ライフサイエンスコーパス: cotton rat

1 a (eastern wood rat), and Sigmodon hispidus (cotton rat).

2 PFU/g; guinea pigs) to 1.8 x 10(5) PFU/gram (cotton rat).

3 cation in the respiratory tracts of mice and cotton rats.

4 (PIV3) infection led to laryngotracheitis in cotton rats.

5 ttenuation in the upper and lower airways of cotton rats.

6 in replication in the respiratory tracts of cotton rats.

7 s were highly attenuated in cell culture and cotton rats.

8 Ad2E4ORF6, which is replication defective in cotton rats.

9 cells and in the upper and lower airways of cotton rats.

10 and triggered strong protective immunity in cotton rats.

11 nic, and protective against RSV challenge in cotton rats.

12 nic, and protective against RSV challenge in cotton rats.

13 n cell culture and were highly attenuated in cotton rats.

14 so triggered a strong protective immunity in cotton rats.

15 ivity, replicated as efficiently as rhMPV in cotton rats.

16 o influence the RSV lung titer in challenged cotton rats.

17 in the upper and lower respiratory tracts of cotton rats.

18 NHBE cells and in the respiratory tracts of cotton rats.

19 nfluenza, only the H5N1 virus was lethal for cotton rats.

20 conferred protection from HPIV3 challenge in cotton rats.

21 ared to live and formalin inactivated RSV in cotton rats.

22 ll tested HPIV strains, both in vitro and in cotton rats.

23 oliferation of spleen cells from MV-infected cotton rats.

24 ollowed by the live measles virus vaccine in cotton rats.

25 cacy of these vaccine candidates in mice and cotton rats.

26 cacy of these vaccine candidates in mice and cotton rats.

27 ipts were more abundant in the lungs of aged cotton rats.

28 ect on cytokine expression in aged and young cotton rats.

29 ered as either a DNA or a protein vaccine in cotton rats.

30 cell culture and establishment of latency in cotton rats.

31 ns and can be resistant to PZ prophylaxis in cotton rats.

32 , has been shown to resist PZ prophylaxis in cotton rats.

33 and were tested for susceptibility to PZ in cotton rats.

34 Intranasal DAS181 in cotton rats, a model for human disease, significantly cu

35 s and chemokines was studied in the lungs of cotton rats after primary or secondary infection with re

36 on mouse, two from wood rats, and one from a cotton rat) also were compared by sodium dodecyl sulfate

37 RSV F (PIV5/F) or G (PIV5/G) protein in the cotton rat and African green monkey models for their rep

38 Results indicate that HIV-1 does infect the cotton rat and S. fulviventer is more susceptible than S

39 component of efficacy by palivizumab in the cotton rat and that antibody-dependent cell-mediated cyt

40 ir immunogenicity and protective efficacy in cotton rats and African green monkeys, which are among t

41 Similar enhanced disease has been seen in cotton rats and children immunized with formalin-inactiv

42 DB1 was also highly immunogenic in cotton rats and elicited broadly neutralizing antibodies

43 ia bissettii was found in a cotton mouse and cotton rats and in I. affinis ticks.

44 The gD/AS04 vaccine was immunogenic in cotton rats and induced serum IgG directed against gD-2

45 ion RSV F elicits neutralizing antibodies in cotton rats and induces complete protection against vira

46 minor, the wood rat (Neotoma floridana), the cotton rat, and the cotton mouse in South Carolina and F

47 isolated from I. minor and the cotton mouse, cotton rat, and wood rat.

48 Hamsters, guinea pigs, cotton rats, and nine inbred strains of mice were inocul

49 bust immunity against RSV infection in mice, cotton rats, and nonhuman primates.

50 as less than that of HSV-2 genital herpes in cotton rats, and yet the model allowed for comparative e

51 Cotton rat antiserum to RSV/B protected against RSV/A an

52 This study set out to determine whether cotton rats are susceptible to infection with HIV type 1

53 We then immunized cotton rats at 0 and 14 days with either control vector,

54 ion mutant established a latent infection in cotton rats at a frequency and with a number of VZV geno

55 In cotton rats, at equivalent concentrations, motavizumab r

56 lobulin production and cell proliferation in cotton rat cells in vitro.

57 r adjuvant) in a preclinical RSV susceptible cotton rat challenge model compared to formaldehyde inac

58 ive transfer of serum from gD/AS04-immunized cotton rats conferred stronger protection against HSV-1

59 otential for producing enhanced disease in a cotton rat (CR) model.

60 V challenge without enhanced lung disease in cotton rats (CRs).

61 erse genetics, and intranasal inoculation of cotton rats elicited RSV-specific antibody and elicited

62 2a CVD 1208 vaccines to deliver mucosally to cotton rats eukaryotic expression plasmid pGA3-mH and Si

63 Cotton rats express alpha2,3-linked sialic acid (SA) and

64 ical trials to prevent HSV and HIV, protects cotton rats from HSV.

65 e prophylactic dose of 15 mg/kg PZ protected cotton rats from infection with F212 but not with MS412.

66 SC-Ad-vaccinated cotton rats had markedly lower influenza titers than RD-

67 VZV-infected cotton rats have been used as a model for latency; viral

68 The CpG ODN markedly increased the cotton rat humoral neutralizing-antibody response to res

69 ant vaccine virus was created which secretes cotton rat IL-4.

70 e used as a mucosal adjuvant in the noses of cotton rats immunized via this route with respiratory sy

71 In cotton rats immunized with NDV-H, neutralizing antibodie

72 an deliver measles DNA vaccines mucosally in cotton rats, inducing measles immune responses (includin

73 ells derived from bronchioalveolar lavage of cotton rats infected with RSV.

74 Cotton rats infected with the ORF29 deletion mutant had

75 Cotton rats inoculated with VZV lacking ORF4 showed redu

76 This study demonstrates that the cotton rat is a permissive small animal model of hMPV in

77 Our data indicate that the cotton rat is a suitable small-mammal model to study the

78 ty of HPF3 to cause extensive disease in the cotton rat lung and that this effect is dissociated from

79 n Vero and murine neuroblastoma cells and in cotton rat lung, although Ed N-522D virus exhibited an a

80 hMPV-infected cotton rat lungs examined on day 4 postinfection exhibit

81 The peak virus titer in cotton rat lungs occurred on day 4 postinfection.

82 Together, these studies suggest that the cotton rat may provide an excellent model to study genit

83 r analysis of RSV replication in vivo in the cotton rat model in naive animals and in animals rendere

84 rvations are relevant to the validity of the cotton rat model itself and to safe development of nonli

85 e previously reported the development of the cotton rat model of hMPV infection and pathogenesis.

86 enital herpes in the novel DMPA-synchronized cotton rat model of HSV-1 and HSV-2 infection.

87 Here we report that in the cotton rat model of measles virus (MV) vaccination passi

88 ctive against A and B subtypes of RSV in the cotton rat model of RSV infection, 2- to 4-fold higher d

89 and dose-dependent antiviral efficacy in the cotton rat model of RSV infection.

90 wt HPF3 and the three variant viruses in the cotton rat model.

91 is protective against RSV/A infection in the cotton rat model.

92 lly administered DAS181 was assessed using a cotton rat model.

93 sion (SE) (GLA-SE) and alum adjuvants in the cotton rat model.

94 antibody for depletion of CD4 T cells in the cotton rat model.

95 d tested their efficacies in both murine and cotton rat models of RSV infection.

96 hMPV-infected cotton rats mounted virus-neutralizing antibody response

97 In cotton rats, passive transfer of MV-specific IgG mimics

98 never exceeded one provirus per 1.8 x 10(5) cotton rat peripheral blood mononuclear cells.

99 In cotton rats, recombinant hMPV with the R329K mutation in

100 Because cotton rat respiratory tract is susceptible to measles v

101 al development over a wide dose range in the cotton rat RSV enhanced-disease model, as suboptimal dos

102 t medroxyprogesterone acetate (DMPA)-treated cotton rat Sigmodon hispidus model of HSV-2 and HSV-1 ge

103 tavirus from Florida which is carried by the cotton rat (Sigmodon hispidus) and is associated with ha

104 ks Ixodes scapularis and Ixodes affinis, the cotton rat (Sigmodon hispidus), and cotton mouse (Peromy

105 Cotton rats (Sigmodon hispidus and S. fulviventer) are s

106 We show that cotton rats (Sigmodon hispidus) are susceptible to avian

107 Intranasal infection of cotton rats (Sigmodon hispidus) resulted in high numbers

108 ung (<2 months old) and aged (>9 months old) cotton rats (Sigmodon hispidus).

109 virus type 2 (HSV-2) readily infects inbred cotton rats (Sigmodon hispidus).

110 y reflects that seen in an animal model, the cotton rat, suggesting that HAE cells provide an ideal s

111 ells more accurately predicts virus yield in cotton rats than does growth in LLC-MK2 cells.

112 n in the lower respiratory tract of mice and cotton rats than rA2-P172.

113 ministered intranasally or subcutaneously in cotton rats, the candidates were highly immunogenic and

114 In cotton rats, the vaccines elicited RSV F- or G-specific

115 In the cotton rat, there was no delayed clearance of any of the

116 SceD is essential for nasal colonization in cotton rats, thus demonstrating the importance of cell w

117 he F and G glycoproteins (FG) were tested in cotton rats to evaluate efficacy and safety.

118 e inflammatory response of Sigmodon hispidus cotton rats to pulmonary infection with wild-type 5 aden

119 us type 3 bronchiolitis and pneumonia in the cotton rat using topical IgG cleared infectious virus wi

120 per and lower respiratory tracts of mice and cotton rats was highly restricted.

121 a subsequent experiment of identical design, cotton rats were challenged with wild-type MV 1 month af

122 When vaccinated cotton rats were challenged with wild-type RSV A, DB1 re

123 Cotton rats were immunosuppressed with cyclophosphamide,

124 Cotton rats were intramuscularly vaccinated using a prim

125 Cotton rats were pretreated intranasally with RSVIg or w

126 2-P172 and rA2-P176 in the lungs of mice and cotton rats were reduced.

127 inflammatory corticosteroid) in RSV-infected cotton rats were used to evaluate the contribution of vi

128 suppression in specific-pathogen-free inbred cotton rats which were infected with measles vaccine and

129 Treatment of cotton rats with indomethacin significantly mitigated lu

130 Pretreatment of cotton rats with MEDI-493 resulted in 99% reduction of l

131 Pretreatment of cotton rats with PRO 2000 gel, a candidate vaginal micro

132 we previously reported (4) that infection of cotton rats with the human respiratory syncytial virus (

133 Inoculation of cotton rats with the ORF17 deletion mutant resulted in a

134 Inoculation of cotton rats with the ORF21 deletion virus resulted in la

135 Immunization of cotton rats with the recombinant vaccinia viruses provid

136 e generated; however, in vivo prophylaxis of cotton rats with these antibodies conferred only about a

137 Importantly, inoculation of cotton rats with these mutants triggered a high level of

138 Importantly, vaccination of cotton rats with these recombinant hMPVs (rhMPVs) with d

139 in the nose and in the respiratory tract of cotton rats without prior adaptation and produced strong