ライフサイエンスコーパス: crowded

1 , because the world is becoming increasingly crowded.

2 glycosylations sequence to prepare a highly crowded 1,2,3-cis configured branching point.

3 s dependency when one reactant is sterically crowded: 1,4-di-tert-butylbenzene (C1), 1,3,5-tri-tert-b

4 ed and charge transfer states) of sterically crowded 9,9'-bianthryl (BAHO) and its 10,10'-disubstitut

5 pins that have decreased unfolding forces in crowded (9 pN) versus diluted (15 pN) buffers, those of

6 HEWL is systematically crowded alternatively with polyethylene glycol (PEG) or

7 ficantly lowest firmness (N) was observed in crowded and chilled salmon whereas the cathepsin L activ

8 rol), just crowded, uncrowded and chilled or crowded and chilled.

9 uin children (for whom living conditions are crowded and colonization occurs during early life) and i

10 Cell membranes are crowded and complex environments.

11 plore the dynamics of proteins and lipids in crowded and complex plasma membrane models, thereby clos

12 Enzymatic reactions occur in a crowded and confined environment in vivo, containing pro

13 In vivo, myosin is crowded and constrained by the fiber lattice as side cha

14 Crowded and dispersed glycans are differently ordered, c

15 ntage to corals in the rigors of the reef, a crowded and fiercely competitive ecosystem.

16 to promote the desired function even in the crowded and fluctuating cellular environment.

17 that the rates of association are similar in crowded and in dilute solutions.

18 of many other regulatory molecules and in a crowded and noisy cellular environment.

19 cell lysate and follow gene expression under crowded and noncrowded conditions.

20 ring in restrictive environments such as the crowded and relatively rigid active site of enzymes.

21 in boron chemistry, is a consequence of the crowded and rigid chemical environment of the boron atom

22 Remarkably, when solitarious locusts are crowded and then reconditioned with the odor-hyoscyamine

23 nstructured peptides labeled at pD 4.0 under crowded and uncrowded conditions confirmed that Ficoll d

24 45481 ), residues 2059-2117, at pD 6.5 under crowded and uncrowded conditions.

25 udied in conditions that do not simulate the crowded and viscous in vivo environment.

26 close together, visual features can become "crowded" and perceptually indistinguishable.

27 l perception, contour interaction, crowding, crowded, and contour interactions.

28 creening tool that can be used in busy, over-crowded, and low-resource primary health care settings t

29 hen subdivided AAC eyes into four subgroups: crowded-angle (CR), lens subluxation (LS) pupillary bloc

30 mber angle width, such that eyes with a more crowded anterior chamber angle undergoing LPI had a grea

31 e they come into contact with many people at crowded areas.

32 a technology can be successful in an already crowded arena.

33 In this crowded assay, SNAREs and SM proteins acted in concert t

34 ggest that, in the apo-state as found in the crowded bacterial cytosol, RTX proteins adopt extended u

35 ifying possible interactions taking place in crowded biological media.

36 quickly couple mechanosensitive elements in crowded biological membranes.

37 l for characterizing the behaviour of highly-crowded biomolecules at the nanoscale.

38 ow as a dispersed film, in contrast to their crowded "bottom-dweller" (B) ancestors.

39 The size of the crowded boundary layer near the overlap ends is also dep

40 odel explains robust and precise wiring in a crowded brain region despite extensive growth cone overl

41 of this downstream kinase cascade produced a crowded branching defect in the intrahepatic biliary net

42 mpared to the case of diluted or molecularly crowded buffer solutions, the G-quadruplex inside the na

43 -parallel G-quadruplex exists in molecularly crowded buffers that mimic cellular environment.

44 sts with non-parallel species (1:1 ratio) in crowded buffers with dehydrating cosolutes [40% w/v dime

45 er a banal scenario: a seated passenger on a crowded bus stands up and someone takes his seat.

46 ore a large eye movement, a target object is crowded by clutter near the target's future location.

47 ypically characterized, the cell interior is crowded by macromolecules, which affects both the thermo

48 Stronger deviation is observed with the more crowded C2 and C3, where steric hindrance increases the

49 Me5)3M complexes in reactions that form less crowded (C5Me5)2M-containing products.

50 emble performance, or to follow a voice in a crowded cafe.

51 the context of an outbreak at its peak, with crowded care centers, randomizing patients to receive ei

52 aromatic carbaporphyrin structures have very crowded cavities with up to six hydrogens being present.

53 he chromatin fiber to find each other in the crowded cell?

54 t it relies on diffusive encounters with the crowded cellular background, made up of protein surfaces

55 significant biological implication is that a crowded cellular environment could influence the mechani

56 These results suggest that in vivo, the crowded cellular environment could strongly influence th

57 Our results indicate that the crowded cellular environment significantly impacts the m

58 esentation of the interactomes in vivo, in a crowded cellular environment, as well as membranes and m

59 gap exists because proteins function in the crowded cellular environment, but are traditionally stud

60 sphorylation can be pseudo-processive in the crowded cellular environment, since rebinding after the

61 reconstituted fusion reactions to mimic the crowded cellular environment.

62 ity and high degree of colocalization in the crowded cellular environment.

63 expected to be particularly sensitive to the crowded cellular environment.

64 identifying molecular components within the crowded cellular environment.

65 of proteins, is essential for understanding crowded cellular environments and for the design of cell

66 folding and protein-protein interactions in crowded cellular environments) and important aspects of

67 Second, subtomograms extracted from crowded cellular environments, contain often fragments o

68 ucial to realistically simulate tomograms of crowded cellular environments, which can then serve as g

69 ll biological processes take place in highly crowded cellular environments.

70 at p-PALM is well-suited to explore numerous crowded cellular environments.

71 acromolecular interactions that organize the crowded cellular interior, requires the measurement of e

72 essential for the function of a complex and crowded cellular machine.

73 f cooperativity between membrane proteins in crowded cellular membranes.

74 l contributions to the physics governing the crowded cellular milieu.

75 ature and ionic strength while emulating the crowded cellular milieu.

76 d in vitro, assuming similar activity in the crowded cellular milieu.

77 deposition is restricted to the molecularly crowded cellular template.

78 is at the individual molecule level within a crowded, cellular environment.

79 Photochemical isomerization in sterically crowded chiral alkenes is the driving force for molecula

80 elevance of DFT treatments on the curved and crowded cluster surfaces where catalysis occurs.

81 just as humans can respond to one voice at a crowded cocktail party.

82 ures of proteins and other molecules produce crowded compartments supporting in vitro transcription a

83 Complex 3 also forms more crowded complexes in reactions with I2, PhCl, and Al2Me6

84 reacts with MeI to make two sterically more crowded complexes, (C5Me5)3ThI, 4, and (C5Me5)3ThMe, 1,

85 [3.3.0]octenone occur on the more sterically crowded concave face.

86 traditional theory, which predicts that more crowded conditions can only increase protein stability,

87 cosity effects of crowding agents that mimic crowded conditions in vivo on "classical" burst phase fo

88 onal and rotational motion of proteins under crowded conditions is highly relevant for understanding

89 ble transfer to visual acuity measured under crowded conditions resulted in reduced processing time o

90 strength in vitro requires macromolecularly crowded conditions that approach those inside the virion

91 inhibited by collisions with neighbors under crowded conditions, whereas its plus end-directed action

92 are important under physiologically relevant crowded conditions.

93 aracteristics of processive motor enzymes in crowded conditions.

94 re processive motor enzymes might operate in crowded conditions.

95 culated from single particle trajectories in crowded conditions.

96 merize was observed even in macromolecularly crowded conditions.

97 key to understanding folding kinetics under crowded conditions.

98 ructure and dynamics of these proteins under crowded conditions.

99 olymer, for HX-MS analysis of proteins under crowded conditions.

100 mestication may involve adaptation to highly crowded conditions.

101 evel of dependence on direct transmission in crowded, confined environments and establish that incuba

102 , the fidelity of the interfaces observed in crowded crystalline arrays has been difficult to establi

103 diffusion of the bulky tRNA complexes in the crowded cytoplasm imposes a physical limit on the speed

104 xplain how organelles orderly cohabit in the crowded cytoplasm.

105 e complicating distortions of the sterically crowded di-t-butyl ether "analog", the physical picture

106 h subjects have to pick one food item from a crowded display via eye movements, we test four models w

107 However, little is known about how crowded DNA modulates facilitated diffusion and target r

108 w nucleic acid motor proteins move along the crowded DNA substrates that are likely to exist in physi

109 ryotic mismatch repair complex, navigates on crowded DNA.

110 ility reduction and coil elongation of large crowded DNAs are due to a complex interplay between entr

111 te to productive thiol oxidation in complex, crowded, dynamic environments.

112 The crowded electron transport proteins in the periplasm of

113 retain their native secondary structure in a crowded environment and are stabilized against degradati

114 nofiber substrate coverage, providing a less crowded environment around fibers, appear to play a role

115 Enzymatic activities in vivo occur in a crowded environment composed of many macromolecules.

116 The efficiency of finding an object in a crowded environment depends largely on the similarity of

117 Cells migrate through a crowded environment during processes such as metastasis

118 The interior of the cell is a densely crowded environment in which protein stability is affect

119 It is clear that a crowded environment influences the structure, dynamics,

120 ferred by RyR because they can fit into this crowded environment more easily.

121 suited to engage interaction partners in the crowded environment of synapses, permitting the formatio

122 Noncoding RNAs must function in the crowded environment of the cell.

123 high efficiency and fidelity in the densely crowded environment of the cell.

124 ules have evolved to fold and operate in the crowded environment of the cell.

125 ver arm probe orientation is detected in the crowded environment of the muscle fiber by using RLC-PAG

126 rocyanine (MC) isomers within the sterically crowded environment of the polymer brushes upon UV irrad

127 h to unambiguously highlight the impact of a crowded environment on a fundamental biological process,

128 on inside cells, where the heterogeneous and crowded environment presents a complex, nonideal system.

129 ngs extend our knowledge of the synapse as a crowded environment that counteracts molecular diffusion

130 The movement through the cytoplasm-a crowded environment where diffusion is slow-is thought t

131 The ribosome exit site is a crowded environment where numerous factors contact nasce

132 bly of holo RNAP takes place in an extremely crowded environment within a cell, and thus far the kine

133 In a crowded environment, how do we hear a single talker whil

134 mong distinct biogenesis machineries in this crowded environment.

135 ibril formation and protein suspensions in a crowded environment.

136 e a fundamental design principle of PPI in a crowded environment.

137 m and ClpB, which in vivo occurs in a highly crowded environment.

138 DNA polymerase/trx is far more compact in a crowded environment.

139 xtures of unknown complexes extracted from a crowded environment.

140 of sufficient copy numbers of complexes in a crowded environment.

141 al applications, are strongly modulated by a crowded environment.

142 cellular chemistry requires knowledge of how crowded environments affect proteins.

143 of these mechanisms: molecular diffusion in crowded environments and cytoskeletal transport along mi

144 reactions rates differ significantly between crowded environments and dilute buffers.

145 cumented that humans yawn less frequently in crowded environments and when under direct observation,

146 motor proteins may be adapted to operate in crowded environments by having molecular properties that

147 Crowded environments inside cells exert significant effe

148 or how motor proteins behave in these highly crowded environments remains unknown.

149 Because virus capsids naturally assemble in crowded environments such as the cell cytoplasm but also

150 es larger rate constant for transcription in crowded environments, strikingly similar to in vivo rate

151 To better understand how translocases act in crowded environments, we used single-molecule imaging to

152 Membrane proteins are frequently present in crowded environments, which favour lateral association a

153 sions of virus shells with macromolecules in crowded environments.

154 get complexes in subtomograms extracted from crowded environments.

155 tions with furans preferentially on the more crowded face.

156 w multimotor cargos would navigate a densely crowded filament with many other motors.

157 evant mutations, further supporting that the crowded fusion assay accurately recapitulates the vesicl

158 Using this crowded fusion assay, we also showed that the SNARE-SM m

159 he influence of hydrogel formation at highly crowded gammaS-WT concentrations up to 500 mg/mL, the pr

160 st how Msh2-Msh3 and Msh2-Msh6 navigate on a crowded genome and suggest how Msh2-Msh3 locates DNA les

161 ic targets via facilitated diffusion along a crowded genome.

162 and thiotolyl donors as well as differently crowded glycosyl acceptors; subtle differences in the st

163 Because crowded growth generally limits nutrient access in biofi

164 picosecond protein and hydration dynamics of crowded hen egg white lysozyme (HEWL) labeled with a met

165 The cytoplasm of Escherichia coli is a crowded, heterogeneous environment.

166 92-9.20), and children living under the most crowded household conditions (RR 5.53, 95% CI 2.36-12.98

167 c risk factors (being female and living in a crowded household).

168 The anterior segment was crowded in closed-angle compared to open-angle eyes.

169 ate into clusters of various densities, most crowded in the crest region, that are surrounded by area

170 r human alphaB-crystallin, which is strongly crowded in vivo and inter alia responsible for preventin

171 ro data cannot be simply extrapolated to the crowded in vivo environment.

172 Proteins and nucleic acids maintain the crowded interior of a living cell and can reach concentr

173 High volume fractions mimicking the crowded interior of biological cells were used.

174 elf-organization events are modulated by the crowded interior of live cells.

175 the dynamic type VI secretion system in the crowded interior of Myxococcus xanthus.

176 d bioreactors with aqueous, macromolecularly crowded interiors can be assembled by liposome stabiliza

177 nders), refugees/internees who were forcibly crowded into camps, and military recruits.

178 by strong internal forces arising from being crowded into the small space of the nucleoid.

179 We investigated the effects of the crowded intracellular environment on early endosomal tra

180 The crowded intracellular environment poses a formidable cha

181 the entropic forces that can compact it in a crowded intracellular environment.

182 ovide protein-specific information about the crowded intracellular environments by offering a genetic

183 Protein signaling occurs in crowded intracellular environments, and while high conce

184 A performance was measured monocularly using crowded Lea symbols with 45 young people with CP (mean a

185 rained a group of adult human amblyopes on a crowded letter identification task to assess whether the

186 t the structural space of protein pockets is crowded, likely complete, and may be represented by abou

187 Reaction of the less crowded LiN(H)Ar(Me6) with [V2Cl3(THF)6](+)I(-) afforded

188 of denaturants near the protein surface and crowded local environment induce the protein collapse, m

189 In a crowded, low income setting, oseltamivir treatment of in

190 To characterize these seeds, a crowded macromolecular environment was mimicked by encap

191 icant ecological effects is encouraging for "crowded" marine environments.

192 e intracellular environment is a complex and crowded medium where the diffusion of proteins, metaboli

193 Intracellular reactions are carried out in a crowded medium where the macromolecules occupy approxima

194 erience is truly comparable to the immensely crowded, membrane-subdivided interior of a eukaryotic ce

195 y gap between the unfolded and folded RNA in crowded MgCl2 solutions.

196 narily selected to function optimally in the crowded milieu of the cell.

197 ide of the modified base from the sterically crowded minor groove.

198 We present a framework to generate crowded mixtures of macromolecular complexes for realist

199 by random co-localization incidents between crowded molecular species and the intrinsic heterogeneit

200 tive size of their transition states and the crowded nature of CO*-covered surfaces.

201 This volume reduction increases the crowded nature of the cytoplasm, which is expected to af

202 These sterically crowded nickel and copper hydroxides catalyze the key al

203 nd were cared for in environments which were crowded, noisy and lacked privacy.

204 rapidly moving, sub-diffraction objects in a crowded, noisy environment.

205 The findings reveal a new role for the crowded nuclear environment in facilitating DNA damage d

206 pproximately 50 ms before a saccade toward a crowded object, we found that not only was there a drama

207 to address the challenges of an increasingly crowded ocean environment.

208 realistic conditions, diffusion of vesicles crowded on the ribbon surface gives rise to a flow field

209 in Xenopus laevis oocytes and in native-like crowded oocyte extract by in-cell NMR spectroscopy.

210 These short cat naps could be adaptions to crowded or confined environments by giving the substrate

211 concentrations sufficient to fold the RNA in crowded or dilute solution.

212 ep of the CaM-target binding mechanism under crowded or osmolyte-rich environments mimicked by ficoll

213 (eg, food insecurity, perinatal infections, crowded or rural living conditions, and interpersonal vi

214 line with models of indirect reciprocity, is crowded out by indirect punishment opportunities.

215 following the megafaunal extinctions likely crowded out their disturbed-ground niche.

216 ctions, the cytoplasmic space is more like a crowded party in a house full of furniture than a game o

217 predicted that brain areas representing the crowded percept would show repetition suppression in cha

218 ured brain activity that correlated with the crowded percept.

219 cal paradigm that allows systematic study of crowded perception within the orientation domain, and we

220 an efficient access to large and sterically crowded polycyclic arenes as well as improving insight i

221 talization into model liquid organelles in a crowded polymer solution.

222 n microscopy suggests that the PSD is highly crowded, potentially restricting the diffusion of recept

223 re major determinants of vesicle mobility in crowded presynaptic terminals.

224 to define a minimal framework for models of crowded protein solution viscosity wherein critical prot

225 In particular, random collisions among crowded proteins generate substantial pressure, which if

226 culty of pseudobase attack at the sterically crowded pyrylium acidic hydrogen position.

227 Ions in such crowded quarters interact strongly with each other as we

228 anical robustness and generate a molecularly crowded reaction environment; and (iii) self-production

229 mbers, triggering extrusion and apoptosis in crowded regions and cell division in sparse regions.

230 In crowded regions of the tissue, a proportion of cells und

231 the importance of maintaining intracellular crowded regions to favor the feasibility of a pathway th

232 when competing speakers are present, as in a crowded restaurant.

233 evels of background noise that approximate a crowded restaurant.

234 ignal intensities of myoglobin peptides from crowded samples containing 300 g L(-1) Ficoll and from u

235 Added to the crowded scene for helper T-cell subsets is the continuou

236 test particle-picking methods in a realistic crowded setting.

237 Our model is generally applicable to other crowded settings.

238 ks (ie, close-up work or finding things on a crowded shelf), mobility (ie, walking down steps, stairs

239 lows the CO to move into the sterically less crowded side of the molecule is preferred.

240 When more sterically crowded silyl enol ethers are employed, an enantioselect

241 research to improve compartmental models in crowded situations.

242 months of age, warm season, male gender, and crowded sleeping conditions.

243 nd spread to various environments, including crowded slums and refugee camps.

244 In contrast, the less crowded Sn(II) hydride [Ar((i)Pr4)Sn(mu-H)]2 (Ar((i)Pr4)

245 While conversing in a crowded social setting, a listener is often required to

246 ed aversions was blocked entirely in acutely crowded solitarious (transiens) locusts, whereas appetit

247 The model predicts that in a crowded solution, at critical values of the volume fract

248 Moreover, in a crowded solution, the chemical potential depends on the

249 cture of the transition state are similar in crowded solutions and in buffer.

250 compare folding free energies in dilute and crowded solutions containing 18% PEG1000.

251 Here, we report that crowded solutions promote intramolecular DNA translocati

252 In crowded solutions with steric cosolutes [40% w/v bovine

253 The ion-ion interactions present in crowded solutions-independent of conformation changes of

254 tein chymotrypsin inhibitor 2 (CI2) in these crowded solutions.

255 -lactamase and its inhibitor protein BLIP in crowded solutions.

256 cal overall association rates in diluted and crowded solutions.

257 When epithelia become too crowded, some cells are extruded that later die.

258 ogical description of these filaments in the crowded space of the cell is challenging, given their sm

259 o accelerate specific reactions within their crowded space.

260 to complex multiplets and severe overlap in crowded spectra, greatly complicating their measurement.

261 Direct application of PCA to crowded spectra, images, and movies (without selecting p

262 ge subunits (>150 residues), the analysis of crowded spectral data presents a challenge, even if thre

263 ostasis when an epithelial layer becomes too crowded; spindle orientation ensures two-dimensional gro

264 ties required for high resolution of densely crowded structures.

265 red in which noncovalent interactions of the crowded substituent cause a variation of the geometry of

266 The steric hindering of the crowded substitution at the central amine group was foun

267 site and excessive enzyme jamming along the crowded substrate.

268 ed to form a family of flexible yet strongly crowded substrates for multiple dehydrocyclizations.

269 accuracy for highly distorted and especially crowded subtomograms.

270 ges provides access to nonplanar, sterically crowded systems that display complex reactivity patterns

271 larger alkyl bromides and are skewed toward crowded systems that offer stabilizing, nonbonded intera

272 e that LBM over-predicts the diffusion in 2D crowded systems, while the proposed coupled SPT-LBM pred

273 ons even though these play a crucial role in crowded systems.

274 We report that both saccade precision and crowded-target reports vary idiosyncratically across the

275 had human observers execute eye movements to crowded targets and measured their ability to identify t

276 y the phenomenological misidentifications of crowded targets: using stimuli that do not easily combin

277 When crowded, the noise appears oriented and perceptually ind

278 When epithelial cells become too crowded, they activate the stretch-activated channel Pie

279 tial organization of molecular assemblies in crowded three-color super-resolution (SR) images.

280 g short-range diffusion of PQ in the protein-crowded thylakoid membrane, thereby optimizing photosynt

281 ar diffusion of photosynthetic components in crowded thylakoid membranes.

282 ful chromosome segregation and division in a crowded tissue environment.

283 o a backpack to facilitate measurement under crowded transportation conditions and to quantify person

284 ther the fish were uncrowded (control), just crowded, uncrowded and chilled or crowded and chilled.

285 rus (RSV) infection in Africa is limited for crowded urban areas and for rural areas where the preval

286 al use of MDMA at rave parties or other hot, crowded venues.

287 assembly of chemically encoded, molecularly crowded, water-rich micro-droplets into periodic defect-

288 However, cell cytoplasm is highly crowded, which makes particle detection challenging.

289 Cellular membranes are densely crowded with a diverse population of integral and membra

290 s function in cellular environments that are crowded with biomolecules, and in this reduced available

291 The literature is crowded with competing theories, including causal models

292 The field of cluster analysis is crowded with diverse methods that make special assumptio

293 me of cargos transporting along microtubules crowded with free motors.

294 Plants inhabit environments crowded with infectious microbes that pose constant thre

295 eins fold and function inside cells that are crowded with macromolecules.

296 d function in cellular environments that are crowded with other macromolecules.

297 oteins must travel along substrates that are crowded with other proteins.

298 Cells are highly crowded with proteins and polynucleotides.

299 (compared to random coil conformations) when crowded, with elongation states that are gamma distribut

300 when membrane-bound proteins become densely crowded within liquid-ordered membrane regions, steric p