ライフサイエンスコーパス: crave

1 th 21 days of abstinence (ie, 'incubation of craving').

2 nt increases in food craving ('incubation of craving').

3 ugs, a phenomenon termed 'incubation of drug craving'.

4 he motivational craving state (incubation of craving).

5 from the drug (incubation of methamphetamine craving).

6 n after 1 day (incubation of methamphetamine craving).

7 ly withdrawal (incubation of methamphetamine craving).

8 king after withdrawal (incubation of cocaine craving).

9 n after 1 day (incubation of methamphetamine craving).

10 han after 1 d (incubation of methamphetamine craving).

11 ergo a comparable magnitude of incubation of craving.

12 espite adverse consequences and intense drug craving.

13 pioids in the neural systems underlying drug craving.

14 rios to investigate the neural correlates of craving.

15 s demonstrated incubation of methamphetamine craving.

16 detect incubation of subjective cue-induced craving.

17 ty accompanies incubation of methamphetamine craving.

18 tic intervention in the treatment of cocaine craving.

19 nsembles that mediate incubation of nicotine craving.

20 om these synapses and thereby reduce cocaine craving.

21 ereafter mediate the expression of incubated craving.

22 ted the development of incubation of cocaine craving.

23 g effects and marginally with alleviation of craving.

24 ant given the habitual nature of cue-induced craving.

25 ereafter mediate the expression of incubated craving.

26 -dependent incubation of cue-induced cocaine craving.

27 nomena of the "sweet tooth" and carbohydrate craving.

28 itofrontal cortex connectivity and levels of craving.

29 DNA demethylation, in incubation of cocaine craving.

30 ment of drug seeking, and incubation of drug craving.

31 olume and surface area with both measures of craving.

32 in craving, in incubation of methamphetamine craving.

33 of incubation of methamphetamine vs cocaine craving.

34 ve disorders and is involved in drug-related craving.

35 striatal shape deformations and cue-induced craving.

36 this brain region's well-established role in craving.

37 clear cells that are correlated with alcohol craving.

38 responses controlling incubation of cocaine craving.

39 lity to substance use disorder by triggering craving.

40 n the neurobiology of alcohol dependence and craving.

41 l striatum were associated with intense drug craving.

42 exogenous ghrelin acutely increases alcohol craving.

43 n withdrawal-dependent incubation of cocaine craving.

44 toxification and the relationship to alcohol craving.

45 Ac MSN synapses during incubation of cocaine craving.

46 se to cocaine use by reducing stress-induced craving.

47 rsely correlated with addiction severity and craving.

48 s (NAc), a critical brain region for cocaine craving.

49 ffects were observed for tobacco and cocaine craving.

50 ure to drug-associated cues that induce drug craving.

51 tive effects) in human laboratory studies of craving.

52 , and, in cocaine-dependent persons, cocaine craving.

53 n animals show incubation of methamphetamine craving.

54 ) on momentary ratings of cocaine and heroin craving.

55 re, as well as reductions in tonic levels of craving.

56 strated time course of incubation of cocaine craving.

57 AMPARs contributes to incubation of cocaine craving.

58 mbles in this new form of incubation of drug craving.

59 otivation to quit cocaine and on cue-induced craving, 24 hours postinfusion.

60 mportant for understanding the basis of drug craving, a key factor in the maintenance of substance-us

61 ep exhibited decreased incubation of cocaine craving, a phenomenon depicting the progressive intensif

62 Using incubation of cue-induced cocaine craving, a rat relapse model depicting progressive inten

63 r scores of depression, anxiety, and alcohol craving after 3 wk of abstinence, which may be important

64 nimal model of incubation of methamphetamine craving after choice-based voluntary abstinence in male

65 a rat model of incubation of methamphetamine craving after choice-based voluntary abstinence.

66 f-administration showed incubation of heroin craving after forced but not voluntary abstinence.

67 r, AZD8529, on incubation of methamphetamine craving after forced or voluntary abstinence.

68 ceptors in the incubation of methamphetamine craving after voluntary abstinence and that DMS neuronal

69 ults show that incubation of methamphetamine craving after voluntary abstinence generalizes to female

70 for sleep intervention to influence cocaine craving after withdrawal.

71 Guanfacine significantly attenuated cocaine craving, alcohol craving, anxiety, and negative emotion

72 Indeed, individuals addicted to alcohol also crave alcoholic beverages and spend time and put much ef

73 Self-reported craving also increased from the nicotine to the placebo

74 t is currently unknown whether incubation of craving also occurs after adolescent-onset nicotine self

75 outcome variable was the increase in alcohol craving (also called urge) for alcohol, assessed by the

76 Our results suggest that incubation of food craving alters brain reward circuitry and macronutrient

77 e-induced relapse than subjective reports of craving, although this hypothesis must be empirically te

78 One study reported that cue-elicited craving among detoxified heroin addicts was substantiall

79 e processing, with subjective intensities of craving and anxiety correlating inversely with extent of

80 rrelated with the number of drinks consumed, craving and anxiety scores.

81 Activation in the amygdala correlated with craving and arousal ratings of alcohol stimuli; correlat

82 They establish that incubation of craving and associated CP-AMPAR plasticity occur much mo

83 erged: managing uncertainty, eating: between craving and aversion, being different and professional h

84 R-E training could attenuate smoking-related craving and behavior.

85 compared between groups and correlated with craving and BMI change.

86 s ability to suppress stress-induced alcohol craving and brain responses in treatment seeking alcohol

87 nectivity and individual differences in food craving and changes in body mass index (BMI).

88 e sensitive to food cues, reporting stronger craving and consuming larger portions after food cue exp

89 x (PFC) can cause lasting reductions in drug craving and consumption.

90 In contrast, craving and CP-AMPAR levels remain high on WD60.

91 vel animal model to study incubation of drug craving and cue-induced drug seeking after prolonged vol

92 The craving and deficits in executive function in the so-cal

93 incubation of both drug and non-drug reward craving and demonstrate an unexpected dissociation in me

94 and can reduce drug-induced motor behaviors, craving and dependence.

95 the NAc in the incubation of methamphetamine craving and describe adaptations in synaptic transmissio

96 t is not implicated in incubation of cocaine craving and does not undergo CP-AMPAR plasticity.

97 ngthened the associations between subjective craving and dorsal striatum and precuneus connectivity w

98 tural rewards while increasing reactivity to craving and drug cues.

99 ments associated with prior drug use provoke craving and drug taking, and set the stage for lapse/rel

100 he ability of drug-associated cues to elicit craving and facilitate relapse.

101 e frontal gyrus and inferior frontal gyrus), craving and interoceptive processing (anterior insula),

102 asures of cue- and stress-induced changes in craving and mood.

103 ation results in withdrawal symptoms such as craving and negative mood that may contribute to lapse a

104 mportant role for hedonic regulation of food craving and obesity in humans and thus may be a valuable

105 m and related clinical manifestations (i.e., craving and persistence of unhealthy habits).

106 Primary outcomes were cue-elicited craving and physiological responding to familiar and nov

107 orrelated negatively with ratings of cocaine craving and positively with how high subjects felt durin

108 ories of the effects of the drug, leading to craving and potential relapse.

109 weakened the associations between subjective craving and precuneus functional connectivity with senso

110 l striatum connectivity correlated with food craving and predicted BMI gains.

111 vides a model of persistent vulnerability to craving and relapse in human addicts.

112 or region (the PIc), is involved in nicotine craving and relapse in humans and rodents.

113 hat closely resembles stressors that promote craving and relapse in humans.

114 ach biases, has been shown to reduce alcohol craving and relapse rates.

115 pharmacological intervention that may reduce craving and relapse with minimal side effects in alcohol

116 opin-releasing factor (CRF) in the IC during craving and relapse, a subsequent experiment found that

117 can be engaged by sleep to regulate cocaine craving and relapse, and demonstrate sleep-based therape

118 In a rat model of drug craving and relapse, cue-induced drug seeking progressiv

119 by triggering drug using memories that drive craving and relapse.

120 ne-seeking behavior, an animal model of drug craving and relapse.

121 s indicate that negative mood states lead to craving and relapse.

122 e to environmental stimuli that trigger drug craving and relapse.

123 strong drug-associated memories that lead to craving and relapse.

124 y of CRF1 blockade in stress-induced alcohol craving and relapse.

125 entions can bidirectionally regulate cocaine craving and seeking after withdrawal.

126 Drug craving and seeking can increase during a period of abst

127 ave been shown to reduce measures of cocaine craving and seeking, raising the hypothesis that regulat

128 PSEs or PNEs while cue-induced self-reported craving and smoking behavior were assessed.

129 states, has recently been implicated in drug craving and social stress.

130 r agonists in decreasing stress-induced drug craving and stress-induced initial heroin lapse.

131 tion by showing that NTX reduced cue-induced craving and subjective responses to MA.

132 e as well as stress and cue-induced nicotine craving and systolic blood pressure (SBP) in both males

133 role of DS in incubation of methamphetamine craving and that this incubation is associated with sele

134 Although cue-induced craving and the QSU were both associated with enlarged s

135 In addiction, risk factors for craving and use include stress and drug-related cues.

136 of dorsal striatal networks relevant to food craving and weight gain.

137 icipants reported the severity of stress and craving and whether they had seen or been offered opioid

138 ings indicate that smoking-induced relief of craving and withdrawal reflects primarily non-nicotine e

139 and the latter was correlated with decreased craving and withdrawal symptoms.

140 metabolizers reported greater reductions of craving and withdrawal than slow metabolizers, with dose

141 related with abstinence-induced increases in craving and withdrawal.

142 included abstinence symptoms (withdrawal and craving) and cognitive test responding (N-back; continuo

143 that NTX would (a) attenuate cue-induced MA craving, and (b) reduce subjective responses to MA admin

144 gical responses, and symptoms of withdrawal, craving, and affect.

145 ding duration and severity of alcohol abuse, craving, and anxiety or depressive symptoms) were signif

146 n associated with later stages of addiction, craving, and cue-induced relapse.

147 Psychiatric, cognitive, nicotine craving, and mood assessments were obtained during activ

148 Chronic drug abuse, craving, and relapse are thought to be linked to long-la

149 ant-reported ratings of nicotine dependence, craving, and self-efficacy were collected.

150 administration was found to reduce anxiety, craving, and stress hormone release, whether these effec

151 thesis tested SL/SDL phenotype, pretreatment craving, and their interaction as moderators of frequenc

152 ficantly attenuated cocaine craving, alcohol craving, anxiety, and negative emotion following exposur

153 t sex-specific effects of guanfacine on drug craving, anxiety, and negative mood with significant eff

154 drawal, when CP-AMPAR levels and cue-induced craving are high, we found that systemic administration

155 In human addicts, drug relapse and craving are often provoked by stress.

156 derlying this 'incubation of methamphetamine craving' are unknown.

157 nificantly related to self-reported cannabis craving as well as problems associated with cannabis use

158 ed with two measures of craving: state-based craving, assessed by the brief questionnaire of smoking

159 ging to treat the drug seeking behaviour and craving associated with relapse.

160 sulin significantly reduced morning nicotine craving (b=3.65, P0.05).

161 Twenty IGD subjects participated in a group craving behavioral intervention (CBI) and were scanned b

162 robiological similarities and differences in craving between these disorders.

163 er withdrawal (incubation of methamphetamine craving), but the underlying mechanisms are largely unkn

164 1 PAM attenuated the expression of incubated craving by reducing CP-AMPAR transmission in the NAc to

165 of the main causes of alcohol relapse is the craving caused by environmental cues that are associated

166 kg) led to further reductions in cue-induced craving compared with the control.

167 low (n = 40) craving for alcohol, with high craving defined as greater than the median.

168 fter prolonged withdrawal, incubated cocaine craving depends on strengthening of nucleus accumbens (N

169 The incubation of cocaine craving describes the time-dependent augmentation of cue

170 procedures used to study incubation of drug craving do not incorporate negative consequences of drug

171 NTX decreased overall subjective ratings of 'crave drug,' 'stimulated,' and 'would like drug access,'

172 re to and dependence on nicotine, as well as craving during abstinence from smoking, without signific

173 Understanding the trajectory of cue-induced craving during abstinence in humans is of importance for

174 Analysis of food craving during the functional magnetic resonance imaging

175 hedonic subjective effects of MA, including craving, during controlled MA administration and as comp

176 pellets would elicit a greater incubation of craving effect than those paired with standard chow (SC)

177 llets and were then tested for incubation of craving either 1 or 30 days after training.

178 xacerfont treatment had no effect on alcohol craving, emotional responses, or anxiety.

179 sure to drug-associated cues, provoking drug craving even after prolonged abstinence.

180 oal of our second study was to replicate the craving findings from the original trial and expand this

181 SL) phenotype interacts with a high level of craving for alcohol and is associated with an improved r

182 s and Relevance: The SL phenotype and a high craving for alcohol independently and particularly in co

183 The SL/SDL phenotype and a high craving for alcohol merit further investigation as facto

184 y pretreatment high (n = 40) or low (n = 40) craving for alcohol, with high craving defined as greate

185 Rats showed robust incubation of craving for both food rewards, although responding for c

186 Finally, incubation of craving for chow and high fat was accompanied by an incr

187 unlike in human laboratory studies to date, craving for cocaine and heroin is greater with the combi

188 cipants also completed subjective ratings of craving for cocaine before presentation of a cue, and ra

189 Objective: To assess cue-induced craving for cocaine in humans using both subjective and

190 onic feelings toward cocaine) and "wanting" (craving for cocaine) after presentation of cocaine-relat

191 duals do not report experiencing feelings of craving for cocaine, an important distinction from depen

192 hat brain stimulation has an acute effect on craving for drugs and alcohol, but few studies have inve

193 Whether there is an increase in craving for high-fat (HF) food over time, which may cont

194 at (a) NTX significantly blunted cue-induced craving for MA and (b) attenuated several of the hedonic

195 Craving for methamphetamine was negatively associated wi

196 s exclusively, did not display incubation of craving for SC pellets, suggesting that prior history wi

197 ive increase in drug intake and a persistent craving for the drug during prolonged abstinence.

198 ated with cumulative methamphetamine use and craving for the drug.

199 fication (incubation) of cue-induced cocaine craving has been demonstrated after withdrawal from this

200 fication (incubation) of cue-induced cocaine craving has been demonstrated after withdrawal from this

201 eval test on withdrawal day (WD) 50-60, when craving has incubated.

202 tionship between cannabis cue reactivity and craving in a sample of 353 participants varying in self-

203 activation and reduce stress-induced alcohol craving in alcohol-dependent patients.

204 vented the emergence of incubation of heroin craving in both sexes.

205 ers might be a risk factor for stress-relief craving in cocaine use disorder.

206 tion for quitting cocaine and on cue-induced craving in cocaine-dependent participants, 24 hours post

207 hysical withdrawal, it decouples stress from craving in everyday life.

208 ocaine and heroin seeking in rats and heroin craving in humans.

209 tate, participants were assessed for alcohol craving in response to stressful or alcohol-related cues

210 The incubation of cue-induced drug craving in rodents provides a model of persistent vulner

211 ygdala activity correlated with decreases in craving in the bias modification but not the sham traini

212 life stress was partly decoupled from opioid craving in the clonidine group, supporting the authors'

213 ited a substantial reduction in alcohol-cued craving in the laboratory, and naturalistic measures rev

214 further characterized incubation of nicotine craving in the rat model by determining whether this inc

215 e noted in measures of depression or cocaine craving in this stress-minimized setting.

216 plicated in incubation of cocaine and heroin craving, in incubation of methamphetamine craving.

217 we used a rat model of incubation of cocaine craving, in which rats were trained to self-administer c

218 Cue-induced methamphetamine craving increases after prolonged forced (experimenter-i

219 ciated with time-dependent increases in food craving ('incubation of craving').

220 ef questionnaire of smoking urges (QSU), and craving induced by smoking-related images.

221 few weeks of withdrawal, cue-induced cocaine craving intensifies, or "incubates," and persists over e

222 Cue-induced cocaine craving is a major cause of relapse in abstinent addicts

223 d to demonstrate that incubation of nicotine craving is also observed after adolescent-onset nicotine

224 After ~1 month of withdrawal, incubated craving is mediated by Ca(2+)-permeable AMPA receptors (

225 tudied whether incubation of methamphetamine craving is observed after suppression of drug seeking by

226 Incubation of cocaine craving is partially mediated by progressive accumulatio

227 mpared with PNEs, was associated with higher craving levels (F(2,180)=18.32, p<0.0001) and greater ad

228 Anxiety and craving levels were assessed with self-report ratings.

229 trast, the subjective assessment of baseline craving (mean [SD] rating: 2 days, 26.05 [9.85]; 1 week,

230 specific relationship was found between both craving measures and the dorsal, but not in ventral stri

231 0.11-1.02; F1,67 = 5.36; P = .02), and high craving moderated heavy drinking (7.1 fewer heavy drinki

232 r methadone provided self-reports of stress, craving, mood, and behavior on electronic diaries for up

233 gest that repeated activation of cue-induced craving networks followed by electromagnetic stimulation

234 Although neither craving nor CP-AMPAR levels were measured in the present

235 incubation of both methamphetamine and food craving occur after punishment-induced suppression of me

236 ults demonstrate that incubation of nicotine craving occurs after adolescent-onset nicotine self-admi

237 onfirmed that 'incubation of methamphetamine craving' occurs under our experimental conditions.

238 hibited, respectively, incubation of cocaine craving on withdrawal day 45.

239 was not influenced by changes in subjective craving or expired carbon monoxide, suggesting that conn

240 llfully cope with discomfort associated with craving or negative affect, thus supporting long-term ou

241 s on any other measures of drinking, alcohol craving, or alcohol-related consequences.

242 SC pellets demonstrated equivalent levels of craving over an abstinence period of 30 days.

243 mcg/kg versus placebo in increasing alcohol craving (p < .05) with a large effect size (d = .94).

244 t across ghrelin doses in increasing alcohol craving (p < .05).

245 ction of comparable magnitude in cue-induced craving (p = .012).

246 ncreasing either urge to drink juice or food craving (p = ns).

247 y pathological drug seeking and intense drug craving, particularly in response to drug-related stimul

248 We found that changes in self-reported craving positively correlated with changes in CBF from t

249 In rats, cue-induced craving progressively intensifies (incubates) during wit

250 ssment; and 2) sums of visual analogue scale craving ratings administered during cue exposure.

251 Cocaine craving ratings positively correlated with the strength

252 Postscan craving ratings were acquired for each image, and behavi

253 e of ibudilast on subjective (including drug craving), reinforcing, and analgesic effects of oxycodon

254 ng changes in subsequent measures of cocaine craving/relapse.

255 he relationship between spine plasticity and craving remains unclear.

256 The mean craving response to both familiar and novel smoking cues

257 The craving response to smoking-associated cues in humans or

258 related with alcohol consumption and alcohol-craving scores.

259 n striatal morphology may be a biomarker for craving severity.

260 time-dependent increase in the motivational craving state (incubation of craving).

261 hology was then related with two measures of craving: state-based craving, assessed by the brief ques

262 Although craving states are important to both cocaine dependence

263 esults indicate a novel mechanism of alcohol craving that involves MMP-9-dependent synaptic plasticit

264 e, we used a rat model of incubation of drug craving, the neuronal activity marker Fos, and the Daun0

265 For cocaine craving, the Stress x Cue interaction term had a positiv

266 astically suppresses drinking, even in water-craving thirsty animals.

267 y play a role in the neurobiology of alcohol craving, thus demonstrating a novel pharmacologic target

268 extinction training substantially attenuated craving to both familiar and novel smoking cues and redu

269 ods), like the smell of brownies, can elicit craving to eat and increase the amount of food consumed.

270 a were analyzed separately for high- and low-craving trials (median split analysis).

271 ective value in midbrain and striatum in low-craving trials that was reversed in high-craving trials.

272 low-craving trials that was reversed in high-craving trials.

273 the dexamethasone-CRF test, but left alcohol craving unaffected.

274 s targeting the neural systems implicated in craving/urge states in addictions.

275 than-additive) effects of stress and cues on craving, using ecological momentary assessment (EMA).

276 lapse in drug addiction is the experience of craving via exposure to cues previously associated with

277 The combination of the SL phenotype and high craving was associated with a strong response to naltrex

278 Incubation of methamphetamine craving was associated with CP-AMPAR accumulation in NAc

279 Expression of incubated craving was decreased by intra-NAc core 1-naphthyl acety

280 Consequently, incubation of cocaine craving was decreased persistently.

281 Craving was evaluated using two established protocols, o

282 Food craving was indicated with subjective ratings of visual

283 Self-reported opioid craving was initially less with XR-NTX than with BUP-NX

284 Subjective food craving was inversely related to dorsolateral PFC activa

285 sma aldosterone levels, alcohol drinking and craving was investigated in alcohol-dependent patients.

286 ween midbrain D2/D3 BPnd and methamphetamine craving was not detected.

287 Heroin craving was significantly reduced under active ibudilast

288 scanning than normal metabolizers; however, craving was unrelated to nAChR availability.

289 Dependence and craving were assessed using standardized questionnaires.

290 e-related measures of subjective anxiety and craving were collected.

291 etween these measures and self-reported drug craving were examined.

292 Subjective effects of oxycodone and drug craving were measured with visual analog scales (VAS) an

293 ion to smoke (smoking topography), mood, and craving were recorded.

294 ape deformations associated with cue-induced craving were specific to striatal subregions involved in

295 cting the interoceptive awareness of tobacco craving with a larger brain network that motivates smoki

296 iagnostic group interaction in self-reported craving, with CD participants reporting strong cocaine c

297 ich extra-striatal regions and is related to craving, withdrawal and smoking behavior.

298 On five separate days, craving, withdrawal, affect, and sustained attention wer

299 moking significantly decreased self-reported craving, withdrawal, and [(11)C]-(+)-PHNO binding in D2

300 All cigarettes equally alleviated craving, withdrawal, and negative affect in the whole sa

301 We also found no significant improvements in craving, withdrawal, or cognitive function.