ライフサイエンスコーパス: cross-coupling

1 f diarylmethanes via copper-catalyzed Ullman cross-coupling.

2 ) complexes is mechanistically essential for cross-coupling.

3 the previous route employing Suzuki-Miyaura cross-coupling.

4 designed around conventional organometallic cross-coupling.

5 opper- or palladium-catalyzed intramolecular cross-coupling.

6 an be functionalized through metal-catalyzed cross-coupling.

7 f C-H bonds as native functional handles for cross-coupling.

8 es that may be employed as pseudohalides for cross-coupling.

9 ed to probe the stereochemical course of the cross-coupling.

10 alpha-hydroxy ketone and a silicon-mediated cross-coupling.

11 ations, such as oxidation, halogenation, and cross-coupling.

12 zation and promoting efficient and selective cross-coupling.

13 radical that is responsible for predominant cross-coupling.

14 i-conjugation was extended using Sonogashira cross-coupling.

15 omatic backbone of the electrophile prior to cross-coupling.

16 was achieved versus competitive C-O and C-N cross-couplings.

17 ra, Stille and Ullmann, but also C-O and C-N cross-couplings.

18 alladium-catalyzed C(sp3)X-C(sp3)ZnX Negishi cross-coupling affording an omega-hydroxy hemiacetal whi

19 Cadiot-Chodkiewicz cross-coupling affords higher yields of rotaxanes than h

20 The C-N cross coupling also established with aryl silanes, exten

21 s: a modern metallacycle-mediated annulative cross-coupling and a new acid-catalysed vinylcyclopropan

22 C16-C18 bond formation in the Suzuki-Miyaura cross-coupling and atropodiastereoselective Dieckmann-ty

23 the efficiency enhancement via resonant mode cross-coupling and matching can be extended to even high

24 A series of palladium-catalyzed cross-coupling and other reactions was employed to assem

25 ential as building blocks for Suzuki-Miyaura cross-coupling and other reactions.

26 olve microwave-assisted Liebeskind-Srogl C-C cross-coupling and palladium-catalyzed decarboxylative c

27 etailed investigation of a surface-catalysed cross-coupling and sequential cyclization cascade of 1,2

28 tives may be accessed through site-selective cross-couplings and N-bromosuccinimide-promoted heteroar

29 transformations entailing allylation, tandem cross coupling, and application to the synthesis 1,3-pol

30 een detected in catalytic reactions, such as cross-coupling, and discusses the potential implications

31 Along with amide bond formation, Suzuki cross-coupling, and reductive amination, the Buchwald-Ha

32 ly synthesized by transition metal catalyzed cross-couplings, and circumvents common issues associate

33 yzed direct arylation, sequential orthogonal cross-couplings, and late-stage silylation of phenolic b

34 pure noncanonical strigolactones by a Stille cross-coupling approach to forge the central diene moiet

35 ive strategy to conventional metal-catalyzed cross-coupling approaches.

36 lysis offers a potential solution, but prior cross couplings are limited to allylic substrates or del

37 orides, thus leading to new knowledge in the cross-coupling arena.

38 Key steps included (a) a Liebeskind-Srogl cross-coupling; (b) a one-pot construction of the tetrac

39 Catalytic enantioselective conjunctive cross-coupling between 9-BBN borate complexes and aryl e

40 onal group tolerance to the venerable Suzuki cross-coupling between alkyl-carboxylic acids and boroni

41 ine derivatives that lead to dehydrogenative cross-coupling between C(sp(2))-H and N-H bonds to produ

42 A nickel-catalyzed conjunctive cross-coupling between non-conjugated alkenes, aryl iodi

43 new thermal and photoinduced copper-mediated cross-coupling between potassium selenocyanate (KSeCN) a

44 gand (EPhos) for the palladium-catalyzed C-N cross-coupling between primary amines and aryl halides h

45 ors with overlapping specificity can lead to cross-coupling between stress and hormone-sensitive path

46 m stromal cells, our results demonstrate how cross-coupling between the CREB/CRTC and JAK/STAT pathwa

47 Nickel-catalyzed enantioselective cross-couplings between symmetric cyclic sulfates and ar

48 Orthogonal site-selective Heck cross-couplings by C-Br/N-C cleavage and mechanistic stu

49 mber of Pd-catalyzed processes, ranging from cross-coupling, C-H activation, to Wacker chemistry.

50 the interfaces remains to be unraveled, such cross coupling can be utilized to manipulate the magneti

51 th multiple bond heterofunctionalisation and cross coupling catalysis.

52 tiation dynamics of an operational palladium cross-coupling catalyst at the bulk and single-molecule

53 ver the past several decades, organometallic cross-coupling chemistry has developed into one of the m

54 ompatible with cell growth and carry out the cross-coupling chemistry in live cell cultures.

55 lective halogenase enzymes with Pd-catalysed cross-coupling chemistry, in one-pot reactions, successf

56 is still relatively uncommon in the field of cross-coupling chemistry.

57 ed as useful surrogates for alkyl halides in cross-coupling chemistry.

58 m ions also display orthogonal reactivity in cross-couplings compared to halides, enabling chemoselec

59 on to define stereoconvergent Suzuki-Miyaura cross-coupling conditions affording (Z)-alpha-methyl-bet

60 ate spirocyclic or annulation products under cross-coupling conditions, remains innocent in this repo

61 re efficient second-generation set of olefin cross-coupling conditions.

62 enantioenriched form through metal-mediated cross coupling, de novo construction of an aromatic ring

63 h can be used to synthetic gain in a cascade cross-coupling/Diels-Alder reaction, delivering borylate

64 istry and enabled a highly efficient Negishi cross-coupling downstream.

65 sing a synergistic iridium photoredox/nickel cross-coupling dual catalysis strategy has been develope

66 Esters are valuable electrophiles for cross-coupling due to their ubiquity and ease of synthes

67 We report an efficient means of sp(2) -sp(3) cross coupling for a variety of terminal monosubstituted

68 e of bromo-carboranes in palladium-catalyzed cross-coupling for efficient B-N, B-O, and unprecedented

69 be combined with site-selective conventional cross-coupling for the regioselective synthesis of poten

70 ized as a common byproduct in Suzuki-Miyaura cross-couplings for decades, this reactivity has not bee

71 The Suzuki-Miyaura cross-coupling gave the best yields when it was catalyze

72 Chemoselective Suzuki-Miyaura cross-coupling generally requires a designed deactivatio

73 completed in nine steps and via Sonogashira cross-coupling, gold-catalyzed cyclization, and an unusu

74 An asymmetric decarboxylative Csp(3)-Csp(2) cross-coupling has been achieved via the synergistic mer

75 A copper-catalyzed selective C-N cross-coupling has been developed based on chelation-ass

76 An asymmetric Ni-catalyzed reductive cross-coupling has been developed to prepare enantioenri

77 A general, efficient method for C-N cross-coupling has been developed using N,N-dimethylocta

78 The field of Ni-catalysed cross-coupling has seen rapid recent growth because of t

79 dvances in the related field of Pd-catalysed cross-coupling have been driven by ligand design, the de

80 into the alkyne functionality by Sonogashira cross-coupling, (iii) synthesis of pyrazole units by the

81 ing does not take place in this sp(2) -sp(3) cross coupling, implying that beta-hydride elimination i

82 cules underwent homocoupling and Sonogashira cross-coupling in an unambiguously heterogeneous mode.

83 ile control allows sequential chemoselective cross-couplings in a single operation in the absence of

84 iels-Alder condensation followed by a Stille cross-coupling is used for the elaboration of the desire

85 Palladium-catalyzed conjunctive cross-coupling is used for the synthesis of enantioenric

86 Suzuki-Miyaura cross-coupling is widely used in the academic and indust

87 rationally simple alternative to traditional cross-coupling macrocyclizations.

88 This C-S cross-coupling method exhibits remarkable functional gro

89 The development of a new decarboxylative cross-coupling method that affords terminal and substitu

90 h (11)C-methyl iodide via the Suzuki-Miyaura cross-coupling method.

91 r previously reported 10-20 min benchtop C-N cross-coupling methodology, affording a broad range of a

92 A wide array of cross-coupling methods for the formation of C-C bonds fr

93 at are challenging to prepare by traditional cross-coupling methods.

94 their counterparts prepared using classical cross-coupling methods.

95 amethylethylenediamine (TMEDA) catalyzes the cross coupling of (bis)pinacolatodiboron with a wide ran

96 This Suzuki-Miyaura cross coupling of alkylpyridinium salts, readily formed

97 tegies have been developed for the homo- and cross coupling of alkynes to enynes via transition metal

98 ng of 2-benzyl-1,3-dithianes with subsequent cross coupling of the pendent thiol with a range of aryl

99 evelopment of a Pd-catalyzed process for the cross coupling of unactivated primary, secondary, and te

100 An asymmetric Ni-catalyzed reductive cross-coupling of (hetero)aryl iodides and benzylic chlo

101 been established by the copper(I)-catalyzed cross-coupling of 1,1-dibromoenamides with nitrogen nucl

102 Buchwald-Hartwig-Migita cross-coupling of 1-thiosugars with 2-iodoglycals has be

103 A copper-catalyzed cross-coupling of 2-alkyl-/2-arylaziridines with benzimi

104 A decarboxylative cross-coupling of 3-substituted picolinic acids with (he

105 A cross-coupling of acyl chlorides with gem-difluorinated

106 ckel dual catalysis has been employed in the cross-coupling of acyl chlorides with potassium alkyltri

107 A copper-catalyzed C(sp(3))-Si cross-coupling of aliphatic C(sp(3))-I electrophiles usi

108 Despite advances in organometallic cross-coupling of alkyl electrophiles, there are few ste

109 y simple, mild, redox-neutral method for the cross-coupling of alpha-hydroxyalkyltrifluoroborates is

110 Copper(II)-catalyzed oxidative cross-coupling of anilines, primary alkyl amines, and so

111 P(t)Bu3)2 as a catalyst for the Pd-catalyzed cross-coupling of aryl bromides with TMSCF2CF3 to afford

112 rocyclic carbene ligands catalyze the Suzuki cross-coupling of aryl chlorides and bromides with alkyl

113 thod for the synthesis of C-P bonds involves cross-coupling of aryl halides and dialkyl phosphites (t

114 The cross-coupling of aryl tosylates with amines and aniline

115 This is the first transition-metal-free cross-coupling of azaallyls with vinyl bromide electroph

116 A Pd(II)-catalyzed enantioselective C-H cross-coupling of benzylamines via kinetic resolution ha

117 ied complexants through multi-Suzuki-Miyaura cross-coupling of bromoheteroarenes with organotrifluoro

118 l- and base-free protocol for intramolecular cross-coupling of C(sp(2))-H and N-H bonds using N-iodos

119 the eliminative dimerization and eliminative cross-coupling of carbenoids is reviewed with a range of

120 raditional alkene syntheses, the eliminative cross-coupling of carbenoids offers a connective approac

121 catalyst and activating the catalyst toward cross-coupling of carbon electrophiles.

122 e also enabled by PAd3 during Suzuki-Miyaura cross-coupling of chloro(hetero)arenes (40 examples) at

123 led to the development of an intermolecular cross-coupling of electronically-differentiated donor an

124 are traditionally required for the effective cross-coupling of ester substrates.

125 xes has been enployed for the Suzuki-Miyaura cross-coupling of four different nucleosides in water un

126 metabolites and the concomitant biorthogonal cross-coupling of halo-metabolites in living cultures.Co

127 evaluated for its proficiency in the Negishi cross-coupling of hindered and electronically deactivate

128 ediated picolinamide directed regioselective cross-coupling of naphthylamines with azoles is develope

129 d at the crossroads: The palladium-catalyzed cross-coupling of nitroarenes has eluded chemists for de

130 first example of a very general Cu-catalyzed cross-coupling of organoaluminum reagents with organohal

131 ighly selective, intermolecular Cu-catalyzed cross-coupling of phenolic nucleophiles.

132 ized ketones via dehydrogenative-dehydrative cross-coupling of primary and secondary alcohols is demo

133 ion conditions and activating agents for the cross-coupling of primary, secondary, and tertiary alkyl

134 ction conditions can also be extended to the cross-coupling of pyrazole and pyrrole scaffolds.

135 An operationally simple and metal-free cross-coupling of quinone monoacetals (QMAs) with 2-naph

136 A novel catalytic system for oxidative cross-coupling of readily oxidized phenols with poor nuc

137 Herein, we report the cross-coupling of secondary and primary ammonium alkylsi

138 The stereospecific cross-coupling of secondary boronic esters with sp(2) el

139 A Ni-catalyzed reductive cross-coupling of styrenyl aziridines with aryl iodides

140 hotoredox-Ni dual catalytic strategy for the cross-coupling of tertiary organoboron reagents with ary

141 regioselective C-H borylation and subsequent cross-coupling of the 2,1-borazaronaphthalene core are r

142 ee terpyridines were obtained through Suzuki cross-coupling of the Ru(II) complexes, and then assembl

143 owed by a palladium-catalyzed Suzuki-Miyaura cross-coupling of the tosylates and pinacol boronic este

144 The cross-coupling of these radicals is catalyzed by copper

145 p tolerance on both partners, permitting the cross-coupling of unprotected primary and secondary amin

146 effects account for the diminished rates of cross-couplings of 1,2-cis C1-stannanes with aryl halide

147 Cross-couplings of alkyl halides and organometallic spec

148 new methods have been developed that effect cross-couplings of an array of alkyl electrophiles, ther

149 demonstrated in its application to oxidative cross-couplings of aromatics via decarboxylative/C-H or

150 Ni-catalyzed cross-couplings of aryl, benzyl, and alkyl thiols with a

151 results presented here show that various C-C cross-couplings of benzothiadiazole, thiophene, and thia

152 atalyzed Suzuki-Miyaura and Buchwald-Hartwig cross-couplings of nitroarenes were reported.

153 ligands gave improved yields for challenging cross-couplings of pharmaceutically relevant substrates

154 here have been no reports of metal-catalyzed cross-couplings of unactivated secondary or tertiary alk

155 trioloxin A (1) has been synthesized through cross-couplings of various enantiomerically pure halocon

156 als in 43-99% yield over two, three, or four cross-couplings on the same scaffold.

157 ide chains were introduced by Suzuki-Miyaura cross-coupling or click reaction.

158 lopyrimidines, followed by glycosylation and cross-couplings or nucleophilic substitutions at positio

159 the analogous intramolecular Suzuki-Miyaura cross-couplings or reductive Yamamoto homocouplings.

160 Aryl chlorides serve as both cross-coupling partners and the chlorine radical source

161 g promises to expand the range of accessible cross-coupling partners even further to include both sin

162 nctionalization, isolation of organometallic cross-coupling partners, and/or stoichiometric waste asi

163 on to activate alkyl halides as nucleophilic cross-coupling partners.

164 ich is consistent with an oxidative addition cross-coupling pathway.

165 Csp(3)-Csp(2) bonds generically via a unique cross-coupling pathway.

166 This then allows control of cross-coupling pathways via promotion or inhibition of o

167 ctional chemical probe with Pd(II)-dependent cross-coupling pathways.

168 re we report the development of a C(sp(3))-H cross-coupling platform enabled by the catalytic generat

169 -MI) was designed and synthesized via Suzuki cross-coupling polymerization in good yields without any

170 able atom-economical alternative to standard cross-coupling polymerization reactions.

171 (pinacolato) group, widely used in catalytic cross-coupling, possess the requisite electronic and ste

172 iridium photoredox and nickel dual-catalyzed cross-coupling procedure for the formation C-N bonds has

173 To address this issue, nickel-catalysed cross-coupling processes can be used to form sp(3)-sp(3)

174 Until recently, the vast majority of cross-coupling processes had used either aryl or alkenyl

175 iling the involvement of different catalytic cross-coupling processes, is highlighted by its applicat

176 boronative and oxidative C(sp(2) )-C(sp(3) ) cross-coupling processes, with excellent functional-grou

177 y enhances the already remarkable utility of cross-coupling processes.

178 which undergo transmetalation leading to the cross-coupling product.

179 elopment of a novel mechanistic paradigm for cross-coupling promises to expand the range of accessibl

180 This oxidative cross-coupling protocol furnishes mono and double C-O co

181 This cross-coupling protocol should enable broad synthetic ap

182 plied to iron-SciOPP catalyzed alkynyl-alkyl cross-couplings, providing the first detailed insight in

183 sters was obtained via a palladium-catalyzed cross-coupling reaction (Hirao coupling) of dialkyl phos

184 of anomeric configuration make the glycosyl cross-coupling reaction a practical tool for the synthes

185 synthesized by the Pd-catalyzed Sonogashira cross-coupling reaction and subsequent [2 + 2] cycloaddi

186 asymmetric iron-catalyzed C(sp(2))-C(sp(3)) cross-coupling reaction between Grignard reagents and al

187 erated through a palladium-catalyzed Ullmann cross-coupling reaction between o-iodonitrobenzene and a

188 prepared using a palladium-catalyzed Ullmann cross-coupling reaction between the appropriate 2-iodocy

189 is a mild, scalable, visible-light-promoted cross-coupling reaction between thiols and aryl halides

190 o-metabolites, develop a mild Suzuki-Miyaura cross-coupling reaction compatible with cell growth and

191 However, under the optimized cross-coupling reaction conditions, the isomerization wa

192 spectroscopic studies suggest that this C-S cross-coupling reaction does not involve a Ni(0)-species

193 This elementary reaction enables a powerful cross-coupling reaction in which a chiral Pd catalyst me

194 atalyzed synthesis of diaryl selenides via a cross-coupling reaction of diaryl diselenides with aryl

195 The efficient Suzuki-Miyaura cross-coupling reaction of halogenated aminopyrazoles an

196 An efficient Suzuki-Miyaura cross-coupling reaction of perfluorinated arenes with ar

197 al and highly stereoselective iron-catalyzed cross-coupling reaction of stereodefined enol carbamates

198 ared by means of either the Liebeskind-Srogl cross-coupling reaction or the Vilsmeier reaction.

199 uctions to build the polyol domain, a Stille cross-coupling reaction to assemble the polyene, and an

200 ynthesis features the stereoselective Stille cross-coupling reaction to set up the whole carbon frame

201 The ability to perform the cross-coupling reaction was facilitated by the regio-con

202 The versatility of the glycosyl cross-coupling reaction was probed in the total synthesi

203 oronic acid (p-tolyl-B(OH)2) in this type of cross-coupling reaction were evaluated (eg, ethyleneglyc

204 anomeric stannanes undergo a stereospecific cross-coupling reaction with aromatic halides in the pre

205 ting group, which otherwise does not allow a cross-coupling reaction, by transformation to the N-oxid

206 ugh an efficient palladium-catalyzed Ullmann cross-coupling reaction, is reductively cyclized under c

207 , has been established in the Suzuki-Miyaura cross-coupling reaction.

208 ized aryl iodides are introduced, subsequent cross coupling reactions can be used for further modific

209 rins were synthesized through Suzuki-Miyaura cross coupling reactions.

210 fective room-temperature palladium-catalyzed cross-coupling reactions (CCRs) of aryl and heteroaryl c

211 implications for the design of N-C(O) amide cross-coupling reactions and control of the molecular co

212 ladium nanoparticle-catalyzed Suzuki-Miyaura cross-coupling reactions and evaluated as human carbonic

213 ves through conventional palladium-catalyzed cross-coupling reactions and iodine-lithium exchange pro

214 derstanding the mechanisms of iron-catalyzed cross-coupling reactions and rational design of novel ir

215 Nickel-catalyzed cross-coupling reactions are experiencing a dramatic res

216 arbon-halogen bond activation to achieve C-C cross-coupling reactions as well as reductive dehalogena

217 report a series of enantioselective C-O bond cross-coupling reactions based on remote symmetry breaki

218 Selected examples of C-N cross-coupling reactions between nine classes of nitroge

219 Transition metal-catalyzed cross-coupling reactions between organic electrophiles a

220 hentic monomer participating in coupling and cross-coupling reactions during lignification.

221 ide N-C(O) bonds are generally unreactive in cross-coupling reactions employing low-valent transition

222 ound to be the resting state in Pd-catalyzed cross-coupling reactions for a range of aryl halides and

223 e equivalents for transition metal-catalyzed cross-coupling reactions has the potential to substantia

224 Csp(2)-Csp(3) cross-coupling reactions have been developed, but enanti

225 Ni-catalyzed cross-coupling reactions have found important applicatio

226 Distinct from nickel-catalyzed cross-coupling reactions involving carbon-centered radic

227 media for thermomorphic palladium-catalyzed cross-coupling reactions is demonstrated.

228 In the past 50 years, cross-coupling reactions mediated by transition metals h

229 eavage of inert C(sp(2))-O bonds relevant to cross-coupling reactions of aromatic ethers catalyzed by

230 Cross-coupling reactions of aryl groups with alpha-fluor

231 Pd-catalyzed Suzuki-Miyaura and Sonogashira cross-coupling reactions of cyclic 1,3-diones in the syn

232 Described herein are the cross-coupling reactions of sulfoxonium ylides with C(sp

233 Although metal-catalyzed cross-coupling reactions of unactivated alkyl electrophi

234 In all cases, the cross-coupling reactions take place rapidly in DMSO in g

235 Pd-catalyzed cross-coupling reactions that form C-N bonds have become

236 Iron-catalyzed cross-coupling reactions using alkynyl nucleophiles repr

237 ruglike electrophiles (informers) in Negishi cross-coupling reactions was evaluated by high-throughpu

238 ter for onward reactivity as demonstrated in cross-coupling reactions with benzoyl chloride that prod

239 ed the development of elusive amide bond N-C cross-coupling reactions with organometallic reagents, a

240 ant implications for the design of new amide cross-coupling reactions with the N-C(O) amide bond clea

241 : 1) Palladium-nanoparticle-catalyzed Suzuki cross-coupling reactions, 2) palladium- or silver-nanopa

242 a directing group for C(sp(2))-H activation/cross-coupling reactions, circumventing the extra steps

243 ity of these intermediates is exemplified by cross-coupling reactions, enabling regiocontrolled synth

244 an important role in a range of Ni-catalyzed cross-coupling reactions, especially those involving alk

245 ve been shown to undergo selective amide N-C cross-coupling reactions, feature a significantly decrea

246 amental characterization of the key steps in cross-coupling reactions, including C-C bond-forming red

247 stration of three mild Pd/Cu-mediated Stille cross-coupling reactions, including the use of a one-pot

248 commercially available starting materials by cross-coupling reactions, many desirable and otherwise d

249 yl: A significant development in alkyl-alkyl cross-coupling reactions, namely the nickel-catalyzed de

250 Within the realm of cross-coupling reactions, organotrifluoroborates provide

251 TTF building block using palladium-catalyzed cross-coupling reactions, such as the Suzuki reaction.

252 n the absence of Pd-catalyzed or Ni-mediated cross-coupling reactions, using 1,4-diketones as surroga

253 In a modular approach, using cross-coupling reactions, we synthesized a series of can

254 abundance, and its ability to promote unique cross-coupling reactions.

255 ortant yet elusive objective for engineering cross-coupling reactions.

256 only proposed as the active intermediates in cross-coupling reactions.

257 lkyl groups to transition metal catalysts in cross-coupling reactions.

258 e proposed key intermediates in Cu-catalyzed cross-coupling reactions.

259 w turnover numbers relative to non-oxidative cross-coupling reactions.

260 nate can serve to direct palladium-catalyzed cross-coupling reactions.

261 ve to traditional transition-metal-catalysed cross-coupling reactions.

262 are particularly valuable in metal-catalyzed cross-coupling reactions.

263 the transmetalation step in Pd/Cu-catalyzed cross-coupling reactions.

264 olithium reagents in the palladium-catalyzed cross-coupling reactions.

265 vinyl triflates, a class of highly versatile cross-coupling reagents, enabling the syntheses of other

266 A cross-coupling/reductive cyclization protocol has been e

267 We demonstrated that the glycosyl cross-coupling resulted in consistently high anomeric se

268 A general and effective sp(2)-sp(3) cross-coupling scheme has been achieved that exhibits to

269 In addition to details on the cross-coupling scope and limitations, full screening eff

270 hree-step metalation, zincation, and Negishi cross-coupling sequence, providing efficient access to a

271 yed in sequential transition-metal-catalysed cross-coupling sequences to unite heterocyclic fragments

272 onaqueous palladium-catalyzed Suzuki-Miyaura cross-coupling (SMC) reaction of Fmoc-protected bromo- o

273 mediate doubly stereoconvergent alkyl-alkyl cross-coupling, specifically, reactions of a racemic pyr

274 Current cross-coupling strategies that can be generalized for se

275 y utilized and relies heavily on traditional cross-coupling strategies that employ organometallics an

276 By contrast, in catalytic cross-coupling, substrates are more distinct and homocou

277 e was constructed via a new type II ARC/CuCN cross-coupling tactic, while the southern hemisphere was

278 Catalytic enantioselective conjunctive cross-couplings that employ Grignard reagents are shown

279 ate esters or used in situ in Suzuki-Miyaura cross couplings to generate 2,3-disubstituted heteroaren

280 the widespread application of Suzuki-Miyaura cross-coupling to forge carbon-carbon bonds, the structu

281 ach catalyst in representative photoredox/Ni cross-coupling to form Csp3-Csp2 bonds using the appropr

282 gage boroxines or B2(pin)2 in stereospecific cross-coupling to form diverse tetrasubstituted cyclopro

283 th (-)-sparteine followed by Pd(0) catalysed cross-coupling to prepare alpha-arylated amines is large

284 :1 ratio with Pd(OAc)2, enables Pd-catalyzed cross-couplings to be run using </=1000 ppm of this pre-

285 E-alkenyl chlorides, applicable to catalytic cross-coupling transformations and found in biologically

286 c 10-Si-5 intermediate that dominates in the cross-coupling under catalytic conditions (i.e., in the

287 s were achieved in the long-range asymmetric cross-coupling (up to 93:7 er and 76% yield) between ary

288 nown since the 1970s, pioneered by Kochi for cross-coupling using alkylmagnesium nucleophiles includi

289 Two sequential Suzuki cross-couplings utilizing the halogen selectivity of thi

290 s, is the first example of a metal-catalyzed cross coupling via C-N bond activation of an amine with

291 Highly chemoselective C-S cross-coupling was achieved versus competitive C-O and C

292 An efficient Negishi cross-coupling was developed for the synthesis of the bi

293 (9)-bromo-meta-carborane during Pd-catalyzed cross-coupling, which enables the formation of B-O and B

294 everages nickel's unique properties in alkyl cross-coupling while avoiding limitations commonly assoc

295 ex across the diene followed by Pd-catalyzed cross coupling with an aryl halide or pseudohalide.

296 precursors in a net redox-neutral Csp3-Csp2 cross-coupling with a broad range of aryl halides.

297 cies, which then undergoes an intramolecular cross-coupling with a carbamoyl chloride.

298 Subsequent palladium-catalyzed cross-coupling with haloarenes furnished the desired tri

299 rbon-bound cyanating reagent which undergoes cross-coupling with the aryl boronic acid.

300 Iron-catalyzed cross-couplings with simple ferric salts have been known