ライフサイエンスコーパス: critical pathway

1 stigation of the mechanisms involved in this critical pathway.

2 ility that bigger eukaryotes possess in this critical pathway.

3 ion of a neuropeptide to activate additional critical pathways.

4 Although CD73 is emerging as a critical pathway and therapeutic target in cardiovascula

5 dase (CD73) on immune cells is emerging as a critical pathway and therapeutic target in cardiovascula

6 ssue hypertrophy and hyperplasia for health, critical pathways and mechanisms in (involuntary) adipos

7 Overall, these results revealed critical pathways and networks that exhibit sustained al

8 is was utilized to characterize and evaluate critical pathways and reactions in G. metallireducens.

9 in leukemogenesis may provide insights into critical pathways and suggest targets for therapy and pr

10 enomics analysis highlighted novel genes and critical pathways associated with kidney function for fu

11 to coordinately regulate multiple members of critical pathways associated with PCD.

12 el in susceptible individuals by providing a critical pathway by which relative tolerance for nucleic

13 eation of a cadre of physicians committed to critical pathways; clinical guidelines; quality assuranc

14 inding to a common site within Smoothened, a critical pathway component.

15 cellular pathway, in which perturbations to critical pathway components are analyzed using DNA micro

16 Our data showed that manipulation of these critical pathway components led to varying degrees of di

17 These data reveal a critical pathway controlling NF-kappaB function in the l

18 ral location in tubular epithelium may alter critical pathways controlling normal tubulogenesis leadi

19 The critical pathways determining the resistance of tumor ce

20 rom Fanconi anemia patients, which lack this critical pathway, fail to be reprogrammed to iPSC under

21 n of PKR and its downstream targets may be a critical pathway for Ad-mda7-mediated apoptosis.

22 We conclude that activation of JNK is a critical pathway for bacterially induced mucosal hyperpl

23 tial steps in translesion synthesis (TLS)--a critical pathway for cell survival and for maintenance o

24 These results reveal a critical pathway for courtship hearing in male and femal

25 Here we identify glutaminolysis as a critical pathway for leukemia cell growth downstream of

26 nd phosphorylation at serine 133, which is a critical pathway for neuronal differentiation.

27 or pathogenesis in TSC and identify a novel, critical pathway for potential therapeutic targeting.

28 Androgen receptor (AR) signaling is a critical pathway for prostate cancer cells, and androgen

29 rafish development and adulthood, defining a critical pathway for stem cell specification.

30 ls to cone photoreceptors is regarded as the critical pathway for the formation of the antagonistic s

31 between the cerebellum and motor cortex is a critical pathway for the integrity of everyday movements

32 One critical pathway for the regulation of potassium efflux

33 rom boreal peatlands is recognized as both a critical pathway for the remobilization of peat C stocks

34 Homology-directed repair (HDR) is a critical pathway for the repair of DNA double-strand bre

35 However, the role of BRCA1 in NHEJ, a critical pathway for the repair of double strand breaks

36 radiation, suggesting that NHEJ is indeed a critical pathway for the repair of DSBs.

37 t signaling cascade has been identified as a critical pathway for the transduction of extracellular s

38 )-cyclin-dependent kinase 8 (CDK8) axis as a critical pathway for these processes, and deregulation o

39 nthesis of phospholipids and glycolipids are critical pathways for virtually all cell membranes.

40 Alternative methods of targeting critical pathways, for example Blys inhibition (atacicep

41 surfaces of the NAPA conformers along these critical pathways have been characterized more accuratel

42 ince blocking CCN1 simultaneously blocks two critical pathways (i.e. SHh and Notch1) associated with

43 Our data suggest that CD134-CD134L is a critical pathway in alloimmune responses, especially rec

44 ositol 3-kinase [PI (3)K]/Akt signaling is a critical pathway in cell survival.

45 to assess the general applicability of this critical pathway in community-based hospitals.

46 beta-catenin and canonical Wnt signaling, a critical pathway in cystic renal disease.

47 des novel insights into EWS-FLI1 turnover, a critical pathway in Ewing sarcoma pathogenesis, and lays

48 In human cells, a critical pathway in gene regulation subjects mRNAs with

49 ults demonstrate that HIF1alpha represents a critical pathway in LSCs and inhibition of the HIF1alpha

50 , we sought to discern whether RasGRP1 was a critical pathway in Ras activation, using a RasGRP1 knoc

51 We conclude that the Nrf-2/HO-1 axis is a critical pathway in the hyperglucidic-mediated dysregula

52 they define calcium-NFAT-Skp2 signaling as a critical pathway in the mechanoregulation of proliferati

53 B-cell receptor (BCR) signaling is a critical pathway in the pathogenesis of several B-cell m

54 s CD45(+)lin(-)Thy1(hi)NKp46(-)) is a second critical pathway in this model.

55 Our results define a critical pathway in which decreased LRP6-mediated Wnt si

56 ing lupus disease progression by targeting 2 critical pathways in disease pathogenesis, type I IFN ac

57 ostate could provide important insights into critical pathways in normal development as well as eluci

58 NAc in cell signaling that may also regulate critical pathways in other organisms.

59 Identifying critical pathways in sarcomagenesis, susceptible subtype

60 t 20 years, genetic studies have illuminated critical pathways in the hypothalamus and brainstem medi

61 sis with the ability to intervene at several critical pathways in the tumorigenesis process will have

62 set of markers to outline the disruption of critical pathways in tumorigenesis and for derivation of

63 y also function in the regulation of another critical pathway involved in cellular and tissue homeost

64 urther establish the Ras/MAPK pathway as the critical pathway involved in cytoskeleton disruption dur

65 element binding protein (CREB) activation, a critical pathway involved in learning and memory.

66 -cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimate

67 Hedgehog (HH) signaling has emerged as a critical pathway involved in the pathogenesis of a varie

68 One critical pathway is the methionine cycle, in which folat

69 Promoter hypermethylation of key genes in critical pathways is common in head and neck cancer and

70 egulatory role of microRNA (miRNAs) in these critical pathways is poorly understood.

71 samples and integrative genomics to uncover critical pathways linked to HCC subtypes with prognostic

72 With aggressive application of critical pathway methods, significant reduction in cost

73 tol (PI) 3'kinase signaling, implicated as a critical pathway of cell survival control in epithelial

74 The model identified staff reentry as the critical pathway of contagion, and provided estimates of

75 d A component of LPS stimulates a unique and critical pathway of innate immune responses that is inde

76 Homologous recombination (HR) repair is a critical pathway of repairing DNA double strand breaks,

77 Thus critical pathways of circadian synchronization are media

78 To begin to determine critical pathways of paraquat + maneb neurotoxicity, the

79 Tractography is being used to define critical pathways prior to surgery.

80 the PTEN/AKT signaling axis was defined as a critical pathway regulated by betaIII-tubulin in NSCLC c

81 pulations, can yield an understanding of the critical pathways regulating cancer stem cells.

82 signaling pathway has emerged as one of the critical pathways regulating cell proliferation, differe

83 l for tissue growth and maintenance, but the critical pathways regulating protein ubiquitination and

84 el therapies specifically designed to thwart critical pathways responsible for this malignancy.

85 y autonomic nervous system activity, but the critical pathway(s) that mediate this influence are uncl

86 This catalyst, absent in humans, provides critical pathway-specific enzymatic steps in the product

87 ed, but the roles of some components of this critical pathway still remain uncharacterized in mammals

88 genomic regions containing genes enriched in critical pathways such as Wnt signaling and promoter mot

89 Autophagy is a critical pathway that integrates numerous regulatory inp

90 nd RIM1alpha, an active zone protein, is the critical pathway that is required for the lasting enhanc

91 r of transcription) in the hypothalamus is a critical pathway that mediates leptin's action.

92 These studies have identified a novel and critical pathway that promotes aberrant vascular prolife

93 ion inhibits the IL-13 activation of several critical pathways that are required for macrophage alter

94 Proteins were identified from several critical pathways that changed at early and late disease

95 and overexpression has provided insight into critical pathways that determine the fate of these multi

96 iprotease imbalance and oxidative stress are critical pathways that exacerbate the pulmonary phenotyp

97 of human prostate cancers, can activate two critical pathways that have been linked to prostate canc

98 mate release and uptake by astrocytes form a critical pathway through which neural activity is linked

99 The critical pathways through which ionizing radiation induc

100 alloproteinase (MMP)-2 and -9 by plasmin are critical pathways through which uPA-expressing macrophag

101 ese findings support the hypothesis that the critical pathway to end-stage fibrosis is not "alveoliti

102 In the absence of an established critical pathway to evaluate patients with syncope prese

103 cipients in the emergency department (ED), a critical pathway to readmission.

104 These results elucidate a critical pathway underlying leptin's induction of dendri

105 Currently, it is unclear how this critical pathway unfolds, in particular, where and when

106 TNFalpha) mRNA levels indicating that these critical pathways were otherwise intact.

107 ly of secreted proteins constitutes one such critical pathway: Wnt proteins rank among the most poten