ライフサイエンスコーパス: cps

1 cps of serotypes 6A/6B have wciNalpha, encoding alpha-1,

2 cps-6 encodes a homologue of human mitochondrial endonuc

3 The peak sensitivity reached 1.3% (13,080 cps/MBq).

4 zed to KD (0.3 g/kg vegetable proteins and 1 cps/5 kg ketoanalogues per day) or continue LPD (0.6 g/k

5 utations (DRMs), 46 (43.4%) with VL >/= 1000 cps/mL and >/=1 DRMs; no HIV RNA data was available for

6 VL < 1000 cps/mL, 7 (6.6%) with VL >/= 1000 cps/mL and no drug resistance mutations (DRMs), 46 (43.4

7 Among participants with VLs >/=1000 cps/mL, 22 of 32 (69%) harbored drug resistance mutation

8 If VL was >/=1000 cps/mL, genotyping was performed.

9 cted in 22% of participants with VLs >/=1000 cps/mL.

10 ctively performed if viral load (VL) >/=1000 cps/mL.

11 , of whom 18 (17.0%) switched with VL < 1000 cps/mL, 7 (6.6%) with VL >/= 1000 cps/mL and no drug res

12 three isogenic pneumococcal strains with 11A cps loci containing wcrL encoding Ser-112 (MBO128) or Al

13 he in vivo node counts ranged from 0 to 1228 cps, while ex vivo counts ranged from 0 to 1516 cps.

14 idence time resolution and sensitivity of 14 cps/kBq.

15 , while ex vivo counts ranged from 0 to 1516 cps.

16 MBq for mouse collimators and from 53 to 175 cps/MBq for rat collimators.

17 rected cdb3-specific SPR signal was 98 +/- 2 cps microCi-1 [mumol band 3]-1.

18 ture with 1.5-mm spatial resolution and 13.3 cps/microCi (0.359 cps/kBq) sensitivity.

19 D and 3D was measured as 1.7 cps/kBq and 7.3 cps/kBq, respectively.

20 over 10 seconds] ranged from 3346 to 47,300 cps and was highly dose-dependent (r = 0.90, P = 0.0002)

21 atial resolution and 13.3 cps/microCi (0.359 cps/kBq) sensitivity.

22 -acetyltransferase genes in the serotype 35C cps locus suggested that it could be incomplete, as the

23 In contrast, the HS:23, HS:36 and HS:23/36 cps sequences were highly conserved.

24 asured with a 70-cm-long line source is 4.36 cps/kBq, whereas the scatter fraction is 40% with a 20 x

25 pants, 14.6%, 15.2% and 11.1% had VLs >/=400 cps/mL at 12, 24, and 36 months, respectively.

26 r having a detectable viral load (VL, >/=400 cps/mL) using Cox models.

27 The system sensitivity varies from 29 to 404 cps/MBq for mouse collimators and from 53 to 175 cps/MBq

28 lts from the commercial probe (8.75 +/- 0.47 cps/kBq).

29 easured with a 70-cm-long line source is 6.6 cps/kBq, whereas scatter fraction is 27% measured with a

30 sensitivity in 2D and 3D was measured as 1.7 cps/kBq and 7.3 cps/kBq, respectively.

31 NU2-1994 analysis, the sensitivity was 12.7 cps/Bq/mL (444 kcps/microCi/mL), the scatter fraction wa

32 The averaged sensitivity was 13.7 cps/kBq at the center of the field of view.

33 evels of MDOs act to signal RcsC to activate cps expression is proposed.

34 Freely available at the WWW URL: http://aims.cps.msu.edu/hiclas/

35 igh sequence homology between the cps-6B and cps-6A loci, serotypes 6A and 6B cannot be differentiate

36 observations demonstrated that cps(Ia)H and cps(III)H encoded the type Ia and III CPS polymerases, r

37 occurring in only two nonclade isolates and cps in four.

38 ronmental isolates revealed that the prp and cps amplicons were detected only in clinical isolates id

39 Oligonucleotide primers targeting prp and cps were combined in a multiplex PCR method that defines

40 RcsF in the activation of both the rprA and cps promoters.

41 In this study we sequenced biosynthetic cps regions, ranging in size from 15 to 34 kb, from sele

42 o high-level constitutive expression of both cps and rprA suggests that the response regulator domain

43 nd low Mg2+, resulting in expression of both cps and ugd genes.

44 Tumor-associated CD11c(+) cells invaded by cps were converted to immunostimulatory phenotypes, whic

45 This is the largest known Campylobacter cps cluster (38 kb excluding flanking kps regions), whic

46 Capsule (cps) gene expression in Escherichia coli is controlled b

47 were characterized for one of nine capsule (cps) genotypes.

48 The capsule (cps) locus of Streptococcus pneumoniae is flanked by the

49 In the capsule gene cluster (cps) of Nm, region A contains the genetic information fo

50 ete sequence of the respective gene cluster (cps).

51 equence motif, conserved between the E. coli cps promoter and the Erwinia amylovora ams promoter and

52 Lastly, common cps gene (cps2ABCD) mutants did not show significant abn

53 ed with specific genes in each corresponding cps locus.

54 by deletion of wcrD from each corresponding cps locus.

55 Correspondingly, cps treatment markedly increased tumor antigen-specific

56 liquid, decrease biofilm formation, decrease cps gene expression, and suppress the DeltascrABC phenot

57 nsive biofilms and aggregates than a defined cps mutant, suggesting that additional factor(s) contrib

58 cross-reactive IgG in sera from TIGR4 Delta cps-colonized mice, with a modest contribution from PpmA

59 Comparison of the determined cps sequences of the HS:1, HS:19 and HS:41 strains with

60 ants with cpsS defects have greatly elevated cps transcription; their high level of cpsA expression w

61 a 35.5-kb DNA fragment containing the entire cps operon.

62 ver, unlike VpsR, CpsR was not essential for cps expression.

63 Capsule gene (cps) expression, which normally occurs at low levels in

64 d polysaccharide capsule biosynthetic genes (cps genes) are primarily clustered at one site located a

65 ivator of the capsular polysaccharide genes (cps), has been identified in Escherichia coli.

66 of capsular polysaccharide synthesis genes (cps) and restriction enzyme digestion.

67 The genes (cps) involved in the synthesis of the colanic acid capsu

68 equencing of nine additional adjacent genes, cps(III)FGHIJKL, neu(III)B, and neu(III)C.

69 f an attenuated strain of Toxoplasma gondii (cps) that cannot replicate in vivo and therefore is not

70 th distinct serologic properties, homologous cps loci, and structurally similar PSs.

71 lar to those of some of the other identified cps loci.

72 The present study identifies cps genes and examines their regulation.

73 ants did not show significant abnormality in cps transcription, although they produced significantly

74 Single amino acid changes in cps genes encoding glycosyltransferases can alter substr

75 "up" mutation (i.e., leading to increase in cps transcription) that normally results in constitutive

76 litates the detection of DNA polymorphism in cps genes and correlates well with serotyping.

77 e between the operons was found to reside in cps(III)H, the putative CPS polymerase gene.

78 ns FWHM in mm (point source sensitivities in cps-MBq) for half-cone beam, fan-beam and parallel-beam

79 pathway; CpsR was required for the increased cps expression observed in scrA deltaopaR strains.

80 Indeed, intraperitoneal cps treatment triggered rejection of established ID8-Veg

81 e acquired a 24 kb capsule synthesis island (cps) by horizontal gene transfer which consists of a syn

82 The molecular interplay of additional known cps regulators was defined by establishing that CpsS, an

83 The treatment required live cps that could invade cells and also required CD8(+) T c

84 eloped to interrogate the capsulation locus (cps) of vaccine serotypes to locate primer pairs in cons

85 , and (v) the capsular polysaccharide locus (cps) did not amplify during the initial MP-PCR but was p

86 Previous work on the meningococcal cps complex in Escherichia coli K-12 indicated that dele

87 Among the non-cps genes identified as conditionally essential was relA

88 /RcsB-mediated transcriptional activation of cps genes.

89 to an inhibitor of swarming and activator of cps expression.

90 In silico analysis of cps from 92 serotypes indicated that a primer pair spann

91 Immunochemotherapeutic applications of cps might be broadly useful to reawaken natural immunity

92 The therapeutic benefit of cps treatment relied on expression of IL-12, but it was

93 Expression of cps(III)H in a type Ia strain resulted in suppression of

94 were associated with increased expression of cps-encoded proteins.

95 ne betaine enhanced the osmotic induction of cps::lacZ by both sucrose and NaCl but had no effect alo

96 Direct intratumoral injection of cps has efficacy against an inducible genetic melanoma m

97 Loss of cps-6 delays breakdown of mitochondrial inner membranes,

98 Reduction of cps-6 activity caused by a genetic mutation or RNA-media

99 In conclusion, although having no impact on cps transcription or the synthesis of the basal repeatin

100 ranscription of the capsular polysaccharide (cps) locus is not well understood.

101 of the biosynthetic capsular polysaccharide (cps) locus.

102 were members of the capsular polysaccharide (cps) operon.

103 lence determinants: capsular polysaccharide (cps), pneumolysin (ply), and pneumococcal surface protei

104 tentially conferring O-antigenic properties (cps and flp).

105 d serotype 42 was unclear, as their reported cps loci are nearly identical.

106 c Nicotiana benthamiana plants expressing Rs-cps dsRNA were obtained and studied.

107 The transcript abundance of Rs-cps dsRNA appeared to be diverse in the different transg

108 R. similis and the transcription level of Rs-cps in R. similis was drastically decreased.

109 ment from the protease gene, cathepsin S (Rs-cps), was cloned into the binary vector pFGC5941 in the

110 Our results suggest that Rs-cps is essential for the reproduction and pathogenicity

111 eover, the bioassay results revealed that Rs-cps transgenic N. benthamiana plants were resistant to R

112 loy in planta RNAi approach to target the Rs-cps gene for the control of plant parasitic nematodes.

113 hing rate of R. similis isolated from the Rs-cps transgenic plants were also significantly reduced.

114 the tumor injection site [counts per second (cps) averaged over 10 seconds] ranged from 3346 to 47,30

115 long line source is 4.79 counts per second (cps)/kBq.

116 gamma mode (5.59 +/- 0.41 counts per second [cps]/kBq) compared surprisingly well with the results fr

117 g avirulent uracil auxotroph vaccine strain (cps) of Toxoplasma triggers novel innate immune response

118 tivated genes, such as the capsule synthesis cps operon, requires the co-activator protein RcsA, wher

119 csA-dependent colanic acid capsule synthesis cps operon.

120 ranscription of genes for capsule synthesis (cps) requires both RcsA and RcsB; transcription of other

121 on of the capsular polysaccharide synthesis (cps) loci of the 2 subtypes identified disruption of the

122 es in the capsular polysaccharide synthesis (cps) locus.

123 etic variation of the capsular PS synthesis (cps) locus is the molecular basis for structural and ant

124 capsules, our observations demonstrated that cps(Ia)H and cps(III)H encoded the type Ia and III CPS p

125 Taken together, our results establish that cps preferentially invades tumor-associated antigen-pres

126 The cps loci of 11A and 11D differ by one codon (N112S) in w

127 The cps monotherapy rapidly modified the tumor microenvironm

128 The cps treatment stimulated a strong CD8(+) T cell-mediated

129 es, are in a chromosomal region known as the cps locus.

130 would then involve PBP genes, as well as the cps operon, and would change both the serotype and the r

131 ue to the high sequence homology between the cps-6B and cps-6A loci, serotypes 6A and 6B cannot be di

132 Both the cps and ply/pspA mutants of a virulent type 6A isolate w

133 We identified mutations in the cps capsule gene cluster, previously unidentified transc

134 Transposon insertions in the cps locus, which contains 11 genes, abolished opacity.

135 nstrated that seven of the nine genes in the cps operon are essential for capsule production, indicat

136 he conserved proteins CpsABCD encoded in the cps operon, by developing knock-out and functional mutan

137 ed large recombination events, involving the cps IV operon and resulting in the expansion of serotype

138 of an approximately 20-kb sequence near the cps locus.

139 , that showed homology with the genes of the cps cluster, involved in polysaccharide biosynthesis, in

140 we showed that the full transcription of the cps genes not only depends on the core promoter immediat

141 o activator proteins and the promoter of the cps genes.

142 truncated galE2 locus and the capture of the cps island en bloc.

143 which the illegitimate recombination of the cps island into the galE allele of the cnl locus results

144 itative analysis showed that transfer of the cps locus had occurred at an elevated rate in beta-lacta

145 n the transcriptional characteristics of the cps locus in S. pneumoniae.

146 termined the transcriptional features of the cps locus in the type 2 virulent strain D39.

147 nucleotide polymorphism at codon 195 of the cps locus wciP gene.

148 by which EsaR governs the expression of the cps locus, which encodes functions required for stewarta

149 Transcription of the cps operon is controlled by at least two positive regula

150 minus of the first open reading frame of the cps operon was found to be homologous to proteins encode

151 ensing in the differential expression of the cps operon.

152 Here we report the characterization of the cps-6 gene, which appears to function downstream of, or

153 c rearrangements both within and outside the cps gene cluster, a mechanism which may be responsible f

154 It is likely that the cps genes are arranged in a single long operon that is a

155 The initial analysis revealed that the cps genes are cotranscribed from a major transcription s

156 estingly, promoter proximal genes within the cps cluster are significantly more acyl-homoserine lacto

157 inversion of the synthetic locus within the cps island during bacterial growth.

158 iously reported that cpsK, a gene within the cps locus of type III GBS, could complement a sialyltran

159 In response to cps treatment of the immunosuppressive ovarian tumor env

160 re, we show this goal can be addressed using cps, an avirulent, nonreplicating uracil auxotroph strai

161 ion (BopD), adherence (Epb pili), virulence (cps loci, gelatinase, SprE) and antibiotic resistances (

162 nts per second/parts per billion and volume (cps/ppbv) at a mass resolution of >8000 m/Deltam (fwhm).

163 However, whereas cps transcription remained RcsA-dependent, ugd transcrip

164 Immunization with cps mutants demonstrated cross-protective immunity follo

165 rts showing that intratumoral treatment with cps activated immune-mediated regression of established