ライフサイエンスコーパス: cranial base

1 display premature fusion of the bones in the cranial base.

2 ein Six2 in the growth and elongation of the cranial base.

3 oid and sphenooccipital synchondroses at the cranial base.

4 scles, intrude into the otherwise mesodermal cranial base.

5 Operative trajectories created through the cranial base, although technically demanding, have led t

6 ent in Kif3a in cartilage and focused on the cranial base and synchondroses.

7 Cephalometric superimpositions on the cranial base and tantalum implants confirmed these quant

8 nied by structural adjustments to the vault, cranial base, and face.

9 d on nonhoning canine teeth, a foreshortened cranial base, and postcranial characters related to facu

10 form derive from a combination of shifts in cranial base angle, cranial fossae length and width, and

11 The cranial base appears to be a skeletal structure in which

12 Long bones and the cranial base are both formed through endochondral ossifi

13 ain factors restricting Six2 function to the cranial base are tissue-specific transcription of the ge

14 fication was delayed in much of the Ihh(-/-) cranial bases but, surprisingly, was unaffected most pos

15 Whereas the growth of the cranial base cartilage is thought to be regulated solely

16 as a potential congenital cause of anterior cranial base defects in humans.

17 al mice deficient in Ihh in cartilage; their cranial base defects only minimally resembled those in K

18 s of primary cilia and hedgehog signaling in cranial base development and chondrocyte maturation, and

19 Wnt/beta-catenin signaling is essential for cranial base development and synchondrosis growth plate

20 d primary cilia make unique contributions to cranial base development and synchondrosis growth plate

21 quired but the molecular network controlling cranial base development is distinct from that in the tr

22 multiple processes during synchondrosis and cranial base development, including growth plate zone or

23 To study their roles in cranial base development, we created conditional mouse m

24 In the absence of Shh, the presumptive cranial base did not undergo chondrogenic commitment as

25 udy was to determine whether the form of the cranial base differs between prepubertal Class I and Cla

26 It is concluded that the shape of the cranial base differs in subjects with Class III malocclu

27 The Ihh(-/-) cranial bases displayed reduced growth and chondrocyte p

28 mirror-image growth plates, are critical for cranial base elongation and development.

29 ror-image growth plates and are critical for cranial base elongation, but relatively little is known

30 The cranial base exerts a supportive role for the brain and

31 gth of the sphenoid, the central bone of the cranial base from which the face grows forward.

32 Kif3a deficiency caused cranial base growth retardation and dysmorphogenesis, wh

33 ent, morphogenesis and tissue origins of the cranial base have not been studied in detail in the mous

34 Here we examined the development of the cranial base in chick and mouse embryos to compare the m

35 it did not reduce the relative length of the cranial base in comparison with total skull length.

36 ature synchondrosis closure in the spine and cranial base in human cases of homozygous achondroplasia

37 The significance of the cranial base in the development of Class III malocclusio

38 Immunohistochemical analysis of the cranial base in transgenic embryos showed reduced staini

39 The vertebrate cranial base is a complex structure composed of bone, ca

40 Reorganization of the central cranial base is among the earliest morphological markers

41 The cranial base is essential for integrated craniofacial de

42 The cranial base is the growth center of the neurocranium.

43 normally demonstrating that induction of the cranial base is uncoupled from formation of the sensory

44 Results indicated that cranial base morphology differed statistically for all a

45 performed for localization of differences in cranial base morphology.

46 likely accounting for why development of the cranial base occurs after the axial skeleton.

47 We compared the cranial base of newborn Pax7-deficient and wildtype mice

48 n in ramus height, body length, and anterior cranial base orientation.

49 nces in morphology occurred in the posterior cranial base region, which generally consisted of horizo

50 ients with CMD tend to have a short anterior cranial base, short upper facial height, and short maxil

51 rved that developmental abnormalities of the cranial base synchondroses involving proliferative chond

52 We hypothesized that the cranial base synchondroses play a key role in the develo

53 ter is highly active at the cranial sutures, cranial base synchondroses, and nasal septum.

54 hondral bone growth and premature closure of cranial base synchondroses.

55 ment, and we hypothesized that they regulate cranial base synchondrosis development and growth.

56 icient orthocephalization, or failure of the cranial base to flatten during development.

57 also examine the tissue origins of the mouse cranial base using a neural crest cell lineage cell mark

58 Mutant post-natal cranial bases were deformed, and their synchondrosis gro

59 chanisms that co-ordinate development of the cranial base with that of the cranial musculature and th

60 differentiation is abnormal in the Six2-null cranial base, with reduced proliferation and increased t