ライフサイエンスコーパス: covalent binding

1 ed that these pretreatments did not decrease covalent binding.

2 uggesting that lysine binding may facilitate covalent binding.

3 ive intermediate and result in lower rate of covalent binding.

4 f immobilization; electrostatic assembly and covalent binding.

5 nd E3 components to the E2p core through non-covalent binding.

6 ast, the FTUCAs did not exhibit any apparent covalent binding.

7 is dependent on FAD binding to Sdh1 but not covalent binding.

8 and suggested one biochemical mechanism for covalent binding.

9 at the recognition site are not involved in covalent binding.

10 eta-93 cysteinyl residue of HbO(2) to form a covalent-binding adduct responsible for the broad spectr

11 nding free energy and the overall reversible covalent binding affinity using a two-state binding mode

12 Covalent binding also reduces the thermal activation ene

13 but exposure to H(2)O(2) results in complete covalent binding and a fully active protein.

14 rotein adducts at 2 hours, a time of maximal covalent binding and before hepatocyte lysis, indicated

15 tion event is not solely dictated by the non-covalent binding and might be influenced by a unique seq

16 The direct covalent binding and the detailed characterization of th

17 pling of the traditional association between covalent binding and toxicity, and suggest that the asse

18 mall set of molecules also demonstrated that covalent binding and/or geometrical constraints to the l

19 iated by an initial metabolic activation and covalent binding, and subsequent activation of macrophag

20 actors include metabolism, bioactivation and covalent binding, and the inhibition of key cell functio

21 Our findings support bacterial-encoded covalent binding as a new molecular principle in host-mi

22 cation of soft organic electrophiles through covalent binding at its cysteine (Cys) thiol group, foll

23 is is likely to be related to the absence of covalent binding between probe, sample, and substrate in

24 ACA allows for covalent binding between proteins and elastomers and thu

25 that the mechanism of toxicity is due to the covalent binding between the DNA methyltransferase (Dnmt

26 XIXIT docking site, which may be assisted by covalent binding but depends on other specific features

27 rt SAM to incubations of tamoxifen inhibited covalent binding by 17-23%.

28 onclusion, the findings demonstrate a novel, covalent binding by Lp(a) which is kringle independent a

29 , essentially overcame the inhibition of the covalent binding by SAM.

30 ging but necessary step in understanding how covalent binding could lead to liver toxicity.

31 tabolites associated with or responsible for covalent binding could not be detected, likely due to th

32 Consistent with the covalent binding data, the VIP-CRA inhibited catalysis b

33 tor (mitochondria with severe GSH depletion, covalent binding) directly inhibited respiration.

34 This non-covalent binding does not change the linking number of t

35 ) were immobilised by entrapping and also by covalent binding for use in synthesis of isoamyl acetate

36 Covalent binding has been demonstrated for CYP4A1, -4A2,

37 metabolites that could explain the in vitro covalent binding in microsomes observed across the speci

38 tigate the hepatotoxicity; however, only the covalent binding in rat, dog, and human microsomes was i

39 The extent of heme covalent binding in the proteins as isolated varies and

40 oquinone derivatives that function as potent covalent-binding, irreversible inhibitors of the kinase

41 concave surface of [60]fullerene, endohedral covalent binding is possible inside a (5,5) SWNT despite

42 An irreversible covalent binding mechanism imparts many desirable pharma

43 pounds presented herein display an efficient covalent binding mode and that the respective covalent l

44 Computational modeling suggested a novel covalent binding mode in active-site CGHCK motifs.

45 resent paper describes the assessment of non-covalent binding (NCB) between milk proteins and polyphe

46 tors overcome this resistance simply through covalent binding, not as a result of an alternative bind

47 The unexpected covalent binding observed in the PGA-DON and PGA-DONV co

48 The covalent binding occurred preferentially at the light ch

49 favoring an ionic pre-adsorption step before covalent binding occurred.

50 ric oligonucleotide adducts derived from the covalent binding of (+/-)-anti-7r,8t-dihydroxy-9t,10-epo

51 a modification of the protein indicative of covalent binding of 2-aminothiazole.

52 bout 160 of the new products were formed via covalent binding of 3-QCA with DOM molecules of above-av

53 mass spectrometry, we have demonstrated the covalent binding of 4-HNE to Daxx.

54 By contrast, covalent binding of 4-hydroxytamoxifen (4-OH-tam) was 3-

55 fied, such as pyocyanin, we propose that the covalent binding of 5MPCA promotes its accumulation in t

56 Accumulation and covalent binding of [(14)C]1a derived radioactivity was

57 Neither CYP2E1 levels nor covalent binding of [14C] CCl4-derived radio-label diffe

58 Ala, Arg, His, and Leu completely eliminated covalent binding of [3H]beta-FNA, although these mutants

59 of other amino acid residues did not affect covalent binding of [3H]beta-FNA.

60 d residue of the mu receptor involved in the covalent binding of [3H]beta-FNA.

61 e of bulky adducts that are generated by the covalent binding of a variety of metabolically activated

62 glutathione conjugates, or in the levels of covalent binding of acetaminophen-reactive metabolites t

63 -ATP monolayers previously oxidized, and the covalent binding of amino-oligonucleotides to pure p-MBA

64 y of proteins which act via an ATP-dependent covalent binding of AMP to their substrates and shows th

65 P1A1 mRNA and CYP1A1/1A2 protein followed by covalent binding of an AF metabolite to DNA, phosphoryla

66 the first crystallographic demonstration of covalent binding of an enzyme by borate.

67 Minor adducts, derived from the covalent binding of anti-benzo[a]pyrene-7,8-dihydroxy-9,

68 Covalent binding of Anti-Cab onto Ag@AgO-PANI nanocompos

69 confined carboxyl groups suitable for direct covalent binding of anti-IGF1 monoclonal antibody.

70 Transglutaminase-catalyzed covalent binding of bioactive peptides targeted to miner

71 idase and holocarboxylase synthetase mediate covalent binding of biotin to histones (DNA-binding prot

72 protein that is essential for mediating the covalent binding of biotin to histones.

73 Additionally, for the first time a covalent binding of both drugs with hTTR was identified

74 The covalent binding of bulky mutagenic or carcinogenic comp

75 In dimeric NIR FPs without Cys15, the covalent binding of BV to capital ES, Cyrillicys256 in o

76 6 in one monomer allosterically inhibits the covalent binding of BV to the other monomer, whereas the

77 Covalent binding of capturing biomolecule (anti-TNF-alph

78 hese products were presumably formed through covalent binding of CBZ phototransformation products wit

79 limination of pathogens from the body is the covalent binding of complement proteins C3 and C4 to the

80 r sulfonic acid) ionomer Eastman AQ38S or by covalent binding of DNA onto oxidized PG.

81 A procedure for covalent binding of DNA to a functionalized mica substra

82 it the fibrillation of alpha-Syn, due to non-covalent binding of DOPAC to alpha-Syn monomer.

83 Covalent binding of endo- or exogenous chemicals to DNA

84 regard to functional significance of 8alpha-covalent binding of flavins to proteins.

85 in and immunoglobulin G-antibody) as well as covalent binding of fluorescently tagged bovine serum al

86 o alter the chromatin structure inducing the covalent binding of genomic DNA with proteins, a feature

87 sly found to modify apolipoprotein B100 with covalent binding of Hb fragments and formation of electr

88 LC-MS revealed the covalent binding of HNE to Mb at both pH values via Mich

89 Covalent binding of IDAM to cellular macromolecules and

90 This effect is mediated by covalent binding of iRGD to plasma albumin through a dis

91 Non-covalent binding of K63-Ubn to 2CARD induces its tetrame

92 Covalent binding of L-764406 was proven by an observed m

93 ected in the alpha subunits by the rapid and covalent binding of Lucifer Yellow vinyl sulfone (LY) to

94 MCF-7 cells, 4'BF significantly reduced the covalent binding of metabolically activated benzo[a]pyre

95 Specific non-covalent binding of metal ions and ligands, such as nucl

96 netics of isoindole formation resulting from covalent binding of NNA to wild-type and mutant opioid r

97 ere we describe a detailed protocol based on covalent binding of nucleophilic groups on Wnt proteins

98 Recently, mass spectrometry identified covalent binding of OPs to tyrosine in a wide variety of

99 p-type sensitization of TiO2 solely based on covalent binding of organic adsorbates.

100 The covalent binding of organosulfur compounds to beta-lacto

101 As no covalent binding of oxygen to the metal occurs in the zi

102 The covalent binding of PA to the N-terminus of the RabGGTas

103 tions and wobble base pairing induced by the covalent binding of POB to the O(6)-position of dG help

104 The biological implications of non-covalent binding of polyphenols to BLG were investigated

105 ons imply that transglutaminases may mediate covalent binding of pro-CpU to other proteins and cell s

106 e grafting of poly(acrylic acid) followed by covalent binding of protein A/G enabled efficient captur

107 These investigations characterize the covalent binding of reactive products of prostaglandin H

108 ed wild-type apoprotein folding, but altered covalent binding of retinal and final folding to bacteri

109 nd the FG loop to that for final folding and covalent binding of retinal.

110 signed preactivated IFO derivatives with the covalent binding of several O- and S-alkyl moieties incl

111 Proteolytic inhibition requires covalent binding of STC2 to PAPP-A and is mediated by a

112 The rate of covalent binding of tamoxifen metabolites, tamoxifen N-o

113 ascorbic acid and glutathione, inhibitors of covalent binding of tamoxifen, produced an elevation of

114 genesis, and molecular modeling, we show the covalent binding of thalassospiramide's alpha,beta-unsat

115 changes in the metal permittivity following covalent binding of the adsorbate layer.

116 In contrast, induction of CYP1A1 and covalent binding of the AF metabolite did not occur in A

117 Covalent binding of the AF metabolite was increased by p

118 -based irreversible inhibitor of cAD through covalent binding of the alkyl chain to the enzyme.

119 Whereas APAP-bioactivating enzymes and covalent binding of the APAP-derived reactive metabolite

120 ate by the ADP-ribosyl cyclase CD38 and (ii) covalent binding of the BFA-ADP-ribose conjugate into th

121 We have characterized the covalent binding of the CO(2) reduction electrocatalyst

122 The biosensor was constructed by covalent binding of the enzyme substrate d-fructose 6-ph

123 2D 1H-1H NMR TOCSY provided evidence of covalent binding of the europium analog of the C-6 compo

124 n ester bond to the heme 5-methyl group, (b) covalent binding of the heme is mediated by an autocatal

125 doxin reductase, and NADH results in partial covalent binding of the heme to the protein.

126 talyst and organic hydroperoxide as oxidant, covalent binding of the hydroperoxide is not required, a

127 This study confirms the irreversible covalent binding of the inhibitor to the kinase by x-ray

128 eaction mechanism could be inferred from the covalent binding of the proteasome-specific inhibitor ep

129 Ubiquitination, the covalent binding of the small protein modifier ubiquitin

130 The electron density map displays covalent binding of the Thr1O(gamma) atoms of all active

131 ctive form of the DD-peptidase shows the non-covalent binding of the two products of the carboxypepti

132 hese effects are thought to be caused by the covalent binding of these species to nucleophilic groups

133 bon nanotubes/gold nanoparticles followed by covalent binding of tyrosinase.

134 Covalent binding of ubiquitin to proteins marks them for

135 ding ligases called E3s, that coordinate the covalent binding of ubiquitin to target proteins.

136 the ATMS/diazotization chemistry facilitated covalent binding of unmodified DNA, and the reusable mic

137 Mass spectrometry demonstrated direct covalent binding of WA to Cys(303) of beta-tubulin in MC

138 consequence of blocking the stimulatory, non-covalent, binding of ubiquitin to the backside of UbcH5B

139 tter through the pironetin end (irreversible covalent binding) or through the colchicine end (reversi

140 In this proof-of-concept study, the use of a covalent binding peptide ligand against VEGF improves tr

141 elastase inhibitors, which offer reversible covalent binding properties.

142 e current methodology for the measurement of covalent binding relies on the use of radiolabeled mater

143 n P450 enzymes, but also show that efficient covalent binding requires placement of the carboxyl clos

144 n general, can be used to predict reversible covalent binding selectivity.

145 t3p cannot bind concurrently to both the non-covalent binding site and the catalytic cysteine of a si

146 sites for allicin, whereas the number of non-covalent binding sites increased for diallyl disulfide.

147 roducing appropriate feature annotations for covalent binding sites, modified sites and cross-links.

148 We conclude that covalent binding state alone, in general, can be used to

149 on warhead scaffold, in both noncovalent and covalent binding states, and for two highly homologous p

150 3A4 and human liver microsomes resulted in a covalent binding stoichiometry equal to 0.93 +/- 0.04 mo

151 s diffusion electrodes (GDEs) by using a non-covalent binding strategy.

152 as also comparable, as determined by using a covalent-binding suicide substrate.

153 A stable covalent binding technique for lipase enzyme immobilizat

154 n APAP bioactivation results in less-intense covalent binding that is more diffuse and spread uniform

155 alcohol dehydrogenase enzyme immobilised by covalent binding through an array composed of carbon Tor

156 nticancer drug, which triggers cell death by covalent binding to a broad range of biological molecule

157 mic nature of the bullvalene core allows for covalent binding to a wide variety of analytes, allowing

158 tion as immunomodulators, apparently through covalent binding to albumin.

159 ed form by sensitive cell lines only and its covalent binding to an intracellular protein.

160 (dimethylamino)propanamide (5), did not show covalent binding to cell-free EGFR-TK in a fluorescence

161 than SFN, these results indicate that direct covalent binding to cellular proteins is an important ea

162 study using mass spectral analysis confirmed covalent binding to Cys249 within the PPARdelta binding

163 d CHO), yet they do not show any evidence of covalent binding to DNA.

164 Drug covalent binding to endogenous proteins (haptenation) is

165 Tyr-398 in MAO B may be involved in the non-covalent binding to FAD.

166 atures a photoreactive moiety for UV-induced covalent binding to GSTs and GSH-binding enzymes.

167 n of the cytochrome c1 cysteines involved in covalent binding to heme nearly abolished immunodetectab

168 timate reactive intermediate that results in covalent binding to microsomal proteins.

169 However, the effect of non-covalent binding to Nedd8 remains unknown.

170 or groove but 1 must diffuse off the DNA for covalent binding to occur.

171 AD was increased further by about 75 mV upon covalent binding to PchF, i.e., PchF(C).

172 ng release of free omega-hydroxyceramide for covalent binding to protein and sealing of the waterproo

173 of a reactive metabolite which demonstrated covalent binding to protein in vitro.

174 nd, releasing free omega-hydroxyceramide for covalent binding to protein, thus forming the corneocyte

175 res of GSTO1 with our inhibitors demonstrate covalent binding to the active site cysteine.

176 -containing C terminus that does not require covalent binding to the membrane domain of ClC-7.

177 ucleophile (CN-), which fluoresces only upon covalent binding to the protein.

178 ATP competes with regular DNA for non-covalent binding to the T4 ligase and is found to signif

179 (64)Cu-L19K-FDNB was assayed for covalent binding to VEGF in vitro.

180 Covalent binding via reaction of one amine group to a bo

181 Covalent binding was achived with Chi modified with spac

182 Covalent binding was attenuated when Lp(a) was pretreate

183 Covalent binding was inhibited when Lp(a) was mildly oxi

184 Significantly greater GSH loss and APAP covalent binding were observed in liver slice mitochondr

185 UALs exhibited significant levels of protein covalent binding, with binding levels ranging from 20.1