ライフサイエンスコーパス: cross-species

1 ugh the type I IFNs generally do not display cross-species activities, rmIFN exhibited high antiviral

2 inogalactan and Pel, that they might display cross-species activity.

3 tes without relying on detailed base-by-base cross-species alignments.

4 eat and fish and 5 plant species detected no cross-species amplification.

5 h data from external sources and facilitates cross-species analyses based on orthology.

6 f RTT and highlight the potential benefit of cross-species analyses in identifying potential disease-

7 Cross-species analyses indicate that both AtDDF1 and AtD

8 Functionality-wise cross-species analyses now enable users to analyse expre

9 This cross-species analysis also validates the importance of

10 iolet radiation-driven mouse cuSCC model for cross-species analysis and demonstrate that cuSCC bears

11 A cross-species analysis identifies a highly conserved seq

12 By using cross-species analysis of expression data, the Notch lig

13 Cross-species analysis of RNA editing in several tissues

14 regulon in each species, and we performed a cross-species analysis of the QS-controlled orthologs.

15 es in individual vertebrates, our integrated cross-species analysis provides valuable insights into t

16 We perform global cross-species and spatial analyses and generate minimum

17 o resolve infection and leave a cross-stage, cross-species, and lasting immunity.

18 This cross-species approach identified unanticipated regulato

19 we examined the fecal microbiome by using a cross-species approach in both rat and human studies of

20 A cross-species approach involving zebrafish and mammalian

21 This cross-species approach is powerful and, as we review her

22 resonance imaging (fMRI), suggesting that a cross-species approach targeting this mechanism might be

23 etic DNA methylation events in MBSHH using a cross-species approach to candidate identification, prio

24 Using a cross-species approach, we first investigated the relati

25 ies (e.g. CRISPR) and support of integrated, cross-species approaches to uncovering gene function usi

26 er of this selection process for identifying cross-species aptamers that can bind human receptors and

27 ssion patterns that are not recapitulated in cross-species assays.

28 Certain RNA viruses can cross species barriers and cause disease in new hosts.

29 Influenza A viruses can cross species barriers and cause severe disease in their

30 new host may help identify viruses poised to cross species barriers before an outbreak occurs.

31 t different levels of pH, the virus can only cross species barriers if HA undergoes mutations that st

32 The capacity of influenza A viruses to cross species barriers presents a continual threat to hu

33 the considerable ability of arenaviruses to cross species barriers.

34 vidence that these viruses have potential to cross species barriers.

35 ens, they do not fully prepare pathogens for crossing species barriers.

36 o detect CCR7, and sort for CCR7 positivity, crosses species being effective on murine and human cell

37 We propose a cross-species bi-clustering approach which first denoise

38 active antibodies were eluted and tested for cross-species binding and reactivity to single-antigen H

39 gainst each targeted virus exhibited limited cross-species binding and, to a lesser extent, cross-neu

40 ral with high affinity but indiscriminately, cross-species binding is rare.

41 ese hot spot residues that explain divergent cross-species binding properties of FcRn.

42 r the next human virus, or which viruses can cross species boundaries.

43 genome, mainly on the X chromosome, has not crossed species boundaries.

44 illus anthracis, indicating a mechanism that crossed species boundaries.

45 tes; the pluripotential methyl-CpH signature crosses species boundaries and is distinct from neuronal

46 We combined quantitative proteomics, cross-species comparative analysis of metabolic pathways

47 We consider evolutionary and cross-species comparative aspects, and integrate availab

48 Cross-species comparative oncogenomics, identifying driv

49 Cross-species comparative studies are a powerful approac

50 istics reported here permit the first direct cross-species comparison of putative homologous ganglion

51 d reciprocal BLAST, we conducted a fly-human cross-species comparison of the phosphoinositide-3-kinas

52 tion and myelination that were validated via cross-species comparison to Ts65Dn trisomy mice.

53 A bioinformatic cross-species comparison using a gene expression signatu

54 y expressed miRNA were further assessed by a cross-species comparison with human osteoblasts and OS c

55 Cross-species comparison within a single MSY phylogeny e

56 cribe a challenge to the animal model and to cross-species comparisons by considering the case of the

57 Cross-species comparisons of genomes, transcriptomes and

58 ebrafish and serve as an important basis for cross-species comparisons of PVN/NPO structure and funct

59 Here, using a novel tool that allows cross-species comparisons of regulatory elements between

60 Recent studies have employed cross-species comparisons of transcription factor bindin

61 analysis of the human data, supplemented by cross-species comparisons to macaques, indicated that CT

62 ecies will facilitate hypothesis generation, cross-species comparisons, annotation of genomes, and an

63 this claim and present arguments based upon cross-species comparisons, EEG findings, and development

64 In cross-species comparisons, the results obtained by diffe

65 s of teaching provides welcome reframing for cross-species comparisons.

66 Basic Local Alignment Search Tool search for cross-species comparisons.

67 Cross-species complementation assays showed that CeGRS1

68 nd plants evolved, phylogenetic analyses and cross-species complementation assays were performed.

69 A cross-species consensus is beginning to emerge suggestin

70 conditions of restricted sleep and addressed cross-species consequences via comprehensive metabolite

71 iota modulate the host signaling and broadly cross-species consequences.

72 Thus, cross-species conservation analysis at the level of co-o

73 Our results mostly reveal cross-species conservation in the distribution and hormo

74 We observed stronger cross-species conservation of regulatory elements in inh

75 ics experiments and both gene family age and cross-species conservation.

76 protein-like features or for genes with poor cross-species conservation.

77 is a micropeptide that shows relatively weak cross-species conservation.

78 ss TCF4 and NRP1 Nevertheless, despite these cross-species conserved subset-specific transcripts, por

79 ened ungulates may be explained by decreased cross-species contact as hosts decline and habitats beco

80 average population density and frequency of cross-species contact.

81 rical cognition, inasmuch as it bolsters the cross-species continuity of the biological system for nu

82 domain [NTD], amino acids [aa] 23 to 90) in cross-species conversion by comparing the conversion eff

83 integrated software and database systems for cross-species data analyses.

84 highlight the value of the AOP framework for cross-species data integration.

85 Cross-species disease transmission between wildlife, dom

86 and ecological end points, (3) facilitating cross-species dose-response evaluation, and (4) highligh

87 9 (BI 665915) that demonstrated an excellent cross-species drug metabolism and pharmacokinetics (DMPK

88 e results show that current models depicting cross species enhancer function as dependent on conserve

89 s of heteroplasmy, we describe an integrated cross-species evaluation of heteroplasmy in mammals that

90 Thus, we found comprehensive cross-species evidence for chronic pain being a state of

91 Thus, we demonstrate converging cross-species evidence for training-induced selective pl

92 These findings provide cross-species evidence of a novel strategy to enhance ex

93 vitro and in vivo perturbation analysis and cross-species evolutionary comparison unveiled a detaile

94 Using a cross-species experiment, we estimated that approximatel

95 These analyses and cross-species experiments in Caenorhabditis elegans and

96 We used cross-species expression experiments to show that Alx1 p

97 To unify efforts, here we have engineered a cross-species expression resource that enables circuits

98 with mechanistic modelling, we show how the cross-species expression resource's dynamics, capacity a

99 eview, we discuss the challenges specific to cross-species extrapolation of neutrophil function durin

100 he molecular basis of sperm-egg recognition, cross-species fertilization, and the barrier to polysper

101 This novel class of cross-species FPR2/Fpr2 agonists should enable translati

102 tebrate lens GRN, implicating these sites in cross species function.

103 mical properties of these proteins and their cross-species functionality show that they are functiona

104 Cross-species gene addition experiments demonstrate that

105 Cross-species gene expression analysis revealed that the

106 Cross-species gene expression comparisons support a role

107 thways not previously associated with DN and cross-species gene nodes and pathways unique to each of

108 about the effect of complex gene homology on cross-species gene set analysis.

109 ower compared to other ad hoc approaches for cross-species gene set analysis.

110 ific TFs affect the expression of conserved, cross-species genes during evolution.

111 loratory analysis of the OFC synaptome found cross-species genetic links to alcohol intake in discret

112 ifier, making it one of the few instances of cross-species genetic modifiers of monogenic traits.

113 a large cohort of human CPCs, we performed a cross-species, genome-wide search for oncogenes within s

114 Mechanistically, cross-species genomic analyses and complete ciliary resc

115 chemoprevention, here we perform integrated cross-species genomic analysis of cuSCC development thro

116 predation by Acinetobacter baylyi increases cross-species HGT by orders of magnitude, and we observe

117 To delineate the factors limiting cross-species HIV-1 transmission, we passaged a modified

118 oach, called XGSA, that explicitly takes the cross-species homology mapping into consideration when d

119 Here we report a cross-species in vivo screen of 84 candidate oncogenes a

120 and Rhino-Deadlock co-evolution has produced cross-species incompatibilities, which may contribute to

121 mportant determinant of viral host range and cross-species infection and a primary target for antivir

122 lications for understanding the mechanism of cross-species infection and replication of HEV.

123 Direct cross-species infection between koalas and gibbons is un

124 Although a single case of fatal cross-species infection by EEHV3 is known, the results d

125 olor coryi) in Florida following the initial cross-species infection from bobcats.

126 data will help to elucidate the mechanism of cross-species infection of HEV in the future.

127 To evaluate the potential of cross-species infection, we determined the pathogenicity

128 nchorless PrP may pose an increased risk for cross-species infection.

129 ells could be critical in protecting against cross-species infection.

130 lation and GPI anchoring, may also influence cross-species infectivity.

131 residues within proteins can be adapted for cross-species, inter-protein analysis, we used statistic

132 These results uncover a dynamic cross-species interaction between human memory T cells a

133 These cross-species interactions have important implications f

134 pears to be a generic mechanism that enables cross-species interactions, as Pseudomonas aeruginosa ce

135 served in two or more species, rendering any cross-species interactome comparison immediately useful.

136 n the course of this work, we have assembled cross-species interactome comparisons that will allow in

137 Finally, cross-species interactome mapping demonstrates that coev

138 ons that might have been responsible for the cross-species jump.

139 f gammaretrovirus infection, and from recent cross-species jumps of gammaretroviruses from rodents to

140 Adaptive evolution is central to cross-species jumps, and this is why understanding the e

141 have not been previously identified in other cross-species jumps.

142 These findings document outcomes of cross-species lentiviral transmission events among felid

143 tanding of processes that promote successful cross-species lentiviral transmissions is highly relevan

144 A switchable cross-species liquid-repellent surface is developed that

145 s chromosomes within the Triticeae preserved cross-species macrocolinearity, except for a few species

146 ic discovery and diagnostics, integration of cross-species mapping efforts with the Mammalian Phenoty

147 esent the first experimental confirmation of cross-species mating in Leishmania, opening the way towa

148 resent distinct species, with no evidence of cross-species mating.

149 pt profile comparison after 3 or 6 h using a cross-species method by hybridizing petunia samples to a

150 Cross-species molecular comparison of mouse and human CL

151 ion system due to inflammatory responses and cross-species molecular incompatibilities represents a m

152 emory and will serve as a foundation for our cross-species, multitechnique approach aimed at elucidat

153 and demonstrate the utility of our method in cross species network inference.

154 This cross-species network analysis uncovered a set of N-regu

155 In this study, we used a cross-species network approach to uncover nitrogen (N)-r

156 This cross-species network approach was validated with member

157 enhanced by incorporating the local and the cross-species network similarity information through the

158 f single organisms, and the establishment of cross-species networks.

159 stand how closely related arenaviruses elude cross-species neutralization by investigating the struct

160 progression and demonstrate the potential of cross-species oncogenomic approaches combined with mouse

161 alization, gene-set enrichment analysis, and cross-species orthologous-gene comparisons.

162 st new human infectious diseases emerge from cross-species pathogen transmissions; however, it is not

163 ine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile and was advanced a

164 ketamine as a model for psychosis, show that cross-species pharmacological experiments targeting rewa

165 nd prove the utility of systematic human and cross-species phenomics analyses in highly heterogeneous

166 interaction networks, clinical relevance and cross-species phenotype comparisons, as well as a wide r

167 It also incorporates cross-species phenotypes and associations to include res

168 ortant anthelmintic is supported by a broad, cross species polypharmacology with PZQ modulating signa

169 features useful for constructing within- and cross-species prediction models.

170 ing the key amino acid positions that govern cross-species prion conversion has not yet been possible

171 s, such as rabbit, show robust resistance to cross-species prion conversion.

172 e prion seed are the primary determinants of cross-species prion specificity both in vivo and in vitr

173 e effects of variability in prion protein on cross-species prion transmission have been studied with

174 d S170N, N174T "rigid loop" substitutions on cross-species prion transmission in vivo and in vitro.

175 Assessing the risk of cross-species prion transmission remains challenging.

176 beta-sheets and lower the energy barrier for cross-species prion transmission, potentially because of

177 ps illuminate the molecular requirements for cross-species prion transmission.

178 t ChAd63-MVA PfUIS3 can also provide partial cross-species protection against challenge with wild-typ

179 We conclude that coevolutionary analysis of cross-species protein interactions holds great promise b

180 been successful, leaving an unmet need for a cross-species psychosis model sensitive to this widely s

181 Our results provide cross-species quantitative measures of the Ca(2+) curren

182 ction-blocking anti-EDA antibodies with wide cross-species reactivity will enable study of the develo

183 on ECM accumulation and offers a convenient cross-species readout that does not require antibodies.

184 ted by all MHC-E molecules tested, including cross-species recognition of human and MCM SIV-infected

185 Here, we quantify the cross-species relationships between presence of dispersa

186 -making aspects of approach motivation using cross-species-relevant tests.

187 aling idea, it is being challenged by modern cross-species research.

188 model organisms, leading the way to improved cross-species research.

189 Furthermore, in contrast to a similar cross-species response in protein phosphorylation states

190 ls of a single plant is well documented, but cross-species RNA transfer is largely unexplored.

191 Using cross-species sequence capture, phylogenomics and genome

192 s and suggest that insects take advantage of cross-species signals in the meal to trigger antiviral i

193 Identifying cross-species similarities and differences in immune dev

194 imbic cortex/area 25 projections, supporting cross-species similarities in OFC topography.

195 a/interspecies in silico approach based on a cross-species similarity search and deeply investigate t

196 H4 drug discovery programs that have studied cross-species structure-activity relationships, with a f

197 Together, complementary cross-species studies are elucidating principles of adap

198 Cross-species studies enable rapid translational discove

199 These cross-species studies link a cholinergic response to a p

200 We present cross-species studies relating fear learning to anxiety

201 Our cross-species study demonstrated that HIV in humans and

202 nt with physiological knowledge; and (iv) no cross-species synchrony was detected in other species-sp

203 ace additional cognitive demands with little cross-species test-relevance.

204 onaviruses (CoVs)-SARS-CoV and MERS-CoV-have crossed species to cause severe human respiratory diseas

205 We performed cross-species transcriptome analyses of mouse and human

206 Cross-species transcriptomics showed that both models ar

207 erefore, GALV and KoRV may have arisen via a cross-species transfer from an intermediate host whose r

208 ather, they became infected with SIV through cross-species transfer from sooty mangabeys in captivity

209 of genetic incompatibilities preventing the cross-species transfer may explain host specificity, the

210 have served as a potential reservoir for the cross-species transfer of adenoviruses to other hosts, a

211 Cross-species transfer of sperm and active seminal fluid

212 ing that it is a critical determinant in the cross-species transfer of viruses between different carn

213 igate the role of HA in the equine to canine cross-species transfer, we used X-ray crystallography to

214 Despite this lack of sequence identity, cross-species transgenesis has identified some cases whe

215 atterns of key regulators are conserved, but cross-species transgenic assays uncovered incompatibilit

216 thy participants, whereas they performed the cross-species-translated five-choice CPT (5C-CPT).

217 Furthermore, cross-species translation is limited by inconsistent fin

218 em combines mixed feedback control loops and cross-species translation signals to autonomously self-r

219 We used a cross-species translational approach to investigate the

220 s in the hippocampus and risk to PPD using a cross-species translational design.

221 o experiments that directly test the in vivo cross-species transmissibility of SIVcpz strains to huma

222 These findings suggest that the cross-species transmission and adaptation of influenza v

223 eally using molecular techniques to quantify cross-species transmission and differentiate covert host

224 DS, and provide insight into the genetics of cross-species transmission and emergence of pathogenic r

225 nding the molecular parameters that regulate cross-species transmission and host adaptation of potent

226 mised individuals and warrant studies on the cross-species transmission and pathogenesis of this nove

227 ge gap is essential for better understanding cross-species transmission and predicting the likelihood

228 We report here that upon cross-species transmission and serial passage of SIVsab

229 roach to examine Brucella abortus evolution, cross-species transmission and spatial spread in the GYE

230 y only specific SIVcpz strains have achieved cross-species transmission and what transmission risk mi

231 Cross-species transmission appears to be quite common am

232 We also found that the cross-species transmission barrier of SIVcpz to humans c

233 mpacts phenotypic diversity in yeast and the cross-species transmission barriers characteristic of pr

234 to the route of infection, and demonstrates cross-species transmission between bobcats and pumas.

235 nce of HIV from nonhuman primates.IMPORTANCE Cross-species transmission episodes can be singular, dea

236 , each of which resulted from an independent cross-species transmission event of simian immunodeficie

237 ades in orangutans and gibbons resulted from cross-species transmission events from humans that occur

238 he mammalian hepadnaviruses, indicating that cross-species transmission events have played a major ro

239 non provides a unique opportunity to examine cross-species transmission events leading to new lentivi

240 yndrome (MERS)-CoV underscores the threat of cross-species transmission events leading to outbreaks i

241 es appear to have emerged through successful cross-species transmission events on more recent time sc

242 Although most such cross-species transmission events result in limited onwa

243 ractions can provide novel insights into the cross-species transmission events that led to the HIV-1

244 the design of strategies aimed at preventing cross-species transmission from natural hosts of SIVs to

245 nfected around 100,000 people, originated by cross-species transmission from western lowland gorillas

246 c drift and shift, genetic reassortment, and cross-species transmission generate new strains with dif

247 population, and the mechanisms governing its cross-species transmission have been only partially eluc

248 to identify microbes with the potential for cross-species transmission in their natural state within

249 despite dog-to-lion transmission dominating cross-species transmission models, infection peaks in li

250 We previously reported natural cross-species transmission of a subtype of feline immuno

251 rovirus (KoRV) most likely originated from a cross-species transmission of an ancestral retrovirus in

252 ogical and adaptive processes that drive the cross-species transmission of astroviruses.

253 It began following the cross-species transmission of EBOV from an animal reserv

254 s, we simulated what might happen during the cross-species transmission of HSV-1 and found that the D

255 luenza A viruses among various host species, cross-species transmission of influenza A viruses occurs

256 rus-host interactions that led to successful cross-species transmission of lentiviruses, we character

257 gh a timescaled phylogenetic analysis that a cross-species transmission of monkey herpesviruses occur

258 man immunological compatibility, the risk of cross-species transmission of porcine endogenous retrovi

259 M5alpha proteins are a potent barrier to the cross-species transmission of retroviruses.

260 ciency virus type 1 (HIV-1) is the result of cross-species transmission of simian immunodeficiency vi

261 HIV-1 resulted from cross-species transmission of SIVcpz, a simian immunodef

262 ar bases for strain-specific host ranges and cross-species transmission of these human and animal RVs

263 ecies barriers contribute to protection from cross-species transmission of these viruses.

264 nitial and fundamental evidence for possible cross-species transmission of TTVs.

265 Cross-species transmission of zoonotic influenza viruses

266 us exposure and contact frequency in driving cross-species transmission remain the subject of debate.

267 Australia (Wallacea), may be relevant to the cross-species transmission to gibbons in Southeast Asia

268 ults have recapitulated the events of SIVcpz cross-species transmission to humans and identified muta

269 ic increases in pathogenicity may occur upon cross-species transmission to new hosts.

270 distribution, may have played a key role in cross-species transmission to other taxa.

271 Evidence of cross-species transmission was also observed with TFHBV.

272 Upon cross-species transmission, AlHV-1 induces malignant cat

273 pathogen emergence, for example, in zoonotic cross-species transmission, and pathogen control, where

274 y in wildlife and determinants of successful cross-species transmission, or spillover, are therefore

275 pecies highlights an increased potential for cross-species transmission, our results indicate that th

276 Despite significant insights into CoV cross-species transmission, replication, and virus-host

277 review the current knowledge of coronavirus cross-species transmission, with particular focus on MER

278 isease dynamics and create opportunities for cross-species transmission, yet predicting host-pathogen

279 , and black lemurs, there was no evidence of cross-species transmission.

280 oring on prion infectivity have not examined cross-species transmission.

281 sion dynamics has been the limited models of cross-species transmission.

282 complex selective pressures associated with cross-species transmission.

283 nd adaptation of SIVs to new hosts following cross-species transmission.

284 er of pathogens shared is a growing risk for cross-species transmission.

285 echanisms for RV diversity, host ranges, and cross-species transmission.

286 This is the first in vivo study of SIVcpz cross-species transmission.

287 rologous env gene could in theory facilitate cross-species transmissions across vertebrate classes, f

288 a possible role for env swapping in allowing cross-species transmissions across wide taxonomic distan

289 ined whether SERINC5 represents a barrier to cross-species transmissions and/or within-species viral

290 presents an important barrier for successful cross-species transmissions of primate lentiviruses.

291 Although cross-species transmissions of retroviruses between vert

292 and predicting the likelihood of additional cross-species transmissions of SIV into humans.

293 y contact, host species barriers can prevent cross-species transmissions of these viruses.

294 models was indicated by good performance in cross-species validations.

295 Findings with cross-species validity are emphasized.

296 The development of tasks with cross-species validity may enable better prediction of t

297 show that our model explains over 40% of the cross-species variation in LL under contrasting light en

298 ts the value of PERV inactivation to prevent cross-species viral transmission and demonstrates the su

299 tify ecological and biological correlates of cross-species virus transmission in bats and rodents, an

300 PORTANCE Understanding the driving forces of cross-species virus transmission is central to understan