ライフサイエンスコーパス: cresol

1 ependent hydroxylation of toluene to yield p-cresol.

2 the hydroxylation of toluene to yield 96% p-cresol.

3 at the meta position, producing primarily m-cresol.

4 n comparison, produces 97% p-cresol and 3% m-cresol.

5 and produced methylhydroquinone (80%) from o-cresol.

6 0 microM and produced 90% p-cresol and 10% m-cresol.

7 erent with resorcinol than with phenol and m-cresol.

8 ylaniline, 3,4-dimethylphenol, and 2-amino-p-cresol.

9 dependent hydroxylation of toluene to form p-cresol.

10 up hydrogen from the reactor walls to form o-cresol.

11 iently prepared in five steps from 2-amino-m-cresol.

12 eaction specificity in HDO of furfural and m-cresol.

13 503 to the p-hydroxybenzyl radical to form p-cresol.

14 dependent hydroxylation of toluene to form p-cresol.

15 lfate (PCS) but no detectable unconjugated p-cresol.

16 Derivatives of p-cresol 1-4 were synthesized, and their photochemical rea

17 for butyric acid, 1 x 10(-4) mug/L air for p-cresol, 1 x 10(-5) mug/L air for indole, and 1 x 10(-5)

18 er than the pK(a) of tyrosine (10.1) or of p-cresol (10.2).

19 mounts (in %) are 2-methyladenine (60.6%), p-cresol (16.3%), adenine (12.5%), 2-(methylthio)adenine (

20 ed 4 electron equiv/mol when titrated with p-cresol (2 electrons from p-cresol and 2 from 4-hydroxybe

21 talyzed the oxidation of catechol, 6-amino-m-cresol, 2-amino-m-cresol, and 2-amino-4-chlorophenol.

22 4-Chloro-m-cresol (4-CmC) is a clinically relevant activator of the

23 4-Chloro-m-cresol (4-CmC) is a potent and specific activator of the

24 nse to high [K(+)], caffeine, and 4-chloro-m-cresol (4-CMC), the maximal tensions generated in Stac3-

25 metric specific force followed by 4-chloro-m-cresol (4-CmC)-evoked maximal contracture force in singl

26 R3), are efficiently activated by 4-chloro-m-cresol (4-CmC).

27 sistent with this interpretation, 4-chloro-m-cresol (4-CMC; 100 microm) increases the rate of Ca(2+)

28 hen, diclofenac, carbamazepine, clozapine, p-cresol, 4-ethylphenol, and 3-methylindole in human liver

29 derived from phenolic compounds including p-cresol, 4-hydroxybenzoate and numerous lignin monomers,

30 In the reaction of NO3 radicals with para-cresol, 4-methyl-2-nitrophenol (4M2NP) and HNO3 were ide

31 gets (diazinon, propiconazole, 4,6-dinitro-o-cresol, 4-nitrobenzyl chloride).

32 ed that the RYR-stimulating agent 4-chloro-m-cresol (4CmC) induced Ca(2+) release and thereby confirm

33 ,6-Trichlorophenol (2) and 2,4,6-trichloro-m-cresol (5) react with calcium hypochlorite (Ca(OCl)(2))

34 udomonas mendocina KR1 oxidizes toluene to p-cresol (96%) and oxidizes benzene sequentially to phenol

35 stores, since the application of 4-chloro-m-cresol, a direct type 1 ryanodine receptor activator, el

36 oaded CD19(+) B and DAKIKI cells, 4-chloro-m-cresol, a potent activator of Ca2+ release mediated by t

37 uld be restored by application of 4-chloro-m-cresol, a ryanodine receptor agonist, indicating that th

38 es that contain the bases-2-methyladenine, p-cresol, adenine, and 2-(methylthio)adenine.

39 infrared spectrum of 4-methylimidazole or p-cresol alone.

40 ol did not increase Tf saturation with Al. p-Cresol also increased Tf-Al uptake in Friend erythroleuk

41 d ryanodine but not for Ca(2+) or 4-chloro-m-cresol, although they all induced Ca(2+) release.

42 4-Chloro-m-cresol, an activator of the skeletal muscle ryanodine re

43 In the presence of tyrosine or p-cresol, an unusual tricyclo[4.3.3.0] adduct has been cha

44 nt Km value of 250 microM and produced 90% p-cresol and 10% m-cresol.

45 n titrated with p-cresol (2 electrons from p-cresol and 2 from 4-hydroxybenzyl alcohol), PchF(C) acce

46 .e., alcohol dehydration and alkylation of m-cresol and 2-propanol in the liquid phase, at high tempe

47 T4MO, in comparison, produces 97% p-cresol and 3% m-cresol.

48 ng precursors 60 and 68 were prepared from m-cresol and 3-ethylphenol, respectively.

49 Odorants such as p-cresol and a sweet-character unknown component were corr

50 The second-order rate constants for p-cresol and ferrocyanide reduction of the mutant compound

51 Both 4-chloro-m-cresol and halothane caused adenosine accumulation in bl

52 erates myriad toxic metabolites, including p-cresol and indoxyl sulfate.

53 By using o-cresol and o-methoxyphenol as model substrates, regiospe

54 %) and methylhydroquinone (9%), to oxidize m-cresol and p-cresol to 4-methylcatechol (100%), and to o

55 onversely, the A107T variant produced >98% p-cresol and p-nitrophenol from toluene and nitrobenzene,

56 Interestingly, p-cresol and phenol, which are the lower ligand in Sporomu

57 ells was significantly altered by 4-chloro-m-cresol and ryanodine.

58 enzyme HydG lyses free tyrosine to produce p-cresol and the CO and CN(-) ligands of the [2Fe](H) clus

59 e electronic and redox properties of bound p-cresol and the covalently bound FAD.

60 Our studies suggest that p-cresol and uremic fractions 4 to 8, 12, 14, and 15 incre

61 e higher acidity of the S1 states of these p-cresols and the ability for excited-state intramolecular

62 ion of catechol, 6-amino-m-cresol, 2-amino-m-cresol, and 2-amino-4-chlorophenol.

63 usion coefficients of benzene, anthracene, m-cresol, and p-nitrophenol in enhanced-fluidity liquid mi

64 thylbenzimidazole, 5-methoxybenzimidazole, p-cresol, and phenol were determined.

65 e are converted into the respective phenols, cresols, and methoxyphenols by fast gas-phase reaction w

66 phenylacetonitrile, cyclobutanone, phenol, p-cresol, aniline) to form ammonia and trans-(DMPE)(2)Ru(H

67 enic bacterium Sporomusa ovata, phenol and p-cresol are converted into alpha-ribotides, which are inc

68 pha-amino group (the aromatic hydrogens of p-cresol are far less subject to exchange) and by imidazol

69 on of biphenyl, naphthalene, m-xylene, and p-cresol are predicted to be distributed among 15 gene clu

70 The oxidative half-reaction of PHHY using m-cresol as a substrate is similarly affected by the mutat

71 nds studied in resorcinol >> phenol > or = m-cresol as determined from their overall free energies of

72 ally characterized cell permeable diformyl-p-cresol based receptor (HL) selectively senses the AsO3(3

73 ing addition and fragmentation reaction of p-cresol-based N-phenylbenzoxazine with aliphatic and arom

74 Phenolic ligands, e.g., phenol and m-cresol, bind to 2Zn(II)-insulin hexamers and induce a co

75 identified compounds including 2,6-dinitro-p-cresol, bisphenol S, clonixin, and triclopyr.

76 nctionalised with 2-(2'-benzothiazolylazo)-p-cresol (BTAC).

77 The degradation of the toxic phenol p-cresol by Pseudomonas bacteria occurs by way of the prot

78 steps and 78% overall yield starting from o-cresol by using a one-pot regiocontrolled dialkylation o

79 teady-state rate constant for oxidation of p-cresol by various forms of PCMH and PchF; both nu(m) and

80 This study examined the form in which p-cresol circulates and quantified its removal by hemodial

81 We conclude that p-cresol circulates in the form of its sulfate conjugate,

82 (Cl(ind)), p-cresol sulfate (Cl(pcs)), and p-cresol (Cl(pc)) averaged only 5 +/- 1, 4 +/- 1, and 14 +

83 they were much less sensitive to 4-chloro-m-cresol (CMC).

84 zation or RyR agonists (caffeine, 4-chloro-m-cresol) compared with wtRyR1.

85 The sensor probe is characterized for p-cresol concentration range from 0microM (reference sampl

86 showed increased Al uptake and toxicity at p-cresol concentrations of 3 mg/dl in culture media.

87 atase resulted in recovery of this peak as p-cresol, confirming its identity.

88 p-Cresol did not increase Tf saturation with Al. p-Cresol

89 richlorobenzene, imidacloprid, 4,6-dinitro-o-cresol, ethylacrylate, malathion, chlorpyrifos, aldicarb

90 BHA, creosol, isoeugenol and di-o-propenyl p-cresol, fewer radicals were trapped by a single phenol m

91 ately 5-fold increase in the percentage of m-cresol formation relative to that of the natural isoform

92 elded shifts of regiospecificity away from p-cresol formation, with F205I giving an approximately 5-f

93 07T produced methylhydroquinone (92%) from o-cresol fourfold faster than wild-type T4MO and there was

94 ake and cell toxicity were proportional to p-cresol from 1.5 mg/dl to 3 mg/dl in culture media.

95 para-monooxygenase variant that formed 75% m-cresol from toluene and 100% m-nitrophenol from nitroben

96 Furthermore, G103S/A107T formed 100% p-cresol from toluene; hence, a better para-hydroxylating

97 involved in the fermentative production of p-cresol from tyrosine in clostridia.

98 It was demonstrated that p-cresol has a charge-transfer interaction with FAD when b

99 itiated oxidation of ortho-, meta-, and para-cresol have been performed in large-volume chamber syste

100 s applied and validated for PCMC (4-chloro-m-cresol), household derived antimicrobial agent with no k

101 the product distribution, and gave o- and p-cresol in a 1:1 ratio.

102 lysis confirmed the structural identity of p-cresol in samples containing the product of hydroxylatio

103 p-Cresol increased Tf-associated Al uptake only because th

104 tudies of the reaction of PCMH[Y384F] with p-cresol indicated that the K(m) for this substrate was un

105 ximately 0.0001), suggesting that 4-chloro-m-cresol-induced adenosine could readily distinguish betwe

106 , and consequently, SOCE after 4-chloro-meta-cresol-induced store depletion was suppressed.

107 p-Cresol is a simple molecular model for the para phenolic

108 including phenol, bisphenol A, catechol and cresols is reported.

109 experiments the gas-phase reaction of ortho-cresol isomer with NO3 yielded (11.5 +/- 0.8) % 6-methyl

110 s observed from the reaction of NO3 and with cresol isomers.

111 Metabolomic analysis identified increased cresol levels in these mice, and exposure of cultured ol

112 pecific oxidation of aromatics (e.g., from o-cresol, M180H forms 3-methylcatechol, methylhydroquinone

113 hF) of the alpha(2)beta(2) flavocytochrome p-cresol methylhydroxylase (PCMH) from Pseudomonas putida

114 The alpha(2)beta(2) flavocytochrome p-cresol methylhydroxylase (PCMH) from Pseudomonas putida

115 Each flavoprotein subunit (PchF) of p-cresol methylhydroxylase (PCMH) has flavin adenine dinuc

116 otein component (PchF) of flavocytochrome, p-cresol methylhydroxylase (PCMH), and cytochrome-free Pch

117 The first enzyme in this pathway, p-cresol methylhydroxylase (PCMH), is a flavocytochrome c.

118 ese proteins are (1) the flavocytochrome c p-cresol methylhydroxylase (rPCMH, 1.85 A resolution) and

119 number of oxidoreductases from the VAO/para-cresol methylhydroxylase flavoprotein family catalyze th

120 variants of the flavoprotein component of p-cresol methylhydroxylase that contain noncovalently or c

121 hexamer containing two zinc ions, with two m-cresol molecules bound at each dimer-dimer interface sta

122 xylene (m-X), o-xylene (o-X), styrene (S), o-cresol (o-C), phenol (PhAl), p-cresol (p-C), indole (ID)

123 , near-quantitative deuterium retention in m-cresol obtained from 4-(2)H(1)-toluene, and partial loss

124 ymphocytes incubated with 0-10 mM 4-chloro-m-cresol or 0-10.7 mM halothane.

125 Similarly, at 1 mM 4-chloro-m-cresol or 0.96 mM halothane, adenosine levels were signi

126 -benzenetricarbaldehyde building blocks in m-cresol or acetic acid, named RT-COF-1 or RT-COF-1Ac/RT-C

127 fter RyR activation (caffeine and 4-chloro-m-cresol) or beta-adrenergic stimulation (isoproterenol).

128 a ryanodine receptor agonist (4-chloro-meta-cresol) or depolarizing pulses were used.

129 eptor (10 mM caffeine, 200 microM 4-chloro-m-cresol, or 10 mM KCl).

130 enzyl alcohol, the intermediate product of p-cresol oxidation by PCMH, reduced PchF(NC) fairly quickl

131 lation was found between the efficiency of p-cresol oxidation by these proteins and E(CT), the energy

132 g of protein were obtained for o-, m-, and p-cresol oxidation by wild-type T4MO, which are comparable

133 also that 4-hydroxybenzaldehyde, the final p-cresol oxidation product, is an efficient competitive in

134 tyrene (S), o-cresol (o-C), phenol (PhAl), p-cresol (p-C), indole (ID), and skatole (SK)).

135 ter at 25 degrees C for benzene, p-xylene, p-cresol, p-dicyanobenzene, and hydroquinone from statisti

136 PCS by decreasing intestinal production of p-cresol, prevented these metabolic derangements.

137 This work examines the use of purified meta-cresol purple (mCP) for direct spectrophotometric calibr

138 nd chemical characteristics of purified meta-Cresol Purple (mCP) pH indicator dye suitable for pH mea

139 scein at pH 6.5, phenol red at pH 7.5, and m-cresol purple at pH 8.5) which permitted separation of s

140 (phenol red) and meta-cresolsulfonphthalein (cresol purple) were synthesized by electrophilic fluorin

141 In contrast, p-cresol rapidly reduced PchF with covalently bound FAD (P

142 c analyses showed areas under the 4-chloro-m-cresol receiver-operating characteristic curves near mor

143 Although 4-chloro-m-cresol receiver-operating characteristic curves revealed

144 ible B cells treated with 0.75 mM 4-chloro-m-cresol relative to controls.

145 nt coupling and high regiospecificity with p-cresol representing >96% of total products from toluene.

146 tical to that of the natural isoform, with p-cresol representing 90-95% of the total product distribu

147 and a decrease in regiospecificity so that p-cresol represents approximately 60% of total products.

148 Its response time is also better than the p-cresol sensor currently available in the market for the

149 ained as compared to the recently reported p-cresol sensor.

150 re, 4-methylimidazole covalently linked to p-cresol, show that a feature near 1540 cm(-1) is unique t

151 luene; for example, G103S/A107G formed 82% o-cresol, so saturation mutagenesis converted T4MO into an

152 usly, Siamwiza and co-workers investigated p-cresol solutions to identify Raman spectroscopic signatu

153 16-fold), indoxyl sulfate (0.21-fold), and p-cresol sulfate (0.39-fold) were much lower than the rate

154 108-fold), indoxyl sulfate (116-fold), and p-cresol sulfate (41-fold) were much greater than the conc

155 e protein-bound solutes indican (Cl(ind)), p-cresol sulfate (Cl(pcs)), and p-cresol (Cl(pc)) averaged

156 k whose mobility corresponded to synthetic p-cresol sulfate (PCS) but no detectable unconjugated p-cr

157 In cultured cells, indoxyl sulfate and p-cresol sulfate activated the EGF receptor and downstream

158 Although p-cresol sulfate and indoxyl sulfate are well studied exam

159 HPLC confirmed the colonic origin of p-cresol sulfate and indoxyl sulfate, but levels of hippur

160 mized mice treated with indoxyl sulfate or p-cresol sulfate as study models.

161 Low clearance of hippurate or p-cresol sulfate associated with greater risk of death ind

162 results suggested that indoxyl sulfate and p-cresol sulfate dock on a putative interdomain pocket of

163 Indoxyl sulfate and p-cresol sulfate have been suggested to induce kidney tiss

164 In conclusion, indoxyl sulfate and p-cresol sulfate may induce kidney tissue remodeling throu

165 eatment: from no reduction in the level of p-cresol sulfate or asymmetric dimethylarginine to signifi

166 Treatment of mice with indoxyl sulfate or p-cresol sulfate significantly activated the renal EGF rec

167 reted solute (hippurate, cinnamoylglycine, p-cresol sulfate, and indoxyl sulfate) clearance using liq

168 ine, 5-hydroxyindole, indoxyl glucuronide, p-cresol sulfate, and indoxyl sulfate.

169 toxins and solutes (e.g., indoxyl sulfate, p-cresol sulfate, kynurenine, creatinine, urate) include t

170 tometric absorption of indoxyl sulfate and p-cresol sulfate.

171 e resonance (LMR) based sensor for urinary p-cresol testing on optical fiber substrate is developed.

172 s undergo deamination reactions, and for all cresols the formation of quinone methides (QMs) was obse

173 ylene, cyclobutanone, aniline, phenol, and p-cresol, the reaction was observed to proceed via ion pai

174 In this study T4MO was found to oxidize o-cresol to 3-methylcatechol (91%) and methylhydroquinone

175 PCMH oxidizes p-cresol to 4-hydroxybenzyl alcohol, which is oxidized sub

176 hydroquinone (9%), to oxidize m-cresol and p-cresol to 4-methylcatechol (100%), and to oxidize o-meth

177 he enzyme first catalyzes the oxidation of p-cresol to p-hydroxybenzyl alcohol, utilizing one atom of

178 A107S produced 3-methylcatechol (98%) from o-cresol twofold faster and produced 3-methoxycatechol (82

179 nterpret the Raman and infrared spectra of p-cresol vapor and extend the previous correlation to the

180 ant Al uptake by MH was observed only when p-cresol was added together with Tf-Al.

181 ospecific oxidation of o-methoxyphenol and o-cresol was changed for significant synthesis of 3-methox

182 dine receptor Ca channels agonist 4-chloro-m-cresol was compared in blood lymphocytes from malignant

183 inhibited, whereas that of CYP1A2-specific o-cresol was increased, results consistent with the format

184 p-Cresol was not toxic to MH in the absence of Tf-Al in me

185 In the FVP of (o-CH(3)O)(2)-PPE, o-cresol was the dominant product.

186 N-o-Vanillidine-2-amino-p-cresol was used as a chelating ligand and 1-undecanol wa

187 It was found that p-cresol was virtually incapable of reducing PchF with non

188 bstitution of 4-(fluoroethynyl)benzenes by p-cresol were determined by (1)H NMR spectroscopy, and the

189 ope distributions of 5'-deoxyadenosine and p-cresol were evaluated using deuterium-labeled tyrosine s

190 tion of CYP2B4-specific benzyl alcohol and p-cresol were inhibited, whereas that of CYP1A2-specific o

191 lorobenzene, imidacloprid, and 4,6-dinitro-o-cresol were not biotransformed.

192 st extensively studied of these solutes is p-cresol, which has been shown to be toxic in vitro.

193 -hexenol, acetic acid, benzyl alcohol, and m-cresol, while the addition of oxygen significantly influ

194 o probe the mechanism of the alkylation of m-cresol with isopropyl alcohol in scCO(2) using Nafion SA

195 s also show a clear preference for binding p-cresol with the hydroxyl group hydrated rather than insi

196 oton transfer to this 4OB(*) radical forms p-cresol, with the conversion of this dehydroglycine ligan

197 iously from these ultrafiltrate fractions (p-cresol, xanthine, tryptophan, hippuric acid, and o-hydro

198 n efficiency of phenol approached 100% while cresols, xylenols, and 4-ethylphenol were 97% or higher

199 eveloped for the characterization of phenol, cresols, xylenols, and alkyl phenols like 4-ethylphenol

200 The reaction of NO3 radicals with meta-cresol yielded (21.2 +/- 1.4) % 3-methyl-2-nitrophenol (

201 otinate mononucleotide (NaMN) to phenol or p-cresol, yielding alpha-O-glycosidic ribotides.