ライフサイエンスコーパス: crenolanib

コーパス検索結果 (１語後でソート)

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1 rogated by the PDGFRalpha-specific inhibitor crenolanib.

2 Using biochemical assays, we determined that crenolanib, a novel TKI, demonstrates type I properties

3 We tested crenolanib against a panel of D835 mutant cell lines and

4 was to examine the therapeutic potential of crenolanib, an inhibitor of PDGF receptor signaling, in

5 Treatment with crenolanib attenuated the skin and heart fibrosis.

6 any resistant colonies in the presence of a crenolanib concentration well below what has been safely

7 Crenolanib delayed the outgrowth of MV4-11 cells in a xe

8 Crenolanib effectively inhibited proliferation and migra

9 ate that the tyrosine kinase inhibitor (TKI) crenolanib effectively suppresses growth of leukemic cel

10 Crenolanib has significant promise for achieving deep an

11 n safely achieved in humans, suggesting that crenolanib has the potential to suppress KD mutation-med

12 ondrial fission and mitophagy in response to crenolanib in FLT3-ITD(+) AML cells expressing stable sh

13 In addition, crenolanib inhibited drug-resistant AML primary blasts w

14 Crenolanib is a highly selective and potent FLT3 tyrosin

15 onstrate that the investigational type I TKI crenolanib is a potent inhibitor of Fms tyrosine kinase-

16 These preclinical data demonstrate that crenolanib is effective against FLT3-ITD containing seco

17 Moreover, crenolanib is highly selective for FLT3 relative to the

18 Another potential advantage of crenolanib is its reduced inhibition of c-Kit compared w

19 Crenolanib is thus an important next-generation FLT3 TKI

20 ning secondary KD mutations, suggesting that crenolanib may be a useful therapeutic agent for TKI-nai

21 Second-generation FLT3 inhibitors such as crenolanib may overcome the resistance of these mutation

22 Crenolanib represents the first TKI to exhibit both kina

23 Moreover, activating FLT3-ITD signaling in crenolanib-resistant AML cells suppressed ceramide-depen

24 ia patients can achieve sufficient levels of crenolanib to inhibit both FLT3/ITD and resistance-confe

25 Crenolanib was active against Ba/F3 cells harboring FLT3

26 In progenitor cell assays, crenolanib was less disruptive of erythroid colony growt

27 death in response to FLT3-ITD inhibition by crenolanib, which was restored by wild-type (WT)-LC3, bu

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