ライフサイエンスコーパス: cramp

1 cathelicidin-related antimicrobial peptide (CRAMP).

2 mice genetically defective in production of CRAMP.

3 epsis by LzMPC treatment required endogenous CRAMP.

4 ent the penetration of the inner membrane by CRAMP.

5 of FPRL1/mouse formyl peptide receptor-2 by CRAMP.

6 ystonias, including torticollis and writer's cramp.

7 tor tasks that elicited dystonia or writer's cramp.

8 e in the patients with dystonia and writer's cramp.

9 cally inhibit S. aureus killing by synthetic CRAMP.

10 by enhanced expression of beta-defensins and CRAMP.

11 not been previously investigated in writer's cramp.

12 oth the CCR2 ligand CCL2 and an Fpr2 agonist CRAMP.

13 ficient sleep time or nocturnal leg jerks or cramps.

14 include bloody diarrhea and severe abdominal cramps.

15 tools with fever, prostration, and abdominal cramps.

16 women, is characterized by painful menstrual cramps.

17 villous blunting that leads to diarrhea and cramping.

18 somotor symptoms (0.96 vs 0.85, P<.001), leg cramps (1.10 vs 0.91, P<.001), and bladder control sympt

19 had nausea (20 [30%] vs 4 [6%]) and stomach cramps (15 [23%] vs 2 [3%]) more often than those receiv

20 uded alopecia (29%), dysgeusia (29%), muscle cramps (29%), and anorexia (14%).

21 vomiting (25%), fatigue (27.3%), and muscle cramps (4.5%).

22 ms (71%), throat discomfort (63%), or muscle cramps (42%).

23 ted nausea (95%), dizziness (72%), abdominal cramps (58%), headache (52%), vomiting (51%), chills (48

24 ed abdominal symptoms were distension (77%), cramping (73%) and nausea (67%).

25 ns were characterized by diarrhea (100%) and cramps (79%-88%) lasting a median of 3-5 days.

26 Patients reported diarrhea (100%), abdominal cramps (93%), fever (93%), bloody stools (72%), and vomi

27 as the ortholog of human cathelicidin/LL37 (CRAMP), a molecule externalized in the NETs.

28 h staphylocidal activities demonstrated that CRAMP, a cationic antimicrobial peptide, is primarily re

29 luate further the expression and function of CRAMP, a peptide corresponding to the predicted COOH-ter

30 but at the expense of symptoms that include cramping abdominal pain, fecal urgency, and diarrhea.

31 pointed molecule capable of penetrating the cramped active sites of tryptase.

32 lectron microscopy that the primary locus of CRAMP activity appears to be intracytoplasmic, rather th

33 f neutrophils and monocytes, indicating that CRAMP acts as a chemotactic factor in vivo.

34 CRAMP also induced calcium mobilization and the activati

35 to cathelin-related anti-microbial peptide (CRAMP), an anti-microbial peptide expressed at high leve

36 t in cathelin-related antimicrobial peptide (CRAMP; an ortholog of the sole human cathelicidin, LL-37

37 roduction tasks in 15 patients with writer's cramp and 15 matched healthy control subjects.

38 bduction movements in patients with writer's cramp and compared them with those of normal aged-matche

39 e further identified increased expression of Cramp and formation of neutrophil extracellular traps in

40 amellar body-derived antimicrobial peptides, CRAMP and mBD3, declined after Ox challenges, parallelin

41 gamma) as well as the antimicrobial peptides CRAMP and mbetaD-3.

42 mplicated in the pathophysiology of writer's cramp and other primary dystonias, endogenous dopamine r

43 DTS modulates the expression of TLR and CRAMP and topical application of TLR agonists in EDE mic

44 Cramping and nausea were the most common adverse effects

45 tors were tender, tiring-exhausting, aching, cramping and sickening.

46 One patient experienced abdominal cramps and diarrhea necessitating interruption of brinci

47 Muscle cramps and hypophosphatemia were more common in the imat

48 Susceptibility to exertional cramps and rhabdomyolysis in myophosphorylase deficiency

49 of inhibitors that extend from the polar and cramped (and so not easily druggable) substrate-binding

50 the antimicrobial peptides beta-defensin 3, CRAMP, and chemokine CXCL10 and its receptor CXCR3 in co

51 and LDC infiltration and induction of IL-22, CRAMP, and mbetaD-3.

52 oms of frequency, nocturnal bowel movements, cramping, and bleeding returned close to baseline values

53 ed AEs, diarrhea, flatulence, abdominal pain/cramping, and constipation were most common.

54 ptoms, including emesis, diarrhea, abdominal cramping, and gastrointestinal bleeding.

55 to peanut experienced lip swelling, stomach cramping, and objective tiredness.

56 siness, disturbed sleep, muscle soreness and cramping, and trouble remembering things.

57 ecological problems, vasomotor symptoms, leg cramps, and bladder control problems, whereas women in t

58 ities included gynecomastia/gynecodynia, leg cramps, and grade 1 or 2 diarrhea.

59 On his return, he developed diarrhea, cramps, and loose stools without blood or mucus in the a

60 , one characterized by exercise intolerance, cramps, and myoglobinuria, and the other dominated by fi

61 elevated CK levels, muscle weakness, muscle cramps, and persistent myalgia and CK elevations after s

62 the arm used for drug infusion, ptosis, leg cramps, and visual and voice changes.

63 Compared to Apoe(-/-) mice, Cramp(-/-) Apoe(-/-) mice exhibit reduced lesion sizes w

64 cathelicidin-related antimicrobial peptide (CRAMP), are important effectors of the innate immune sys

65 d vice versa, suggesting the use of FPRL1 by CRAMP as a receptor.

66 ed in middle life with incapacitating muscle cramps associated with calf hypertrophy and only mild cl

67 and cathelin-related antimicrobial peptide (CRAMP), both known inflammatory mediators.

68 nts often report that early symptoms include cramps brought on by cold or exertion.

69 Unexpectedly, we found that mature CRAMP, but not Ac2-26, induced ROS production through an

70 ion in patients with arthritis and menstrual cramps, but they have not provided any benefit to patien

71 concentrations of human (LL-37) and murine (CRAMP) cathelicidins, human alpha-defensin (HBD-1, HBD-2

72 e of antimicrobial human (LL-37) and murine (CRAMP [cathelin-related antimicrobial peptide]) cathelic

73 Mice deficient in the gene encoding CRAMP (Cnlp(-/-)) demonstrate impaired lung bacterial cl

74 DBS treatment of tardive dystonia, writer's cramp, cranial dystonia, myoclonus dystonia, and off-sta

75 oprotein E-deficient mice, pDC depletion and Cramp-deficiency in bone marrow reduced atherosclerosis

76 Wild-type and CRAMP-deficient animals were exposed to cigarette smoke

77 CRAMP-deficient hosts demonstrated less intense cytokine

78 CRAMP-deficient mice exhibited significantly lower bladd

79 yed early neutrophil influx were observed in CRAMP-deficient mice infected with Pseudomonas aeruginos

80 evident as early as 1 hour after infection, CRAMP-deficient mice showed no baseline alterations in i

81 n was delayed early but increased by 48 h in CRAMP-deficient mice, which was associated with enhanced

82 of lung tumors in wild-type mice, but not in CRAMP-deficient mice.

83 tment of myeloid cell into tumor tissue in a CRAMP-dependent manner.

84 ne marrow chimera experiments indicated that CRAMP derived from bone marrow cells rather than structu

85 dmitted to the hospital because of abdominal cramping, diarrhea, hematochezia, fever to a peak temper

86 l disturbances, breast tenderness, abdominal cramping, dizziness, headache, and mood changes.

87 Whereas Cramp/DNA complexes aggravated atherosclerotic lesion fo

88 be stimulated to produce interferon-alpha by Cramp/DNA complexes, and we further identified increased

89 that the murine mature cathelicidin peptide (CRAMP), encoded by the mouse gene (Camp), is functionall

90 Additionally, CRAMP exerted bactericidal activity against K. pneumonia

91 Although CRAMP exhibits in vitro antibacterial activity against U

92 tase-polymerase chain reaction also detected CRAMP expression in adult testis, spleen, stomach, and i

93 l ligation and puncture caused a decrease in CRAMP expression in the liver, whereas enteral administr

94 CRAMP expression is induced in the lung in response to i

95 yokymia, neuromyotonia, Isaacs' syndrome and Cramp-Fasciculation Syndrome to describe the motor manif

96 1 had significantly (P < .05) more abdominal cramps, fatigue, transient hearing loss, febrile neutrop

97 and vaginal itching, low back pain, uterine cramps, fetal distress, and preterm labor.

98 This gene, named Cramp for cathelin-related antimicrobial peptide, was ma

99 Thus, CRAMP functions as both a chemoattractant for phagocytic

100 eas enteral administration of LzMPC restored CRAMP gene expression in these animals.

101 , mBD4 (short interfering RNA knockdown), or CRAMP (genetic knockout) exhibited enhanced disease seve

102 or 2 adverse events of loss of taste, muscle cramps, hair loss, and weight loss.

103 ary angiopathy with nephropathy aneurysm and cramps (HANAC) syndrome.

104 tary angiopathy, nephropathy, aneurysms, and cramps (HANAC) syndrome.

105 CRAMP has been shown to have both antimicrobial and angi

106 rine cathelin-related antimicrobial peptide (CRAMP) has been reported to inhibit S. Typhimurium growt

107 tients with task-specific dystonia (writer's cramp) have impaired cortical inhibition likely arising

108 n of cathelin-related antimicrobial peptide (CRAMP; human LL-37 orthologue), and mouse beta defensin

109 d for the extracellular release of AnxA1 and CRAMP in a subcutaneous air pouch model.

110 ive N-terminal peptide Ac2-26, and processed CRAMP in limited fashion.

111 the neutrophil granule protein cathelicidin (CRAMP in mouse, LL37 in human) in atherosclerosis.

112 lapse of symptoms such as abdominal pain and cramping in patients with irritable bowel syndrome.

113 erved except for mild diarrhea and abdominal cramping in the infusion group on the infusion day.

114 city was grade 3/4 diarrhea and/or abdominal cramps in six of 12 patients treated at 24 mg/m(2), desp

115 idin cathelin-related antimicrobial peptide (CRAMP) in a murine model of Fusarium solani keratitis.

116 cathelicidin-related antimicrobial peptide (CRAMP) in macrophages and enhanced bactericidal activity

117 l-derived cathelicidins (human: LL37, mouse: CRAMP) induce adhesion of classical monocytes but not of

118 Furthermore, CRAMP induced the chemotaxis of human embryonic kidney 2

119 CRAMP-induced calcium flux in monocytes was desensitized

120 Injection of CRAMP into mouse air pouches resulted in the recruitment

121 Writer's cramp is a task-specific focal hand dystonia characteriz

122 aken together, our findings demonstrate that CRAMP is an important contributor to effective host muco

123 CRAMP is released from emigrated neutrophils and then tr

124 by permeability barrier requirements and (2) CRAMP is required for permeability barrier homeostasis.

125 Unlike in mouse macrophages, in which CRAMP is upregulated during infection, camp gene express

126 um toxin is clinically effective in writer's cramp, it does not reverse the associated dysfunction of

127 ccinia pox formation occurred in four of six CRAMP knockout animals and in only one of 15 control mic

128 CRAMP knockout mice and control animals were inoculated

129 However, whether CRAMP, like human cathelicidin/LL-37, also exhibits a di

130 We have observed that CRAMP, like LL-37, was chemotactic for human monocytes,

131 ased expression of the antimicrobial peptide Cramp/LL37 in atherosclerotic lesions may thus stimulate

132 traps complexed to the antimicrobial peptide Cramp/LL37 in autoimmune disease.

133 ECR and FCR co-contraction in writer's cramp may be a compensatory process under voluntary cont

134 xel-based results also suggest that writer's cramp may be associated with reduced striatal dopamine r

135 findings suggest that patients with writer's cramp may have divergent responses in striatal dopamine

136 BD-3 production ex vivo and was required for CRAMP, mBD-3, and mBD-14 expression in response to S. au

137 to Fpr2(-/-) mice, in the inflamed airway of CRAMP(-/-) mice, DC trafficking into the peribronchiolar

138 espite an apparent increase in mBD3 protein, CRAMP-/- mice delayed permeability barrier recovery, att

139 AAF the bulky AAF moiety would reside on the cramped minor groove side of the template.

140 CRAMP mRNA and protein were localized to the salivary gl

141 EDE decreased CRAMP mRNA and protein.

142 and cathelin-related antimicrobial peptide (CRAMP) (murine homologues of hBD2 and LL-37, respectivel

143 patients with dystonia (n = 6) and writer's cramp (n = 5).

144 erse events attributed to X-82 including leg cramps (n = 2), elevated alanine aminotransferase (n = 2

145 weight loss of 20% or more (n=6) and muscle cramps (n=2).

146 ed rotation and multiple pulse spectroscopy (CRAMPS) NMR spin exchange measurements in combination wi

147 in type or underlying mechanism (eg, painful cramps, nociceptive pain, or neuropathic pain).

148 zol--elevated liver-enzyme levels and muscle cramps--of grade 2 or less occurred in 41% and 33% of th

149 d 62%, respectively) without causing pain or cramping or increasing serum creatine kinase.

150 scle, causing exercise intolerance, myalgia, cramps, or fixed weakness, which often affects extraocul

151 e intestinal problems (P = 0.009 for pain or cramps; P = 0.02 for excessive gas).

152 patients with fever and abdominal symptoms (cramping, pain, distention, diarrhea, GI bleeding), shou

153 most common side effect was lower abdominal cramping/pain (P = .01).

154 reased serum creatinine level, insomnia, leg cramps, paresthesias, and tremor, were managed with dose

155 Ac2-26 and CRAMP peptides enhanced the release of CXCL2 by CG/NE ne

156 The mature human (LL-37) and mouse (CRAMP) peptides are encoded by similar genes (CAMP and C

157 ians; repetitive tasks, prolonged or awkward/cramped positions, and bending/twisting were contributor

158 the same task repeatedly, working in awkward/cramped positions, working in the same position for long

159 myeloid cells showed impaired recruitment of CRAMP-positive cells into the lung.

160 A Streptococcus revealed that both LL-37 and CRAMP potently inhibited bacterial growth.

161 He also experienced progressive muscle cramps, profound sweating, bowel disturbances (diarrhoea

162 ccommodated in the shallow and comparatively cramped recognition pocket; it has fewer hydrogen bondin

163 eletal muscle, causing exercise intolerance, cramps, recurrent myoglobinuria, or fixed weakness, whic

164 Thus, CRAMP represents the first antibiotic peptide found in c

165 The human and mouse cathelicidins (LL-37 and CRAMP, respectively) are expressed at select epithelial

166 Antiserum against CRAMP revealed abundant expression in myeloid precursors

167 As in ITD, our patients with writer's cramp showed impaired activation of the contralateral pr

168 nd unaffected hand in patients with writer's cramp showed significantly less reduction in 20- to 30-H

169 e side chains and that confined movements of cramped side chains within and through the tunnel fine-t

170 In atherosclerotic aortas, we could detect CRAMP specifically in neutrophils, but not in monocytes

171 n (CPE) is responsible for the diarrheal and cramping symptoms of human C. perfringens type A food po

172 acterized by sensory paresthesias and muscle cramps that are notably exacerbated by cooling.

173 of increasingly severe neuropathic pain and cramps that have been poorly responsive to a variety of

174 Cathelin-related antimicrobial peptide (CRAMP), the orthologue of human cathelicidin/LL-37, is t

175 ic GI symptoms (eg, gas, diarrhea, abdominal cramping), there were no significant differences between

176 enty-five patients (89%) experienced pain or cramps/tired muscles, whereas 3 (11%) remained symptom-f

177 Functional studies showed CRAMP to be a potent antibiotic against Gram-negative ba

178 lly, simultaneous administration of OVA with CRAMP to mice promoted both humoral and cellular Ag-spec

179 both Mig-14 and VirK inhibit the binding of CRAMP to Salmonella, and demonstrate that Mig-14 is an i

180 cathelicidin-related antimicrobial peptide (CRAMP), to innate mucosal immunity in a mouse model of G

181 atients with torticollis, nine with writer's cramp, two with blepharospasm and 16 healthy control sub

182 ns, the anti-microbial activity of LL-37 and CRAMP was determined against the common wound pathogen g

183 By use of intravital microscopy, CRAMP was found to be deposited by activated neutrophils

184 The murine cathelicidin (CRAMP) was detected in the adult by reverse-transcriptio

185 ed rotation and multiple pulse spectroscopy (CRAMPS), water adsorption, and nitrogen measurements rev

186 ractice, whereas many patients with writer's cramp (WC) have a history of average hand use.

187 ors reported more musculoskeletal stiffness, cramps, weakness and joint swelling (P < .001), cataract

188 oss-correlograms from patients with writer's cramp were either flat or modulated by a 11-12-Hz tremor

189 these antimicrobial peptides, and LL-37 and CRAMP were rapidly cleaved by released amebic cysteine p

190 Grade 0, 1, 2, and 3 abdominal cramps were observed in 32%, 45%, 21%, and 2% of patient

191 of diarrhea, nausea, vomiting, and abdominal cramps, were recorded.

192 ases, except the mouse antimicrobial peptide CRAMP, which we speculate works in part by inhibiting cy

193 control subjects and patients with writer's cramp while they write a stereotyped word repetitively a

194 or a mouse macrophage antimicrobial peptide (CRAMP), while SodCI remained tethered within the peripla

195 r acute effects included diarrhea and muscle cramping, while with repeated dosing, anorexia and fatig

196 CD spectral analysis showed that CRAMP will form an amphipathic alpha-helix similar to ot

197 logy of two idiopathic focal dystonias: hand cramp with excessive cocontractions of agonist and antag