ライフサイエンスコーパス: critical

1 sses used for its benefit-risk assessment is critical.

2 ptake of HIV testing among youths at risk is critical.

3 hree important minor metals often considered critical.

4 rnative, lower energy approaches are equally critical.

5 The use of Cs2CO3 as base is critical.

6 d, then the adaptive immune responses became critical.

7 In addition, we show the critical ability of the system to generalize beyond trai

8 s a specialized form of autophagy, providing critical amino acids that activate mTOR and enable the m

9 Importantly, a critical analysis of speeds of sound in ILs vs those in

10 Here, we identify TIAM1 as a critical antagonist of CRC progression through inhibitin

11 New engineered materials have critical applications in different fields in medicine, e

12 ogical rigor was assessed using the relevant Critical Appraisal Skills Programme tools.

13 rast agents have been widely used to provide critical assessments of disease for both clinical and ba

14 ehavioral disorders, and that dynamics are a critical axis of manipulation for causal optogenetic stu

15 Together, this work demonstrates the critical balance between assembling virions that are sta

16 plicing factor, Ptbp1, revealed that it is a critical barrier for the acquisition of cardiomyocyte-sp

17 rom the pollen tube to the female gametes, a critical barrier to interspecific hybridization.

18 The p53 transcription factor is a critical barrier to pancreatic cancer progression.

19 racterization of DNA microviscosity provides critical biophysical insights into nuclear crowding, nuc

20 Our studies offer a glimpse into how these critical bone cells respond to mechanical load in vivo,

21 al hotspots, which ultimately leads to their critical, but poorly recognized role in regional greenho

22 tudy shows major concerns in the delivery of critical care across Latin America, particularly in huma

23 ion of women and racial/ethnic groups across critical care fellowship types.

24 ions addressed by IOM-compliant pulmonary or critical care guidelines were addressed by expert panels

25 d, and their relationships to the receipt of critical care intervention and inhospital mortality were

26 tial Organ Failure Assessment for predicting critical care intervention was 38%.

27 alence of and risk factors for burnout among critical care medicine physician assistants.

28 The sensitivities (95% CI) for the two critical care nurses when using the Arabic CAM-ICU compa

29 phen thus produces modest fever reduction in critical care patients, along with clinically important

30 All children admitted to the pediatric critical care units on designated study days (n = 994).

31 Critical care units.

32 1 (BECN1) is a key regulator of autophagy, a critical catabolic homeostasis pathway that involves seq

33 A critical challenge to translating field effect transisto

34 hat LAMP is thermodynamically stable below a critical chiAC, above which LAM3 emerges.

35 UAS1), then it subsequently binds to UAS2 (a critical cis-regulatory site located approximately 600 b

36 veal SMURF2 as an important regulator of the critical communication between osteoblasts and osteoclas

37 Fe is a critical component of record-activity Ni/Fe (oxy)hydroxi

38 lopment and indicate that mRNA handling is a critical component of SMA.

39 act with the membrane fusion protein AcrA, a critical component of the AcrAB-TolC efflux pump in Esch

40 ing infection by hijacking the function of a critical component of the IFN response pathway.

41 on these results, we conclude that Hop is a critical component of the piRNA pathway and that it main

42 Antibodies are critical components of the human adaptive immune system,

43 nd stability is increasingly recognized as a critical control point in dynamically altering gene expr

44 ntrol procedures such as the Hazard Analysis Critical Control Point system by seafood companies, the

45 erent coupling regions, and does not require critical coupling at both or at any one of the two coupl

46 Critical coupling in two-region coupling is a collective

47 d, i.e. above a critical magnetic field or a critical current for superconductors.

48 provide a high-resolution structure of this critical cytokine and we reveal its functional interacti

49 collectively initiate a new behavior once a critical density is reached.

50 A critical determinant of Cr(VI) generation within soils a

51 ous findings, showing that pigmentation is a critical determinant of skin aging.

52 thesis that the P2X7-PANX1 pore complex is a critical determinant of spreading depolarization suscept

53 neurons to dissect/identify NPC subtypes and critical developmental stages of alternative lineage spe

54 e NE thereby facilitating phosphorylation of critical downstream targets.

55 JAK1 is a critical effector of pro-inflammatory cytokine signaling

56 ion channels, however new evidence points to critical effects on intra-neuronal microtubules, a targe

57 tial for a wide impact on science, and are a critical element for unravelling the structural dynamics

58 the distribution of tree species because of critical environmental tolerances related to growth, mor

59 on that includes components of the virulence-critical ESX-1 secretion system.

60 culating cells within the vascular wall is a critical event in chronic inflammatory processes, such a

61 Transformation to aggressive lymphoma is a critical event in the clinical course of follicular lymp

62 A severe critical event was defined as the occurrence of respirat

63 A critical examination of these interactions could expand

64 Critical factors involved in invasion have been identifi

65 s during infection in vivo Macrophages are a critical first line of defense against respiratory patho

66 The identification of LTR-RTs is critical for achieving high-quality gene annotation.

67 Rather, it is critical for activating endosomal toll-like receptors an

68 ons demonstrate that tyrosine 470 and 88 are critical for allosteric modulatory effects of SRI-compou

69 e at the Phe position in the alpha1-helix is critical for alphaLbeta2 activation because trimming the

70 TRIM23 was critical for autophagy-mediated restriction of multiple

71 Chloride transport by the renal tubule is critical for blood pressure (BP), acid-base, and potassi

72 cross-talk on tumor cell phenotypes that are critical for cancer initiation and progression.

73 ted by polyrhamnose polysaccharides that are critical for cell envelope integrity and cell shape and

74 ion factor that controls expression of genes critical for cell survival under hyperosmotic conditions

75 ate interpretation of pathogenic variants is critical for delivering solid clinical molecular diagnos

76 Nuclear movement is critical for developmental events, cell polarity, and mi

77 imely exit of these proteins from the TGN is critical for effective pre-invasive immune responses aga

78 RAD51 mediator proteins (i.e. paralogs) are critical for efficient HR in mammalian cells.

79 ring their developmental dispersal, which is critical for embryogenesis.

80 The hippocampus is critical for episodic memory, and synaptic changes induc

81 s FGFR1, expressed by all ICM cells, that is critical for establishment of a PrE identity.

82 Acetylcholine in the neocortex is critical for executive function [1-3].

83 orona diameter and select the smallest size, critical for favoring protein-protein contacts and trigg

84 essential internal RNA modification that is critical for gene expression control in most organisms.

85 ) and androstenedione (Andro), respectively, critical for generating glucocorticoids and androgens.

86 el accrual, while disengagement from ZO-1 is critical for GJ channel closure and transitioning GJ cha

87 Thyroid and glucocorticoid hormones are critical for heart maturation.

88 entify CD4(+) T cell subsets with properties critical for improving cancer immunotherapy.

89 lated disc is a continuous and rapid process critical for intercellular coupling.

90 his site plays a role in AR stability and is critical for its transcriptional activity.

91 at super-enhancers in highly expressed genes critical for liver function.

92 g cancer tissues and its expression level is critical for lung cancer cell proliferation, which may s

93 GA signaling in the somatic anther tissue is critical for male meiotic cell wall formation and thus p

94 ippocampus and prefrontal cortex, structures critical for memory processes.

95 me b5 reductase 3 expression and activity is critical for NO-stimulated cGMP production and vasodilat

96 hanisms controlling cardiac specification is critical for our understanding of how heart formation is

97 extent of breast cancer by a pathologist is critical for patient management for tumor staging and as

98 a core hub of the "salience network" that is critical for perception of interoceptive signals and emo

99 ic diversity of mycorrhizal fungi, which are critical for plant fitness, biogeochemical cycling and o

100 Mitotic rounding during cell division is critical for preventing daughter cells from inheriting a

101 FICANCE STATEMENT Neuronal energy levels are critical for proper CNS function, but the relative roles

102 ine generated by cells at the injury site is critical for protection from IRI through bone marrow-der

103 oliferation and migration responses that are critical for regeneration by targeting proregenerative P

104 patient resuscitation preferences on issues critical for researchers and research consumers to under

105 Convenient and intuitive data interfaces are critical for researchers to easily upload, analyze and v

106 Assembly of the ASC speck is critical for signaling by the inflammasome.

107 ecent work has consistently shown XIAP to be critical for signaling downstream of the Crohn's disease

108 ylase-2 (HDAC2), an epigenetic regulator, is critical for stress-induced cardiac hypertrophy.

109 at the presence of SOS1/EPS8/ABI1 complex is critical for sustained EMT traits of ovarian cancer cell

110 intestinal polypeptide (VIP), a neuropeptide critical for synchrony in the adult SCN, and its recepto

111 scanning mutation of Epep revealed residues critical for Tbx3, Klf4 and Esrrb transcript repression,

112 Here we report that PI3K signaling is critical for the control of West Nile virus (WNV) infect

113 fluid transport through porous materials is critical for the development of lateral flow assays and

114 These polymorphisms may be critical for the development of specialized plant feedst

115 the RNA, rather than an encoded protein, is critical for the eventual recovery of transcription.

116 Notably, CSCs are critical for the formation and maintenance of liver meta

117 s form a coiled-coil interaction known to be critical for the formation of NuRD.

118 Pigment regeneration is critical for the function of cone photoreceptors in brig

119 sition occupied by W972 within WT Arkadia is critical for the function of RING and that it depends on

120 lation, indicating that these activities are critical for the in vivo function of STN1.

121 f the viral 5' untranslated region (UTR), is critical for the initiation of dengue virus replication,

122 Strategies to resolve replication blocks are critical for the maintenance of genome stability.

123 beta-mediated cell cycle arrest, yet remains critical for the pathological, EMT-inducing arm of TGFbe

124 ruitment via settlement of pelagic larvae is critical for the persistence of benthic marine populatio

125 Substrate recognition and binding are critical for the regulation of this reaction.

126 aunting challenge for clinicians but will be critical for the success of disease-modifying therapies.

127 growth and physiology during development are critical for their spawning success.

128 vealed that an "aromatic key" of nectin-2 is critical for this interaction, whereas variations in the

129 target genes, those p53-inducible genes most critical for tumor suppression remain elusive.

130 the study of protein acetylation dynamics is critical for understanding of how this modification infl

131 Studies of protein unfolding mechanisms are critical for understanding protein functions inside cell

132 ticular, magnetic resonance imaging (MRI) is critical for visualizing soft tissue and organs, with ov

133 t leads to disruption of axonal transport, a critical function for neuronal survival.

134 Our study thus uncovers a critical function of CaCC-mediated cytoplasmic Cl(-) hom

135 -1 subunits and uncover a previously unknown critical function of the middle subunit in CAF-1.

136 and zygotic knockout further revealed Aire's critical functions for spindle assembly in preimplantati

137 rs transcribed in breast cancer cells direct critical gene regulatory networks that promote pathogene

138 epression by opposing H3K27me3 deposition at critical genomic regulatory regions.

139 ignificantly increased the expression of two critical gluconeogenic enzymes, phosphoenolpyruvate carb

140 tabolite of BaP, with subsequent mutation of critical growth control genes.

141 The intestinal mucous layer provides a critical host defense against pathogen exposure and epit

142 y, and was confirmed by the test against the critical HR being more than 2.03 (p=0.003 for the reduce

143 unoengineering with optogenetics to overcome critical hurdles in cancer immunotherapy.

144 be particularly beneficial in the setting of critical illness and injury.

145 ted with susceptibility to influenza-related critical illness in children or with critical illness se

146 Delirium is a prevalent complication of critical illness in children, with identifiable risk fac

147 related critical illness in children or with critical illness severity.

148 age among older (>/= 65 yr old) survivors of critical illness.

149 neficial or adverse effects in patients with critical illness.

150 dence that complement activation serves as a critical immunomodulator in lung cancer progression, act

151 es that the presence of CD4(+) T cells is of critical importance but mast cells, antibodies, and baso

152 isms that drive behavioral dysfunction is of critical importance for quantitative diagnosis and syste

153 the pathophysiology of DWMI is therefore of critical importance.

154 Type I interferons (IFN-I) are critical in antimicrobial and antitumor defense.

155 he ability to synthesize and test FAHFAs was critical in elucidating the roles of these lipids, but t

156 erals and associated biological materials is critical in geomicrobiology and environmental research.

157 This ability is particularly critical in neurons, which comprise vast, highly differe

158 Epithelial dysfunction is critical in the pathology of many respiratory diseases,

159 onstructs, we identified a NF-kappaB site as critical in this activation.

160 y release GLP-1 (glucagon-like peptide 1), a critical incretin that regulates blood glucose homeostas

161 eutic and diagnostic interest, but obtaining critical information from the physiologically relevant h

162 heir evolution [1], has been one of the more critical innovations contributing to their extraordinary

163 level of understanding of miRNA biology and critical insights into the many translational applicatio

164 The study provides critical insights into the mechanisms of strain relaxati

165 Critical Intermediate calculation files provided as Tabl

166 000x unit cost reduction to $0.20, and is a critical, key challenge.

167 We further identified SYK as a critical kinase that phosphorylates MyD88, promoted MyD8

168 ironments worldwide will continue to provide critical knowledge about the factors that impact the nat

169 overcome a critical threshold, i.e. above a critical magnetic field or a critical current for superc

170 luences islet function and survival and is a critical marker of islet integrity following rodent isle

171 The field has recently reached a critical mass of compelling data that throws light on se

172 miscuous activator on cryptic promoters is a critical mechanism for specifying precise gene activatio

173 ic removal of CDF1-dependent repression is a critical mechanism in photoperiodic flowering.

174 Our insights into a critical mechanism in satellite cell homeostasis during

175 ding to recent experience is thought to be a critical mechanism supporting long-term memory stabiliza

176 ontrast to the p19ARF-MDM2-p53 pathway, is a critical mediator of colorectal tumorigenesis following

177 Type I interferons (IFNalpha/beta) are critical mediators of any anti-viral immune response and

178 in biology by oxidase enzymes, includes the critical O-O bond reductive cleavage step.

179 This review aimed to provide a critical overview of the current knowledge on the effect

180 sults demonstrated that the LZA element is a critical part of the low zinc homeostasis pathway.

181 using standardized, systematic methods, are critical, particularly from low- and middle-income conte

182 ssue hypertrophy and hyperplasia for health, critical pathways and mechanisms in (involuntary) adipos

183 Life-critical perceptual decisions often involve searching la

184 s are thought to play a key role during the "critical period" of brain development, the nature and ti

185 canonical model of plasticity confined to a critical period.

186 al neuronal functions.SIGNIFICANCE STATEMENT Critical periods are developmental windows of opportunit

187 re easily be breached by inflammation during critical periods of brain development.

188 m the protoplanetary disk, would constrain a critical phase of planetary formation by unveiling the u

189 mechanisms enabled by defects, size effects, critical phenomena, anharmonicity, and the spin degree o

190 or tuning appropriate materials to a quantum critical point.

191 ower of an ultrashort laser pulse, P, to the critical power of self-focusing, Pcr, playing the role o

192 Our results provide critical preclinical evidence supporting treatment of ep

193 scillators and identify DNA replication as a critical process in the circadian mechanism.

194 ; however, its applicability as a method for critical quality and comparability assessment has until

195 Threshold-seq addresses the critical question of how many reads need to support a sh

196 However, a critical question when analyzing high-dimensional and he

197 Our discovery prompts critical re-evaluation of prevailing uplift models of th

198 Fibronectin (FN) is a critical regulator of extracellular matrix (ECM) remodel

199 These data implicate cAMP signaling as a critical regulator of genomic stability against platinum

200 We show that the PNN protein Brevican is a critical regulator of interneuron plasticity.

201 studies identify SHP1 and SYK crosstalk as a critical regulator of MyD88 post-translational modificat

202 Notch is a critical regulator of T cell differentiation and is acti

203 in ascites, we show that IRF4 and MAFB were critical regulators of monocyte differentiation into mo-

204 d we found that miR172-AP2, miR156-SPLs were critical regulatory nodes contributing to the diversity

205 We show that a critical reliance on glycolysis renders lung SqCC vulner

206 also reveals the presence of this motif with critical residues in the homolog of other Helicobacter g

207 ced expression or loss of phosphorylation at critical residues of different classes of specific trans

208 However, a critical review of existing literature yielded numerous

209 Here we identify a critical role for ETAA1 in this process by surveying ran

210 etic loss-of-function experiments revealed a critical role for FOXO transcription factors in mediatin

211 These results demonstrate a critical role for genetic variation in ChrY in regulatin

212 Our data suggest a critical role for nonclassical monocytes in the patholog

213 ger polySia chains on SynCAM 1, suggesting a critical role for polyST autopolysialylation in substrat

214 Together, our study implicates a critical role for Set1A catalytic methyltransferase acti

215 a-secretase phosphorylation by SRPK2 plays a critical role in aggravating AD pathogenesis.

216 NM myosin II plays a critical role in airway SM contraction that is independe

217 Reactive oxygen species (ROS) play a critical role in cell signaling and proliferation.

218 hondria-associated ER membrane (MAM) plays a critical role in cellular energetics and calcium homeost

219 Epigenetic regulation of chromatin plays a critical role in controlling embryonic stem (ES) cell se

220 .IMPORTANCE The antiviral kinase PKR plays a critical role in controlling HCMV replication.

221 Cytokines play a critical role in directing the discrete and gradual tran

222 khead box transcription factor FOXC1 plays a critical role in embryogenesis and the development of ma

223 tion in caveolae biogenesis, Cavin-2 plays a critical role in endothelial cell maintenance and functi

224 virus (HBV)-encoded X protein (HBx) plays a critical role in HBV-related hepatocarcinoma development

225 Here, we show that BMP signaling plays a critical role in looping morphogenesis of the avian smal

226 Therefore, we suggest that SHANK3 has a critical role in neuronal morphogenesis in placodal neur

227 porting materials (ETMs) used in PSCs play a critical role in PSCs performance.

228 it of the Lassa glycoprotein complex plays a critical role in receptor recognition.

229 t WASp is a novel substrate of ALK and has a critical role in regulating invasiveness and oncogenesis

230 tly, it has been reported that GSDMD plays a critical role in regulating lipopolysaccharide and NLRP3

231 Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the

232 nom peptide toxins such as conotoxins play a critical role in the characterization of nicotinic acety

233 xxphi motif, but not dileucine motif, play a critical role in the earliest stages of AP2 activation a

234 prominent theories arguing that it played a critical role in the evolution of vocal communication, i

235 HC; encoded by CBFB-MYH11) and RUNX1 plays a critical role in the pathogenesis of this leukemia.

236 We also demonstrated a critical role of the p53-CXCR2 axis in mediating RSV-ind

237 The critical role of two-phase hydrodynamic properties on no

238 Our results also highlight the critical role played by antigen density in regulating CA

239 In particular, it highlights some of the critical roles and functions of anodes in MFCs, strategi

240 In plants, regulated cell death (RCD) plays critical roles during development and is essential for p

241 ased SR luminal Ca(2+) These findings define critical roles for Stac3 in EC coupling and human diseas

242 Protein detection and quantification play critical roles in both basic research and clinical pract

243 he mitochondrial adaptor molecule MAVS plays critical roles in coordinating both virus-induced type I

244 nd Igf2 are linked imprinted genes that play critical roles in development.

245 e CCR4 and the PXLXP motif of rice CAF1 play critical roles in OsCCR4-OsCAF1 interaction.

246 tes catalyzed at faster rates with potential critical roles in protein activation, including the hist

247 miRNAs) are small, non-coding RNAs that play critical roles in the post-transcriptional regulation of

248 h endothelial venules, the results highlight critical roles of innate/inflammatory responses in SIVma

249 broad participation in these evolutionarily critical roles, the anucleate platelet is uniquely mamma

250 We show numerically that both exhibit critical scaling near the transition point.

251 ro binding assays, and inhibition of LRP6 or critical signaling cascades downstream of LRP6, includin

252 hout rMSC aggregates were implanted into rat critical-sized calvarial defects (CSD).

253 th observational and experimental support of critical slowing down along natural stress gradients in

254 We find critical slowing down in the data at the level of Califo

255 MPORTANCE HCV-associated liver fibrosis is a critical step for end-stage liver disease progression.

256 A critical step in creating an artificial photosynthesis s

257 poelastin, in response to heat and salt is a critical step in the assembly of elastic fibers in vivo,

258 cyte transmigration across vessel walls is a critical step in the innate immune response.

259 Critical steps in forming the vertebrate limb include th

260 s generally considered to be one of the most critical steps in hapten-specific antibody production.

261 Exploratory research into the critical steps in metal-organic framework (MOF) activati

262 appear intermittently at stresses above the critical stress.

263 uperconductivity, and show that the observed critical supercurrent enhancement is compatible with a m

264 The review was conducted using critical synthesis and included qualitative, quantitativ

265 otein and RNA levels, implicating FoxM1 as a critical target for cyclin B1 inhibition during MVM infe

266 which AGMT began to consistently exceed that critical temperature was 1988.

267 To stop the tuberculosis epidemic, it is critical that we interrupt tuberculosis transmission.

268 demonstrated for the first time that the FE critical thickness can reach the theoretical limit of 3.

269 lost when external perturbations overcome a critical threshold, i.e. above a critical magnetic field

270 nd gene regulatory networks, it is therefore critical to accurately annotate cell type-specific TSS a

271 owing to their dense PEG coating, which was critical to achieving widespread transgene expression th

272 s interactions with resident airway cells is critical to advancing knowledge on asthma pathogenesis a

273 physics of such motor-filament materials is critical to developing a physical model of the cytoskele

274 Critical to elucidating their physiological role is the

275 in addition to tanning bed avoidance, it is critical to emphasize sun protection and skin cancer scr

276 ds to predict missing methylation states are critical to enable genome-wide analyses.

277 Critical to enhancing understanding will be disentanglin

278 Rapid learning can be critical to ensure elite performance in a changing world

279 ysis quantifying the contribution of factors critical to epitope presentation, such as protein cleava

280 Obtaining a detailed family history is critical to identify families who will benefit from gene

281 milarity between native and invaded areas is critical to identifying niche shifts during species inva

282 ge-scale and facile production of SiC NWs is critical to its successful application.

283 The physiological origin of this pain (critical to its treatment) remains unknown, although spa

284 The most prominent example, which is critical to mammalian survival, is that of pancreatic al

285 ealth effects through inhalation exposure is critical to mitigating its potential impact on public he

286 , indicating that this pro-drug approach was critical to obtain the desired activity in vivo.

287 While mitophagy is critical to pancreatic beta-cell function, the posttrans

288 t the correct parameterization of sigma w is critical to simulate realistic cirrus properties.

289 Critical to such transformation is to provide affordable

290 progress, and to present policy initiatives critical to the nation's health and fiscal integrity.

291 Patient safety is critical to the provision of quality health care and thu

292 still an unresolved issue, even though it is critical to the understanding of the functional properti

293 associated with phase-separated systems are critical to understanding the unusual behaviours of hete

294 rgeted to block ERalpha gene expression is a critical topic of endocrine therapy.

295 E/D)-xn and determined that K74 and K76 were critical Ubc9 residues interacting with the negatively c

296 for mood and anxiety disorders represents a critical unmet need.

297 Together, these data identify a critical vulnerability resulting from the reliance of HC

298 Balancing protein expression is critical when optimizing genetic systems.

299 ed candidate genes that could be involved in critical yet missing steps of astaxanthin biosynthesis,

300 nd distribution is an important component of Critical Zone science, but is highly challenging to inve