1 line cortisol at 60 min of < 9 mug/dL) after cosyntropin (250 mug) administration and a random plasma

2 re (basal) and three times after intravenous cosyntropin (ACTH 1-24) injection.

3                                        Short cosyntropin (adrenocorticotropic hormone; ACTH) stimulat

4                                  Resting and cosyntropin-stimulated cortisol levels were obtained bef

5 Adrenal insufficiency was determined using a cosyntropin stimulation test in all studies.

6                                          The cosyntropin stimulation test is the initial endocrine ev

7 asia, is in place in many countries, however cosyntropin stimulation testing might be needed to confi

8 dary adrenal insufficiency for the high-dose cosyntropin test (P < 0.001), but AUCs for the 250-micro

9                                          The cosyntropin test performs well in patients with primary

10 95%, summary ROC analysis for the 250-microg cosyntropin test yielded a positive likelihood ratio of

11  secondary adrenal insufficiency (250-microg cosyntropin test), and secondary adrenal insufficiency (

12 nd secondary adrenal insufficiency (1-microg cosyntropin test), respectively.

13 or primary adrenal insufficiency (250-microg cosyntropin test), secondary adrenal insufficiency (250-

14 aracteristics of the 250-microg and 1-microg cosyntropin tests are similar.

15 1), but AUCs for the 250-microg and 1-microg cosyntropin tests did not differ significantly (P > 0.5)

16 specificity data for 250-microg and 1-microg cosyntropin tests; these curves were then compared by us

17                         Cortisol response to cosyntropin varies considerably among healthy persons.

18 level <20 microg/dL post-low-dose (1 microg) cosyntropin was considered diagnostic of adrenal insuffi