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1 >1 h after removal of drug presumably via a covalent attachment.
2 si-face of the flavin ring, near the site of covalent attachment.
3 eties positioned strategically to facilitate covalent attachment.
4 -avidin chemistry, as well as through direct covalent attachment.
5 ntigen) self-assembled onto Au-electrode via covalent attachment.
6 ur results support D35 as being the point of covalent attachment.
7 This GAF domain by itself is sufficient for covalent attachment.
8 he sulfenyl amide residue to generate stable covalent attachments.
10 avoids loss of biological activity caused by covalent attachment; (2) we constructed a well-blocked s
11 portant in adhesion, implying a mechanism of covalent attachment analogous to that used by human comp
12 e next identified residues important for the covalent attachment and selected the FrdA(E245) residue,
13 polymer multilayers, and permits the direct covalent attachment and subsequent patterning of chemica
17 tubes (CNTs) via three different preparation covalent attachment (CA), enzyme coating (EC) and enzyme
18 Ts) via three different preparation methods: covalent attachment (CA), enzyme coating (EC) and enzyme
19 nd sequencing demonstrated that the sites of covalent attachment for each probe were high within the
21 l ligand to the heme iron in preparation for covalent attachment; (ii) to spatially position the two
22 ile probes for this receptor, with sites for covalent attachment in peptide positions 12 and 14, surr
23 tin-like photolabile probes having sites for covalent attachment in positions 21 and 23 and used sequ
25 nist photolabile GLP1 probes having sites of covalent attachment in positions 6 and 12 of the 30-resi
27 hotolabile benzoylphenylalanines as sites of covalent attachment, in positions known to label distinc
30 s of a functional protein microarray such as covalent attachment, native protein conformation, homoge
31 nocomposite was applied as the interface for covalent attachment of 3'-amine-terminated capture probe
32 This requires bridging receptor subunits via covalent attachment of 4,4'-bis(maleimido)azobenzene to
33 4(OPr(i))20 nanoparticles, functionalized by covalent attachment of 4-nitrophenyl-acetylacetonate or
34 rescence microscopy to monitor the localized covalent attachment of 5- (and 6)-carboxytetramethylrhod
35 al peptide biosynthetic pathways, catalyzing covalent attachment of a 4'-phosphopantetheinyl group to
40 ystallographic analyses demonstrate that the covalent attachment of a cyanide anion to the indoline f
41 s also modified with a silica shell to allow covalent attachment of a cyclic RGD peptide and an organ
42 e plasma membrane is accomplished in part by covalent attachment of a farnesyl moiety to the conserve
43 ds that are used to derivatize DNA or RNA by covalent attachment of a heavy atom (i.e., bromine at th
45 he closed channel and that this is broken by covalent attachment of a larger lipophilic moiety at the
46 uding Ras GTPase family members, require the covalent attachment of a lipid group by protein farnesyl
47 human serum albumin conjugate through stable covalent attachment of a maleimido-C34 analog onto cyste
49 eudocontact shifts, which are invoked by the covalent attachment of a paramagnetic lanthanoid chelati
50 s determined that AnkX directly mediates the covalent attachment of a phosphocholine moiety to Rab1.
51 on the suppression of PI resistance using a covalent attachment of a phosphonic acid motif to a pept
52 fficient amounts of primary amine groups for covalent attachment of a polyethylene glycol antifouling
55 unctionality is demonstrated by simultaneous covalent attachment of a rhodamine FRET acceptor and bin
56 ntroduced at 12 positions in hSERT to enable covalent attachment of a rhodamine-based fluorophore.
57 cytochrome P450-BM3 (CYP102A1) has required covalent attachment of a Ru(II) photosensitizer to a non
60 osttranslational modification of proteins by covalent attachment of a small protein ubiquitin (Ub) or
61 at FOXA2 is post-translationally modified by covalent attachment of a small ubiquitin related modifie
64 Drosophila Fic (dFic) mediates AMPylation, a covalent attachment of adenosine monophosphate (AMP) fro
65 ity of the VHH scaffold and sortase-mediated covalent attachment of Ags suggests their broader applic
67 s consisting of carboxylic groups that allow covalent attachment of amine-terminated oligonucleotide
68 nalized pCB is shown to be recovered only by covalent attachment of amino acid deactivation agents to
70 s are multidomain proteins that catalyze the covalent attachment of amino acids to their cognate tran
71 wire in between gold electrodes, followed by covalent attachment of amino-modified probe oligonucleot
72 rface acted as a template for the subsequent covalent attachment of aminohexyl-modified DNA oligonucl
74 w, and general method for the reversible non-covalent attachment of amphiphilic DNA probes containing
75 attributed to nonuniform charge arising from covalent attachment of ampholytes to the benzophenone-fu
76 contribution, we describe the synthesis and covalent attachment of an analogue of the flavin mononuc
77 This is one of the first examples where the covalent attachment of an ionophore drastically improves
78 er of NO bioactivity is S-nitrosylation, the covalent attachment of an NO moiety to a protein cystein
79 2) selectivity and to enhance drug safety by covalent attachment of an organic nitrate moiety as a ni
84 matic electrode is based on the step-by-step covalent attachment of AuNPs and Lc molecules to porous
85 um groups with ERGO and subjected to further covalent attachment of Azure A (Azu-A) mediator or gluco
86 Zn(2+) binding in an engineered site and the covalent attachment of benzocaine-methanethiosulfonate t
88 ated into the framework to provide sites for covalent attachment of biologically relevant cargoes whi
90 The BirA-catalyzed reaction involves the covalent attachment of biotin to AccB, a subunit of acet
91 irA catalyzes the adenylation and subsequent covalent attachment of biotin to the biotin carboxyl car
93 u NPs) are decorated on the GO layer for the covalent attachment of biotin, which is then used to sel
95 ger, cucumber, milk, and lettuce) even after covalent attachment of BREs to carboxy groups of CBMAA.
96 ates a stable thioester bond, leading to the covalent attachment of C3b to cell-surface or protein-su
97 robe and PAMAM-Dendrimers/AuNPs was used for covalent attachment of CA125-antibody and completing the
98 e-linked glycosylation, the co-translational covalent attachment of carbohydrates to asparagine side
99 combining this stereoelectronic effect with covalent attachment of carboxylate as a base, aniline ra
100 vel adhesion layer is described that enables covalent attachment of cell adherent molecules to the su
102 eveloped HNO-sensing electrode, based on the covalent attachment of cobalt(II) 5,10,15,20-tetrakis[3-
103 chemical technique since it leads to direct covalent attachment of conjugated alkynes to silicon.
104 rastically enhance the ECL is established by covalent attachment of coreactants N,N-diethylethylenedi
105 s-linked CpaN dimer provides a model for the covalent attachment of Cpa to target receptors and thus
107 x in a precise 1:1 stoichiometry followed by covalent attachment of Cy5-Trolox conjugates onto dendri
108 describe a novel method that integrates the covalent attachment of DNA handles to target proteins wi
111 parent SBA-15 materials and allow efficient covalent attachment of ethynylated organic moieties thro
112 uccinate dehydrogenase (SDH) is dependent on covalent attachment of FAD on the ~70-kDa flavoprotein s
113 homologs, but the mechanisms underlying the covalent attachment of FAD remain to be fully elucidated
114 d in reaction catalysis and in mediating the covalent attachment of FAD, whereas Tyr-448 serves as an
115 tochondrial protein Sdh5 is required for the covalent attachment of flavin adenine dinucleotide (FAD)
116 of the channel is faithfully mimicked by the covalent attachment of fluorescein at a cysteine residue
119 site of GFP-like proteins, and may allow for covalent attachment of functional groups to the protein
121 n integrated modified electrode based on the covalent attachment of glucose dehydrogenase (GDH) enzym
124 A hallmark of our assembly strategy is the covalent attachment of guideRNA and editing enzyme by ap
125 All models propose that CcmFH facilitates covalent attachment of haem to the apocytochrome; namely
127 chondrial cytochrome c assembly requires the covalent attachment of heme by thioether bonds between h
131 ata show (i) that E310 serves as the site of covalent attachment of heme to the protein backbone of r
133 we characterize "polyphosphorylation" as the covalent attachment of inorganic polyphosphate (polyP) t
134 be discerned, thereby demonstrating a robust covalent attachment of intact clusters to the graphene s
136 ct with the C-terminal ester of 3, forming a covalent attachment of L-Lys-D-Ala to the natural produc
139 merization chemistry, thereby leading to the covalent attachment of longer graft copolymer chains to
140 cus aureus transpeptidase SrtA catalyzes the covalent attachment of LPXTG-containing virulence and co
143 ey step in FA-BRCA pathway activation is the covalent attachment of monoubiquitin to FANCD2 and FANCI
144 Interaction with Tsg101 is strengthened by covalent attachment of monovalent ubiquitin to HIV-1 p6.
146 residues 1-10 comprise a consensus motif for covalent attachment of myristate, a hydrophobic 14-carbo
149 Correct folding of ER proteins requires covalent attachment of N-linked glycan oligosaccharides.
150 llin-type proteins has been shown to require covalent attachment of Nedd8 (neural precursor cell-expr
151 sponses is through S-nitrosylation, that is, covalent attachment of NO to cysteine residues to form S
152 Glycosylation is a stepwise procedure of covalent attachment of oligosaccharide chains to protein
153 ional modification of substrate proteins via covalent attachment of one or a chain of ubiquitin molec
157 ted cross-linking reactions resulting in the covalent attachment of pathogenic Staphylococcus aureus
158 w that both CpcS-I and CpcU are required for covalent attachment of PCB to Cys-82 of the PC beta subu
159 IRT2, a tryptic peptide originating from the covalent attachment of photoactivated 4 was identified.
163 in a process referred to as pupylation, the covalent attachment of prokaryotic ubiquitin-like protei
164 operties of the conducting pathway opened by covalent attachment of propyl-MTS were the same as those
165 amine-poly(ethylene glycol)-carboxyl allowed covalent attachment of proteins to the particles using s
166 peptidoglycan as a surface organelle for the covalent attachment of proteins, however, an assembly pa
168 that the critical factor may be the lack of covalent attachment of PS to protein in intact Pn, highl
169 old nanoparticles (AuNPs-PAMAM) was used for covalent attachment of PSA-aptamer and HRP linked aptame
171 rufin ligase catalyzed the site-specific and covalent attachment of resorufin to various cellular pro
172 has been demonstrated to be responsible for covalent attachment of RUB1 to the SCF (Skpl Cdc 53 F-bo
175 nucleic acids at specific sites requires the covalent attachment of spin labels, which involves rathe
176 4-mercaptobenzoic acid onto a gold surface, covalent attachment of streptavidin and further immobili
177 High-affinity labeling is demonstrated by covalent attachment of streptavidin, thus enabling the t
178 O-Linked glycosylation often involves the covalent attachment of sugar moieties to the hydroxyl gr
180 ve to SUMO-1 overexpression, suggesting that covalent attachment of SUMO-1 to p6 is detrimental to HI
181 ipass transmembrane enzyme that mediates the covalent attachment of the 16-carbon fatty acid palmitat
182 o-ACPs) are post-translationally modified by covalent attachment of the 4'-phosphopantetheine group t
184 bable nucleophile, thus acting as a site for covalent attachment of the acyl molecule and formation o
185 roxysuccinimide ester groups resulted in the covalent attachment of the alkene as a monolayer on the
186 d unprecedented reaction mechanism involving covalent attachment of the alpha,beta-unsaturated aldehy
187 ing surface served as a stable layer for the covalent attachment of the anti-human CRP antibody.
189 This forms the basis for the convenient covalent attachment of the cation exchanger to the polym
191 s detectable after the complex catalyzes the covalent attachment of the DNA to Deltacap by suicide cl
194 e initial step of protein priming, i.e., the covalent attachment of the first nucleotide to the prote
196 uration (Ccm) system is known to promote the covalent attachment of the haem to periplasmic apocytoch
197 igestion of the G248E P450(cam) mutant after covalent attachment of the heme releases 5-hydroxyheme,
198 hat a carboxylic radical mediates the normal covalent attachment of the heme to the protein in the ma
201 This dimer formation is eliminated here by covalent attachment of the ionophore to the polymer matr
202 terized by a longer duration consistent with covalent attachment of the ligand to functionally import
203 rgo S-palmitoylation, the post-translational covalent attachment of the long chain fatty acid palmita
205 Ls contain a reactive electrophile, enabling covalent attachment of the photoswitch to naturally occu
208 f its amino-terminal domain as the region of covalent attachment of the position 12 probe, whereas th
209 een used as the substrates of PPTase for the covalent attachment of the probes to a specific Ser resi
212 n product is a thiol-cyanine adduct in which covalent attachment of the thiol to the polymethine brid
213 nilino-8 naphthalene sulfonate (ANS) and the covalent attachment of the thiol-reactive fluorophore, m
214 all affinity for ssDNA is a byproduct of the covalent attachment of the two domains via a short flexi
216 quitin ligase, which becomes functional upon covalent attachment of the ubiquitin homologue neural-pr
219 alogous to ubiquitination that culminates in covalent attachment of the ubiquitin-like protein Nedd8
220 E3 ubiquitin ligases are regulated by the covalent attachment of the ubiquitin-like protein Nedd8
221 ography (UHPLC) applications was prepared by covalent attachment of the Whelk-O1 selector to spherica
223 nds of the bundle facilitates the subsequent covalent attachment of these monolayer ensembles onto th
225 E2s (UbcH6 and UBE2E2) uniquely requires the covalent attachment of Ub to the active site cysteine of
226 me system in which substrates, marked by the covalent attachment of Ub, are degraded by the 26 S prot
233 st-translational modification of proteins by covalent attachment of ubiquitin or a polyubiquitin chai
234 nal modification of cellular proteins by the covalent attachment of ubiquitin regulates protein stabi
237 between-RING E3 ligase that functions in the covalent attachment of ubiquitin to specific substrates,
239 omplex enzymatic process that results in the covalent attachment of ubiquitin, through Gly-76 of ubiq
241 s a chemical surface modification method for covalent attachment of various polymers by using silane-
242 eptidase SrtA isoform is responsible for the covalent attachment of virulence and colonization-associ
243 ortase transpeptidase is responsible for the covalent attachment of virulence- and colonization-assoc
244 ion rates were dependent on both the site of covalent attachment on the DNA and the size of the bound
245 the listeria bacteriophage endolysin Ply500: covalent attachment onto FDA approved silica nanoparticl
246 ed on the surface of live cells using either covalent attachment or non-covalent insertion, while mai
247 presentation of relevant carbohydrates using covalent attachment or supramolecular self-assemblies.
248 ectrode-electrolyte interface either through covalent attachment or surface adsorption, enabling the
249 ational studies have provided details of the covalent attachment process that leads to formation of t
250 alysis, we are able to define a single AzBCQ covalent attachment site lying within the digestive vacu
252 of thiol-ene chemistry allows for a range of covalent attachment strategies in a fast and reliable ma
253 the same washing treatment, indicating that covalent attachment targets MIANS to a critical location
255 on the gold surface of an SPR sensor through covalent attachment to a self-assembled monolayer (SAM)
257 s circuit conductance to monitor and control covalent attachment to an electrically connected SWNT.
262 of biosynthetic intermediates, displayed via covalent attachment to carrier proteins, by catalytic do
263 d PV3) with various anchoring groups for the covalent attachment to Co(3)O(4) catalyst nanoparticles
264 ents can be rendered membrane impermeable by covalent attachment to cobalamin (Cbl) through a photocl
265 to the cytochrome c synthetase (CcmF/H) for covalent attachment to cytochrome c by unknown mechanism
267 e catalytic tyrosine residue responsible for covalent attachment to DNA is located in a smaller subun
268 and isophorone diisocyanate was performed by covalent attachment to free isocyanate groups from PUU m
270 lly modified phospholipid anchors capable of covalent attachment to O(6)-methylguanine DNA methyltran
277 s the orientation of the inactivator and its covalent attachment to the active site Cys, but the stru
278 minal "sorting signal" that targets them for covalent attachment to the cell wall by sortase enzyme.
286 ing the DNA strand to be transferred and for covalent attachment to the resulting 5'-phosphate end, a
287 phosphate at the nick has been activated by covalent attachment to the tyrosine mimic, p-nitrophenol
288 e terminus at the nick has been activated by covalent attachment to the tyrosine mimic, p-nitrophenol
289 of the completed polypeptide chain from its covalent attachment to transfer RNA in the ribosomal pep
293 y (e.g., electrostatic, hydrogen bonding, or covalent attachment) to attach scFv to preformed functio
294 ed on the porous iridium oxide electrodes by covalent attachment using (3-aminopropyl)triethoxysilane
295 uired for positioning the first cysteine for covalent attachment, whereas the histidine of CXXCH posi
296 the subsequent single strand of DNA (ssDNA) covalent attachment, which after hybridization with its
297 obe must approach the target biomolecule for covalent attachment, while avoiding irreversible adhesio
298 bind irreversibly to WT CB1 but exhibited no covalent attachment with the mutants and behaved as an a
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