ライフサイエンスコーパス: crevice

1 might indicate changes in the catalytic heme crevice.

2 ange in the B chain to expose the A3-related crevice.

3 rinse on neutrophil function in the gingival crevice.

4 e acidic residues close to the MTSEA binding crevice.

5 alternative orientations in the binding-site crevice.

6 the selectivity filter formed an interdomain crevice.

7 lso extends into the active-site hydrophobic crevice.

8 henicol binds to the exit tunnel hydrophobic crevice.

9 thereby contacts antibiotics bound at either crevice.

10 bulky oxidizing agent to the ligand binding crevice.

11 113), which lies deep within the active site crevice.

12 acids that are exposed to the ligand-binding crevice.

13 ntribute to the surface of this binding-site crevice.

14 ntribute to the surface of this binding-site crevice.

15 ifferentially accessible in the binding-site crevice.

16 ntribute to the surface of this binding-site crevice.

17 , M7) and form a cluster in the binding-site crevice.

18 from the alveolar crest toward the gingival crevice.

19 water-accessible surface of the binding-site crevice.

20 water-accessible surface of the binding-site crevice.

21 the cytoplasmic portion of the binding-site crevice.

22 in fields up to 1 mm closer to the gingival crevice.

23 ntribute to the surface of this binding-site crevice.

24 cupies the entire Y-shaped substrate-binding crevice.

25 cysteines are accessible in the binding site crevice.

26 resides in a negatively charged hydrophilic crevice.

27 abolism which can accumulate in the gingival crevice.

28 D2 receptor, is exposed in the binding-site crevice.

29 water-accessible surface of the binding-site crevice.

30 bstituent packs within a nonpolar interchain crevice.

31 r mutation Y220C creates a druggable surface crevice.

32 he targeting of an additional subsite in the crevice.

33 cysteines are accessible in the binding-site crevice.

34 t this site would destabilize the R-specific crevice.

35 water-accessible surface of the binding-site crevice.

36 egrees of openness of the corresponding heme crevice.

37 SEA modification occurred within the binding crevice.

38 surface of the water-accessible binding-site crevice.

39 ffinity CS-binding region within its central crevice.

40 water-accessible surface of the binding-site crevices.

41 ater molecules are mainly located in surface crevices.

42 water-accessible surface of the binding-site crevices.

43 ition of silver atoms on the ends and in the crevices.

44 lisecond dynamics of bound waters in protein crevices.

45 nt of the concept of high-dielectric aqueous crevices.

46 bic plug that separates the water-accessible crevices.

47 annels (1.5 mm x 1.6 mm x 0.1 mm) with small crevices (125 mum x 75 mum and 125 mum x 137 mum).

48 he distal site-a surface-exposed hydrophobic crevice 17 A away from the active site.

49 nstrate that flagella are able to reach into crevices, access additional surface area, and produce a

50 tion allows for the investigation of binding-crevice accessibility at position 278 and suggests that

51 Our data reveal the binding-crevice accessibility of residues T270 (7.35), A273 (7.3

52 The substitution occurs within a crevice adjoining the classical receptor-binding surface

53 bly other eNTPDases) contains a water-filled crevice allowing access of water and hydrophilic compoun

54 A set of residues lying along this crevice (amino acids 49, 50, and 53) is suggested to be

55 Finally, we have identified a hydrophobic crevice and a charged region at the tail of each protome

56 an N lobe and a C lobe to clamp RNA-binding crevice and exhibits two protruding extensions in both l

57 P-binding site maps to the side of the dimer crevice and extends to near the dimer interface.

58 4) and Phe(237) in TM5 face the binding-site crevice and form a metal-binding center with His(297) an

59 phyromonas gingivalis colonizes the gingival crevice and is etiologically associated with periodontal

60 ccessible on the surface of the binding-site crevice and is occluded by bound agonist.

61 how these cells live and die in the gingival crevice and periodontal pocket.

62 the Met80 heme ligand swung out of the heme crevice and replaced by a water molecule.

63 water-accessible surface of the binding-site crevice and that 9 of these are occluded by bound antago

64 rial plaque accumulation around the gingival crevice and the subsequent inflammation and destruction

65 ty of bacterial colonization in the gingival crevice and to explore the relationship between shifts i

66 m a directed survey of the human subgingival crevice and to isolate bacteria having rod-like morpholo

67 environment of the tunnel, revealing binding crevices and free-energy barriers for single amino acids

68 Finally, surfaces featuring crevices and peaks incorporate between 3.5 and 20 times

69 nctional lifespan of neutrophils in gingival crevices and periodontal pockets and therefore into the

70 mes body weight when traversing the smallest crevices and up to nearly 900 times body weight without

71 immobilized phenyl ligand into a hydrophobic crevice, and that this crevice is closed or tightened wh

72 ounding, development of prominent intercrypt crevices, and absence of apical mucus plugs.

73 The hydrophobic interactions in the binding crevice are much stronger than those observed in cyclode

74 The LMP1 motif is presented in the TRAF3 crevice as a close structural mimic of the PVQET motif i

75 somycin binds to the active-site hydrophobic crevice, as does the aromatic ring of puromycin, while t

76 l zone, which bends the tissue and creates a crevice at the blastopore lip.

77 rred to form the surface of the binding-site crevice based on our application of the substituted-cyst

78 ified regions surround the large hydrophobic crevice based on the NCS-1 crystal structure, this crevi

79 Cysteine is bound in a crevice between adjacent LbetaH domains and underneath a

80 The H+ is released into a water-filled crevice between helices IX and X which becomes transient

81 , EpsH contains at its surface a hydrophobic crevice between its variable and conserved beta-sheets,

82 3 domain loop and CD4 docks to a hydrophobic crevice between MHCII alpha2 and beta2 domains.

83 e-stranded DNA during continued unwinding; a crevice between RecB and RecC increasingly narrows durin

84 (+) (Kv) channel showed that lipids occupy a crevice between subunits.

85 the role of Val(A3), which projects within a crevice between the A- and B-chains.

86 CBR inhibitors target a crevice between the N-terminal portion of the bridge hel

87 e foot-like component and indicates that the crevice between the two lobes comprising the functional

88 e concentration of positive charge along the crevice between the two subdomains suggests that this co

89 ocking studies shows Na(V)beta1 lying in the crevice between the voltage-sensing and pore domains of

90 the N-phenethyl group of fentanyl deep in a crevice between transmembrane (TM) helices II and III wh

91 to a site located in an extracellular-facing crevice between transmembrane segments S2 and S3 in the

92 three elongated receptors snuggled into long crevices between pairs of monomers of the homotrimeric l

93 tor mechanisms but unexpectedly showed large crevices between subunits within the transmembrane (TM)

94 the (p-aminobenzoyl)glutamate (pABG) binding crevice by approximately 0.5 A.

95 erial diversity within the human subgingival crevice by comparing 264 small subunit rDNA sequences fr

96 t that became accessible in the binding-site crevice by use of methanethiosulfonate ethylammonium (MT

97 omal RNA genes (SSU rDNA) in the subgingival crevice by using quantitative PCR.

98 tors that are accessible in the binding-site crevices by the substituted cysteine accessibility metho

99 Asp17 is positioned in the crevice, close to the substrate thioester C=O, which in

100 re of residues 6.55-6.60 to the binding-site crevice, combined with the divergent amino acid sequence

101 tases and creates a deeper substrate binding crevice, consistent with the ability of InhA to recogniz

102 We follow "crevice corrosion" processes in real time in different p

103 material degradation and dissolution (e.g., crevice corrosion) of polycrystalline nonnoble metals, a

104 affected sextant as determined by probeable crevice depth (PD) at initial examination (IE).

105 -like regions at the ends of the interdomain crevice (elastase fold) are used by heparin to bridge th

106 udopilus with EpsH at its tip, the conserved crevice faces away from the helix axis.

107 th K in position 29 when found in saliva and crevice fluid can influence community biofilm compositio

108 ola to grow in a medium that mimics gingival crevice fluid, suggesting that the spirochaete may use s

109 s tunnel to the catalytic triad into a broad crevice for accelerated substrate entry and product exit

110 s 4 and 3 in the NK(2)R in forming a binding crevice for MTSEA.

111 tcrop surrounded by tropical forest use rock crevices for refuge and appear dorsoventrally compressed

112 ue for A. laevis may reflect its specialized crevice-foraging hunting technique.

113 tors, is contained within a water-accessible crevice formed among its seven membrane-spanning segment

114 tors, is contained within a water-accessible crevice formed among its seven membrane-spanning segment

115 tors, is contained within a water-accessible crevice formed among its seven membrane-spanning segment

116 tors, is contained within a water-accessible crevice formed among its seven membrane-spanning segment

117 ules, is contained within a water-accessible crevice formed among its seven transmembrane segments (T

118 CRs), is contained within a water-accessible crevice formed among its seven transmembrane segments (T

119 CRs), is contained within a water-accessible crevice formed among its seven transmembrane segments (T

120 g cleft located at the bottom of a 15-A-deep crevice formed between the N- and C-terminal lobes.

121 In the first structure, a positively charged crevice formed by loops 1 and 2 was identified as the si

122 is suggestive of a loose docking within the crevice formed by the open faces of the delta and delta'

123 ed conformation by a direct interaction at a crevice formed by the S4-S5 loop.

124 The mutation (a crevice-forming substitution at a conserved back surface

125 Our results suggest that intersubunit crevices found in the TM domain of the ATP-bound crystal

126 alyx (ECG) in images of the healthy gingival crevice (GC).

127 gs obtained from clinically healthy gingival crevices (GC-w) variably, but significantly, delayed apo

128 ly bond the two PDMS layers and seal off the crevices generated from the thickness of the membranes.

129 stride period only decreased at the smallest crevice height (4 mm), whereas slipping and the probabil

130 istent with Cys 34 being located in a narrow crevice in close proximity to an anionic charge.

131 nds to a previously unidentified hydrophobic crevice in mdm2.

132 the T(6) surface but within an intersubunit crevice in R-containing hexamers.

133 oposed to target a predominantly hydrophobic crevice in the "trimerization domain" of the GLAST monom

134 logue, there is a well-formed AdoHcy-binding crevice in the catalytic domain.

135 surface of the water-accessible binding-site crevice in the dopamine D2 receptor.

136 while the aglycone acceptor binds in a deep crevice in the N-terminal domain.

137 These results suggest a crevice in the p66 thumb subdomain of HIV-1 RT supports

138 es that form the surface of the binding-site crevice in the third and fifth membrane-spanning segment

139 cture possesses a pronounced electropositive crevice in the vicinity of the 3(10) helix, that might p

140 Cockroaches rapidly traversed crevices in 300-800 ms by compressing their body 40-60%.

141 pocket-finding algorithm to identify surface crevices in close proximity to residues determined to be

142 hat the electric field is focused by aqueous crevices in the channel protein.

143 he eyes are reduced in size, have furrows or crevices in the retina, and show a disturbed patterning

144 tion of amino acid residues into hydrophobic crevices in the RNA.

145 ening or closing of the ATP site or of other crevices in the S1 structure.

146 were docked into the PPDK N-terminal domain crevice, in an orientation consistent with substrate/cof

147 efficiently deployed by wedging them in reef crevices, in 1.5 to 7% of the time required for traditio

148 o compete with CD40 for binding to the TRAF3 crevice, influencing downstream signaling to B lymphocyt

149 This crevice is adjacent to the non-overlapping ganglioside-b

150 The crevice is amenable to protein engineering to further en

151 nd into a hydrophobic crevice, and that this crevice is closed or tightened when S1 is in the S1** Mg

152 absent from the A1, A2, and A3 domains, this crevice is shown to correspond to the ristocetin binding

153 ous poxvirus D8 orthologs revealed that this crevice is structurally conserved.

154 anometer proximity or have coalesced to form crevices, is paramount to achieving maximum SERS enhance

155 which forms one wall and the floor of a long crevice leading from the active-site loop.

156 inding site within the Fab formed a distinct crevice lined by a high proportion of apolar amino acids

157 nd is bound by the SH3-like domain in a deep crevice lined by aliphatic amino acid residues and passe

158 The two beta-sheets pack together to form a crevice, lined with conserved hydrophobic residues: we s

159 icted model, that RNA binds in a deep, basic crevice located entirely within the N-terminal domain.

160 Docking of DHPs inside this crevice located the DHP ring between Phe-1159 of IIIS6 a

161 e located in three symmetrically placed deep crevices located at the interface of two adjacent subuni

162 st adjustments to the main chain of the heme crevice loop and is facilitated by a trimethyllysine 72-

163 utation of Tml72 (yK79H variant) in the heme crevice loop to Ala72 (WT*K79H variant) affects the dyna

164 e based on the NCS-1 crystal structure, this crevice may be the association site of KChIPs for the ch

165 movement, it has been suggested that aqueous crevices may penetrate the protein, reducing the extent

166 tors revealed that around the biaryl, a fine crevice might exist in the gp120 binding site.

167 ariants Met102-->Ala and Leu133-->Gly, and a crevice mutant, Phe104-->Ala, were further characterized

168 Positively charged crevices near the active site may explain the enzyme's p

169 -bound protein allows an exposed hydrophobic crevice, near the membrane surface, to serve as a potent

170 High-speed videography revealed crevice negotiation to be a complex, discontinuous maneu

171 Midway between these crevices, nucleotide A2103 of H.marismortui (2062 Escher

172 , one c-di-GMP molecule binds to the central crevice of a STING dimer, using a series of stacking and

173 ically with the lysines surrounding the heme crevice of Cc.

174 cidic residues on opposite sides of the heme crevice of cytochrome c(1) are involved in binding posit

175 The central positively charged crevice of D8 was predicted to be the CS binding site by

176 VACV-304-binding sites along the CS-binding crevice of D8, combined with different efficiencies of b

177 antagonists are anchored in the interdomain crevice of GBR1 by an overlapping set of residues.

178 A crevice of hydrophobic residues linking the polar edge o

179 mobile C-terminal helix inside a hydrophobic crevice of NCS-1 to impede Ric8a interaction.

180 F1-11 can bind to the edge of and within the crevice of the active site of MPO.

181 late group of the subunit into the conserved crevice of the chaperone cleft and the subsequent positi

182 teine becomes accessible in the binding site crevice of the constitutively active beta2 receptor.

183 at the Pi binding site is located within the crevice of the PPDK N-terminal domain, at a site that is

184 ifferentially accessible in the binding-site crevice of these receptors.

185 er loop of kallistatin bound to the reactive crevice of tissue kallikrein indicated that the P2 resid

186 e-repulsion mutation in the receptor-binding crevice of TRAF3 ablated binding of both LTbetaR and NIK

187 f propionic and butyric acid in the gingival crevices of periodontal subjects with severe and mild di

188 tly colonized the 3-D surface, localizing to crevices of the EEC model and interacting with multiple

189 n of residues accessible in the binding-site crevices of these receptors by the substituted cysteine

190 uminal domain which binds to a saddle-shaped crevice on a distal tip of BoNT/B.

191 the D2R peptide bind within the hydrophobic crevice on Ca(2+)/NCS-1, but only one copy of the GRK1 p

192 Lys249, Arg307, and Lys311 flanking a small crevice on the p66 thumb subdomain outside the primer-te

193 of the cofactor resides in a solvent-exposed crevice on the protein surface and makes contact with a

194 HveA-Y23 fits into a crevice on the surface of gD and was previously shown to

195 nd HveA-Y23, a residue that protrudes into a crevice on the surface of gD.

196 recognition is mediated in the same binding crevice on the surface of TRAF3.

197 n BAFF-R is accommodated in the same binding crevice on TRAF3 that binds two related TNFRs, CD40 and

198 The PQQAT motif is bound in the same binding crevice on TRAF3 where CD40 is bound, providing a molecu

199 rahydrofuran and acetonitrile molecules into crevices on the enzyme surface and especially into the a

200 ic stability of the receptor by wedging into crevices on the hydrophobic surface of A2AR, increasing

201 f organisms that may recolonize the gingival crevice once antibiotic therapy is complete.

202 Two hydrophobic crevices, one at the peptidyl transferase center and the

203 reserve the structural integrity of the heme crevice: only the nonfunctional His variant allows carbo

204 Thus, the mechanism of heme crevice opening depends upon the position of the ligand

205 T*K79H variant) affects the dynamics of heme crevice opening through a small destabilization of both

206 aking direct contact with the NAD(+)-binding crevice or the donor loop.

207 raphies, where they rapidly became lodged in crevices or cemented to the benthos by encrusting organi

208 P. borchgrevinki by blowing air into subice crevices or pursued them into the platelet ice.

209 Water-filled crevices penetrating into the interior of the membrane-s

210 s which lose their viability within gingival crevices, periodontal pockets and the oral cavity die by

211 s collected from clinically healthy gingival crevices, periodontal pockets, and the oral cavity (sali

212 horter (> or = 40%), consistent with aqueous crevices pervading both the extracellular and intracellu

213 charged residues located in the RNA-binding crevice play a key role in RNA binding and virus replica

214 ed flow, or how surface topography (grooves, crevices, pores) influence QS-mediated communication.

215 ty in these acceptor substrates binds to the crevice present at the acceptor substrate binding site o

216 These crevices reduce substrate surface area available to the

217 By varying substrate crevice sizes, we determine the conditions under which h

218 We challenged cockroaches with horizontal crevices smaller than a quarter of their standing body h

219 ic acid (LXA(4)) was applied to the gingival crevice subject to periodontitis.

220 77 binds adjacent to the BH3 peptide-binding crevice, suggesting the possibility of cross-talk betwee

221 eric factors that permit opening of the heme crevice, suggests that higher organisms have evolved to

222 disulfide bond is deeper in the binding-site crevice than is the N-terminal part of E2.

223 main generates an intimate substrate-binding crevice that allows for recognition and dephosphorylatio

224 p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilize

225 vaginalis ferredoxin (Tvfd) showed a unique crevice that exposed the redox center.

226 ite in doubly-wound alpha/beta folds forms a crevice that is located at the switch point between the

227 rhelical hydrogen bonds and a ligand-binding crevice that is partially covered by a beta-hairpin form

228 almitoylation site and near to an interhelix crevice that is typical of cholesterol binding sites.

229 syntrophic relationships in the subgingival crevice that promote colonization by secondary fermenter

230 ly adaptive "hot spots" in the TRAF3-binding crevice that promote molecular interactions driving spec

231 iative interactions with a number of surface crevices that are generally between secondary structural

232 ly by inducing the formation of water-filled crevices that extend into the interior of the protein.

233 opens up the possibility of probing the deep crevices that occur in microelectronic circuits, and the

234 avity of the Met102-->Ala mutant into a deep crevice through an additional substitution, but the doub

235 ion of how the introduction of submicrometer crevices to a surface affects attachment of Escherichia

236 After traversing horizontal crevices to enter a vertically confined space, cockroach

237 glycans, whereas in the second structure the crevice was not evident as loops 1 and 2 adopted differe

238 hours in the presence or absence of gingival crevice washings (GC-w) to study the effect of GC-w on n

239 and so may protrude beyond the A3-associated crevice, we investigated analogs containing A3 substitut

240 y interact with residues in the main binding crevice, we show that the 7TM-conserved bridge is essent

241 he most part, the newly created peri-implant crevices were colonized by specific bacteria within 2 we

242 ng Cys-285 to the margin of the binding site crevice where it becomes accessible to MTSEA.

243 cellular portion of M6 into the binding-site crevice where it would be more broadly accessible than t

244 Its ecological niche is the gingival crevice, where the organism adapts to the challenges of

245 Dimerization leads to a large, bowl-shaped crevice, which might be involved in vivo in protecting s

246 e sites of the dimer are connected by a long crevice, which might indicate its potential ability to a

247 f the substrate ligand are bound in a narrow crevice while the nucleotide moiety rests on the protein

248 h-affinity lock-and-key mechanism above this crevice with an unusually large antibody-antigen interfa

249 chains are accommodated within a native-like crevice with minimal distortion.

250 /32 can be attributed to a shallower binding crevice with reduced positive electrostatic charge.

251 nt side chain remains buried in a nativelike crevice with small adjustments in surrounding side chain

252 gating arginines on S4 toward a water-filled crevice within the VSD and allows salt-bridge interactio

253 included only areas adjacent to the gingival crevice, without knowledge or quantitation of alveolar c