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2 e cortical representations of the two digits costimulated above-resonance shifted closer, potentially
3 A-1, which has been shown previously both to costimulate activated effector CD4(+) and CD8(+) T cells
6 globin-specific 3.L2 murine T cell hybridoma costimulates activation for IL-2 secretion both with ant
8 of covalently dimeric and wild type B7-1 to costimulate Ag-specific T cell proliferation was also as
11 Engagement of NKG2D triggers NK cells and costimulates Ag-specific effector CD8 alphabeta T cells.
12 D86 expressed by NSCs are functional and can costimulate allogeneic cells in a mixed lymphocyte react
13 of a second signal is tied to its ability to costimulate (along with stimulation through the TCR) pro
15 ns between CD28 and members of the B7 family costimulate and enhance T cell responses, recent evidenc
19 rafts followed by ex vivo anti-CD3/anti-CD28 costimulated autologous T cells at day 2 after transplan
20 fusion of in vivo vaccine-primed and ex vivo costimulated autologous T cells followed by post-transpl
21 sm to explain how CD22 and BCR signaling can costimulate B-cell proliferation and induce apoptosis in
22 ule as anti-CD154-conjugated Sepharose beads costimulated B cell responses induced by engaging surfac
23 -stimulated B cells, whereas IL-21 primarily costimulated B cells activated by anti-IgM or anti-IgM p
28 fore, that B7.2 expressed on T cells may not costimulate but instead inhibit the T cell response by p
30 ntracellular domain of FasL is sufficient to costimulate by enhancing the phosphorylation of Akt, ERK
33 ells: Primary human naive T cells are better costimulated by CD81, whereas the memory T-cell subsets
34 enograft model, CD30CAR(+) EBV-CTLs could be costimulated by EBV-infected cells and produce antitumor
36 and P2Y G-protein-coupled receptors that are costimulated by nucleotides released during physiologic
37 xpression of CD86 on CVID B cells, even when costimulated by the BCR, or induce production of IL-6 or
40 similar to that achieved with CD28- or 4-1BB-costimulated CARs, and heightened persistence was simila
41 te that alloreactive T cells expressing CD28-costimulated CD19 CARs experience enhanced stimulation,
48 through the NK high-affinity IL-2 receptor, costimulates CD56(bright) NK cells to secrete IFN-gamma.
49 lasmic domain of Fas ligand is sufficient to costimulate CD8(+) T cells by driving Fas ligand recruit
53 optimal CD8 T cell proliferation, 4-1BB also costimulated CD8 T cell proliferation independently of I
54 ing receptor complex that triggers NK cells, costimulates CD8 alpha beta and V(gamma)9V(delta)2 gamma
55 irectly stimulates NK cells and macrophages, costimulates CD8(+) T cells, and plays a substantial rol
59 We hypothesized that sialic acids on the costimulated cell surfaces may contribute to the inhibit
60 was significantly enhanced and sustained in costimulated cells compared with that seen in cells stim
62 anti-TCR Ab-stimulated cells but not in CD28-costimulated cells, suggesting that CHX may also act by
63 he caspase-independent mode of cell death in costimulated cells, these findings suggest the activatio
65 Taken together, our results reveal that B7H costimulates clonal expansion of, and cognate destructio
66 ntigen-activated B cells can express B7h and costimulate cognate antigen-activated T cells through IC
67 CYT that is specifically unable to bind MKP6 costimulates considerably larger quantities of IL-2 from
68 th in TCR-activated DP thymocytes but do not costimulate DP thymocytes to initiate the differentiatio
70 y the natural ligand RAE1epsilon was able to costimulate effector functions of a murine CTL line gene
71 We propose that CD94/NKG2 heterodimers may costimulate effector functions of differentiated Th1 cel
72 NKG2D receptor, which activates NK cells and costimulates effector T cells, are inducibly expressed u
75 Polyclonal peripheral blood CD4+ cells were costimulated ex vivo and subjects were given infusions o
77 umor-infiltrating donor lymphocytes could be costimulated ex vivo to preferentially activate/expand a
78 ed to express the chimeric receptor and were costimulated ex vivo with beads coated with anti-CD3 and
81 tes that exogenous IL-18, which can directly costimulate gammadelta T cells, eliminates the need for
84 elated CD4 T cells, suggesting that the dual costimulated helper cells are themselves helped by a CD1
85 ory molecule for T cell activation, and CD46-costimulated human T cells induce a Tr1 Treg phenotype w
87 ably transfected pCD86 in CHO cells modestly costimulates human T cell proliferation and IL-2 secreti
91 pha 2,3-linked sialic acids from IL-1 + IL-4-costimulated HUVEC by sialidase significantly increased
93 g cells inhibits their subsequent ability to costimulate IFN-gamma and IL-4 production from CD4+ T ce
94 d addition of exogenous IL-12 enables ECs to costimulate IFN-gamma at a level comparable to that obse
96 inding to the 4-1BB receptor and was able to costimulate IL-2 and IFN-gamma release from peripheral T
99 neal macrophages (PEMs) with immobilized mAb costimulated IL-12 production, in contrast to previously
103 an umbilical vein endothelial cells strongly costimulates IL-2 production by human T cells, comparabl
105 tibodies or recombinant proteins that either costimulate immune cells or block immune inhibitory path
112 mice failed to produce IL-12p70 and did not costimulate liver lymphocytes for IFN-gamma production i
114 stigate the influence of TNF receptor (TNFR)-costimulated lymphocytes on collagen expression in fibro
116 umber of TNF family members whose triggering costimulates maximal proliferation of activated T cells.
117 cell-released DPPIV is able to function as a costimulating molecule for the response to the recall Ag
118 jor histocompatibility (MHC) class I and II, costimulating molecules and intercellular cell adhesion
121 study we have evaluated the role of NKG2D in costimulating mouse and human naive and effector CD8+ T
122 nly transfer of human T cells expressing the costimulated MOv19-BBzeta CAR mediated tumor regression
124 sduced to express conventional MOv19-zeta or costimulated MOv19-BBzeta CARs secreted various proinfla
126 ransfectants expressing the OX-2 protein can costimulate murine CD4+ T cells to proliferate in an Ag-
127 gement by ligand or mAb is not sufficient to costimulate naive or effector CD8+ T cell responses in c
128 ty of constitutively active Ras and Raf-1 to costimulate NF-AT activity with a calcium ionophore.
129 d CHO-CD86, in the presence of anti-CD3 mAb, costimulated NFAT-dependent transcriptional activation.
131 motaxis as culture supernatants derived from costimulated NK cells induced migration of both naive an
132 signaling pathways, we show here that OSCAR costimulates one of the major FcRgamma-associated pathwa
133 act with ligands in the B7 family and either costimulate or co-inhibit signals through antigen-specif
136 show that the PI3K signaling pathway in CD28-costimulated p110delta D910A/D910A T cells is impaired,
139 abolished PD-1 binding capacity could still costimulate proliferation and cytokine production of T c
140 ule(s) are required for human macrophages to costimulate proliferation of B cells triggered via their
141 uman macrophages generated in vitro strongly costimulate proliferation of dense human tonsillar B cel
144 rrows of Stat5a(-/-) mice, but did stimulate/costimulate proliferation of these cells from Stat5a(+/+
145 T cells via their expressed CD40L, which can costimulate proliferation with CD3 or promote germinal c
146 und that ligands known to directly induce or costimulate proliferation, namely, anti-IgM (anti-Ig), a
150 the CD2 molecule by its ligand CD58 clearly costimulated proliferation, cytokine production, and eff
151 ceptors on differentiated Th1 cells in vitro costimulates proliferation and cytokine production with
152 e that engagement of B7-H1 on CD4(+) T cells costimulates proliferation and secretion of IL-10, and s
154 normal donor CD3+ T cells, it significantly costimulates proliferation of CD3+ T cells induced by CD
156 emotactic peptide-1, are capable of directly costimulating purified human T cell and human T cell clo
157 ection model that ectopic B7h expression can costimulate rejection by CD8(+) T cells in the absence o
158 ther a long or a short cyt tail inhibited or costimulated, respectively, TCR/CD3 complex plus CD28 me
159 and B7.2 were comparable in their ability to costimulate responses in T cells previously primed in vi
160 t or Bcl-2 transgenic B cells, IL-21 readily costimulated responses to anti-CD40 while proliferation
163 l TSP1 receptors in T lymphocytes can elicit costimulating signals, in this study we show that intact
168 ytokine responses induced by these different costimulating stages and how they are influenced by host
171 mined the transfectants for their ability to costimulate T cell proliferation in vitro and to induce
172 regression, EL4-B7.2 transfectants failed to costimulate T cell proliferation or induce tumor regress
173 The double transfectant EL4 cells could costimulate T cell proliferation that could be blocked b
178 Here we show that although EL4-B7.1 cells costimulate T cells and induce tumor regression, EL4-B7.
180 econdary receptors are up-regulated that can costimulate T cells in concert with TCR engagement.
181 istic Ab or 4-1BB ligand-expressing APCs can costimulate T cells, the physiological significance of 4
189 In order to elucidate the parameters which costimulate T-cell-independent antipolysaccharide antibo
190 at multivalent configurations of the aptamer costimulated T cell activation in vitro and mediated tum
191 distinct epitopes on the CD137 glycoprotein costimulated T cell activation irrespective of the engag
192 ICD), we examined whether anergized and CD28-costimulated T cell clones were equally sensitive to Fas
193 hyperproliferation of T cells, and TIM-4-Ig costimulated T cell proliferation mediated by CD3 and CD
196 strates that adoptive transfer of autologous costimulated T cells (1) is feasible in heavily pretreat
197 identify a downregulation of miR-150 in CD46-costimulated T cells and identify the glucose transporte
198 -CD3 mAb in the presence of CC-4047 directly costimulated T cells and increased Th1-type cytokines.
199 5 expression and R5 susceptibility to CD3/28 costimulated T cells and some transformed cell lines.
200 ng escalating doses of anti-CD3/CD28 ex vivo costimulated T cells as a therapeutic adjunct for patien
201 antigen-presenting cells bearing chemokines costimulated T cells by a previously unknown two-step co
202 liferation, CTLA-4 engagement prevented ICOS-costimulated T cells from producing IL-4, IL-10, and IL-
203 prominent difference between ICOS- and CD28-costimulated T cells is the quantity of IL-2 produced.
204 transfer of tumor antigen vaccine-primed and costimulated T cells leads to augmented and accelerated
206 n recall, but even without recall these dual-costimulated T cells respond to signal 3 cytokines such
207 Most importantly, proliferation of TRAIL-R costimulated T cells was strongly impaired, but no apopt
208 nd how signal 3 responses functioned in dual-costimulated T cells we showed that IL-2 induced IL-36R
212 e incubated with conditioned media from TNFR-costimulated T lymphocytes, and type I collagen expressi
213 al, but not complete, inhibition of monocyte-costimulated T-cell proliferation-suggesting that both C
214 h is constitutively expressed by T cells and costimulates T cell activation in a CD28-independent man
219 d TNF-like cytokine that interacts with DR3, costimulates T cells and augments anti-CD3 plus anti-CD2
222 n (CD47) is a broadly expressed protein that costimulates T cells, facilitates leukocyte migration, a
224 s a recently described B7-like molecule that costimulates T-cell growth and cytokine secretion withou
226 with the functional predominance of B7-1 in costimulating T cell activation when employing APCs from
229 oplasmic tail decreased its effectiveness in costimulating T cell proliferative response and early IL
230 and more proinflammatory and were better at costimulating T cells in vitro, compared with the B6 cou
232 yte reaction, immobilized RELT is capable of costimulating T-cell proliferation in the presence of CD
242 e showed that wild-type PCBD1 binds HNF1B to costimulate the FXYD2 promoter, the activity of which is
243 the unique role of CD28 signaling is not to costimulate the initial activation of naive T cells, but
244 40R by the OX-40 ligand (OX-40L) is known to costimulate the production of cytokines by activated T l
245 ined the capacity of murine B7-1 and B7-2 to costimulate the production of IL-4 by murine CD4+ T lymp
247 atients, and that its ligation with collagen costimulated the production of IL-17 by polarized human
248 opulations studied, our data suggest that FL costimulates the expansion of very primitive B cell prog
250 ell adhesion, provides survival signals, and costimulates the production of proinflammatory cytokines
251 nisms of this response, we showed that SDF-1 costimulates the transcriptional activities in normal hu
252 lized autoantibodies to B7-H1 are capable of costimulating the proliferation of CD4(+) T cells in vit
253 aising the T cell activation threshold while costimulating the release of proinflammatory cytokines b
255 lls, after being painted with B7-1, can self-costimulate themselves, elicit enhanced proliferative an
256 t CD56(bright) and CD56(dim) NK cells can be costimulated through different receptors, which may allo
261 sively with the nonprocessed coactivator and costimulates transcription of an HCF-1-dependent target
262 +) Tconv proliferation, but they only weakly costimulated Treg proliferation and IgG2a production, wh
263 augmented the proliferative capacity of CD28-costimulated Tregs, Foxp3 expression and suppressive fun
265 We tested the feasibility and safety of costimulated, tumor-derived donor lymphocyte (TDL) infus
268 F4 and TNFRSF25 independently and additively costimulate vaccine-induced CD8(+) T cell proliferation
274 iferate spontaneously in vitro and cannot be costimulated with anti-CD28 mAb consistent with a hypera
275 on post-AlloSCT; tumor cell suspensions were costimulated with anti-CD3/anti-CD28 Ab-coated magnetic
277 row Mphi from IFN-gammaR-intact MRL-Fas(lpr) costimulated with CSF-1 or GM-CSF and IFN-gamma was redu
282 iferation and sprouting of endothelial cells costimulated with IGF-1 and TNFalpha via reduced feedbac
287 A or G, Y = C or T, W = T or A) hot spots if costimulated with T cells and IgM crosslinking, the pres
290 e bone marrow-derived dendritic cells (BMDC) costimulated with TLR4 agonists and proapoptotic chemoth
292 eceptors also enhanced Ca(2+) responses when costimulated with type 1 protease activated and M1 musca
293 human monocyte-derived dendritic cells (DCs) costimulated with YGPs and the TLR4 ligand lipopolysacch
294 cid 1 receptors are translated and active in costimulating, with the alpha1-adrenergic receptor, the
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