ライフサイエンスコーパス: critical illness

1 s a risk factor for delirium and coma during critical illness.

2 g of the transition from acute to persistent critical illness.

3 hey open up a new area for drug discovery in critical illness.

4 GLN requirements may increase with critical illness.

5 e meaningful measure of renal function after critical illness.

6 ticles investigating bone pathophysiology in critical illness.

7 rden of cardiovascular and noncardiovascular critical illness.

8 are neuroprotective in preclinical models of critical illness.

9 factor for adverse events among survivors of critical illness.

10 inical severe infection but without signs of critical illness.

11 odel for evaluation of novel therapeutics in critical illness.

12 t regarding baseline health and frequency of critical illness.

13 late select biological mechanisms underlying critical illness.

14 ss syndrome and is associated with degree of critical illness.

15 mary variable of interest was anxiety during critical illness.

16 ic obstructive pulmonary disease (COPD), and critical illness.

17 ier can prevent and/or treat delirium during critical illness.

18 sociated with state and trait anxiety during critical illness.

19 roved outcomes among high-risk children with critical illness.

20 empirically defining the onset of persistent critical illness.

21 ral manifestations of cardiac dysfunction in critical illness.

22 loring mild cognitive impairment and risk of critical illness.

23 rts account for the shifting epidemiology of critical illness.

24 their longer term benefits for survivors of critical illness.

25 re for all families of patients with chronic critical illness.

26 n's hospitals with outcomes in children with critical illness.

27 e onset of kidney injury in animal models of critical illness.

28 ospital outcomes of patients with persistent critical illness.

29 p disturbances that persist or develop after critical illness.

30 age among older (>/= 65 yr old) survivors of critical illness.

31 d in a population of patients with a medical critical illness.

32 ital regionalization of nontrauma, nonarrest critical illness.

33 duces many of the findings reported in human critical illness.

34 n increasing proportion of pediatric chronic critical illness.

35 ommonplace among older adults who survived a critical illness.

36 l methods to improve sleep in the setting of critical illness.

37 6%) met the consensus definition for chronic critical illness.

38 te to increased cortisol availability during critical illness.

39 nd manage disputes in patients with advanced critical illness.

40 perience in the management of cardiovascular critical illness.

41 oss a range of muscle groups associated with critical illness.

42 current state of research examining sleep in critical illness.

43 sms underlying this change in a rat model of critical illness.

44 ave functional implications for survivors of critical illness.

45 imum dose of hydrocortisone treatment during critical illness.

46 ike growth factor-binding protein-3 early in critical illness.

47 sical disability common amongst survivors of critical illness.

48 e is largely restricted to the first week of critical illness.

49 rtisol and total cortisol profiles exists in critical illness.

50 h-related quality of life among survivors of critical illness.

51 tions, existence of comorbid conditions, and critical illness.

52 abolic rate characterizes the acute phase of critical illness.

53 sex may be less important in other forms of critical illness.

54 ew psychiatric diagnoses and treatment after critical illness.

55 ut other patient-centered outcomes following critical illness.

56 is a predictor of post-coma delirium during critical illness.

57 or undercoded in a substantial proportion of critical illness.

58 neficial or adverse effects in patients with critical illness.

59 cid homeostasis and in muscle wasting during critical illness.

60 its acute and chronic metabolic role during critical illness.

61 recovery and 25 (19%) progressed to chronic critical illness.

62 who received mechanical ventilation during a critical illness.

63 ciated with the onset and clinical course of critical illness.

64 alth-related quality of life in survivors of critical illness.

65 inical severe infection but without signs of critical illness.

66 treatment of hyponatremic encephalopathy in critical illness.

67 d thrombocytopenia in surgical patients with critical illness.

68 hese metabolic pathways, are elevated during critical illness.

69 y might be particularly weak in survivors of critical illness.

70 patient-specific diagnosis and treatment of critical illness.

71 le novel biomarkers and biologic targets for critical illness.

72 ter major noncardiac surgery associated with critical illness.

73 ter the risk of depression and anxiety after critical illness.

74 management of injury and repair responses in critical illness.

75 ight-dark patterns may support recovery from critical illness.

76 organ dysfunction are predictive of chronic critical illness.

77 are associated with delirium duration during critical illness.

78 en's hospitals and outcomes in children with critical illness.

79 prominent role in the delayed recovery from critical illness.

80 nctional capacity is commonly impaired after critical illness.

81 different pathological conditions, including critical illnesses.

82 biting necroptosis in experimental models of critical illnesses.

83 following: 1) Frontiers in the management of critical illness; 2) Biogenesis, characterization, and f

84 somatosensory functions between survivors of critical illness 6 months after ICU discharge and contro

85 Cases of persistent critical illness accounted for only 51 509 (5.0%) of the

86 t is independently associated with increased critical illness admission.

87 pairment independently increases the risk of critical illness admissions.

88 ticenter cohort enrolling adult survivors of critical illness after respiratory failure and/or shock

89 ne the incidence and risk factors of chronic critical illness after severe blunt trauma.

90 Mortality after critical illness among older adults varies by insurance

91 ratory pressure of 14 cm H2O at the onset of critical illness and 26.7% received rescue oxygenation t

92 mass and function is a common consequence of critical illness and a range of chronic diseases, but th

93 chiatric disease in predisposing patients to critical illness and an increased but transient risk of

94 ral, and emotional changes, can occur during critical illness and appear as clinically similar to del

95 Delirium is common during critical illness and associated with adverse outcomes.

96 Cardiac complications are common in critical illness and associated with grave consequences.

97 cquired weakness is a common complication of critical illness and can have significant effects upon f

98 njury is a common and severe complication of critical illness and cardiac surgery.

99 families from harm that is both inherent to critical illness and iatrogenic.

100 n predisposes patients to the development of critical illness and increases mortality.

101 t differentiate patients prone to persistent critical illness and infections following injury, indepe

102 port to patients and families facing chronic critical illness and inform interventions to support sur

103 plied for participation in the United States Critical Illness and Injury Trials Group: Critical Illne

104 be particularly beneficial in the setting of critical illness and injury.

105 leading cause of infection in the setting of critical illness and injury.

106 ntions that continue after the first week of critical illness and into the post-ICU and post-hospital

107 Critical illness and mortality were more frequent in sur

108 n the United States and developed for severe critical illness and multiple organ failure secondary to

109 es Critical Illness and Injury Trials Group: Critical Illness and Outcomes Study, an observational st

110 treatment of the septic patient with chronic critical illness and persistent inflammation-immunosuppr

111 The relationship between critical illness and psychiatric illness is unclear.

112 ogical muscle characterization of a model of critical illness and recovery reproduces many of the fin

113 w perspectives on nutritional support during critical illness and recovery.

114 measuring alterations in circadian rhythm in critical illness and review methods to measure sleep in

115 ever, up to now, their clinical relevance in critical illness and sepsis is unclear.

116 the usefulness of iron-chelating therapy in critical illness and sepsis.

117 Insights from her own encounter with critical illness and study of disturbance and recovery l

118 infusion can suppress plasma glucagon during critical illness and study the role of illness-induced g

119 The physiological effects of critical illness and the clinical interventions of inten

120 inee confidence in the management of cardiac critical illness and the performance of cardiac-specific

121 rly changes in bone functional properties in critical illness and their relationship to changes in bo

122 y of premorbid function within 6 months of a critical illness and to identify independent predictors

123 ients (5.2% [95% CI, 5.0%-5.3%]) developed a critical illness and were admitted to an ICU within 2 ye

124 tudy--ie, younger than 12 years, no signs of critical illness, and haemoglobin 100 g/L or lower (if a

125 ndrome is common in children recovering from critical illness, and several risk factors are predictiv

126 fascial characteristics that occur early in critical illness, and to relate these to microscopic his

127 signs of severe infection, without signs of critical illness, and whose caregivers did not accept re

128 ood-brain barrier/neurological injury during critical illness are associated with prolonged delirium

129 Increasing numbers of survivors of critical illness are at risk for physical, cognitive, an

130 Murine models of critical illness are commonly used to test new therapeut

131 Several of the acute-phase adaptations to critical illness are due to or accentuated by the concom

132 Survivors of critical illness are frequently left with long-lasting d

133 Outcomes for children with chronic critical illness are not defined.

134 Renal outcomes after critical illness are seldom assessed despite strong corr

135 ce, hospital mortality, and costs of chronic critical illness are substantial.

136 Typical for critical illnesses are substantial alterations within th

137 2 hours as independent predictors of chronic critical illness (area under the receiver operating curv

138 ritical care physicians recognise persistent critical illness as a specific syndrome, yet few data ex

139 We defined recovery from critical illness as Palliative Performance Scale score o

140 Defining the onset of persistent critical illness as the time at which diagnosis and illn

141 othalamic releasing factors on recovery from critical illness as well as on long-term rehabilitation

142 MD decreased significantly in the year after critical illness at both femoral neck and anterior-poste

143 nctive nature of nutritional intervention in critical illness, be focused on physical function and as

144 fference in this neuropsychiatric context of critical illness between children on the one hand and ad

145 ng 165 adult patients with H1N1pdm09-related critical illness between September 2013 and March 2014,

146 Despite the acute derangements of critical illness, both acute and chronic health factors

147 understanding of the neurobiology following critical illness, both in early and in adult life, may l

148 Finally, we examine known risk factors for critical illness brain injury and, based on these data,

149 We then review the characteristics of critical illness brain injury, which can vary in severit

150 of cognitive impairment-which we refer to as critical illness brain injury-and review the history and

151 Oxygen is vital during critical illness, but hyperoxia may harm patients.

152 Onset of persistent critical illness can be empirically measured at a popula

153 Critical illness causes long-term psychological and func

154 on an explorative clinical study of chronic critical illness (CCI) patients aimed at assessing the l

155 ort caregivers of patients who have survived critical illness; consequently, the caregivers' own heal

156 Among patients meeting chronic critical illness criteria through sepsis, the infections

157 The risk of critical illness did not vary by socioeconomic circumsta

158 5 (24.5%) of 51 509 patients with persistent critical illness died and only 23 968 (46.5%) of 51 509

159 nction in ICU Survivors study who survived a critical illness due to respiratory failure or shock wer

160 Among CMV-seropositive adults with critical illness due to sepsis or trauma, ganciclovir di

161 reventive strategies to reduce the burden of critical illness, educate our noncritical care colleague

162 se of mortality and were instead a marker of critical illness (eg, tracheostomy).

163 e data streams will advance understanding of critical illness, enable real-time clinical decision sup

164 Family caregivers of patients with chronic critical illness experience significant psychological di

165 Frail survivors of critical illness experienced greater impairment in healt

166 rance of cortisol is markedly reduced during critical illness, explained by suppressed expression and

167 These neuroendocrine responses to critical illness follow a biphasic pattern.

168 ss in improving psychological recovery after critical illness for patients and their family members.

169 people with acute myocardial infarction and critical illness has always attracted controversy.

170 ponses to such fasting in the acute phase of critical illness has shown to beneficially affect outcom

171 Survivors of critical illness have an increased prevalence of bone fr

172 Older adults who survive critical illness have physical and cognitive declines re

173 fundamental importance of our patients' pre-critical illness health status, their intrinsic suscepti

174 tionally for the prevention and treatment of critical illness, holding great promise to improve the a

175 son-years (95% CI, 6.6, 21.6) or 1.3% of all critical illness hospitalizations (95% CI, 0.7%, 2.3%).

176 e estimated that 26,760 influenza-associated critical illness hospitalizations (95% CI, 14,541, 47,46

177 ncidence rates of adult influenza-associated critical illness hospitalizations and compared them with

178 There were only 2,612 critical illness hospitalizations with International Cla

179 in medical intensive care units with chronic critical illness (i.e., adults mechanically ventilated f

180 Factors related to the acute critical illness, ICU practices, such as heavy sedation,

181 During critical illness, impaired endothelial vascular reactivi

182 of the microbiome has prevented or modulated critical illness in animal models and clinical trials.

183 ted with susceptibility to influenza-related critical illness in children or with critical illness se

184 Delirium is a prevalent complication of critical illness in children, with identifiable risk fac

185 Survivors of critical illness in early life are at risk of long-term-

186 ired systemic capillary leak associated with critical illness in humans.

187 Cytomegalovirus reactivation may complicate critical illness in latent carriers of the virus, even i

188 CSA was also lower in infants with higher critical illness in the first 24 hours of life, exposure

189 e, outcomes, and associated costs of chronic critical illness in the United States.

190 ant from specific physiological responses to critical illness in this population and the nature of th

191 U-related PTSD (i.e., PTSD anchored to their critical illness) in the year after hospitalization.

192 t that elevated glucagon availability during critical illness increases hepatic amino acid catabolism

193 Weakness induced by critical illness (intensive care unit acquired weakness)

194 ortality is low after severe trauma, chronic critical illness is a common trajectory in survivors and

195 Critical illness is a time of extreme vulnerability for

196 d dependence on mechanical ventilation after critical illness is an emerging public health challenge;

197 status at hospital discharge in survivors of critical illness is associated with increased postdischa

198 The prolonged phase of critical illness is hallmarked by a uniform suppression

199 RATIONALE: Critical illness is hallmarked by muscle wasting and dis

200 on of glucagon and its metabolic role during critical illness is lacking.

201 Pathogenesis of NTIS in long-term critical illness is more complex and includes suppressio

202 ce describing long-term changes in BMD after critical illness is needed to further define this relati

203 Critical illness is not a discrete disease state or synd

204 mpairment after major noncardiac surgery and critical illness is not associated with the surgery and

205 The epidemiology of chronic critical illness is not well characterized.

206 Chronic critical illness is particularly common in the elderly a

207 The central role of the microbiome in critical illness is supported by a half century of exper

208 t of protein intake on outcomes in pediatric critical illness is unclear.

209 comes for those aged 18 years and older with critical illness is unclear.

210 outcomes in nonimmunosuppressed adults with critical illness is unknown.

211 ypolipidemia, which may occur with trauma or critical illness, is clinically associated with bacteria

212 ernal causes of circadian arrhythmia include critical illness itself and subjective experience of dis

213 ts and neuromuscular dysfunction acquired in critical illness; limitations include studies with a hig

214 Critical illness may be a potential determinant of cance

215 -2][IGFBP7] measured early in the setting of critical illness may identify patients with AKI at incre

216 as suppressed or deficient during prolonged critical illness, may be a promising strategy to enhance

217 Obesity and critical illness modify pharmacokinetics of antibiotics,

218 s among ICU survivors, as well as decreasing critical illness mortality.

219 Future trials to test therapies for critical illness must ensure that study designs are adeq

220 tients is an important factor triggering the critical illness myopathy (CIM).

221 ibution from critical illness polyneuropathy/critical illness myopathy and severe sepsis/septic shock

222 patients for critical illness polyneuropathy/critical illness myopathy and those with severe sepsis/s

223 akness, critical illness polyneuropathy, and critical illness myopathy.

224 Interventions to reduce anxiety during critical illness need to be considered and evaluated for

225 ts and neuromuscular dysfunction acquired in critical illness (odds ratio, 1.21; 95% CI, 0.67-2.19),

226 Patients with chronic critical illness often exhibit "a persistent inflammatio

227 dy of literature has shown that survivors of critical illness often struggle with cognitive impairmen

228 potential relationship between the impact of critical illness on cognitive function and employment st

229 studies are needed to analyze the impact of critical illness on cognitive function.

230 tudy using data from the multicenter, cohort Critical Illness Outcomes Study.

231 luid balance, acute kidney injury, and other critical illness parameters.

232 At 4 months, chronic critical illness patients had higher mortality (16.0% vs

233 Chronic critical illness patients were more likely to be dischar

234 ssess the impact of a discharge diagnosis of critical illness polyneuromyopathy on health-related out

235 r abnormalities and a discharge diagnosis of critical illness polyneuropathy and/or myopathy along wi

236 nical importance of a discharge diagnosis of critical illness polyneuropathy and/or myopathy and the

237 athy, patients with a discharge diagnosis of critical illness polyneuropathy and/or myopathy had fewe

238 national database, a discharge diagnosis of critical illness polyneuropathy and/or myopathy is stron

239 to patients without a discharge diagnosis of critical illness polyneuropathy and/or myopathy, patient

240 7 ICU patients with a discharge diagnosis of critical illness polyneuropathy and/or myopathy, we matc

241 ts who did not have a discharge diagnosis of critical illness polyneuropathy and/or myopathy.

242 Critical illness polyneuropathy is a common disorder in

243 The prevalence of dysphagia in critical illness polyneuropathy is not known.

244 Dysphagia is frequent among patients with critical illness polyneuropathy treated in the ICU.

245 s to evaluate the prevalence of dysphagia in critical illness polyneuropathy using fiberoptic endosco

246 r blocking agents and ICU-acquired weakness, critical illness polyneuropathy, and critical illness my

247 ning euglycemia may reduce the prevalence of critical illness polyneuropathy.

248 factors for the development of dysphagia in critical illness polyneuropathy.

249 ribution from studies examining patients for critical illness polyneuropathy/critical illness myopath

250 showed a disproportionate contribution from critical illness polyneuropathy/critical illness myopath

251 organ dysfunction syndrome that is causal to critical illness progression.

252 , especially the aged, are suffering chronic critical illness, rarely fully recover, and often experi

253 proves that nutritional interventions during critical illness reduce mortality.

254 atements for the diagnosis and management of critical illness-related corticosteroid insufficiency (C

255 and understanding of the pathophysiology of critical illness-related corticosteroid insufficiency (C

256 The patients with critical illness-related corticosteroid insufficiency ha

257 ught to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.

258 is useful in the diagnosis or management of critical illness-related corticosteroid insufficiency.

259 dysfunction with poorer clinical outcomes in critical illness remain unclear.

260 ts and neuromuscular dysfunction acquired in critical illness remains unclear.

261 Critical illness represents a life-threatening disorder

262 study, about 1 in 20 patients experienced a critical illness resulting in ICU admission within 2 yea

263 ll as strategies that can overcome them in a critical illness setting.

264 tration, rather than traditional measures of critical illness severity, should be considered in ident

265 related critical illness in children or with critical illness severity.

266 ated with IFITM3 expression levels, nor with critical illness severity.

267 in would decrease the time that survivors of critical illness spent in delirium or coma.

268 Influenza A (H1N1pdm09)-related critical illness still predominantly affects relatively

269 rojections on ICU admission rather than true critical illness substantially overstate the workforce g

270 ripheral skeletal muscle architecture during critical illness, supplementing more detailed characteri

271 Two thirds of children with chronic critical illness survive for at-least 5 years, but there

272 Critical illness survivors (n = 84) and controls (n = 44

273 s disorder symptoms occurred in one fifth of critical illness survivors at 1-year follow-up, with hig

274 es is essential to improving the outcomes of critical illness survivors.

275 Study in critical illness survivors.

276 , the most severe toxicity, presents a novel critical illness syndrome with limited data regarding di

277 isorder were found to be common 1 year after critical illness, the occurrence of delirium during ICU

278 Among families of patients with chronic critical illness, the use of palliative care-led informa

279 Despite the elevated cortisol levels during critical illness, tissue resistance to glucocorticoids i

280 road interpretation of indications, such as "critical illness." To refine criteria for appropriate ca

281 cal function following PICU admission in the critical illnesses under study.

282 xiety (state and trait) were assessed during critical illness using the Faces Anxiety Scale and the t

283 incidence estimate for influenza-associated critical illness was 12.0 per 100,000 person-years (95%

284 Chronic critical illness was defined as an ICU stay lasting 14 d

285 The cumulative incidence of critical illness was greatest for small intestinal (17.2

286 Risk of critical illness was highest at ages 60 to 69 years and

287 Reduction in employment after critical illness was present in the majority of our ICU

288 omplex intervention to improve recovery from critical illness, we sought to identify pharmacological

289 itled "Lumpers and Splitters: Phenotyping in Critical Illness," we highlight promising approaches to

290 is, and pulmonary embolism developing during critical illness were assessed.

291 us seropositive, immunocompetent adults with critical illness were enrolled in this study.

292 Patients who developed chronic critical illness were older (55 vs 44-year-old; p = 0.01

293 this study, fentanyl pharmacokinetics during critical illness were strongly influenced by severe live

294 e is associated with reduced delirium during critical illness, whereas discontinuation of statin ther

295 In the early stages of critical illness, whether artificial feeding is better t

296 Atrial fibrillation in critical illness, whether new-onset or recurrent, is ind

297 f the hypothalamic-pituitary-adrenal axis in critical illness, which is diagnosed by a suppressed cor

298 All cases of PICU chronic critical illness with length of stay more than 28 days a

299 While one patient experienced critical illness with multi-organ failure requiring mech

300 ripheral skeletal muscle architecture during critical illness with ultrasound were included.