ライフサイエンスコーパス: crippled

1 frequent when the apoptotic mechanisms were crippled.

2 ypes, and virus production was significantly crippled.

3 rbamoyl phosphate and the rest were severely crippled.

4 contrast, G50A and G50C viruses are severely crippled and form much smaller plaques.

5 Cre recombinase ("on-state"), the intron is crippled and the target gene is disrupted by a series of

6 onstrate that different Jbeta substrates are crippled at different steps of cleavage by distinct comb

7 In addition, mutants of PLC-beta3 with crippled autoinhibition dramatically accelerated the hyd

8 In this study, we crippled autophagy in HSCs by conditionally deleting the

9 ntiating Hag secretion, the mutation of fliS crippled both motility and flagellar filament assembly,

10 Mutations that crippled both the EBS and GC box suppressed both basal a

11 nsp16 interaction was disturbed proved to be crippled but viable.

12 en Cln proteins, we compared CLN2, CLN3, and crippled (but still partially active) CLN2 genes in a ra

13 when the Sln1p/leucine zipper construct was crippled by a mutation of one of the internal leucines,

14 leverage the power of these technologies is crippled by the absence of suitable 'front-end' methods

15 ten structurally preserved, but functionally crippled, by CDKN2A/ARF loss in melanoma, rescue of p53

16 This crippled CI was shown to lack subunits of the "N assembl

17 viral genome disrupted cohesin binding, and crippled colony formation in 293 cells.

18 revealed the presence of a faster migrating crippled complex.

19 rt protein, while the Cys154-->Gly mutant is crippled conformationally.

20 evoid of gamma134.5 or its amino terminus is crippled for viral growth and release.

21 ical Hodgkin lymphoma (cHL) as derived from "crippled" germinal center B cells that have frequently a

22 histone H3 mutants enhances silencing at the crippled HMR locus HMRae via restoring Sir binding and t

23 utations that cause increased silencing of a crippled HMR silencer in a rap1 mutant background.

24 NKX2-5 mutants, including those with a crippled homeodomain, bound hundreds of targets includin

25 4A) resulted in an enzyme which was severely crippled in catalysis, in agreement with its position as

26 ly subjected to LPS triggering were severely crippled in IL-12 and TNF-alpha production, a result of

27 uld be reduced artificially but was severely crippled in its ability to be reduced by physiological e

28 CVD 908-htrA in tissue culture and was more crippled in its ability to proliferate after invasion.

29 nds the TRS far less tightly and is severely crippled in its RNA unwinding activity.

30 e of these 2 mutants (and 2 others that were crippled in other RanBP1 functions) retained some abilit

31 boring mutations within two C/EBP sites were crippled in their ability to replicate in U937 promonocy

32 hey had overwhelming air superiority and had crippled Iraq's command and control capability).

33 thionine-binding site of PRMT1 substantially crippled its nuclear receptor coactivator activity.

34 as a second-site reverent when catalytically crippled mutants, E165D and H95N, were subjected to rand

35 Crippled, non-replicative viruses have been used as vect

36 ations that either restored the asymmetry or crippled one PIF binding site.

37 ds to compromised p53 acetylation as well as crippled p53 transcriptional activation, accumulation an

38 ds to compromised p53 acetylation as well as crippled p53 transcriptional activation, accumulation, a

39 r hexamethylene amiloride than were the more crippled parental viruses with the single alanine insert

40 A crippled parvovirus vector was constructed, based on a c

41 ly, selective disruption of this short-helix crippled PDLIM2 in shutting Tax to the nuclear matrix fo

42 idues resulted in viruses with significantly crippled phenotypes and proteins that failed to assemble

43 The crippled protease activity of Casp9-TM in the presence o

44 wo-thirds of the Gal4AD (gal4D) results in a crippled protein with only 3% the activity of the wild-t

45 hat delta hly and prfA mutants were the most crippled, requiring 100-fold more mutant bacteria than w

46 oduce IL-5, IL-13, and IL-22 and resulted in crippled responses to intestinal infection with Citrobac

47 restore Ser51 phosphorylation by PKR with a crippled substrate-binding site.

48 mutations and histone deacetylase mutations crippled the association of Tup1 with target loci.

49 Yeast producing DppIVA crippled the recruitment and differentiation of monocyte

50 d by insertion of arginines, which initially crippled the resulting protein, but red fluorescence cou

51 ired for interaction with compound I-XW-053, crippled the virus at an early, preintegration step.

52 g RAS mutations may propagate immunoglobulin-crippled tumour cells, which usually represent a minorit

53 hemical reductants rescued the catalytically crippled variant form in both of these reactions.

54 placement of all three cysteines resulted in crippled virus with significantly reduced yields.

55 genous NEDD4L inhibited the release of these crippled viruses and led to cytokinesis defects.

56 WI/SNF, whereas the functioning of ARS121 is crippled when SWI/SNF is inactivated.

57 evolutionised management of elderly patients crippled with arthritis, with very good long-term result

58 Both pseudogene exons are multiply crippled with RNA splice sites destroyed, and open readi