ライフサイエンスコーパス: covalent bond

1 replacing an interhelical ionic bond with a covalent bond.

2 ganic reaction: the breaking and making of a covalent bond.

3 ivalent to half the mechanical strength of a covalent bond.

4 escent probe in tissue by the formation of a covalent bond.

5 ld in place via the inhibitory His(105)-heme covalent bond.

6 l properties of a charge-shift rather than a covalent bond.

7 cysteine residue with which they form a key covalent bond.

8 ew strategy to construct a B(sp(3))-B(sp(3)) covalent bond.

9 lyst activity is modulated through a dynamic covalent bond.

10 h is observed in transition metal coordinate covalent bonds.

11 OFs by reversible formations of two types of covalent bonds.

12 ysis was used to break down proanthocyanidin covalent bonds.

13 ticles to the surface of the TFBG using only covalent bonds.

14 arge neutral and more stable due to existing covalent bonds.

15 t bonding mechanism from that of traditional covalent bonds.

16 rogen bonds, coordination bonds, and dynamic covalent bonds.

17 A also were applied, suggesting formation of covalent bonds.

18 of atoms, including the potential of forming covalent bonds.

19 composed of light elements linked by strong covalent bonds.

20 that are joined by 'mechanical' rather than covalent bonds.

21 wo components are linked through two dynamic covalent bonds.

22 s the two systems by forming very stable B-O covalent bonds.

23 only been realized in materials with strong covalent bonds.

24 ising monoaromatic units that are linked via covalent bonds.

25 A that controls and records the formation of covalent bonds.

26 before reaching forces sufficient to cleave covalent bonds.

27 ic and more than 1300 have other intra-chain covalent bonds.

28 ugh space", rather than through conventional covalent bonds.

29 works 1-6 provides fundamental insights into covalent bonding.

30 pramolecular chemistry and the robustness of covalent bonding.

31 e of poly(ether sulfone) (PES) membranes via covalent bonding.

32 ns, thereby offering additional evidence for covalent bonding.

33 topic abundance (4.7%) establish the through-covalent-bond (29)Si-O-(29)Si connectivities of distinct

34 ation of the actinide 5f valence orbitals in covalent bonds across the actinide series.

35 The stability of covalent bonds against desorption and pressurized liquid

36 The non-covalent bonds allow the extrusion of the inks into supp

37 as strong, or stronger, mechanically as the covalent bonds along the polymer backbone.

38 an off-centre position, forming a short H-S covalent bond and a longer H...S hydrogen bond in a stru

39 mparable to the theoretical value of a La-La covalent bond and is shorter than reported values for ot

40 lization protocols such as physisorption and covalent bonding and detection techniques such as ampero

41 About half of this derives from its covalent bonding and half from its electrostatic interac

42 In contrast, the significant covalent bonding and large spin-orbit contributions asso

43 epends on matrix-material properties such as covalent bonding and soft versus hard materials.

44 tical responses due to their strong in-plane covalent bonding and weak out-of-plane interactions.

45 found to sensitize ground-state Cu(I)-Au(I) covalent bonds and near-unity phosphorescence quantum yi

46 ation/photoreduction, breaking and making of covalent bonds, and excited-state proton transfer (ESPT)

47 can and mixed-linkage beta-glucan-xyloglucan covalent bonds, and may therefore strengthen ageing Equi

48 the substrate by electrostatic interactions, covalent bonds, and physical interpenetration.

49 d material, a robust framework consisting of covalent bonds, and, most importantly, pronounced stabil

50 olyketide biosynthesis, indicate how dynamic covalent bonds are best used in functional systems.

51 examples in which different types of dynamic covalent bonds are similarly used in tandem.

52 Dynamic covalent bonds are unique because of their dual nature.

53 n character (i.e., there is no formal F-Mg-F covalent bonding arrangement).

54 lly encapsulate all-trans-retinal and form a covalent bond as a protonated Schiff base.

55 a indicate a weakening of the intramolecular covalent bond as well as persistence of semiconducting b

56 Exploiting exchangeable covalent bonds as dynamic cross-links recently afforded

57 eptide of proinsulin is replaced by a single covalent bond--as a key intermediate for the efficient t

58 echanical properties of both noncovalent and covalent bonding at the interface between the nanofiller

59 F in the FIB solution catalyzes formation of covalent bonds at only the interface between stromal mol

60 ation of Pb dimers and I trimers with strong covalent bonds at some of the intrinsic defects.

61 noscale filler and the orientation of X-type covalent bonds at the nanoparticle-ligand interface are

62 hibitors exhibited hindered rotation along a covalent bond axis, and the existence of atropisomer chi

63 ucture of silver-ammonia-FOX exhibits unique covalent bonding behavior, which is supported by NBO cal

64 for the definition of the bond order of the covalent bonds being (3-beta)/2, and this accounts for t

65 urred via ester and ether and other types of covalent bonds besides HA sequestration.

66 tion involving an intermediate with a single covalent bond between a quinoid adduct and cofactor is p

67 ured on silica (Si)-based beads by forming a covalent bond between an azide group on the surface and

68 ssociation is followed by the formation of a covalent bond between an electrophile on the ligand and

69 On the basis of the covalent bond between enzyme and isomerized 5-FU we prop

70 ization strategy based on the formation of a covalent bond between propargyl-terminated glycans and s

71 large value of binding enthalpy suggesting a covalent bond between selenium and AtSBP1.

72 of transglutaminase (TGase), which creates a covalent bond between the agent and the side chain of a

73 Since R-cdA and S-cdA contain an 8,5'-covalent bond between the base and sugar moieties, they

74 yclopurine 2'-deoxynucleosides, containing a covalent bond between the deoxyribose and the purine bas

75 not support unequivocally the existence of a covalent bond between the drug and GSK-3beta.

76 ydride transfer precedes the cleavage of the covalent bond between the enzymatic cysteine and the pro

77 involving an activated glycosyl donor with a covalent bond between the glycosyl moiety and the leavin

78 tituted by 5-fluorouridine (5-FU), reveals a covalent bond between the isomerized target base and tyr

79 ordinate heme chemistry and bears an unusual covalent bond between the nonaxial His(117) and a heme p

80 also suggest that the traditionally proposed covalent bond between the protein and substrate (the C6-

81 al and experimental studies suggest that the covalent bond between the protein and substrate is actua

82 These results predict a covalent bond between the serine nucleophile and tungsta

83 e being formed prior to the formation of the covalent bond between the substrate and the active-site

84 reveals that PP1 selectivity is defined by a covalent bond between TTN and a PP1-specific cysteine re

85 Covalent bonding between C and S is observed in the nano

86 situ ultraviolet photopolymerization induces covalent bonding between neighboring PCDA molecules in a

87 The intriguing covalent bonding between neighbouring tubes creates a un

88 wedge are correlated with periodic trends in covalent bonding between the metal and the cyclopentadie

89 The selective generation of covalent bonds between and within proteins would provide

90 nclusion that PL inhibits GSTP1, which forms covalent bonds between GSH and various electrophilic com

91 ins of mature MPO protomers, and (iii) three covalent bonds between heme and the protein.

92 d the crosslinker, resulting in formation of covalent bonds between O-GlcNAc-modified proteins and ne

93 These involve covalent bonds between the C8 positions of guanine (G*)

94 nd lactoperoxidase (LPO) is the existence of covalent bonds between the prosthetic group and the prot

95 Ccm is responsible for the formation of covalent bonds between the thiol groups of two cysteines

96 nzymatic, or chemoenzymatic formation of new covalent bonds between two polypeptides, or between a si

97 which involved formation of weak reversible covalent bonds between vicinal hydroxyl groups of arabit

98 The ability to catalyze covalent bond breakage in isolated small molecules using

99 r structures, which are not held together by covalent bonds but by non-covalent mechanical interactio

100 an also be used to detect the formation of a covalent bond by catalyCEST MRI.

101 drimers of fourth generation (PAMAM G4) with covalent bonding by electro-oxidation method.

102 Laccase catalyzed the formation of covalent bonds by oxidizing unreactive hydroquinone moie

103 Covalent bonds can be made in two ways, applying irrever

104 These reversible covalent bonds can be triggered through molecular trigge

105 The resulting materials with dynamic covalent bonds can show full property recovery after mul

106 gical systems are cross-linked by dityrosine covalent bonds catalyzed by the peroxidase/oxidase syste

107 d theoretical aspects are discussed, and the covalent-bond CEE, rigidity-aggregated CEE, or supramole

108 According to the covalent bond classification (CBC) method, two-electron

109 hat have captured an electron and have had a covalent bond cleaved yet do not immediately dissociate

110 on partners and products, but their internal covalent bond configurations as well.

111 is the interaction is best viewed as a weak covalent bond delocalized over 22 atoms.

112 non-covalent interactions or as permanent as covalent bonds, depending on conditions.

113 he reaction center in these reactions is one covalent bond distant from the norbornane or norbornene

114 binding-induced cleavage of the Lys(629)-PLP covalent bond, dynamic motion of the cobalamin-binding d

115 espite numerous strategies involving dynamic covalent bond exchange for dynamic and self-healing mate

116 d in the context of conventional theories of covalent bonding for d- and f-block metal complexes.

117 We report here on the use of covalent bond formation among monomers, compensating for

118 d a validated 8-N-benzyladenosine ligand for covalent bond formation and confirmed targeted irreversi

119 cysteine residue in the ATP binding site via covalent bond formation and demonstrates high levels of

120 covalent motions, resulting from reversible covalent bond formation and dissociation.

121 dy precipitated COF, indicating both dynamic covalent bond formation and irreversible precipitation.

122 chemistry the study of the interplay between covalent bond formation and noncovalent interactions has

123 -(13)C(2)]ThDP, enables both confirmation of covalent bond formation and response in 4'-aminopyrimidi

124 We thus demonstrate that neither enzymes nor covalent bond formation are required for robust chemical

125 Selective covalent bond formation at a protein-protein interface p

126 k polymer could effectively heal via dynamic covalent bond formation at sub-ambient temperature.

127 to the external walls of the SWCNTs; and (2) covalent bond formation between amine-modified aptamers

128 -receptor pair as an example, we demonstrate covalent bond formation between an alphaErbB2-VSF mutant

129 and toxicology assays demonstrated that the covalent bond formation between compound 47 and the prot

130 ex was bound to the active site of GSTP1; no covalent bond formation between hPL and GSTP1 was observ

131 o the Fe(3)O(4)/MWCNTs nanocomposite film by covalent bond formation between the amine groups of enzy

132 Our findings document covalent bond formation between the asparagusic acid moi

133 rements together provided strong evidence of covalent bond formation between the photoacids and the p

134 tly requiring a minor groove environment for covalent bond formation between their C11-position and t

135 generally slow partly because of reversible covalent bond formation by some gliptins, and partly bec

136 thus providing diversity and flexibility in covalent bond formation for protein research and protein

137 group provided a direct tool to distinguish covalent bond formation from physisorption of proteins.

138 Compared to LHA, the SHA showed enhanced covalent bond formation in the absence of laccase, sugge

139 rsible coordination chemistry and reversible covalent bond formation is described.

140 The mechanism of covalent bond formation of the model sulfonamide sulfath

141 Covalent bond formation to Cys-154 was confirmed by incu

142 metal cluster chemistry with dynamic organic covalent bond formation to give a new crystalline, exten

143 Reversible covalent bond formation under thermodynamic control adds

144 By using the Uaa and cysteine, spontaneous covalent bond formation was demonstrated between an affi

145 m of inhibition by these inhibitors involves covalent bond formation with the side chain of the conse

146 th processes, which involve a combination of covalent bond formation, degenerate bond exchange, and n

147 en bonds between peptides were reinforced by covalent bond formation, enabling the fiber elongation.

148 ity toward the active site Cys, resulting in covalent bond formation, loss of the halide, and irrever

149 rsors into their desired geometries prior to covalent bond formation, we are able to produce compound

150 ensation reactions based on only one type of covalent bond formation.

151 pyridinium and pyrimidinium ions, suggesting covalent bond formation.

152 lf-assembly pathways can enable control over covalent bond formation.

153 g reactions were responsible for the initial covalent bond formation.

154 ectively modifying the lipid of interest via covalent bond formation.

155 lely attributed to global enzyme closure and covalent-bond formation.

156 interactions (e.g. strept(avidin)/biotin) or covalent bond formations (e.g. inverse electron demand D

157 tion (Aza-IP), a technique that exploits the covalent bond formed between an RNA methyltransferase an

158 heir subsequent closure by multiple directed covalent bond-forming reactions, provides a powerful str

159 dy and the intermediate affinity of this non-covalent bond, fully assembled probes do not aggregate o

160 ntermolecular ionic bonds and intramolecular covalent bonds has been achieved in this surface system.

161 systems that employ a single type of dynamic covalent bonds have been reported.

162 rging class of framework materials linked by covalent bonds, hold potential for various applications

163 SCAN accurately describes the balance among covalent bonds, hydrogen bonds, and van der Waals intera

164 P surface via maleimide/thiol group-mediated covalent bonding improves the macrophage (MP)-targeting

165 However, disulfide bonds being an additional covalent bond in the protein structure represent a chall

166 d PuO(2)(+) are considered in the context of covalent bonding in actinyls.

167 re is a strong competition between ionic and covalent bonding in cubic phase providing a link between

168 role of directional coordination bonding or covalent bonding in extended crystalline frameworks.

169 theory was originally introduced to explain covalent bonding in the H2 molecule within a quantum mec

170 elements is the increased role of f-orbital covalent bonding in the latter.

171 cture calculations to quantify the extent of covalent bonding in-arguably-one of the most difficult s

172 The specific targeting of covalent bonds in a local, anisotropic fashion using mec

173 that can direct the formation of the desired covalent bonds in a precise and concise fashion while av

174 The broad interest of using reversible covalent bonds in chemistry, in particular at its interf

175 nging from the dissociation and formation of covalent bonds in non-covalent complexes through the rea

176 on a molecule, thereby producing direct Au-C covalent bonds in situ between the molecule and gold ele

177 presence of components linked by reversible covalent bonds in slow exchange and bearing adequate coo

178 n from the MSW core, followed by scission of covalent bonds in the bottlebrush backbones.

179 Scission of C horizontal line C covalent bonds in the brush backbone occurred due to ste

180 s are bacterial secreted enzymes that cleave covalent bonds in the cell-wall peptidoglycan, thereby f

181 s is determined by the force required to cut covalent bonds in the molecules.

182 estrain the relative orientation between two covalent bonds instead of a simple distance between two

183 ur cores as modular units subject to various covalent bond interactions that lead to different struct

184 Covalent bonding interactions between the Lewis acid and

185 tions ((1)J approximately 50 Hz), evidencing covalent bonding interactions between the reaction cente

186 duced dimers have the shortest and strongest covalent bonding interactions seen in any neutral pi-dim

187 ls radii) and its ability to form strong non-covalent bonding interactions with pi-electron-rich PAHs

188 Here we genetically introduce a new type of covalent bond into proteins by enabling an unnatural ami

189 ver, the incorporation of orthogonal dynamic covalent bonds into functional systems is a surprisingly

190 ty constants in terms of sigma- and pi-donor covalent bonding, ionic bonding, and solvent effects.

191 Upon blue light activation, a covalent bond is formed between VVD residue Cys108 and i

192 Such a covalent bond is not present in the wild-type SHV-1 or i

193 e show that the unique directionality of the covalent bonding is found to stem from a chain of highly

194 Reversible covalent bonding is often used for the creation of novel

195 expected 4f- and 5d-orbital participation in covalent bonding is presented in the context of recent s

196 In this context, the generation of transient covalent bonds is a fundamental tool for nonequilibrium

197 knotted polymers without breaking or forming covalent bonds is challenging, as the chain needs to be

198 ional purely organic cages driven by dynamic covalent bonds is described.

199 3D N-doped graphene crosslinked by covalent bonds is fabricated through thermal treatment o

200 reactant close together and to form the C-C covalent-bond is estimated to be ~10 kcal/mol.

201 these protein macrocomplexes, by introducing covalent bonds, is a prerequisite before their analysis

202 tes an uneven distribution of tension in the covalent bonds, leading to spatially controlled bond sci

203 These labile covalent bonds may display similar behavior to sialic ac

204 Polymers bearing dynamic covalent bonds may exhibit dynamic properties, such as s

205 Non-covalent bonds, more likely salt bridge and ionic intera

206 -of-plane weakening of the three-dimensional covalent bond network of boron along different shear def

207 ormation creates a strong, three-dimensional covalent bond network that resists large shear deformati

208 compressed Al-B bond unsettles the existing covalent bond network.

209 he electronic structures of 1-3 and indicate covalent bonding of an E2(3-) ligand with a mixed-valent

210 Covalent bonding of graphene oxide quantum dots (GOQDs)

211 on the frequency shift before and after the covalent bonding of Lys.

212 f the Venus fluorescent protein results in a covalent bonding of the two halves of the Venus molecule

213 tances are substantially longer than for the covalent bonds of either HCl or H(2)O.

214 proteins that can be cross-linked, by either covalent bonds or association of helical domains or both

215 n of the biomolecules, with formation of new covalent bonds or cleavage of existing bonds.

216 +) and Na(+) in the absence of a net charge, covalent bonds, or lone-pair donor groups.

217 electron transfer are often held in place by covalent bonds, pi-pi interactions or hydrogen bonds.

218 Interfacial covalent bonding, possibly strengthened by d-electron ac

219 ust molecules on account of the formation of covalent bonds rather than fragile supermolecules result

220 the ability of oxygen to enter into a fourth covalent bonding relationship has been visited in theory

221 and reactions of the oxo groups to form new covalent bonds remain rare.

222 captured HIV-1 Env trimers via a more stable covalent bond, resulting in enhanced germinal center B c

223 This tutorial review summarizes non-covalent bonding, reversible reactions and responsive mo

224 Catcher until the force exceeded 1 nN, where covalent bonds snap.

225 ids connected by strong metallic, ionic, and covalent bonds, such as Ti2 AlC, Ti3 AlC2 , and Ta4 AlC3

226 elf-healing, and the primary classes are the covalent bonding, supramolecular assemblies, ionic inter

227 eir shape and molecular architecture through covalent bonds that are ubiquitous throughout the networ

228 Disulfide bridges are commonly found covalent bonds that are usually believed to maintain str

229 almost continuously from strong, essentially covalent bonds that lead to irreversible or 'static' bin

230 e release of small molecules via cleavage of covalent bonds that were not integral components of the

231 rst C-H functionalization could involve Ru-N covalent bond, the second C-H functionalization most lik

232 that, even in the absence of direct Cu-O-Mn covalent bonding, the interfacial CuO2 planes of superco

233 s reversible binding through covalent or non-covalent bonds, thermodynamic equilibration and structur

234 kg/mol) and reversible linkages that protect covalent bonds, these megasupramolecules overcome the ob

235 d macromolecules connected by transient, non-covalent bonds; they are a fascinating class of soft mat

236 Aided by intertubular covalent bonding, this material takes full advantage of

237 s transforms the C-O bond from a principally covalent bond to a complete charge-shift bond with princ

238 tivation of the substrate via formation of a covalent bond to an active site cysteine.

239 tric data that reveal that pironetin forms a covalent bond to cysteine-316 in alpha-tubulin via a Mic

240 isplatin, phenanthriplatin can form only one covalent bond to DNA.

241 on acceptor by force-induced cleavage of the covalent bond to form a fluorescent dipolar dye.

242 ded protein designed to spontaneously form a covalent bond to its peptide-partner SpyTag.

243 mechanism of inactivation occurring though a covalent bond to Lys257 of the CYP3A4 apoprotein.

244 mes, our catalysts apply a single reversible covalent bond to recognize and bind to specific function

245 irecting group to substrates via a transient covalent bond to render the directing group catalytic.

246 ted activation and subsequent formation of a covalent bond to the apoprotein.

247 ivity, and by (ii) capturing the DNA through covalent bond to the functionalized surface, enabling a

248 with the peptide SpyTag form an irreversible covalent bond to the SpyCatcher protein via a spontaneou

249 ligand, which operates through a reversible covalent bond to the substrate, has been applied to the

250 te that U employs both 5f and 6d orbitals in covalent bonding to a significant extent.

251 ecular sulfur species in the cathode through covalent bonding to and physical confinement in a conduc

252 used and provide a mechanism of adhesion by covalent bonding to target molecules on host cells that

253 iew summarizes the use of orthogonal dynamic covalent bonds to build functional systems.

254 ere conducted which indicated that they form covalent bonds to DNA, have only minor impact on the cel

255 em I, with a cleaved signal sequence and two covalent bonds to haem.

256 Linking molecular building units by covalent bonds to make crystalline extended structures h

257 150 years, chemical reactions that make new covalent bonds to polycyclic aromatic hydrocarbons (PAHs

258 were transformed to metabolites which formed covalent bonds to proteins and/or lipids in the gut as s

259 itin-related modifier (SUMO) is attaching by covalent bonds to substrate protein.

260 Here, organic molecules are linked by covalent bonds to yield crystalline, porous COFs from li

261 have been used on many length scales to form covalent bonds, to alter polymer conformations, and to b

262 erates dissociation of a variety of internal covalent bonds, to an extent that correlates well with t

263 geometries as a prelude to the formation of covalent bonds under equilibrium control--an additional

264 iral center(s) are separated by more than 12 covalent bonds, up to 82% ee was observed.

265 urement of the frequency changes in specific covalent bonds upon complex formation, information drawn

266 nded to Au metal electrodes with direct Au-C covalent bonds using the scanning tunneling microscope b

267 anic frameworks (COFs), the chemistry of the covalent bond was extended to two- and three-dimensional

268 rts the promise that with orthogonal dynamic covalent bonds we can ask questions that otherwise canno

269 New covalent bonds were genetically introduced into proteins

270 e thermodynamic stability of a carbon-carbon covalent bond), which is remarkable for a supramolecular

271 his seminal work on what became known as the covalent bond, which has since occupied a central role i

272 4f-orbitals participated only marginally in covalent bonding, which was consistent with historical d

273 We also demonstrate how strong non-covalent bonds, which are versatile for controlled prote

274 active thioester-containing proteins to form covalent bonds, which may enable strong adhesion to host

275 avin mononucleotide chromophore that forms a covalent bond with a cysteine upon illumination.

276 The formation of a covalent bond with adjacent cysteine-366 thiol was was p

277 ch exerted its inhibitory efficacy through a covalent bond with BTK Cys481.

278 Human butyrylcholinesterase made a covalent bond with CBDP on Ser198 to yield five adducts

279 Human albumin made a covalent bond with CBDP, adding a mass of 170amu to Tyr4

280 /or propagate the activation signal once the covalent bond with H105 has been broken.

281 new MR contrast probe, 2CHTGd, which forms a covalent bond with its target protein and results in a d

282 ts are linked by a genuine d(10)-d(10) polar-covalent bond with ligand-unassisted Cu(I)-Au(I) distanc

283 t, 4-iodo-6-phenylpyrimidine (4-IPP) forms a covalent bond with Pro-1 of both proteins, resulting in

284 ll molecules are tagged with alkyne and form covalent bond with proteins.

285 ustered near the residue K257, which forms a covalent bond with retinal through a Schiff base linkage

286 tion because the intermediate ketene forms a covalent bond with surrounding macromolecules.

287 e small-molecule inhibitor of PDI, forming a covalent bond with the active site cysteines of PDI.

288 ulfide pharmacophore that forms a reversible covalent bond with the catalytic cysteine in STEP.

289 ity label unnatural amino acid that can form covalent bonds with adjacent molecules upon UV irradiati

290 we have previously shown to form reversible covalent bonds with cysteine thiols.

291 A number of proteins form covalent bonds with DNA as obligatory transient intermed

292 ecreasing relative concentrations of SMZ-LHA covalent bonds with increasing initial SMZ concentration

293 significant portion of the added SMZ formed covalent bonds with LHA, but only a very small fraction

294 Sulfonamide antibiotics form stable covalent bonds with quinone moieties in organic matter v

295 soft electrophile that preferentially forms covalent bonds with soft nucleophiles.

296 embly of molecules; atoms form molecules via covalent bonds with structures defined by the stationary

297 bly, even elimination of the retinal-protein covalent bond, with the fully conjugated bacterioruberin

298 erials are a family of materials with strong covalent bonding within layers and weak van der Waals in

299 ible formation and breaking of rather strong covalent bonding within molecules.

300 to accelerate chemical reactions at specific covalent bonds without applying an external force.