ライフサイエンスコーパス: cowpox

1 oding the vaccinia virus F17 protein and the cowpox A-type inclusion protein are known to possess seq

2 Several determinants are immunogenic in cowpox and ectromelia (mousepox) virus infections, and i

3 Cowpox and monkeypox viruses have taken an alternate app

4 ass I-like protein (OMCP) is conserved among cowpox and monkeypox viruses, secreted by infected cells

5 es, notably, vaccinia virus (VACV), but also cowpox and myxoma viruses, are able to evade host IFN re

6 t mammalian poxviruses, including monkeypox, cowpox, and ectromelia.

7 ecies variola, vaccinia, camelpox, mousepox, cowpox, and monkeypox virus.

8 against cells infected with orthopoxviruses, cowpox, and vaccinia virus.

9 orthopoxvirus isolates, including monkeypox, cowpox, and vaccinia viruses, for rapid detection.

10 Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia, but not murine leukemia or adenovi

11 ajor virus, camelpox, buffalopox, monkeypox, cowpox, and variola minor viruses.

12 Monkeypox (MPXV) and cowpox (CPXV) are emerging agents that cause severe huma

13 es, including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), and variola viruses.

14 including viruses that produce ATIs, such as cowpox, ectromelia, and raccoonpox viruses, as well as t

15 Some orthopoxviruses, e.g., the cowpox, ectromelia, and raccoonpox viruses, form large,

16 different strains and isolates of camelpox, cowpox, ectromelia, gerbilpox, herpes, monkeypox, myxoma

17 , we used recombinant VACVs that express the cowpox full-length ATIp or we transfected plasmids encod

18 for the prodrugs (<0.1-50 muM) vs vaccinia, cowpox, human cytomegalovirus, and herpes simplex type 1

19 induce apoptosis from studies utilizing the cowpox ICE inhibitor protein CrmA, the synthetic tetrape

20 inhibitor of complement enzymes (SPICE), and cowpox inflammation modulatory protein (IMP) were simila

21 of the hemagglutinin (HA) gene in camelpox, cowpox, monkeypox, and vaccinia viruses.

22 an orthopoxviruses (OPV): variola, vaccinia, cowpox, monkeypox, camelpox, ectromelia, and taterapox v

23 Overexpression of the cowpox protein CrmA blocked tumor necrosis factor (TNF)-

24 istically how CPXV203 coordinates with other cowpox proteins to thwart antigen presentation.

25 accinia virus Ankara) and one strain each of cowpox, rabbitpox, and ectromelia viruses.

26 The cowpox serpin CrmA is a potent (Ki < 20 nM) and selectiv

27 The cowpox serpin crmA suppresses host apoptosis and inflamm

28 optotic pathway is potently inhibited by the cowpox serpin CrmA, suggesting that Mch5 could be the ta

29 The crmD gene was interrupted in three other cowpox strains examined and absent in various other orth

30 , and other protease inhibitors, such as the cowpox viral serine protease inhibitor, CrmA, and N-alph

31 Cowpox virus (Brighton Red strain) possesses one of the

32 The cowpox virus (CPV) CrmA and the equivalent rabbitpox vir

33 owever, CD8(+) T cells of mice infected with cowpox virus (CPV) or VV recognized APC infected with VV

34 sential for full virulence and, like crmA of cowpox virus (CPV), is reported to inhibit the interleuk

35 Further analysis revealed that, unlike cowpox virus (CPV), MPV did not interfere with MHC expre

36 Thus, the cowpox virus (CPXV) uses genes encoding CPXV12 and CPXV2

37 nfectious Rift Valley fever virus (RVFV) and cowpox virus (CPXV) was also not affected by BST-2 expre

38 ses like variola virus, monkeypox virus, and cowpox virus (CPXV), but not vaccinia virus, encode a un

39 oximately 1.4 kb of sequence present only in cowpox virus (CPXV).

40 ence to a potent inhibitor of apoptosis from cowpox virus (crmA).

41 irus (VV) (EC(50) = 4.6 +/- 2.0 microM), and cowpox virus (CV) (EC(50) = 2.0 +/- 0.3 microM).

42 he 204-bp amplicon allowed discrimination of cowpox virus (melting temperature [T(m)], 56.40 degrees

43 (m)s, 61.9 to 62.2 degrees C), 40 strains of cowpox virus (T(m)s, 61.3 to 63.7 degrees C), 8 strains

44 egulate inflammation (myxoma virus SERP1 and cowpox virus [CPV] crmA/SPI-2) or apoptosis (myxoma viru

45 by either late (the AmEPV spheroidin or the cowpox virus A-type inclusion [ATI]) or early (the AmEPV

46 nt complex with A25, a truncated form of the cowpox virus A-type inclusion matrix protein.

47 derate activities (EC(50) 39 microM) against cowpox virus and severe acute respiratory syndrome coron

48 nto the A-type inclusions (ATIs) produced by cowpox virus BR.

49 The gene is disrupted in the genome of cowpox virus Brighton Red (BR), demonstrating that altho

50 Cowpox virus Brighton red strain (CPV) contains a gene,

51 esolution crystal structure of OMCP from the cowpox virus Brighton Red strain, revealing a truncated

52 Exposure to 2(-5)x10(6) pfu of cowpox virus by aerosol or intranasally (inl) was lethal

53 Cowpox virus contamination was detected in 6 additional

54 deletion in the CPXV012 gene in an ancestral cowpox virus created the current form of CPXV012 that is

55 In contrast, XIAP, cowpox virus CrmA and baculovirus p35 inhibited TRAIL-in

56 rom the patient's lesion tested positive for cowpox virus DNA.

57 a recombinant fusion protein comprised of a cowpox virus encoded NKG2D binding protein (OMCP) and a

58 Cowpox virus encoded protein CPXV203 blocks MHCI surface

59 virus encode one vTNFR, the broad host range cowpox virus encodes all vTNFRs.

60 ineering this change back into the wild-type cowpox virus genome conferred resistance to ST-246, sugg

61 Since the cowpox virus hr gene overcomes vaccinia virus host range

62 gion of the genome that is type-specific for cowpox virus identified a gene, vCD30, encoding a solubl

63 The efficacy of cidofovir for treatment of cowpox virus infection in BALB/c mice was investigated i

64 been reported to be orally active in lethal cowpox virus infection in mice.

65 Following cowpox virus infection in normal mice, NK cells were gre

66 irst known human case of laboratory-acquired cowpox virus infection in the United States and the ensu

67 Cowpox virus is an Orthopoxvirus that can cause infectio

68 Mutant cowpox virus lacking its MHC class I inhibitors is marke

69 nal A26p, determined by complementation of a cowpox virus occlusion-defective mutant, its role in occ

70 The cowpox virus protein CPXV012 deprives the endoplasmic re

71 By contrast, overexpression of the cowpox virus protein CrmA blocked apoptosis induced by e

72 The cowpox virus protein CrmA, a known inhibitor of ICE fami

73 CAP activity is inhibited by CrmA, a cowpox virus protein that prevents host cell apoptosis.

74 variola, monkeypox, camelpox, vaccinia, and cowpox virus species and strains.

75 rthopoxvirus species, similar to the current Cowpox virus species.

76 combinant region consistent with a strain of cowpox virus stored in the research laboratory's freezer

77 The cowpox virus V061 gene is homologous to vaccinia virus F

78 Cowpox virus variants selected in cell culture for resis

79 CrmA (a serpin from cowpox virus) and zVAD-FMK (N-benzyloxycarbonyl-Val-Ala-

80 t orthopox viruses (smallpox, monkeypox, and cowpox virus) of the synthesized nucleosides are describ

81 mos cells with two different vaccinia virus (cowpox virus) strains.

82 d infection following footpad inoculation of cowpox virus, a natural pathogen of rodents.

83 ng extreme vulnerability to monkeypox virus, cowpox virus, and vaccinia virus and thus providing a un

84 response modifier A (CrmA), a product of the cowpox virus, prevents programmed cell death initiated b

85 structure to 1.85-A resolution of vCCI from cowpox virus, the prototype of this poxvirus virulence f

86 In contrast, expression of CrmA, a cowpox virus-derived inhibitor of the Ced-2-like proteas

87 DN) caspase-8, cytokine response modifier A (cowpox virus-encoded antiapoptotic protein), or DN Fas-a

88 nd antiviral activity in vaccinia virus- and cowpox virus-infected human cells.

89 s I down-regulation on priming of functional cowpox virus-specific CD8(+) T cells.

90 of ATIs was confirmed in cells infected with cowpox virus.

91 ier A, a potent caspase-1 inhibitor from the cowpox virus.

92 cells challenged with the vaccinia virus or cowpox virus.

93 actor receptor family known to be encoded by cowpox virus.

94 e cytomegalovirus (MCMV), vaccinia (VV), and cowpox viruses (CV).

95 s assays cross-reacted with newly identified cowpox viruses.