ライフサイエンスコーパス: cripple

1 rbamoyl phosphate and the rest were severely crippled.

2 frequent when the apoptotic mechanisms were crippled.

3 ypes, and virus production was significantly crippled.

4 t porphyria occasionally causes frequent and crippling acute neurovisceral attacks associated with in

5 contrast, G50A and G50C viruses are severely crippled and form much smaller plaques.

6 Cre recombinase ("on-state"), the intron is crippled and the target gene is disrupted by a series of

7 spread by engaging machinery that ultimately cripples and kills infected cells, yet they are also pos

8 steolysis with carpal and tarsal resorption, crippling arthritic changes, marked osteoporosis, palmar

9 In time, a debilitating, crippling arthritis, hemophilic arthropathy, develops.

10 onstrate that different Jbeta substrates are crippled at different steps of cleavage by distinct comb

11 In addition, mutants of PLC-beta3 with crippled autoinhibition dramatically accelerated the hyd

12 In this study, we crippled autophagy in HSCs by conditionally deleting the

13 lococcus aureus therapy that can effectively cripple bacterial infection, neutralize secretory virule

14 ntiating Hag secretion, the mutation of fliS crippled both motility and flagellar filament assembly,

15 Mutations that crippled both the EBS and GC box suppressed both basal a

16 nsp16 interaction was disturbed proved to be crippled but viable.

17 en Cln proteins, we compared CLN2, CLN3, and crippled (but still partially active) CLN2 genes in a ra

18 when the Sln1p/leucine zipper construct was crippled by a mutation of one of the internal leucines,

19 leverage the power of these technologies is crippled by the absence of suitable 'front-end' methods

20 ten structurally preserved, but functionally crippled, by CDKN2A/ARF loss in melanoma, rescue of p53

21 pecifically target only ICL1 are unlikely to cripple C. neoformans growth in vivo.

22 Defects in cytoskeletal proteins can cripple cell strength and may cause cardiomyopathy.

23 s the chromatin binding ability of GATA3 but cripples chromatin reprogramming ability, resulting in f

24 This crippled CI was shown to lack subunits of the "N assembl

25 viral genome disrupted cohesin binding, and crippled colony formation in 293 cells.

26 revealed the presence of a faster migrating crippled complex.

27 rt protein, while the Cys154-->Gly mutant is crippled conformationally.

28 ncreases the dimensionality of the models to crippling degrees, and typically are not validated again

29 scent lifetime measurements circumvented the crippling dimness of an ER-tuned fluorescent redox-respo

30 ng, more individuals are forced to live with crippling disability resulting from the stroke.

31 a clear conclusion as to the nature of this crippling disease has yet to be identified.

32 A crippling dwarfism was first described in the Miniature

33 y one million children each year and imposes crippling economic burdens on families and nations world

34 In this study we show that loss of Id2 cripples effector differentiation and instead programs C

35 t it also overcomes memory issues that would cripple existing tools.

36 evoid of gamma134.5 or its amino terminus is crippled for viral growth and release.

37 c lethality interactions with mutations that cripple genes involved in DNA replication and DNA double

38 ical Hodgkin lymphoma (cHL) as derived from "crippled" germinal center B cells that have frequently a

39 a species and that perturbation of this site cripples heterochromatic gene silencing.

40 histone H3 mutants enhances silencing at the crippled HMR locus HMRae via restoring Sir binding and t

41 utations that cause increased silencing of a crippled HMR silencer in a rap1 mutant background.

42 NKX2-5 mutants, including those with a crippled homeodomain, bound hundreds of targets includin

43 ) is the causative agent of poliomyelitis, a crippling human disease known since antiquity.

44 ns, and propose that Tat-induced suppression cripples immune surveillance to HIV infection.

45 4A) resulted in an enzyme which was severely crippled in catalysis, in agreement with its position as

46 ly subjected to LPS triggering were severely crippled in IL-12 and TNF-alpha production, a result of

47 uld be reduced artificially but was severely crippled in its ability to be reduced by physiological e

48 CVD 908-htrA in tissue culture and was more crippled in its ability to proliferate after invasion.

49 nds the TRS far less tightly and is severely crippled in its RNA unwinding activity.

50 e of these 2 mutants (and 2 others that were crippled in other RanBP1 functions) retained some abilit

51 boring mutations within two C/EBP sites were crippled in their ability to replicate in U937 promonocy

52 inity of Cdc42 for intersectin, yet severely cripples interaction with Dbs, a normally potent exchang

53 Fortuitous yet crippling interactions between an IRES and surrounding h

54 Sli15 phenocopies mutations that selectively cripple Ipl1 kinase activation.

55 hey had overwhelming air superiority and had crippled Iraq's command and control capability).

56 thionine-binding site of PRMT1 substantially crippled its nuclear receptor coactivator activity.

57 cterized as interacting with Hoxc-8 and then crippling its DNA-binding ability.

58 redominant nuclear localization of Tmod-1 by crippling its nuclear export mechanism.

59 a significant step forward in overcoming the crippling limitation of nitrogenase's sensitivity toward

60 ation and few mtDNA repair mechanisms exist, crippling mitochondrial mutations are exceedingly rare.

61 els, which then signaled via PKA and Epac to cripple MPhi phagocytosis and interfered with cytoskelet

62 new connection between dormancy, ABA, and a cripple mucilage formation due to a naturally occurring

63 is a dramatic neuromuscular disease in which crippling muscle weakness is evident from birth.

64 us (CHIKV), a reemerging arbovirus, causes a crippling musculoskeletal inflammatory disease in humans

65 as a second-site reverent when catalytically crippled mutants, E165D and H95N, were subjected to rand

66 he central nervous system are among the most crippling neurological diseases affecting patients at va

67 Crippled, non-replicative viruses have been used as vect

68 owever, tumors often evade immune control by crippling normal DC function.

69 ogates the SUMO conjugation pathway, broadly crippling nuclear function in proliferating cells of the

70 rgeting of this axis was associated with the crippling of several other signaling axes.

71 et for induction of CXCR3 downregulation and crippling of Th1 cells.

72 ations that either restored the asymmetry or crippled one PIF binding site.

73 e were replaced with oligo-U loops, severely crippling or ablating the native RNA splicing function.

74 euronal function and survival and often have crippling or fatal consequences.

75 ly 50 years ago in two sisters with a severe crippling osteolysis.

76 ds to compromised p53 acetylation as well as crippled p53 transcriptional activation, accumulation an

77 ds to compromised p53 acetylation as well as crippled p53 transcriptional activation, accumulation, a

78 The hallmark of alphavirus disease is crippling pain and inflammation of the joints, a similar

79 The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an e

80 , and debilitating arthritis associated with crippling pains that persist for weeks and even years.

81 r hexamethylene amiloride than were the more crippled parental viruses with the single alanine insert

82 A crippled parvovirus vector was constructed, based on a c

83 ly, selective disruption of this short-helix crippled PDLIM2 in shutting Tax to the nuclear matrix fo

84 ording to Krauss, this left a void that will cripple, perhaps fatally, any early effort to ensure lon

85 nction to alter host actin dynamics and thus cripple phagocytosis.

86 tal inflammatory responses and concomitantly crippling phagocytosis, a primary mechanism used by thes

87 idues resulted in viruses with significantly crippled phenotypes and proteins that failed to assemble

88 e most common group O alleles share a common crippling polymorphism, a growing number of alleles feat

89 eous population of natively folded RNAs is a crippling problem encountered when preparing RNAs for st

90 The crippled protease activity of Casp9-TM in the presence o

91 wo-thirds of the Gal4AD (gal4D) results in a crippled protein with only 3% the activity of the wild-t

92 e Rbf1, but strikingly, these mutations also cripple repression activity.

93 hat delta hly and prfA mutants were the most crippled, requiring 100-fold more mutant bacteria than w

94 oduce IL-5, IL-13, and IL-22 and resulted in crippled responses to intestinal infection with Citrobac

95 ry (92.6% vs 63.0%; P = .001), and long-term crippling sequelae (55.6% vs 15.2%; P < .001).

96 the high proportion (55.6%) of patients with crippling sequelae.

97 ance against T cell-mediated killing because crippling signaling capacity of B7-H1 but not PD-1 ablat

98 bditis elegans C02H7.2 expressed a series of crippling substitutions in the matrix, strongly suggesti

99 restore Ser51 phosphorylation by PKR with a crippled substrate-binding site.

100 measuring and understanding some of the most crippling symptoms of some of the most debilitating illn

101 ET, APE, lamins, and histones, are likely to cripple the cellular repair response to promote cell dea

102 PKR mutations that cripple the eIF2alpha-binding site impair phosphorylatio

103 the deterioration of adjacent joints and may cripple the long-term function of the lower extremity.

104 tuberculosis might be assisted by drugs that cripple the pathway by which Mtb buffers, sequesters, an

105 ative action in the admissions process would cripple the profession's ability to achieve racial and e

106 native receptor interactions, however, would cripple the virus for growth in production cells.

107 mutations and histone deacetylase mutations crippled the association of Tup1 with target loci.

108 Yeast producing DppIVA crippled the recruitment and differentiation of monocyte

109 d by insertion of arginines, which initially crippled the resulting protein, but red fluorescence cou

110 ired for interaction with compound I-XW-053, crippled the virus at an early, preintegration step.

111 at the carboxyl end of the cytoplasmic tail cripples the ability of EBV to cause lymphoblastoid cell

112 ssion of multiple virulence determinants and cripples the ability of the organism to adapt to the hos

113 on of specific amino acids within this motif cripples the antitumor actions of GRIM-19.

114 nation and degradation of p53 by Hdm2, which cripples the cellular p53-mediated antiviral response.

115 deed, a dominant negative mutant of KCNQ4_v1 cripples the currents of the entire KCNQ4 channel family

116 us deletion of the S1 and KH domains further cripples the enzyme with respect to RNA substrates.

117 ene encoding NIK in alymphoplasia (aly) mice cripples the function of NIK in p100 processing, causing

118 argeted mutation in Gata4 (Gata4(ki)), which cripples the GATA4-FOG2 interaction, exhibit a profound

119 ebilitating disease that in its final stages cripples the patient.

120 Crippling the AdnA phosphohydrolase active site did not

121 ) IL-27 exerts immunosuppressive activity by crippling the Ag processing machinery in immature DCs un

122 he virus usually wins the race, irreversibly crippling the immune system before an effective cellular

123 Crippling the program genetically or pharmacologically i

124 ed the attenuation of the Deltalpp mutant by crippling the spread of the double mutant to the periphe

125 was diminished when we mutated the TATA box, crippling transcription.

126 g RAS mutations may propagate immunoglobulin-crippled tumour cells, which usually represent a minorit

127 s accessibility control element function and cripples V(D)J recombination of chromosomal gene segment

128 hemical reductants rescued the catalytically crippled variant form in both of these reactions.

129 virus trigger cellular defense responses to cripple viral replication, and viruses have evolved coun

130 placement of all three cysteines resulted in crippled virus with significantly reduced yields.

131 genous NEDD4L inhibited the release of these crippled viruses and led to cytokinesis defects.

132 WI/SNF, whereas the functioning of ARS121 is crippled when SWI/SNF is inactivated.

133 evolutionised management of elderly patients crippled with arthritis, with very good long-term result

134 Both pseudogene exons are multiply crippled with RNA splice sites destroyed, and open readi