture and composition in the heart, as

30 Costameres are cellular sites of mechanotransduction in

31 Costameres are composed of focal adhesion proteins, incl

32 A central question in muscle biology is how costameres are formed and become aligned with underlying

33 desmin due to homologous recombination, most costameres are lost.

34 te with beta-spectrin at the sarcolemma when costameres are lost.

35 ystrophin, dystroglycan, and microtubules at costameres as well as protection of muscle from exercise

36 n-glycoprotein complex, and by extension the costamere, as harboring signaling components has receive

37 uscle fiber fragility as a result of loss of costamere-associated dystrophin and dystroglycan.

38 ween dystrophin and MTs has been documented, costamere-associated MTs are disrupted when dystrophin i

39 end on beta2 spectrin and ankyrin-B, whereas costamere association of ankyrin-B required beta2 spectr

40 In addition, costamere-association of dynactin-4 did not require dyst

41 ing myofilaments to the cell surface through costameres at the sarcolemma and desmosomes at intercala

42 s via interactions with alpha-actinin and to costameres at the sarcolemma via interactions with vincu

43 e fibers and at Z-line and M-line domains at costameres at the sarcolemmal membrane.

44 uscle, focal adhesion-like structures called costameres attach myofibrils at the periphery of muscle

45 that lack Thin function through progressive costamere breakdown.

46 d beta-DG require ankyrin-G for retention at costameres but not delivery to the sarcolemma.

47 selectively stabilizes the Z line domains of costameres, but that cytokeratins associate with all thr

48 not essential for mechanical coupling of the costamere complex and the sarcomere lattice.

49 ts may also be an important precursor to the costamere disarray observed in dystrophin-deficient musc

50 ptor protein family member ponsin in nascent costameres during muscle differentiation, which is media

51 keratins associate with all three domains of costameres, even in the absence of desmin.

52 resent study, we investigated the process of costamere formation ("costamerogenesis") in differentiat

53 The global control of costamere gene expression adds another dimension by whic

54 provide insight into the mechanism by which costamere genes are regulated by Mef2A.

55 -disc and peripheral structures, such as the costamere, have yet to be discovered.

56 (PINCH) and UNC-96, components of an M-line costamere in nematode muscle.

57 unctions directly downstream of MEF2A at the costamere in striated muscle potentially playing a role

58 uscle-specific protein that localizes to the costamere in striated muscle.

59 mouse muscle even though it was localized to costameres in situ.

60 in, and Na,K-ATPase are also concentrated in costameres, in control myofibers, and mdx muscle.

61 Many of these genes are essential for costamere integrity and function.

62 cardiomyocyte survival through regulation of costamere integrity.

63 Resolution of a functional costamere interactome is still limited but likely to be

64 een these proteins resulted in loss of their costamere-localizing activity and increased muscle fiber

65 This also resulted in inhibition of costamere maturation.

66 skeletal muscle, beta 1D was concentrated in costameres, myotendinous, and neuromuscular junctions.

67 In obscurin KO mice, localization at costameres of dystrophin, but not of beta-dystroglycan,

68 Cytokeratins 8 and 19 concentrate at costameres of striated muscle and copurify with the dyst

69 aments to the intercalated disk and membrane costameres of the heart.

70 rophin, a major component of skeletal muscle costameres, on the behaviour of single MS channels.

71 tion factor-binding sites in this network of costamere promoters that may provide insight into the me

72 ype and desmin-null fibers revealed that the costamere protein talin colocalized with the Z-disk prot

73 e products localize to the peripheral Z-disc/costamere region.

74 l structures within the cell: myofibrils and costameres, respectively.

75 mma of fast-twitch muscle is organized into "costameres," structures that are oriented transversely,

76 lated in CMs and is specifically detected at costameres, suggesting its importance in the compensator

77 protein talin (Tln) is a component of muscle costameres that links integrins ultimately to the sarcom

78 in skeletal muscle but uniquely localizes to costameres, the cytoskeletal networks that couple periph

79 te at the sarcolemma at all three domains of costameres when the latter are retained in desmin -/- mu