ライフサイエンスコーパス: crest

1 potent state through mesendoderm to DE (Wave-Crest).

2 connective tissue is derived from the neural crest.

3 to the floor of maxillary sinus and alveolar crest.

4 fector of Endothelin signaling in the neural crest.

5 e direct descendants of the embryonic neural crest.

6 Part A of the C-CREST-1 and C-CREST-2 trials led to the selection of a t

7 The goals of part A of C-CREST-1 and C-CREST-2 were to compare the efficacies of

8 Part A of the C-CREST-1 and C-CREST-2 trials led to the selection of a three-drug regi

9 The goals of part A of C-CREST-1 and C-CREST-2 were to compare the efficacies of two doses (300

10 from the cemento-enamel junction to the bone crest; 2) tooth torque (TT); 3) labial cortical bone thi

11 es adhesion to fibronectin in Xenopus neural crest, a highly migratory embryonic cell population.

12 pecimens reveal large, hollow, osseous nasal crests: a craniofacial novelty for mammals that is remar

13 originates from both mesoderm and the neural crest, an ectodermal cell population, via an epithelial

14 al endothelial cells are derived from neural crest and because of postmitotic arrest lack competence

15 molecular underpinnings of potency in neural crest and blastula cells.

16 e not only to neural tube but also to neural crest and epidermis.

17 system tumor that originates from the neural crest and is the most common and deadly tumor of infancy

18 the invasive tumor edges, and in the neural crest and limb buds of mouse embryos.

19 Cranial neural crest and metastatic melanoma cells avoid DAN protein st

20 vel factor that inhibits uncontrolled neural crest and metastatic melanoma invasion and promotes coll

21 e aetiology, differentiating from the neural crest and migrating through the developing embryo to spe

22 lopment, including markers of cranial neural crest and of placodes.

23 ebrate embryos contains precursors of neural crest and placode cells, both defining vertebrate charac

24 ical cells are the ectodermal cranial neural crest and placode lineages.

25 orm multi-region sequencing, including iliac crest and radiology-guided focal lesion specimens from 5

26 TORC1 signaling, presence of specific neural crest and SMC markers, expression of VEGF-D and female s

27 plex spectrum of abnormalities in the neural crest and the crest-derived cell types.

28 Exaggerated cranial structures such as crests and horns, hereafter referred to collectively as

29 Bone marrow aspiration from the iliac crests and in vivo sentinel lymph node mapping were perf

30 UVmax in the axial skeleton (spine and iliac crests) and proximal limbs.

31 s, osteoid accumulation on the alveolar bone crest, and significant differences in several bone prope

32 When the measurement from the bone crest at the implant was </=5 mm, the papilla was comple

33 tomic-layer-deposited TaN1+x /Ta2 O5 /TaN1+x crested barrier selector yields a large nonlinearity (>1

34 memory cell with a mem-ristor and a trilayer crested barrier selector, showing repeatable nonlinear c

35 al and fate, so that only the cranial neural crest can contribute to the craniofacial skeleton in viv

36 Shh)-induced proliferation of cranial neural crest cell (cNCC) mesenchyme is required for upper lip c

37 cial abnormalities to deficiencies in neural crest cell (NCC) craniofacial precursors early in develo

38 to be enriched for genes involved in neural crest cell (NCC) development and vasculogenesis.

39 models, to demonstrate that defective neural crest cell (NCC) development explains RCPS craniofacial

40 th factors, and its functions include neural crest cell (NCC) maintenance, specifically NCC migration

41 ransition, acquisition of avian trunk neural crest cell (NCC) polarity is prerequisite for directiona

42 defects were associated with aberrant neural crest cell behavior.

43 Among the genes that are involved in neural crest cell development, some genes are more sensitive to

44 re typically attributed to defects in neural crest cell development.

45 cranial facial defects, arising from neural crest cell differentiation and migration problems.

46 Our analysis shows that, before neural crest cell exit from the hindbrain, DAN is expressed in

47 nd the repertoire of vertebrate trunk neural crest cell fates during normal development, highlight th

48 ation than it does to modulate normal neural crest cell growth.

49 ell transcriptome analysis of cranial neural crest cell migration at three progressive stages in chic

50 f function of DAN results in enhanced neural crest cell migration by increasing speed and directional

51 late morphogenesis, defective cranial neural crest cell migration in capzb(-/-) mutants results in lo

52 However, the signals that regulate neural crest cell migration remain unclear.

53 ns that are known to be inhibitory to neural crest cell migration.

54 etero-oligomer, which impacts cardiac neural crest cell migration.

55 r of CXCR4, a gene involved in embryo neural crest cell migration.

56 tumor plasticity with reversion to a neural crest cell migratory phenotype.

57 cular diversity and dynamics within a neural crest cell migratory stream that underlie complex direct

58 y also be involved in the survival of neural crest cell population during development.

59 Ift88 also resulted in a decrease in neural crest cell proliferation during early stages of palatoge

60 yonic development, a subpopulation of neural crest cell-derived melanocytes migrates and incorporates

61 ENS is controlled by the interplay of neural crest cell-intrinsic factors and instructive cues from t

62 The cardiac neural crest cells (cNCCs) and the second heart field (SHF) pla

63 Cranial neural crest cells (CNCCs) delaminate from embryonic neural fol

64 m cell populations, including cranial neural crest cells (CNCCs), have not been assessed.

65 Cranial neural crest cells (crNCCs) migrate from the neural tube to the

66 sease is caused by failure of enteric neural crest cells (ENCCs) to fully colonize the bowel, leading

67 colonization of the bowel by enteric neural crest cells (eNCCs), the ENS precursors.

68 regions that are active in both human neural crest cells (hNCC) and mouse embryonic craniofacial tiss

69 Neural crest cells (NCC) are multi-potent cells of ectodermal o

70 Neural crest cells (NCC) are stem cells that generate different

71 opment by combining human-PSC-derived neural crest cells (NCCs) and developing human intestinal organ

72 Here we show that neural crest cells (NCCs) and their derivatives provide an esse

73 Neural crest cells (NCCs) are highly patterned embryonic cells

74 t the in vivo collective migration of neural crest cells (NCCs) depends on such confinement.

75 ebrate traits, including emergence of neural crest cells (NCCs), in which neofunctionalization of the

76 ng NBL based on the transformation of neural crest cells (NCCs), the progenitor cells of the SNS, iso

77 morphants have impaired migration of neural crest cells and deregulation of sox10 expression from th

78 markers of human sensory neurons from neural crest cells and established a critical role for the JNK

79 ofacial skeleton is derived from both neural crest cells and mesodermal cells; however, the majority

80 ively infects stem-cell-derived human neural crest cells and peripheral neurons in vitro, leading to

81 al pigmentation as both the migratory neural crest cells and pigment localized only to PNA-free areas

82 CAX is expressed in neural crest cells and required for their migration in vivo.

83 wig's epithelial root sheath, cranial neural crest cells and stem cells residing in developing and ad

84 Neural crest cells are both highly migratory and significant to

85 However, trunk neural crest cells are generally regarded as nonskeletogenic, a

86 Neural crest cells are induced at the neural plate border by th

87 ng embryonic development, multipotent neural crest cells are specified at the lateral borders of the

88 the hypoxic stage, a large number of neural crest cells arise from the head neural tube by epithelia

89 ng, we further demonstrate that trunk neural crest cells do, in fact, give rise to odontoblasts of tr

90 oper migration and differentiation of neural crest cells during neuritogenesis.

91 During development, vagal neural crest cells fated to contribute to the enteric nervous s

92 Neural crest cells give rise to a diverse array of derivatives

93 In the head, cranial neural crest cells give rise to the dentine-producing cells (od

94 le that was largely subsumed by vagal neural crest cells in early gnathostomes.

95 specification and emigration of trunk neural crest cells in embryos of a cartilaginous fish, the litt

96 en supply helps to stop emigration of neural crest cells in the head.

97 h, our experiments suggest that trunk neural crest cells in the last common ancestor of tetrapods and

98 the embryonic head no longer produces neural crest cells in vivo, despite the capability to do so in

99 pluripotent stem cell-derived enteric neural crest cells into developing human intestinal organoids,

100 We propose that these trunk-derived neural crest cells may be homologous to Schwann cell precursors

101 Neural crest cells migrate throughout the embryo, but how cells

102 ucing components of this circuit into neural crest cells of the trunk alters their identity and endow

103 nial vessels, MCs derived from either neural crest cells or mesoderm emerged around the preformed EC

104 Rdh10 is specifically required in non-neural crest cells prior to E10.5 for proper choanae formation,

105 Chick premigratory cranial neural crest cells reduce Cadherin-6B (Cad6B) levels through se

106 ation of both myogenic stem cells and neural crest cells requires capzb.

107 ic nervous system (ENS) develops from neural crest cells that migrate along the intestine, differenti

108 rtebrates arises primarily from vagal neural crest cells that migrate to the foregut and subsequently

109 tiated by migrating Delta1-expressing neural crest cells that trigger NOTCH signaling and myogenesis

110 s a physical boundary that constrains neural crest cells to discrete streams, in turn facilitating th

111 ing from human and chimpanzee cranial neural crest cells to systematically and quantitatively annotat

112 ation of the lateral line primordium, neural crest cells, or head mesendoderm.

113 n outcomes observed experimentally in neural crest cells, we must either carefully tune our parameter

114 mbryo, chromatophores derive from the neural crest cells.

115 red to produce a sufficient number of neural crest cells.

116 lar dynamics that affects the NNE and neural crest cells.

117 h aberrant differentiation of cranial neural crest cells.

118 a rare benign tumor arising from the neural crest cells.

119 nd are believed to differentiate from neural crest cells.

120 originate from either mesenchymal or neural crest cells.

121 in endothelial, but not myocardial or neural crest, cells.

122 metalloprotease critical for cranial neural crest (CNC) cell migration.

123 Dlx5-positive cranial neural crest (CNC) cells are in direct contact with myoblasts d

124 iminate Ift88 specifically in cranial neural crest (CNC) cells.

125 he Hippo signaling pathway in cranial neural crest (CNC) development is poorly understood.

126 extended to a wild avian species, the double-crested cormorant (DCCO; Phalacrocorax auritus), in orde

127 Two species of fish-eating birds, the Double-crested Cormorant (Phalacrocorax auritus) and the Caspia

128 e., CEH and chicken PCR array) to the double-crested cormorant demonstrated the portability of the te

129 waDP were administered to chicken and double-crested cormorant hepatocytes to determine effects on 7-

130 avian ToxChip PCR arrays-chicken and double-crested cormorant-were utilized, and xDP altered the exp

131 nd in the St. Lawrence River, Canada, double-crested cormorants (Phalacrocorax auritus) were collecte

132 progenitor cell population called the neural crest, craniofacial disorders are typically attributed t

133 Knockdown of HEXIM1 rescues zebrafish neural crest defects and human melanoma proliferation defects t

134 GF-stimulated PI3K/Akt signaling, and neural crest defects in CAPE-treated embryos are suppressed by

135 Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-

136 t support the formation of particular neural crest derivatives may be used to reprogram specific neur

137 demonstrates that mutation of Erk2 in neural crest derivatives phenocopies the human Pierre Robin seq

138 te to metastasis, but melanocytes are neural crest derivatives that have undergone EMT during embryon

139 newal capacity and differentiate into neural crest derivatives, including epidermal pigment-producing

140 shown to generate homologues of other neural crest derivatives.

141 Neural crest derived bone harbors HSCs that function similarly

142 Finally, we identify similar neural-crest derived cells in both the avian and non-human prim

143 ulation is an important driver of the neural crest-derived aspects of Chd7 dependent CHARGE syndrome.

144 Neural crest-derived bones differ from appendicular bones in de

145 Whether neural crest-derived bones harbor HSCs is elusive.

146 d body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells alrea

147 We discover neural crest-derived catecholaminergic cells associated with ze

148 Shh also inhibited enteric neural crest-derived cell (ENCC) proliferation, promoted neuron

149 upport of this role of ES to regulate neural crest-derived cell fate and differentiation in vivo, kno

150 em Tomato reporter strain to identify neural crest-derived cell lineages including the peripheral aut

151 showing stable YFP expression in all neural crest-derived cell populations despite loss of Wnt1 expr

152 of abnormalities in the neural crest and the crest-derived cell types.

153 ves may be used to reprogram specific neural crest-derived cell types.

154 atorial labeling of zebrafish cranial neural crest-derived cells (CNCCs) to define global gene expres

155 Mice lacking Jagged1 or Notch2 in neural crest-derived cells (NCCs) of the pharyngeal arches disp

156 nduce iridophore differentiation from neural crest-derived cells and pigment progenitor cells.

157 Indeed, Tbx1 is expressed in the neural crest-derived hyoid bone primordium, in addition to meso

158 med during embryogenesis, such as the neural crest-derived melanocyte.

159 the assumption of a major fraction of neural crest-derived neuroendocrine cells in both the human and

160 at Tbx1 is required for mesoderm- and neural crest-derived osteoblast differentiation and normal skel

161 ptic vesicle neuroectoderm, lens, and neural crest-derived periocular mesenchyme induced severe eye a

162 ECD donors that exhibited features of neural crest-derived progenitor (NCDP) cells by showing absence

163 clonal units founded by postmigratory neural crest-derived progenitors.

164 Our results suggest that neural-crest-derived Schwann cell precursors made an important

165 ultiple myocardial-, epicardial-, and neural crest-derived signals.

166 vestigate the fate restriction in the neural crest-derived stem cells and intermediate progenitors in

167 n, cardiac defects, and overgrowth of neural crest-derived structures seen in Nf1-/-embryos.

168 e development and in the formation of neural crest-derived structures, including aortic arch, thymus,

169 f the heart and restricting growth of neural crest-derived tissues.

170 posed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive 'neuroepithelia

171 nd lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose e

172 l and non-redundant role for CHC22 in neural crest development and in the genesis of pain and touch s

173 t the signals required for subsequent neural crest development remain poorly characterized.

174 roles for Chd7 at multiple points of neural crest development viz., migration, fate choice and diffe

175 o cultures for chemicals that disrupt neural crest development, as read out by crestin:EGFP expressio

176 relevant groups (e.g., Wnt signaling, neural crest development, sensory placode specification, ciliog

177 pathways, including those involved in neural crest development.

178 for specific genes in early steps of neural crest development.

179 e dysregulated at the time of cardiac neural crest development.

180 igated the role of CHC22 in two human neural crest differentiation systems; human induced pluripotent

181 el intracellular pathway required for neural crest differentiation.

182 asuring cemento-enamel junction and alveolar crest distance.

183 doderm and redefine the boundaries of neural crest diversification.

184 nail2, and Snail2 fails to expand the neural crest domains in the absence of Ezh2.

185 rate was higher in CREST ineligible than in CREST eligible patients (11.4% versus 4.9%; P=0.001).

186 ring the second phase of turtle trunk neural crest emigration.

187 ssor Snail2, to ensure proper cranial neural crest EMT.

188 mutation, disrupted the activity of a neural crest enhancer downstream of FGFR2 both in vitro and in

189 larization Endarterectomy vs Stenting Trial (CREST) enrollment criteria.

190 They derive from the neural crest, express numerous neurogenic markers, and mediate

191 e apportionment of neural tube versus neural crest fates.

192 tantly, Axud1 is sufficient to rescue neural crest formation after disruption of Wnt signaling.

193 g and transcriptional cues to mediate neural crest formation.

194 acid phenethyl ester (CAPE) disrupts neural crest gene expression, migration, and melanocytic differ

195 uced BMP signaling maintained a trunk neural crest gene signature in melanomas.

196 orsal midline with high expression of neural crest genes, pluripotency factors, and lineage markers.

197 advances, direct linkages within the neural crest GRN are being uncovered.

198 ss, including loss of oral bone and alveolar crest height (ACH).

199 y that El Faro encounters a rogue wave whose crest height exceeds 14 meters while drifting over a tim

200 profiling of the cranial versus trunk neural crest in chick embryos, we identified and characterized

201 to the floor of maxillary sinus and alveolar crest in the 1(st) molar and 2(nd) molar regions.

202 awed vertebrates, is expressed in the neural crest in the mandibular process but not in the maxillary

203 The rate was higher in CREST ineligible than in CREST eligible patients (11.4%

204 Delivery to the crest, instead of the T-tubule opening, resulted in a mu

205 The neural crest is a dynamic progenitor cell population that arise

206 it remains controversial whether the neural crest is a heterogeneous or homogeneous population.

207 The neural crest is a transient, multipotent embryonic cell populat

208 The neural crest is a transient, multipotent population of cells th

209 The neural crest is an embryonic population of multipotent stem cel

210 the endogenous Snail2 promoter in the neural crest is beta-catenin dependent.

211 that Meis1 inactivation in the mouse neural crest leads to an altered sympatho-vagal regulation of c

212 These results show that neural crest-like reprogramming achieved by a single factor is

213 os and that ablation of Pdgfrb in the neural crest lineage results in increased nasal septum width, d

214 with angle-of-repose lee slopes and sinuous crest lines, making them unlike terrestrial wind ripples

215 tubule LTCCs had open probability similar to crest LTCCs, but exhibited approximately 40% greater cur

216 We conclude that male crested macaques base their immigration strategy on rela

217 stigated individual immigration decisions in crested macaques, a primate species with a high reproduc

218 2, OCT4, LGR5, TP63 (p63), as well as neural crest marker genes PSIP1 (p75(NTR)), PAX3, SOX9, AP2B1 (

219 normal human melanocytes express the neural crest marker p75 and become multipotent.

220 ambeosaurinae, suggesting that osseous nasal crests may require a highly specific combination of onto

221 that inhibition of eIF2B also drives neural crest migration and yeast invasiveness, our results sugg

222 By coupling studies of neural crest migration in vivo and in vitro with mathematical m

223 Similarly, NA transiently inhibits neural crest migration in Xenopus embryos in a Snail1-dependent

224 capzb is also required for trunk neural crest migration, as evident from melanophores disorganiz

225 ssion demonstrated the enhancement of neural crest migration.

226 cell morphology, differentiation and neural crest migration.

227 s optimum coincides with the width of neural crest migratory streams analyzed across different specie

228 The CREST model stratified patients immediately after resusc

229 Our model establishes the groove-crest modulation of tissue thickness as a morphometric p

230 yo, melanoblasts originating from the neural crest must traverse the dermis to reach the epidermis of

231 Neural crest (NC) cells arise early in vertebrate development,

232 Delamination of neural crest (NC) cells is a bona fide physiological model of e

233 features are modeled in mice carrying neural crest (NC) deletion of UTX, including craniofacial dysmo

234 dorsal pouch endoderm and neighboring neural crest (NC) mesenchyme.

235 A fundamental property of neural crest (NC) migration is contact inhibition of locomotion

236 eep sequencing in mouse, we find that neural crest (NC) only differentiates into vascular smooth musc

237 The neural crest (NC) represents multipotent cells that arise at th

238 his hypothesis, we ablated Fn1 in the neural crest (NC), a population of multi-potent progenitors exp

239 oducible derivation of neuroectoderm, neural crest (NC), cranial placode (CP), and non-neural ectoder

240 order that affects derivatives of the neural crest (NC).

241 d by abundance of adults and larvae of great crested newts (Triturus cristatus).

242 e microgap with respect to the alveolar bone crest, occlusion, and use of a polished collar have trad

243 cteristics, resembling neuroectoderm, neural crest, ocular-surface ectoderm, or surface ectoderm.

244 effect of the distance between the alveolar crest of a full-ceramic implant to the lowest point of t

245 ted 10 boulders of Ferrar Dolerite along the crest of the moraine and analyzed mineral separates of p

246 versal tubules (T-tubules) to the non-native crest of the sarcolemma, where their open probability wa

247 nd that incursion of marine water beyond the crest of this ridge, forming an ocean cavity beneath the

248 s that is remarkably comparable to the nasal crests of lambeosaurine hadrosaur dinosaurs.

249 isms, and strengthens a framework for neural crest ontogeny that is separable from neural and mesoder

250 he anterior mandibular-stream cranial neural crest or from multiple embryonic cell populations evolvi

251 PD/CMM-targeted cells share neural crest origin and melanogenesis capability.

252 this cell population, and point to a neural crest origin of dentine throughout the ancestral vertebr

253 The neural crest origin of DPSC makes them a useful source of prima

254 Neuroblastoma, an embryonal cancer of neural crest origin, shows metastases frequently at diagnosis.

255 agen-rich stroma of the cornea have a neural crest origin.

256 hildhood cancer derived from cells of neural crest origin.

257 mutant PDGFRA transgenes in cells of neural crest origin.

258 C-SURGE (PN-3682-021) and C-CREST Part C (PN-3682-011 and -012) were open-label, mul

259 often do not exhibit comparable early neural crest phenotypes.

260 lineage progenitors for neural plate, neural crest, placodes and epidermis.

261 xistence of a vagally derived enteric neural crest population in the lamprey.

262 Neural crest populations along the embryonic body axis of verte

263 lanocytes and melanoma cells toward a neural crest precursor-like state.

264 neage tracing to show that individual neural crest precursors are multipotent.

265 Neural crest precursors generate diverse cell lineages during d

266 n factors regulating multipotency and neural crest progenitor characteristics.

267 we show that cKit delineates cardiac neural crest progenitors (CNC(kit)).

268 in gene is expressed embryonically in neural crest progenitors (NCPs) and specifically reexpressed in

269 , through reprogramming of HCECs into neural crest progenitors by activating p120-Kaiso-RhoA-ROCK-can

270 inal tract are derived from dedicated neural crest progenitors that colonize the gut during embryogen

271 %) would have been excluded according to the CREST protocol (Carotid Revascularization Endarterectomy

272 Although CARM1 is expressed in the neural crest region in early development, coinciding with early

273 ive expression differences of crucial neural crest regulators.

274 ed versus observed probability of CED with a CREST score (coronary artery disease, initial heart rhyt

275 ment scan by tiling-deletion and sequencing (CREST-seq), for the unbiased discovery and functional as

276 At shallower reef crest sites (3-4 m), benthic community structure recover

277 vin-betaA ( Inhba(-/-)) and mice with neural crest-specific inactivation of Bmp4 ( Bmp4(ncko/ncko)) b

278 tor-alpha) under control of the sox10 neural crest-specific promoter.

279 ase CUL3 is an essential regulator of neural crest specification whose aberrant activation has been l

280 27 methylation, results in defects in neural crest specification, migration and craniofacial cartilag

281 ulation of multiple genes involved in neural crest specification, similar to the effects of Wnt1 knoc

282 of differentiating cells in favour of neural crest specification.

283 These neural crest stem cell (NCSC)-like cells display self-renewal c

284 Here we identify a neural crest stem cell niche that centers around the dorsal mid

285 Neural crest stem cells (NCSCs) and Schwann cells (NCSC-SCs) de

286 ic manipulation, from human epidermal neural crest stem cells [hEPI-NCSC(s)] present in the bulge of

287 Interestingly, neural and neural crest stem cells express distinct pluripotency signature

288 share many biological properties with neural crest stem cells.

289 In addition, the CREST study (Carbapenem-Resistant Enterobacteriaceae in

290 nificant dimensional changes in the alveolar crest that may preclude implant placement.

291 The ability of neural crest to contribute mesodermal derivatives to the baupla

292 eralizability of trials like the SAPPHIRE or CREST to the Medicare population may be limited, undersc

293 tional signature of the most invasive neural crest Trailblazer cells that is consistent during migrat

294 Altered Hand2 expression in the neural crest transformed the maxillae into mandibles with dupli

295 Smarcb1 loss in early neural crest was necessary to initiate tumorigenesis in the cra

296 Mean distance between PSAA and alveolar crest was the shortest in the 2(nd) molar region.

297 l study, trabecular bone biopsies from iliac crest were collected intra-operatively from 28 severe AI

298 migratory cell population called the neural crest, which arises from the edges of the central nervou

299 e regulatory program that imbues the cranial crest with its specialized features.

300 tion of neuroendocrine cells from the neural crest, with the secretory and basal cells being of uroge