ライフサイエンスコーパス: crowding

1 2] models of the phenomenon known as 'visual crowding'.

2 tion and basic visual phenomena (e.g. visual crowding).

3 eeth, enamel and dentin hypoplasia, or teeth crowding.

4 tional basis for their 'grouping' account of crowding.

5 ing of the functional role of macromolecular crowding.

6 cesses, including adsorption, desorption and crowding.

7 on, number of wards worked in, and household crowding.

8 ose-pectin contacts are not due to molecular crowding.

9 ting that CCVs sort their cargo by molecular crowding.

10 itol), which increases intracellular protein crowding.

11 with averaging than substitution accounts of crowding.

12 below a characteristic threshold because of crowding.

13 ll cytoplasm is slowed down due to molecular crowding.

14 ta, with a simple modification for chromatin crowding.

15 challenging situation with respect to steric crowding.

16 ts to greatly reduce spectral complexity and crowding.

17 l system for studying the effects of protein crowding.

18 react with [Ge9{Si(TMS)3}3](-) due to steric crowding.

19 g scaffolding, wedging, oligomerization, and crowding.

20 % CI, 1.16-2.34); higher vs. lower levels of crowding (124 of 398 [31.2%] vs. 64 of 373 [17.2%]; OR,

21 r: 1) Little irregularity index for anterior crowding; 2) molar and canine class relationship; 3) pre

22 Multiple proposals have attempted to explain crowding [3], and each is supported by compelling psycho

23 1.42; 95% CI, 1.04-1.93), a higher level of crowding (316 of 416 [76.0%] vs. 258 of 406 [63.5%]; OR,

24 we assessed the influence of macromolecular crowding, a biophysical phenomenon that regulates intra-

25 Consequently crowding, a nonspecific phenomenon believed to arise fro

26 Thermodynamic analysis indicates that crowding activation of Hsp90 is entropically driven, whi

27 Finally, we find that crowding activation works by a different mechanism than

28 A crowding-adaptation to LBM has been developed using SPT,

29 rbed ionic balance, in addition to molecular crowding, affects membrane trafficking.

30 The presence of crowding agent (polyethylene glycol) significantly incre

31 bulk cleavage assays in the presence of the crowding agent show that the ribozyme's activity increas

32 ere increased, especially in the presence of crowding agent, compared to sonicated nonglycated protei

33 Y-labeled S16Meso depend on the level of the crowding agent.

34 ence and presence of an inert macromolecular crowding agent.

35 e gained on how high concentrations of inert crowding agents and osmolytes fit into a kinetic framewo

36 structural monomers and the smaller protein crowding agents as combinatorial, truncated Lennard-Jone

37 solution conditions such as temperature and crowding agents consequently affect IDPs more than their

38 tion of excess Rubisco (24:1, L8S8/Rca6) and crowding agents did not modify catalytic rates.

39 alts, viscosity enhancers or macro-molecular crowding agents has an impact on the physical properties

40 pendences on the volume fraction, varphi, of crowding agents in the nucleus, including a broad range

41 osome sedimentation analysis, we showed that crowding agents increase iSAT yields by enhancing transl

42 We introduced macromolecular crowding agents into reconstituted fusion reactions to m

43 ssays to determine the effect of a molecular crowding agents on the folding and catalysis of a model

44 ey can be independently altered by molecular crowding agents or via external fields.

45 face densities of ZipA or in the presence of crowding agents that favor the accumulation of FtsZ poly

46 aining high concentrations of macromolecular crowding agents would give new insights into the structu

47 itro measurements in the presence of polymer crowding agents.

48 cale organization assumed for macromolecular crowding agents.

49 immobile structures rather than to diffusing crowding agents.

50 olyethylene glycol and yeast cell extract as crowding agents.

51 Protein crowding also affects bilayer properties, such as membra

52 Here, we investigated whether crowding also plays a role in age-related changes in rea

53 Protein crowding alters the sub-diffusive behavior of proteins a

54 reading speed (a decrease by 30%) and larger crowding: an enlargement of crowding zone (an increase b

55 scopic model for the combined effect of both crowding and adsorption upon the fibrillation of a dilut

56 These results suggest that both crowding and binding limit escape of AMPARs from the syn

57 CS data, we describe how the effects of cell crowding and binding to affinity sites manifest themselv

58 t-steps influenced by ambient conditions and crowding and by M. tuberculosis itself.

59 nt effects in RNA folding, such as molecular crowding and cotranscriptional kinetic effects, may ulti

60 how mushrooms tolerate and even benefit from crowding and explains their high water needs.

61 complexes are highly reactive due to steric crowding and few crystallographically characterizable Th

62 This process induces cargo crowding and inward membrane buckling, followed by const

63 same tendency as the olfactory perception in crowding and isolation, respectively.

64 During crowding and isolation, the activities of octopamine and

65 ocessing speed may lead to overcoming foveal crowding and might be the enabling factor for generaliza

66 However, the fact that apical crowding and muscle enlargement also occur in orbits wit

67 ent in spectral quality arising from reduced crowding and narrowed linewidths, and accurate analysis

68 of different shapes and sizes under various crowding and noise levels.

69 Here, we discovered that macromolecular crowding and reducing agents increase overall iSAT prote

70 AT protein synthesis through the addition of crowding and reducing agents, provides a thorough unders

71 ss formation based on the ideas of molecular crowding and resultant string-like cooperative rearrange

72 crowding, including the correlation between crowding and saccades.

73 In this work, the effects of molecular crowding and several physiologically important metal ion

74 icability of the method: 1) the influence of crowding and shape on the lateral diffusion of proteins

75 ons from accepted theories of macromolecular crowding and show that cosolutes commonly used to mimic

76 Because Piezo1 senses both mechanical crowding and stretch, it may act as a homeostatic sensor

77 rises, which we interpret by alluding to ant crowding and subsequent jamming.

78 drogenation, attributed to molecular surface crowding and suppression of sterically-demanding adsorpt

79 nown to be necessary to overcome cytoplasmic crowding and the limited range of diffusion within reaso

80 ching, we manipulated both light quality (as crowding and the red-to-far-red light ratio) and phospha

81 g cellular cargos to overcome macromolecular crowding and to navigate obstacles along microtubule tra

82 During the weeks following peak crowding and trough sunlight, there was a midwinter peak

83 may include modifiable social (eg, poverty, crowding) and biological factors (not explored in this a

84 and induced by stressors such as heat, cold, crowding, and anoxia.

85 t-sized salmon were sampled before or during crowding, and before and after pumping and live chilling

86 ver the course of repeated cycles of growth, crowding, and dispersal.

87 harper resonance lines, ameliorates spectral crowding, and enables measuring of crucial distances bet

88 retical models of one-dimensional transport, crowding, and jamming.

89 ors such as cytoskeleton, lipid composition, crowding, and molecular interactions deviate lateral dif

90 undamentally different way of thinking about crowding, and on this basis we claim to have provided a

91 of reactions, water structure and viscosity, crowding, and other cellular activities.

92 mbers were mode of delivery, infant feeding, crowding, and recent antibiotic use.

93 The effects of CA concentration, molecular crowding, and the conformational variability of CA are d

94 loss of low-frequency relaxations caused by crowding, and the jamming transition, which is related t

95 ration water change as a function of protein crowding?; and (ii) upon hydrogel formation of gammaS-WT

96 he excluded-volume effects of macromolecular crowding are expected to cause compaction of unfolded an

97 tribution, but they induce the local current crowding around the voids: this local current crowding e

98 Our findings identify protein crowding as an important principle in determining LD pro

99 ce energy transfer to quantify the effect of crowding as mimicked by commonly used biocompatible poly

100 ntly overcome, namely the substantial steric crowding at both reactive sites, the nucleophilic additi

101 chanism is strongly influenced by the steric crowding at the Pd catalyst by either a biaryl phosphine

102 ntained by a related but distinct mechanism: crowding avoidance.

103 steady state where line tension and lateral crowding balanced.

104 tein exclusion is also influenced by lateral crowding, binding protein affinity, and thermally-driven

105 We conclude that crowding broadens the fitness landscape by stabilizing c

106 ble volume can be affected by macromolecular crowding, but the effects of crowding in cells are compl

107 Crowding by a dense brush of unfolded biomolecules, in c

108 Thus, crowding by either dynein microtubule binding domain or

109 The impact of crowding by high-molecular-weight polyethylene glycol on

110 the unstable intermediate states), and that crowding by large molecules reduces noise more efficient

111 olecules reduces noise more efficiently than crowding by small molecules.

112 used to study the effects of macromolecular crowding by two globular proteins, i.e., bovine pancreat

113 Macromolecular crowding can alter the structure and function of biologi

114 se protein stability, recent work shows that crowding can destabilize proteins through transient attr

115 application of ultrasound and macromolecular crowding can improve efficiency of MR.

116 from their observations that macromolecular crowding can lead to robustness in gene expression, resu

117 ferent sizes (actin and ATP), macromolecular crowding can modulate the kinetics of individual steps o

118 amentally important and that sandwiching and crowding can replace the stabilizing effect of the membr

119 ctions; thermodynamic and kinetic effects of crowding; cellular membrane modeling; and modeling of ch

120 r survey completion rate, ED factors (eg, ED crowding), child factors (eg, triage level, medical comp

121 ty, switching free energy and macromolecular crowding collectively control riboswitch activation.

122 Here, we report that molecular crowding comparable to that in the cell compensates for

123 n dextran solutions that mimic intracellular crowding conditions (0-40%), and determine the effects o

124 Macromolecular crowding conditions accelerate reactions and stabilise p

125 We determined that molecular crowding conditions and cations, such as Na(+), K(+), Mg

126 37 degrees C, especially under the molecular crowding conditions and in the presence of K(+) or Ca(2+

127 e classical manifestation of such scheme the crowding conditions are neglected.

128 The application of HIUS under crowding conditions can be a new approach for enhancemen

129 Moreover, the crowding conditions may change the directionality of rea

130 mode, feeding type, antibiotic exposure, and crowding conditions, in relation to respiratory tract mi

131 athic alpha-helices in response to increased crowding conditions, such as high concentrations of glyc

132 ses of the G-quadruplexes, under PEG-induced crowding conditions, with the corresponding mesophases o

133 matter inside cells, usually referred to as crowding conditions.

134 sp60 and Hsp70 chaperones are insensitive to crowding conditions.

135 ed the salt concentration and macromolecular crowding conditions.

136 c pressure, thus mimicking in vivo molecular crowding conditions.

137 embly of enzymes occurs even under cytosolic crowding conditions.

138 n solution or immobilized on a surface under crowding conditions.

139 form of the holoenzyme, even under molecular crowding conditions.

140 This methodology takes into account crowding conditions; not only the space fraction occupie

141 ests that, although volume-induced molecular crowding contributes to trafficking defects, it alone ca

142 ing on the microtubule lattice, with greater crowding converting the motor from minus end-directed to

143 usly reducing proton line width and spectral crowding despite a high local proton density in clouds.

144 Nevertheless, crowding did not rescue the high fraction of folded but

145 The crowding effect in particular has received considerable

146 The crowding effect increases both the efficiency and averag

147 centuate transcriptional bursting due to the crowding effect of chromatin.

148 eling, could bring about significant spatial crowding effect that stiffens the 2 degrees H/D vibratio

149 molecules and in this way to incorporate the crowding effect to the LBM.

150 NA folding measurements, which identify that crowding effects are dominated by entropic rather than e

151 similarities predict variation in growth and crowding effects for the 315 most abundant tree species

152 ttached to macroscopic surfaces suggest that crowding effects may be particularly significant under t

153 al representation of the chains predicts the crowding effects only for collapsed protein chains.

154 o structures of proteins can be generated by crowding effects, local pH changes, specific and nonspec

155 Challenging the view from in vitro crowding effects, we find that the cells destabilize the

156 not introduce undesirable electrostatic and crowding effects.

157 ding the protein, a mechanism reminiscent of crowding effects.

158 rowding around the voids: this local current crowding enhances the lateral void growth and coalescenc

159 iverse biopolymers, creating a heterogeneous crowding environment, the impact of which on RNA folding

160 s competing with crowding or shape-dependent crowding favoring more compact states inside the cell ov

161 ry of overflow metabolism based on molecular crowding following the proteomic fractions formulation.

162 However, crowding for a day resulted in neural MS-AFLP fingerprin

163 artifact protein-protein binding born of the crowding forces present within drying electrospray dropl

164 ential is better compensated when counterion crowding happens.

165 Models of such "crowding" have generally been driven by the phenomenolog

166 ppressor p53 is necessary and sufficient for crowding hypersensitivity.

167 Our data show that crowding i), increases three to four orders of magnitude

168 macromolecular crowding, but the effects of crowding in cells are complex and difficult to track.

169 To emulate the effect of crowding in cells, we studied actomyosin cycle reactions

170 Despite the ubiquity of molecular crowding in living cells, the effects of crowding on the

171 ying mechanistic explanation for orientation crowding in peripheral vision.

172 Our findings suggest that crowding in posterior cortical atrophy can be regarded a

173 of the catalyst structure, caused by steric crowding in the catalyst pocket of one enantiomeric tran

174 nding of NTRs to FG Nups increases molecular crowding in the NPC transport channel, it is unclear how

175 shown to be enhanced by volume exclusion or crowding in the presence of a high concentration of chem

176 of winged offspring produced in response to crowding in this polyphenism.

177 seek to elucidate the role of macromolecular crowding in transcription and translation.

178 Our results demonstrate that macromolecular crowding in two dimensions can play a significant role i

179 findings that shed some light on the role of crowding in various cellular processes, such as reductio

180 The probe with the highest sensitivity to crowding in vivo yields the same macromolecular volume f

181 ecision account for much of the variation in crowding, including the correlation between crowding and

182 Our results suggest that crowding increases with age.

183 ause milder water deficit and macromolecular crowding induce high alpha-helix levels in vitro, sugges

184 f membranes, a condition mimicking molecular crowding induced by dehydration during freezing.

185 We find that the extent of crowding-induced compaction is dependent not only on cro

186 mbrane-free microcompartments resulting from crowding-induced liquid/liquid phase separation (LLPS) o

187 We conclude that the crowding-induced myosin conformational change plays a ma

188 come: stretch induces cell division, whereas crowding induces extrusion.

189 le changes in CA concentration and molecular crowding influencing self-assembly and the ensemble of s

190 Macromolecular crowding intensifies oxidative modifications of WP, as w

191 Crowding interferes with basic tasks such as letter and

192 cial crowders, required to simulate cellular crowding, introduce overwhelming interferences to mass s

193 Crowding is a breakdown in the ability to identify objec

194 We show that molecular crowding is a key factor in explaining the switch from O

195 Macromolecular crowding is commonly understood in terms of an entropic

196 We demonstrate that the effect of protein crowding is critically dependent on the stability of the

197 ns, demonstrating that the effect of protein crowding is highly dependent on the stability of the pro

198 Macromolecular crowding is known to profoundly influence the kinetic an

199 an unexpected discovery that macromolecular crowding is required for reconstituting the vesicle fusi

200 -type cells causes their compaction and that crowding is sufficient for scrib(KD) cell elimination.

201 riven microtubule sliding can be reversed by crowding it with non-Cut7 proteins.

202 Instead, molecular crowding itself completely alters the mechanism by which

203 g tomograms of cellular environments at high crowding levels and assess the DoG particle picking meth

204 often enhancing assembly efficiency at high crowding levels even while impeding it at lower crowding

205 wding levels even while impeding it at lower crowding levels in a nucleation-limited model.

206 With increasing macromolecular crowding levels, the precision of particle picking remai

207 rceptual errors that are reported across the crowding literature.

208 ty was found to be significantly affected by crowding, live chilling and storage time.

209 The apparent insensitivity of lambda N to crowding may also be due in part to weak attractive inte

210 Age-related changes in crowding may in part explain slower reading in older adu

211 ations between reading speed and each of the crowding measures.

212 ealed that at the same membrane tension, the crowding mechanism requires far higher protein coverage

213 determined their dynamic features within the crowding membrane environment using live-cell fluorescen

214 As predicted by a crowding model, proteins compete for binding to the surf

215 Molecular crowding modifies biochemical reaction rates and decreas

216 that protein interactions and the extent of crowding modulate the lifetimes of the excited state in

217 igher per capita birth rates, more household crowding, more children per family, and lower rates of s

218 he model includes terms representing protein crowding, myofilament lattice hindrance, and binding to

219 s critical biophysical insights into nuclear crowding, nucleic acid based pharmaceutical development,

220 t shows the transition from overscreening to crowding of counterions at the interface at the highest

221 for several perceptual phenomena produced by crowding of orientation and raises the possibility that

222 umed to be anomalous due high macromolecular crowding of the milieu.

223 ide chains, which are consistent with steric crowding of the side chains around the phosphodianion at

224 Crowding of the viral interior influences the DNA and pr

225 itions (0-40%), and determine the effects of crowding on both DNA mobility and conformation.

226 been given to the effects of macromolecular crowding on cell physiology.

227 ) to compare the effect of acute and chronic crowding on DNA methylation in the central nervous syste

228 rtant and widely debated effects of cellular crowding on genome-sized DNA.

229 al approaches to test the effect of synaptic crowding on receptor movement and positioning in Sprague

230 lar crowding in living cells, the effects of crowding on the dynamics of genome-sized DNA are poorly

231 udies have highlighted the role of molecular crowding on the effects of hypertonicity, the effects of

232 bility to formally investigate the effect of crowding on the main outcome.

233 of stepping direction is the degree of motor crowding on the microtubule lattice, with greater crowdi

234 The observed effects of macromolecular crowding on the myosin-ligand interaction cannot be expl

235 ing to measure the effects of macromolecular crowding on the size of a protein complex, SOD (superoxi

236 xperimentally, we report here the effects of crowding on the stability of a simple, surface-attached

237 The effects of "molecular crowding" on elementary biochemical processes due to hig

238 Macromolecular crowding opens new avenues for a more rational design in

239 tively from that observed in the presence of crowding or adsorption alone.

240 ells: long-range interactions competing with crowding or shape-dependent crowding favoring more compa

241 tic influence of curvature on the collective crowding or spreading of tissue-synthesizing cells induc

242 Macromolecular crowding ought to stabilize folded forms of proteins, th

243 Consistent with these hypotheses, crowding out was driven by those who donated higher amou

244 roborates the mediating role of attention in crowding out.

245 Crowding particularly impairs object perception in perip

246 we present a unifying computational model of crowding phenomena that reconciles conflicting explanati

247 Our goal was not to model all crowding phenomena, such as the release from crowding wh

248 it is still underappreciated, macromolecular crowding plays a critical role in life as we know it.

249 Consequently, macromolecular crowding plays a major role in determining LD protein co

250 Molecular crowding plays a significant role in regulating molecula

251 ghlights the often overlooked role molecular crowding plays in regulating molecular structure and fun

252 art to weak attractive interactions with the crowding proteins, which may compensate for the effects

253 In vitro studies show that macromolecular crowding, rather than changes in monolayer lipid composi

254 Our results show that macromolecular crowding reduces noise (as measured by the kurtosis of t

255 ed only in the two grains within the current crowding region, where high density and divergence of el

256 We found that the amount of crowding required to induce membrane curvature is correl

257 rster resonance energy transfer (FRET)-based crowding-sensitive probes and investigate the role of th

258 Accordingly, macromolecular crowding should constitute an integral element of any re

259 Altogether, we demonstrate that crowding, spatial localization, and saccadic precision s

260 single-molecule kinetics of solute molecular crowding, specifically focusing on GAAA tetraloop-recept

261 ses spatio-temporal differences in molecular crowding states that are sufficient to drive accumulatio

262 ken the binding of RT to DNA while increased crowding strengthens the binding.

263 develop pericardial edema when challenged by crowding stress or exposed to elevated cortisol stress,

264 odologies for the simulation of diffusion in crowding systems is the Monte Carlo algorithm (MC) which

265 al reports that underlie performance in this crowding task more generally: aggregate errors cannot be

266 ystem uses nucleation-limited assembly, with crowding tending to promote off-pathway growth in a nonn

267 more detailed readouts on the macromolecular crowding than a single sensor.

268 Large molecules are less effective at crowding than water and ions.

269 arameters consistent with the extreme steric crowding that previously has given unusual (C5Me5)(-) re

270 dration transition induced by macromolecular crowding that slows the hydration dynamics up to an orde

271 saccharides, substantially ordered by glycan crowding, that encase the protein component of Env and e

272 can affect processes ranging from acuity and crowding (the deleterious effect of clutter on object re

273 Crowding, the inability to recognize objects in a clutte

274 Crowding, the inability to recognize objects in clutter,

275 Upon self-crowding, the population of this robust surface hydratio

276 ior of systems of anisotropic particles upon crowding through DEFs.

277 alphaS can be tuned by two-dimensional (2D) crowding through simultaneous binding of a second protei

278 However, the contribution of macromolecular crowding to receptor retention remains poorly understood

279 educational attainment, language isolation, crowding, unemployment, and percentage of immigrants.

280 he effective membrane viscosity or molecular crowding upon membrane bending.

281 in the fovea, earlier studies report foveal crowding upon very brief exposures or following spatial

282 al questions regarding the effect of protein crowding, using gammaS-WT and gammaS-G18V: (i) how do th

283 Crowding was calculated for all tuberculosis-affected ho

284 The degree of crowding was determined by measuring crowding zone (the

285 Crowding was induced using 400 MW PEG (polyethylene glyc

286 Less clear is the effect of crowding when its influence is incorporated into a compl

287 crowding phenomena, such as the release from crowding when target and flanks differ in color or depth

288 r preference for gregarious volatiles during crowding, whereas gregarious locusts avoided their volat

289 ty of Hsp90 is highly sensitive to molecular crowding, whereas the ATPase activities of Hsp60 and Hsp

290 volume and subsequent increase in molecular crowding which severely alters the biophysical propertie

291 Molecular crowding, which is microtubule independent, causes the e

292 Crowding with conspecifics drives a behavioural transfor

293 to the lack of techniques capable of probing crowding with the required temporal and spatial resoluti

294 We therefore compared crowding with two measures of spatial localization: Land

295 in vitro all the probes can be compressed by crowding, with a magnitude that increases with the probe

296 change is altered dramatically by molecular crowding within the peptide monolayer.

297 ufficient in this regard, and that molecular crowding within the synapse is critical to preserve suff

298 30%) and larger crowding: an enlargement of crowding zone (an increase by 31%) and shrinkage of the

299 gree of crowding was determined by measuring crowding zone (the distance between a target and flanker

300 We first compared the size of crowding zones with the precision of saccades using an o