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1 proteotoxic stress and genotoxic DNA-histone crosslinks.
2 chitecture, such as molecular weight between crosslinks.
3 rsible hydrogen bonds and permanent covalent crosslinks.
4 of kinetically distinct reversible covalent crosslinks.
5 nly located at sites of putative intrastrand crosslinks.
6 ovalent dimerization and formation of larger crosslinks.
7 ates replication traverse of DNA interstrand crosslinks.
8 ues to form intra- or intermolecular protein crosslinks.
9 ent of protein-mediated, dynamic chromosomal crosslinks.
10 ch as double-stranded breaks and interstrand crosslinks.
11 mage pathways responsible for correcting DNA crosslinks.
12 poration of dynamic monodentate metal-ligand crosslinks.
13 tomer of poly(glycolide-co-caprolactone) and crosslinked.
14 he solubility of oat protein despite limited crosslinking.
15 inds to CD33 and if C1q mediates CD33/LAIR-1 crosslinking.
16 ular phagocytosis) and direct apoptosis with crosslinking.
17 -electron resonance (DEER) spectroscopy, and crosslinking.
18 tein biotinylation with RNA-protein chemical crosslinking.
19 equirements of LOXL2 that enable collagen IV crosslinking.
20 e catalytic site involved in protein-protein crosslinking.
21 l-amount dynamic CB[8]-mediated non-covalent crosslinking (2.5 mol%), yields extremely stretchable an
23 are then associated through protein-protein crosslinking across the synapse, extracted from the tiss
24 ith light in a photoreactive binary blend of crosslinking acrylate and urethane, wherein phase separa
27 effect on MT stability than do longitudinal crosslinking activities, and that introducing a bias tow
28 ds at the internal microstructure of the 17h-crosslinked aerogel were more uniform and coating with s
30 fective cellular response to DNA interstrand crosslinking agent and telomere maintenance, underscorin
31 that cause replication stress, including the crosslinking agent mitomycin C (MMC) and the replication
32 lease formaldehyde, a potent protein and DNA crosslinking agent that organisms produce in substantial
34 of NONO sensitizes cells to the interstrand crosslinking agent, cisplatin, whereas knockdown of XLF
35 to hyroxyurea, DNA alkylating drugs and DNA crosslinking agents, but this sensitivity is suppressed
36 s and G2/M accumulation upon exposure to DNA crosslinking agents, gammaH2AX and 53BP1 foci accumulati
39 cid probes embedded in permeable, physically crosslinked, alginate beads were also engineered and pro
43 of thermal treatment (after atomization) on crosslinking and bioactivity of microspheres was tested.
45 table 4-thiouridine (4SU) combined with UV-A crosslinking and compare the results with published data
48 e prepared by desolvation and glutaraldehyde crosslinking and functionalized by cysteamine dihydrochl
52 e combined in vivo psoralen-mediated RNA-RNA crosslinking and high-throughput sequencing to identify
54 ing photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP), we isol
58 e basic physicochemical principles of matrix crosslinking and osmotic swelling are universal, our fin
61 chemical initiator, or thermal agitation for crosslinking and thus provides a nontoxic and facile app
62 pposed to LOX, is the principal isoform that crosslinks and stabilizes insoluble collagen deposition
64 complexes preserved in vivo by formaldehyde crosslinking, and coupled with mass spectrometry to iden
67 hyaluronic acid hydrogel that uses a tandem crosslinking approach, where the first crosslinking (gue
70 Based on pull-down experiments, chemical crosslinking, bacterial two-hybrid experiments and nucle
73 Furthermore, our study indicates that non-crosslinked biologic scaffold implantation is biocompati
74 s a fundamental advance in the generation of crosslinked biomaterials, especially in the form of soft
75 in peptic fluid, NLC loading and citric acid crosslinking brought about much higher decrease in diges
78 ork of poly(dimethylsiloxane) polymer chains crosslinked by coordination complexes that combines high
79 of around 100 nm and the "rigid-soft" system crosslinked by nanocrystal domains like silk protein dop
82 -co-methyl acrylate/spiropyran (SP) hydrogel crosslinked by SP mechanophore demonstrates multi-stimul
85 ity and organization as a result of collagen crosslinking by the lysyl oxidase (LOX) family of enzyme
92 secreted into the extracellular matrix that crosslinks collagens by mediating oxidative deamination
96 ts with increasing glyceraldehyde (mimicking crosslinking conditions) and chondroitinase-ABC concentr
100 nse and morphology of microporous physically-crosslinked cryogels are compared to those of heat-treat
101 e the cost effectiveness of corneal collagen crosslinking (CXL) for progressive keratoconus from the
102 the safety and efficacy of corneal collagen crosslinking (CXL) for the treatment of corneal ectasia
103 the safety and efficacy of corneal collagen crosslinking (CXL) for the treatment of progressive kera
104 to corneal transplantation; corneal collagen crosslinking (CXL) is a relatively non-invasive procedur
105 f the film and the substrate, and tailor the crosslink degree/gradient of the film to allow for moist
108 Compared to original uncrosslinked nanogels, crosslinking did not change particle size, polydispersit
111 long uninterrupted three- and four-stranded crosslinked DNA-DNA structures that may originate in viv
112 er et al. (2017) show that by non-covalently crosslinking DNA, BAF promotes chromosome coalescence, p
113 required for resolving cytotoxic DNA-protein crosslinks (DPCs)- a function that had only been attribu
119 high enzyme loading and stability because of crosslinked enzyme coatings on intact CNTs, while obviat
120 challenge due to the involvement of various crosslinking enzymes in the multistep, hierarchical proc
124 ces and interactions of FliG through in vivo crosslinking experiments in cells that lack either all o
126 mammalian spectraplakin protein, ACF7 (Actin-Crosslinking Factor 7), promotes focal adhesion dynamics
127 coherence NMR revealed that Q237 is rapidly crosslinked first by FXIIIa followed by Q366 and Q328.
130 irect spectroscopic evidence for the kind of crosslinks formed and for the conversion reached in a co
134 ous and finely meshed microstructure for the crosslinked gels compared to non-crosslinked counterpart
135 In contrast to the heat-treated chemically-crosslinked gels, the elastic modulus of the physical cr
136 ly active peptides constrained with covalent crosslinks generally have shapes that have evolved to fi
137 andem crosslinking approach, where the first crosslinking (guest-host) enabled injection and localize
141 vacancy-driven gelation to obtain chemically crosslinked hydrogels from defect-rich 2D molybdenum dis
142 During replication-coupled DNA interstrand crosslink (ICL) repair, the XPF-ERCC1 endonuclease is re
144 entral role in the repair of DNA interstrand crosslinks (ICLs) and regulates cellular responses to re
145 Defects in the repair of DNA interstrand crosslinks (ICLs) are associated with the genome instabi
150 (TRAMP complex) and Nab3 (NNS complex) by UV crosslinking immediately following glucose withdrawal (0
152 igh-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP), we identif
154 s, proteomics and high throughput sequencing crosslinking immunoprecipitation) to evaluate simultaneo
156 d to a stable translocation intermediate was crosslinked in vivo to a second SecA protomer at its 1M6
158 sslinking mechanism and establish a role for crosslinking in the partitioning of CTxB to ordered doma
160 immunogold labeling and revealed dityrosine crosslinks in Lewy bodies in brain tissue from PD patien
161 stigating the repair and consequences of DNA crosslinks in metazoan development and in adult post-mit
162 protease required for resolving DNA-protein crosslinks in vivo whose function is compromised in Ruij
164 tro toward a soluble substrate, but fails to crosslink insoluble collagen IV within the extracellular
165 approach resulted in 14 new, systematically crosslinked insulin analogues whose structures and funct
170 a large protein family that is implicated in crosslinking keratin intermediate filaments during hair
171 hanical tuning by mixing reversible covalent crosslinking kinetics is found to be independent of othe
172 components of inter-microtubule bridges that crosslink kinetochore fibers (K-fibers) are still largel
173 kers to undergo intra- to interpolymer chain crosslinking leading to the formation of polymeric film.
175 sRNA-mRNA duplexes can be recovered using UV-crosslinking, ligation and sequencing of hybrids (CLASH)
177 he data and model suggest that NuMA-mediated crosslinks locally bear load, providing mechanical isola
179 purified Scc2-Scc4 and cohesin, we performed crosslinking mass spectrometry and interaction assays th
181 Here, we combine X-ray crystallography and crosslinking mass spectrometry to outline how TRIP13 rec
183 hat CTxB stabilizes raft domains via a lipid crosslinking mechanism and establish a role for crosslin
185 g tumor retention, multi-responsive boronate crosslinked micelles (BCM) for ovarian cancer therapy.
186 BCM-PTX) exhibited higher stability than non-crosslinked micelles (NCM) in the presence of plasma or
191 min exhibited sustained release profile from crosslinked nanogels in simulated gastrointestinal fluid
194 h transitioned from a densely and covalently crosslinked network to one with larger distances between
197 te processing of an unhooked ICL to a single crosslinked nucleotide, and find that it provides only a
199 Apoptosis in malignant cell is induced by crosslinking of cell surface non-internalizing receptors
200 y of GG dinucleotides determines the initial crosslinking of cisplatin, binding of proteins to the ge
206 ibe Staphylococcus aureus sortase A-mediated crosslinking of SCRII to produce stable catalysts for ef
207 the backbone allowed for the intramolecular crosslinking of single chains via the addition of [Pt(1,
208 this article is based on the hypothesis that crosslinking of starch can make it a potential wall mate
212 We show that VEGF90K is generated by the crosslinking of VEGF165, catalysed by the enzyme tissue
213 ch as activated carbon, carbon nanotubes and crosslinked or holey graphenes are used exclusively as t
216 erate conformationally restricted (disulfide-crosslinked) peptide derivatives with suppressed vasocon
217 tional synthases capable of polymerizing and crosslinking peptidoglycan to build the exoskeletal matr
219 We find that duplex distortion induced by a crosslink plays a crucial role in translesion synthesis,
220 ning multiple carboxylic acid groups at each crosslinking point in the polymeric network, which shrin
221 lly magnified by embedding them in a densely crosslinked polyelectrolyte gel, anchoring key labels or
222 e of the DNA cage, consist of a monodisperse crosslinked polymer core with a predetermined pattern of
223 ing layer increases the adhesion strength of crosslinked polymethacrylate resin on mineral surfaces b
228 e hypothesis, which posited that Fc receptor crosslinking produced the increased affinity of antigen-
230 how that the highly conserved actin filament crosslinking protein fimbrin is a critical Cdk1 target f
231 brium network consisting of filaments, actin-crosslinking proteins (ACPs) and motors--confers cell st
232 nd experimental evidence suggest that static crosslinking proteins are required to appropriately rest
233 gn and fabricate a hybrid polymer network by crosslinking randomly branched polymers carrying motifs
236 quential photodegradation and photoinitiated crosslinking reactions to soften and then stiffen the hy
239 e-strand break (DSB) repair, DNA interstrand crosslink repair, repair of stalled replication forks an
241 approximately 23%; however, the pre-gelation crosslinking resulted in a higher CrI value (i.e. approx
242 lly encoded photo-crosslinkers and pair-wise crosslinking revealed distinct footprints of agonists an
243 Here we report a new approach to designing crosslinked, rigid polymer nanofilms with enhanced micro
244 g the empirical mixing of assorted monomers, crosslinking schemes, and occluded swelling agents, but
249 Hydrogen/deuterium exchange and chemical crosslinking showed that Rca structurally destabilizes e
250 nd in-depth characterization of platinum(II)-crosslinked single-chain nanoparticles (Pt(II) -SCNPs) t
251 hods that can amplify cDNAs that truncate at crosslink sites and we show that computational analyses
253 While BLs can both bind to the target and crosslink st-AuNPs, their latter function is essentially
254 e of the volatile, trans-2-hexenal, from the crosslinked starch aerogel and led to slower lethality o
255 hese results indicate that precipitation and crosslinking steps of EPC have an important role in main
259 "dry" elastomers, largely because reversible crosslinks such as hydrogen bonds are often polar motifs
260 ansfer, native electrophoresis, and chemical crosslinking suggest that Ca(2+) does not affect ABD1 bu
262 l as from increases in serum CTX (C-terminal crosslinking telopeptide of type I collagen) and TRACP-5
263 ) possessing intramolecular dynamic covalent crosslinks that can transform into polymer films through
264 lesions and with cysteine substitutions that crosslinked the PAS beta-scaffold to the HAMP AS-2 helix
265 nt of the nucleic acid scaffold, essentially crosslinking the RNAP and the nucleic acids to prevent t
266 previous work demonstrated that this enzyme crosslinks the 7S domain, a structural domain that stabi
268 transverse filaments within this structure 'crosslink' the axes of homologous chromosomes, stabilizi
269 ics, polymerize the glycan strands of PG and crosslink them into the cell wall meshwork via attached
271 C1-RPA-induced incisions and digest past the crosslink to quantitatively complete the unhooking react
275 SiMPull) assay combined with in vivo protein crosslinking to count individual alpha-SYN protein and a
276 mechanical strength of alginate-based MN by crosslinking to facilitate skin penetration, thus suppor
278 Here we utilized site-specific in vivo photo-crosslinking to thoroughly map SecY regions that are in
279 ect the molecular kinetics of the reversible crosslinks to the macroscopic dynamic mechanical behavio
280 logical model suggests that dense, transient crosslinks to the spindle along k-fibers bear the load o
282 nuous flow requires local remodeling through crosslink unbinding and and/or filament disassembly.
283 etry analysis showed that these peptides are crosslinked via the oxidative quinone ring of the tyrosi
290 ilicity) by spray-drying, using maltodextrin crosslinked with citric acid as encapsulating material.
294 hells and oxygen-permeable polystyrene cores crosslinked with metal-free purely organic phosphors.
298 oncanonical amino acids (ncAAs) to construct crosslinks within or between proteins has emerged as a u
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