ライフサイエンスコーパス: crotonyl-CoA

1 the thermodynamically stable normal product, crotonyl-CoA.

2 h both crotonyl-ACP and the model substrate, crotonyl-CoA.

3 ylation of glutaryl-CoA to produce CO(2) and crotonyl-CoA.

4 i) of 4.0 and 12.9 microM, respectively, for crotonyl-CoA.

5 loyl-CoA, 3-oxopimeloyl-CoA, glutaconyl-CoA, crotonyl-CoA, 3-hydroxybutyryl-CoA and acetyl-CoA as obs

6 positive (+38 mV) than did optimal product (crotonyl-CoA) (+31 mV), a finding opposite of that obser

7 Catalysis of the syn hydration of crotonyl-CoA, absent in the wild-type 4-chlorobenzoyl-Co

8 e catalyzes the oxidation of glutaryl-CoA to crotonyl-CoA and CO(2) in the mitochondrial degradation

9 ation and decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2).

10 acid of Glu370 also protonates the transient crotonyl-CoA anion following decarboxylation.

11 Protonation of the crotonyl-CoA anion occurs by a 1,3-prototropic shift cat

12 725 nm-absorbing species is the delocalized crotonyl-CoA anion that follows decarboxylation and that

13 xylation, and Arg94 stabilizes the transient crotonyl-CoA anion.

14 also driven by the concomitant reduction of crotonyl-CoA by NADH, a process called electron bifurcat

15 on of the DeltaacuI::kan mutant phenotype by crotonyl-CoA carboxylase/reductase from R. sphaeroides w

16 sion is based on the following findings: (i) crotonyl-CoA carboxylase/reductase, a key enzyme of the

17 inhibited by a mutation in the gene encoding crotonyl-CoA carboxylase/reductase, demonstrating that a

18 d the midpoint potential for the butyryl-CoA/crotonyl-CoA couple (E(BCoA/CCoA)) to shift 14 mV negati

19 CoA with bulk solvent and (b) protonation of crotonyl-CoA dienolate by solvent-derived protons under

20 The protonation of crotonyl-CoA dienolate following decarboxylation of glut

21 lar 1,3-prototropic shift for protonation of crotonyl-CoA dienolate.

22 erization of enzyme activity with respect to crotonyl-CoA, hexenoyl-CoA, and dodecenoyl-CoA substrate

23 (2015) discover that levels of intracellular crotonyl-CoA impact the histone acylation landscape, pro

24 ance (lambda(max) approximately 725 nm), and crotonyl-CoA is found as the sole product.

25 e availability of the appropriate substrate (crotonyl-CoA) is limiting.

26 or decreasing the cellular concentration of crotonyl-CoA leads to enhanced or diminished gene expres

27 in the presence and absence of a butyryl-CoA/crotonyl-CoA mixture.

28 recycled, resulting in the simple equation: crotonyl-CoA + NADH + H(+) = butyryl-CoA + NAD(+) with K

29 polymerase (Lpp0650), but not enzymes of the crotonyl-CoA pathway (Lpp0931-0933) are involved in PHB

30 to increase plasmid-based expression of both crotonyl CoA reductase gene (ccr) and the erythromycin r

31 A ccr-blocked mutant showed no detectable crotonyl-CoA reductase activity and, compared to the wil

32 In addition to a crotonyl-CoA reductase gene (fkbS), at least two other g

33 r the heterologous AT seemed to be limiting, crotonyl-CoA reductase, a primary metabolic enzyme invol

34 The product of orf4* (cer) is crotonyl-CoA reductase, which converts acetoacetyl-CoA t

35 ha, beta-unsaturated thioesters catalysed by crotonyl-CoA reductase/carboxylase (CCRC) homologues.

36 o and in vitro experiments revealed that the crotonyl-CoA reductase/carboxylase SalG has broad substr

37 crR, was shown to regulate the expression of crotonyl-CoA reductase/carboxylase, an enzyme of the eth

38 ds, correlating with the reduced activity of crotonyl-CoA reductase/carboxylase.

39 hydratase catalyzes the hydration of trans-2-crotonyl-CoA to 3(S)-HB-CoA, 3(S)-hydroxybutyryl-CoA wit

40 ase (CCR), which catalyzes the conversion of crotonyl-CoA to butyryl-CoA in the presence of NADPH, wa

41 ans, which couple the exergonic reduction of crotonyl-CoA to butyryl-CoA to the endergonic reduction

42 uced ferredoxin and Dh-FADH(-) that converts crotonyl-CoA to butyryl-CoA.

43 E144-catalyzed stepwise addition of water to crotonyl-CoA which is bound in an s-trans conformation i

44 e regulated by the cellular concentration of crotonyl-CoA, which can be altered through genetic and e

45 a) a rapid exchange of C-4 methyl protons of crotonyl-CoA with bulk solvent and (b) protonation of cr

46 hydrogenase decarboxylates glutaconyl-CoA to crotonyl-CoA without oxidation-reduction reactions of th