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1 diseases in which the immune system plays a critical role.
2 ration at T >/= 300 degrees C, also played a critical role.
3 ion induced secondary electron emission play critical roles.
4 tions, in which "silent" NMDA receptors play critical roles.
6 ly seen in blood disorders underscores their critical roles and highlights the need to develop target
8 ace receptors to activate the pathway, plays critical roles both in embryonic development and the mai
10 In plants, regulated cell death (RCD) plays critical roles during development and is essential for p
16 have impaired glucose sensing, indicating a critical role for brain GLUT4 in sensing and responding
18 etic loss-of-function experiments revealed a critical role for FOXO transcription factors in mediatin
20 sue of Immunity, Liew et al. (2017) reveal a critical role for invariant natural killer T (iNKT) cell
22 RTANCE We describe here for the first time a critical role for miR-424 in the regulation of HPV repli
25 lation, and the NGD pathway, and establish a critical role for NGD in maintaining ER homeostasis.
26 severe human disease, thereby emphasizing a critical role for NK cells in human antiviral defense.
33 ger polySia chains on SynCAM 1, suggesting a critical role for polyST autopolysialylation in substrat
35 ear extinction in the amygdala, suggesting a critical role for RIN1 in preventing the persistence of
37 ilds on prior work to further substantiate a critical role for skin migratory dendritic cells and in
44 Drosophila and mouse TRPA1 channels reveal a critical role for the fifth transmembrane domain (S5) in
47 brown adipose tissue (BAT) is known to play critical roles for both basal and inducible energy expen
49 ased SR luminal Ca(2+) These findings define critical roles for Stac3 in EC coupling and human diseas
50 iseases are neurological in nature revealing critical roles for this class of proteins in the brain.
52 representation of the sensory space plays a critical role in acuity and fine discrimination during s
53 reveal that Ag-specific CD4 TRM cells play a critical role in adaptive immunity against reinfection a
54 M)-rich environments, oncogenic KRAS plays a critical role in adenocarcinomas by promoting PI3K/Akt s
58 l lateral parabrachial nucleus (PBel) play a critical role in arousal to elevated CO2 or hypoxia.
59 se studies show that BET proteins may have a critical role in asthma pathogenesis by altering type 17
62 informatics and computational biology play a critical role in bioscience and biomedical research.
63 AMP-activated protein kinase (AMPK) plays a critical role in blocking modifications to the chromatin
67 (2) dissolution of available calcite plays a critical role in buffering pH; (3) high salinity in gene
68 nosensitive transcriptional activator with a critical role in cancer, regeneration, and organ size co
69 e hypothesis that 5-HT2CR in the BLA plays a critical role in CeA plasticity and neuropathic pain beh
71 hondria-associated ER membrane (MAM) plays a critical role in cellular energetics and calcium homeost
72 usion, our study suggests that I-PTH plays a critical role in cellular proliferation, proteoglycan di
75 vidence demonstrating that APC(Cdh1) plays a critical role in choosing the repair pathways in S/G2 ce
76 n paid to mean cloud properties due to their critical role in climate projections; however, less rese
78 Epigenetic regulation of chromatin plays a critical role in controlling embryonic stem (ES) cell se
80 TEMENT The extracellular environment plays a critical role in coordinating neuronal migration and neu
81 onent of the SC lateral element, SYCP3 has a critical role in defining the specific chromosome archit
82 esearch suggests evolution could also play a critical role in determining expansion speed but control
84 otions of the tectorial membrane (TM) play a critical role in determining the frequency selectivity o
85 ntly downregulated in prostate cancer, has a critical role in determining tumor-initiating potential
88 memory, the hippocampus is thought to play a critical role in disambiguating (pattern separating) rep
89 etinoid X receptor alpha (hRXRalpha) plays a critical role in DNA binding and transcriptional activit
90 53BP1-dependent end-joining pathway plays a critical role in double strand break repair and is uniqu
93 khead box transcription factor FOXC1 plays a critical role in embryogenesis and the development of ma
94 tion in caveolae biogenesis, Cavin-2 plays a critical role in endothelial cell maintenance and functi
95 Collectively, our data show that p32 plays a critical role in energy homeostasis and represents a pot
96 despite their size, small-bodied bees play a critical role in facilitating long-distance pollen-media
100 together, we conclude that autophagy plays a critical role in growth, asexual/sexual sporulation, deo
101 virus (HBV)-encoded X protein (HBx) plays a critical role in HBV-related hepatocarcinoma development
104 data strongly suggest that MZ B cells play a critical role in initiating FVIII inhibitor formation an
106 he pre- and postsynaptic compartments play a critical role in initiating plastic changes in biologica
110 ranscripts and isoforms, and both may play a critical role in lifespan extension through insulin sign
111 IL-10 is an immunomodulatory cytokine with a critical role in limiting inflammation in immune-mediate
113 or, 15-epi lipoxin A4 (15-epi LXA4), plays a critical role in limiting neutrophil activation and tiss
114 Here, we show that BMP signaling plays a critical role in looping morphogenesis of the avian smal
115 genetic background-dependent manner, plays a critical role in mammalian eyelid development and closur
117 el fluctuations and seamount location play a critical role in marine evolution, mainly by intermitten
118 protein-tyrosine phosphatases (PTPs), play a critical role in metastatic progression of cancers.
119 hese results indicate that calpain-1 plays a critical role in mGluR-LTD and is involved in many forms
120 findings establish that cholesterol plays a critical role in modulating GIRK activity in the brain.
121 We also demonstrate that cholesterol plays a critical role in modulating neuronal GIRK currents.
122 excitatory cholinergic modulation may play a critical role in mPFC deactivation in neuropathic pain a
124 whether the N-linked glycan has a similarly critical role in multimeric, avidly binding Fcs, is unkn
126 also been implicated in playing a unique and critical role in neurodegeneration; however, structural
127 actor for ADHD, potentially by virtue of its critical role in neurodevelopment and synaptic plasticit
128 Therefore, we suggest that SHANK3 has a critical role in neuronal morphogenesis in placodal neur
131 The p53 tumor suppressor protein plays a critical role in orchestrating the genomic response to v
132 -cell-specific transcription factor, plays a critical role in oxidative stress-mediated drug resistan
133 rst direct evidence that Kir channels play a critical role in physiological endothelial responses to
137 y, these data demonstrate that IL-33 plays a critical role in promoting ILC2 egress from the bone mar
138 ntestinal intraepithelial lymphocytes play a critical role in promoting intestinal homeostasis, altho
139 t the peptidyl-tRNA in the P site and play a critical role in promoting the synthesis of polyproline
140 r findings indicate that PBF and PTTG have a critical role in promoting thyroid cancer that is predic
144 ) and Antarctic Bottom Water (AABW) played a critical role in regulating hemispheric and global clima
145 t WASp is a novel substrate of ALK and has a critical role in regulating invasiveness and oncogenesis
146 tly, it has been reported that GSDMD plays a critical role in regulating lipopolysaccharide and NLRP3
147 ed a novel cellular signaling network with a critical role in regulating the replication of multiple
150 he ubiquitin-proteasome system (UPS) plays a critical role in removing unwanted intracellular protein
151 igh-level MDM2 but not MDM4 has a consistent critical role in retinoblastoma cell proliferation in vi
152 ant features (e.g. species or genes) plays a critical role in revealing the contributors (i.e. pathog
154 c furosemide, ClC-Kb/K2 is assumed to have a critical role in salt handling by the thick ascending li
155 ding domain 3 (Mbd3) and the complex plays a critical role in self-renewal and neuronal differentiati
156 factor (GEF) Son of Sevenless (SOS) plays a critical role in signal transduction by activating Ras.
157 Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the
159 ward delays at the decision point and play a critical role in suppressing impulsive choice by regulat
161 that hydrogen(s) present at C10 of AA play a critical role in the catalysis of prostaglandin and thro
162 (erythroid-derived 2)-like 2 (NRF2) plays a critical role in the cellular antioxidant response under
163 dentify a mode of cIAP1 regulation playing a critical role in the cellular response to apoptotic path
164 nom peptide toxins such as conotoxins play a critical role in the characterization of nicotinic acety
165 immiscible systems of binary alloys plays a critical role in the design of multicomponent alloys.
166 eta in a synergistic manner, and NMD plays a critical role in the determination of the p53beta follow
167 cus bpsABCD has been demonstrated to serve a critical role in the development of mature biofilms form
168 and their metabolic products, likely plays a critical role in the development of obesity-associated i
170 xxphi motif, but not dileucine motif, play a critical role in the earliest stages of AP2 activation a
171 e data suggest that NCgl2760/Rv0227c plays a critical role in the elongation of the mannan backbone o
172 prominent theories arguing that it played a critical role in the evolution of vocal communication, i
173 a interactions at the sensory ganglia play a critical role in the genesis of herpetic neuralgia.
174 (IL-10)-producing B cells (B10 cells) play a critical role in the immune system balance by negatively
175 results suggest that FABP4 and FABP5 have a critical role in the maintenance, longevity and function
177 is potentiated by TxA2 and that TxA2 plays a critical role in the most proximal event of CLEC-2 signa
178 Abnormalities of mucus viscosity play a critical role in the pathogenesis of several respiratory
179 HC; encoded by CBFB-MYH11) and RUNX1 plays a critical role in the pathogenesis of this leukemia.
180 ved in male cell differentiation and plays a critical role in the regulation of chromatin functions i
182 el subunit of MCUC, has been shown to play a critical role in the response to beta-adrenoreceptor sti
183 or CXCR4 and its chief ligand CXCL12 plays a critical role in the retention and migration of hematopo
185 ction of double-strand breaks (DSBs) plays a critical role in their detection and appropriate repair.
186 d that the NPs chemical composition played a critical role in their in vivo biodistribution and toxic
190 odel where the eVP30-eNP interaction plays a critical role in transcription initiation and provides a
192 is (PUMA) and showed that these cells play a critical role in tumor progression that is independent o
193 9 as a novel regulator of AKT pathway with a critical role in tumorigenesis and chemo-response in pan
194 n hypothesized the fungal metabolism plays a critical role in virulence though specific nutrient sour
195 tical circuit assembly are thought to play a critical role in vulnerability to schizophrenia (SZ), bu
196 Protein detection and quantification play critical roles in both basic research and clinical pract
197 ressed in lung epithelial cells, IL-33 plays critical roles in both innate and adaptive immune respon
198 rmediates, or excited states, which can play critical roles in both protein folding and function.
202 gration, and surface receptor integrins play critical roles in controlling the organization of cytosk
203 he mitochondrial adaptor molecule MAVS plays critical roles in coordinating both virus-induced type I
210 er regulator of brain development that plays critical roles in establishing cortical connections to o
213 f its downstream target AMPKalpha, which has critical roles in governing cancer cell energy metabolic
214 munity and allergic immune surveillance play critical roles in host responses to pathogens, parasites
217 RAKs) are serine/threonine kinases that play critical roles in initiating innate immune responses aga
218 residue toward the C terminus of ORF52 play critical roles in its ability to rearrange the architect
220 lopment in humans and other species and play critical roles in many physiological and pathophysiologi
221 ion as molecular coincidence detectors, have critical roles in models of learning, and are associated
222 an RNA- and channel-binding regulator, with critical roles in neural circuit formation and function.
226 GAI, RGA and SCR (GRAS) family proteins play critical roles in plant development and signalling.
228 tes catalyzed at faster rates with potential critical roles in protein activation, including the hist
230 at is present in most mammalian cells, plays critical roles in signaling pathways and cell cycle prog
232 e induced by interleukin-27 (IL-27) and have critical roles in the control of autoimmunity and resolu
233 miRNAs) are small, non-coding RNAs that play critical roles in the post-transcriptional regulation of
235 ents of the cancer microenvironment and play critical roles in the regulation of tumor progression.
236 a and prefrontal cortex (PFC) appear to have critical roles in these disorders; however, abnormalitie
238 ion as transcriptional coactivators and play critical roles in various cellular processes, including
240 ifferential methylation analysis uncover the critical role of Aid as a key epigenetic regulator.
241 vessels and provide genetic evidence of the critical role of AVR in the countercurrent exchange mech
243 Functional analysis further implicates a critical role of c-Fos in initiating, but not maintainin
245 e studies should be conducted to explore the critical role of CAR in survival of cancer patients.
247 udies of CD40L-deficient patients reveal the critical role of CD40L-CD40 interaction for the function
249 of genome-wide mediation effects suggests a critical role of cryptic gene regulation underlying many
252 performed with Clec7a(-/-) mice support the critical role of Dectin-1 for inflammasome activation, r
253 un02 inactivation procedure to demonstrate a critical role of dorsomedial striatum neuronal ensembles
254 broad biological significance because of the critical role of folate in normal cell function and the
257 ERK1/2 activation dynamics, highlighting the critical role of intracellular calcium in shaping the pE
261 Cripto-1 potentiated signaling, revealing a critical role of membrane association for its establishe
264 odified by sensory entrainment, supporting a critical role of ongoing oscillations in the integration
265 ensory entrainment, providing evidence for a critical role of ongoing oscillations in the temporal or
270 ides additional evidence with respect to the critical role of RH as an influencing factor in AOD-prec
274 t1/GSK3beta/TAZ/YAP signaling and confirms a critical role of TAZ/YAP in mediating the profibrotic re
277 IGNIFICANCE STATEMENT This paper unveils the critical role of the brake potassium current IKD in dama
278 for functional multimerization and reveal a critical role of the C-terminal tail region of IN in hig
280 auditory/vestibular impairments confirms the critical role of the HC proteome for normal IE function,
283 ospho-mimetic mutants of FoxM1b identified a critical role of the Plk1 phosphorylation sites in regul
287 n types of medical waste and highlighted the critical role of waste packaging in successful steriliza
288 h endothelial venules, the results highlight critical roles of innate/inflammatory responses in SIVma
289 poiesis and leukemogenesis and highlight the critical roles of METTL14 and m(6)A modification in norm
292 These led to a proper estimation of the critical roles of volume of activation (Delta( not equal
293 peptide signals and their co-receptors play critical roles patterning and maintaining barrier integr
295 Not only does this study underscore the critical role that these proteins play in the viral repl
297 broad participation in these evolutionarily critical roles, the anucleate platelet is uniquely mamma
298 hyl-D-aspartate (NMDA) receptors have played critical roles throughout the history of neuropharmacolo
299 within behavioral decision research gives a critical role to associative cognitive processes, sugges
300 d the interaction with gas molecules plays a critical role, which may represent a gas-molecular-adsor
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