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1 sses used for its benefit-risk assessment is critical.
2 ptake of HIV testing among youths at risk is critical.
3 hree important minor metals often considered critical.
4 rnative, lower energy approaches are equally critical.
5 The use of Cs2CO3 as base is critical.
6 d, then the adaptive immune responses became critical.
8 s a specialized form of autophagy, providing critical amino acids that activate mTOR and enable the m
13 rast agents have been widely used to provide critical assessments of disease for both clinical and ba
14 ehavioral disorders, and that dynamics are a critical axis of manipulation for causal optogenetic stu
16 plicing factor, Ptbp1, revealed that it is a critical barrier for the acquisition of cardiomyocyte-sp
19 racterization of DNA microviscosity provides critical biophysical insights into nuclear crowding, nuc
20 Our studies offer a glimpse into how these critical bone cells respond to mechanical load in vivo,
21 al hotspots, which ultimately leads to their critical, but poorly recognized role in regional greenho
22 tudy shows major concerns in the delivery of critical care across Latin America, particularly in huma
24 ions addressed by IOM-compliant pulmonary or critical care guidelines were addressed by expert panels
25 d, and their relationships to the receipt of critical care intervention and inhospital mortality were
29 phen thus produces modest fever reduction in critical care patients, along with clinically important
32 1 (BECN1) is a key regulator of autophagy, a critical catabolic homeostasis pathway that involves seq
35 UAS1), then it subsequently binds to UAS2 (a critical cis-regulatory site located approximately 600 b
36 veal SMURF2 as an important regulator of the critical communication between osteoblasts and osteoclas
39 act with the membrane fusion protein AcrA, a critical component of the AcrAB-TolC efflux pump in Esch
41 on these results, we conclude that Hop is a critical component of the piRNA pathway and that it main
43 nd stability is increasingly recognized as a critical control point in dynamically altering gene expr
44 ntrol procedures such as the Hazard Analysis Critical Control Point system by seafood companies, the
45 erent coupling regions, and does not require critical coupling at both or at any one of the two coupl
48 provide a high-resolution structure of this critical cytokine and we reveal its functional interacti
52 thesis that the P2X7-PANX1 pore complex is a critical determinant of spreading depolarization suscept
53 neurons to dissect/identify NPC subtypes and critical developmental stages of alternative lineage spe
56 ion channels, however new evidence points to critical effects on intra-neuronal microtubules, a targe
57 tial for a wide impact on science, and are a critical element for unravelling the structural dynamics
58 the distribution of tree species because of critical environmental tolerances related to growth, mor
60 culating cells within the vascular wall is a critical event in chronic inflammatory processes, such a
61 Transformation to aggressive lymphoma is a critical event in the clinical course of follicular lymp
65 s during infection in vivo Macrophages are a critical first line of defense against respiratory patho
68 ons demonstrate that tyrosine 470 and 88 are critical for allosteric modulatory effects of SRI-compou
69 e at the Phe position in the alpha1-helix is critical for alphaLbeta2 activation because trimming the
71 Chloride transport by the renal tubule is critical for blood pressure (BP), acid-base, and potassi
73 ted by polyrhamnose polysaccharides that are critical for cell envelope integrity and cell shape and
74 ion factor that controls expression of genes critical for cell survival under hyperosmotic conditions
75 ate interpretation of pathogenic variants is critical for delivering solid clinical molecular diagnos
77 imely exit of these proteins from the TGN is critical for effective pre-invasive immune responses aga
83 orona diameter and select the smallest size, critical for favoring protein-protein contacts and trigg
84 essential internal RNA modification that is critical for gene expression control in most organisms.
85 ) and androstenedione (Andro), respectively, critical for generating glucocorticoids and androgens.
86 el accrual, while disengagement from ZO-1 is critical for GJ channel closure and transitioning GJ cha
92 g cancer tissues and its expression level is critical for lung cancer cell proliferation, which may s
93 GA signaling in the somatic anther tissue is critical for male meiotic cell wall formation and thus p
95 me b5 reductase 3 expression and activity is critical for NO-stimulated cGMP production and vasodilat
96 hanisms controlling cardiac specification is critical for our understanding of how heart formation is
97 extent of breast cancer by a pathologist is critical for patient management for tumor staging and as
98 a core hub of the "salience network" that is critical for perception of interoceptive signals and emo
99 ic diversity of mycorrhizal fungi, which are critical for plant fitness, biogeochemical cycling and o
100 Mitotic rounding during cell division is critical for preventing daughter cells from inheriting a
101 FICANCE STATEMENT Neuronal energy levels are critical for proper CNS function, but the relative roles
102 ine generated by cells at the injury site is critical for protection from IRI through bone marrow-der
103 oliferation and migration responses that are critical for regeneration by targeting proregenerative P
104 patient resuscitation preferences on issues critical for researchers and research consumers to under
105 Convenient and intuitive data interfaces are critical for researchers to easily upload, analyze and v
107 ecent work has consistently shown XIAP to be critical for signaling downstream of the Crohn's disease
109 at the presence of SOS1/EPS8/ABI1 complex is critical for sustained EMT traits of ovarian cancer cell
110 intestinal polypeptide (VIP), a neuropeptide critical for synchrony in the adult SCN, and its recepto
111 scanning mutation of Epep revealed residues critical for Tbx3, Klf4 and Esrrb transcript repression,
113 fluid transport through porous materials is critical for the development of lateral flow assays and
115 the RNA, rather than an encoded protein, is critical for the eventual recovery of transcription.
119 sition occupied by W972 within WT Arkadia is critical for the function of RING and that it depends on
121 f the viral 5' untranslated region (UTR), is critical for the initiation of dengue virus replication,
123 beta-mediated cell cycle arrest, yet remains critical for the pathological, EMT-inducing arm of TGFbe
124 ruitment via settlement of pelagic larvae is critical for the persistence of benthic marine populatio
126 aunting challenge for clinicians but will be critical for the success of disease-modifying therapies.
128 vealed that an "aromatic key" of nectin-2 is critical for this interaction, whereas variations in the
130 the study of protein acetylation dynamics is critical for understanding of how this modification infl
131 Studies of protein unfolding mechanisms are critical for understanding protein functions inside cell
132 ticular, magnetic resonance imaging (MRI) is critical for visualizing soft tissue and organs, with ov
136 and zygotic knockout further revealed Aire's critical functions for spindle assembly in preimplantati
137 rs transcribed in breast cancer cells direct critical gene regulatory networks that promote pathogene
139 ignificantly increased the expression of two critical gluconeogenic enzymes, phosphoenolpyruvate carb
142 y, and was confirmed by the test against the critical HR being more than 2.03 (p=0.003 for the reduce
145 ted with susceptibility to influenza-related critical illness in children or with critical illness se
146 Delirium is a prevalent complication of critical illness in children, with identifiable risk fac
150 dence that complement activation serves as a critical immunomodulator in lung cancer progression, act
151 es that the presence of CD4(+) T cells is of critical importance but mast cells, antibodies, and baso
152 isms that drive behavioral dysfunction is of critical importance for quantitative diagnosis and syste
155 he ability to synthesize and test FAHFAs was critical in elucidating the roles of these lipids, but t
156 erals and associated biological materials is critical in geomicrobiology and environmental research.
160 y release GLP-1 (glucagon-like peptide 1), a critical incretin that regulates blood glucose homeostas
161 eutic and diagnostic interest, but obtaining critical information from the physiologically relevant h
162 heir evolution [1], has been one of the more critical innovations contributing to their extraordinary
163 level of understanding of miRNA biology and critical insights into the many translational applicatio
168 ironments worldwide will continue to provide critical knowledge about the factors that impact the nat
169 overcome a critical threshold, i.e. above a critical magnetic field or a critical current for superc
170 luences islet function and survival and is a critical marker of islet integrity following rodent isle
172 miscuous activator on cryptic promoters is a critical mechanism for specifying precise gene activatio
175 ding to recent experience is thought to be a critical mechanism supporting long-term memory stabiliza
176 ontrast to the p19ARF-MDM2-p53 pathway, is a critical mediator of colorectal tumorigenesis following
181 using standardized, systematic methods, are critical, particularly from low- and middle-income conte
182 ssue hypertrophy and hyperplasia for health, critical pathways and mechanisms in (involuntary) adipos
184 s are thought to play a key role during the "critical period" of brain development, the nature and ti
186 al neuronal functions.SIGNIFICANCE STATEMENT Critical periods are developmental windows of opportunit
188 m the protoplanetary disk, would constrain a critical phase of planetary formation by unveiling the u
189 mechanisms enabled by defects, size effects, critical phenomena, anharmonicity, and the spin degree o
191 ower of an ultrashort laser pulse, P, to the critical power of self-focusing, Pcr, playing the role o
194 ; however, its applicability as a method for critical quality and comparability assessment has until
199 These data implicate cAMP signaling as a critical regulator of genomic stability against platinum
201 studies identify SHP1 and SYK crosstalk as a critical regulator of MyD88 post-translational modificat
203 in ascites, we show that IRF4 and MAFB were critical regulators of monocyte differentiation into mo-
204 d we found that miR172-AP2, miR156-SPLs were critical regulatory nodes contributing to the diversity
206 also reveals the presence of this motif with critical residues in the homolog of other Helicobacter g
207 ced expression or loss of phosphorylation at critical residues of different classes of specific trans
210 etic loss-of-function experiments revealed a critical role for FOXO transcription factors in mediatin
213 ger polySia chains on SynCAM 1, suggesting a critical role for polyST autopolysialylation in substrat
218 hondria-associated ER membrane (MAM) plays a critical role in cellular energetics and calcium homeost
219 Epigenetic regulation of chromatin plays a critical role in controlling embryonic stem (ES) cell se
222 khead box transcription factor FOXC1 plays a critical role in embryogenesis and the development of ma
223 tion in caveolae biogenesis, Cavin-2 plays a critical role in endothelial cell maintenance and functi
224 virus (HBV)-encoded X protein (HBx) plays a critical role in HBV-related hepatocarcinoma development
225 Here, we show that BMP signaling plays a critical role in looping morphogenesis of the avian smal
226 Therefore, we suggest that SHANK3 has a critical role in neuronal morphogenesis in placodal neur
229 t WASp is a novel substrate of ALK and has a critical role in regulating invasiveness and oncogenesis
230 tly, it has been reported that GSDMD plays a critical role in regulating lipopolysaccharide and NLRP3
231 Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the
232 nom peptide toxins such as conotoxins play a critical role in the characterization of nicotinic acety
233 xxphi motif, but not dileucine motif, play a critical role in the earliest stages of AP2 activation a
234 prominent theories arguing that it played a critical role in the evolution of vocal communication, i
235 HC; encoded by CBFB-MYH11) and RUNX1 plays a critical role in the pathogenesis of this leukemia.
239 In particular, it highlights some of the critical roles and functions of anodes in MFCs, strategi
240 In plants, regulated cell death (RCD) plays critical roles during development and is essential for p
241 ased SR luminal Ca(2+) These findings define critical roles for Stac3 in EC coupling and human diseas
242 Protein detection and quantification play critical roles in both basic research and clinical pract
243 he mitochondrial adaptor molecule MAVS plays critical roles in coordinating both virus-induced type I
246 tes catalyzed at faster rates with potential critical roles in protein activation, including the hist
247 miRNAs) are small, non-coding RNAs that play critical roles in the post-transcriptional regulation of
248 h endothelial venules, the results highlight critical roles of innate/inflammatory responses in SIVma
249 broad participation in these evolutionarily critical roles, the anucleate platelet is uniquely mamma
251 ro binding assays, and inhibition of LRP6 or critical signaling cascades downstream of LRP6, includin
253 th observational and experimental support of critical slowing down along natural stress gradients in
255 MPORTANCE HCV-associated liver fibrosis is a critical step for end-stage liver disease progression.
257 poelastin, in response to heat and salt is a critical step in the assembly of elastic fibers in vivo,
260 s generally considered to be one of the most critical steps in hapten-specific antibody production.
263 uperconductivity, and show that the observed critical supercurrent enhancement is compatible with a m
265 otein and RNA levels, implicating FoxM1 as a critical target for cyclin B1 inhibition during MVM infe
268 demonstrated for the first time that the FE critical thickness can reach the theoretical limit of 3.
269 lost when external perturbations overcome a critical threshold, i.e. above a critical magnetic field
270 nd gene regulatory networks, it is therefore critical to accurately annotate cell type-specific TSS a
271 owing to their dense PEG coating, which was critical to achieving widespread transgene expression th
272 s interactions with resident airway cells is critical to advancing knowledge on asthma pathogenesis a
273 physics of such motor-filament materials is critical to developing a physical model of the cytoskele
275 in addition to tanning bed avoidance, it is critical to emphasize sun protection and skin cancer scr
279 ysis quantifying the contribution of factors critical to epitope presentation, such as protein cleava
281 milarity between native and invaded areas is critical to identifying niche shifts during species inva
285 ealth effects through inhalation exposure is critical to mitigating its potential impact on public he
290 progress, and to present policy initiatives critical to the nation's health and fiscal integrity.
292 still an unresolved issue, even though it is critical to the understanding of the functional properti
293 associated with phase-separated systems are critical to understanding the unusual behaviours of hete
295 E/D)-xn and determined that K74 and K76 were critical Ubc9 residues interacting with the negatively c
299 ed candidate genes that could be involved in critical yet missing steps of astaxanthin biosynthesis,
300 nd distribution is an important component of Critical Zone science, but is highly challenging to inve
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