ライフサイエンスコーパス: crucial

1 the complex dynamics of the Earth system is crucial.

2 potential adverse pregnancy outcomes will be crucial.

3 vailable clinical and imaging information is crucial.

4 ly their test-retest stability, thus becomes crucial.

5 anding of the polymerogenic intermediates is crucial.

6 ulator of G-protein signaling Gbeta5-R7 is a crucial activator of muscarinic M3 receptor-stimulated i

7 channel activity but were contingent on the crucial AIS protein, protein kinase CK2.

8 ment response, quantification of HEs becomes crucial and hence clinicians now seek to measure the are

9 IFICANCE STATEMENT: Pitch and timbre are two crucial aspects of auditory perception.

10 gaps remain in our understanding of several crucial aspects of MP exposure and risk assessment, incl

11 , and ICOS-ICOSL interactions were similarly crucial at late times for maintenance of the Tfh and GC

12 around heated/cooled colloidal particles is crucial because the experimental and numerical determina

13 Early diagnosis of metastatic infection is crucial, because specific treatment is required.

14 They play crucial biological functions and are implicated in neuro

15 lack of structural tools is identified as a crucial bottleneck, limiting the full development of gly

16 Late adolescence is a crucial, but underexplored, developmental stage with res

17 he hypothesis that SIRT1 may actually play a crucial causal role in overload-induced hypertrophy of s

18 In this commentary, we highlight a crucial challenge posed by the proposal of Lake et al. t

19 These studies reveal a crucial circuit mechanism by which animals adjust their

20 Mitochondria are crucial compartments of eukaryotic cells because they fu

21 Visualization is a crucial component in their analysis.

22 teine-Rich Protective Antigen (PfCyRPA) is a crucial component of a ternary complex, including Reticu

23 alpha-SNAP is a crucial component of Orai1 channels, and its depletion d

24 Soil is a crucial component of the biosphere and is a major sink f

25 rns of phrenic premotor neurons, which are a crucial component of the inspiratory circuit.

26 Thus, dorsomedial prefrontal cortex is a crucial component of the short-term memory network, and

27 Antiviral inflammatory responses are a crucial component of WNV pathology, and understanding ho

28 ogy of white matter tracts, which constitute crucial components of epileptogenic networks, is unknown

29 eins have been shown to strategically target crucial components of the type I interferon system.

30 the vibrational temperature, highlighting a crucial controlling factor for the injection and propaga

31 ves non-covalent protein delivery, providing crucial design parameters for the creation of more poten

32 FOXP3 serves as a prognostic biomarker and a crucial determinant of immunosuppressive microenvironmen

33 Nettle et al. miss the crucial difference between adaptive models of storing en

34 Invertase-mediated sugar release seems to be crucial during the first hour of fermentation, while amy

35 d activators of transcription 5 (STAT5s) are crucial effectors of tyrosine kinase oncogenes in myeloi

36 e T-cell intrinsic IL-18R/MyD88 pathway as a crucial element for induction of cognate Th1 responses a

37 personal coordination, or joint action, is a crucial element of social interaction, but the dynamics

38 of statistically significant outcomes adds a crucial element to the global assessment of trial findin

39 e IDS gene encoding iduronate-2-sulfatase, a crucial enzyme in the lysosomal degradation pathway of d

40 Our results provide crucial evidence for genotypic sex determination facilit

41 Furthermore, an increased level of G9a is a crucial factor in mediating the hypoxic response by down

42 snail transcriptional repressor SNAI2, each crucial factors in mediating EMT.

43 The prefrontal cortex (PFC) is crucial for accurate memory performance when prior knowl

44 ems.Coherent control of two-level systems is crucial for achieving fidelity in spectroscopy and quant

45 boration with the risk modelling industry is crucial for assessing risk accurately and, where appropr

46 ent in the Alzheimer's disease (AD) brain is crucial for both clinical diagnosis and monitoring AD di

47 ating mitochondrial Ca(2+) uptake, a process crucial for Ca(2+) signaling, bioenergetics, and cell de

48 ancers drive the biogenesis of master miRNAs crucial for cell identity by enhancing both transcriptio

49 s18alpha:Mis18beta subcomplex and M18BP1, is crucial for CENP-A homeostasis.

50 he small F508del-CFTR subpopulation might be crucial for CF therapy development.

51 aenorhabditis elegans AWA neurons, which are crucial for chemotaxis, we uncovered a Ca(2+) NFL leadin

52 ng global patterns of biodiversity change is crucial for conservation research, policies and practice

53 ir tick vectors and vertebrate reservoirs is crucial for continuance of the enzootic cycle as well as

54 herefore, accurate differential diagnosis is crucial for correct patient management.

55 ion under combination therapies is therefore crucial for correctly predicting treatment outcomes.

56 s to study neutralization by antibodies, are crucial for developing cost-effective and yet rigorous a

57 ing of the stratigraphy, information that is crucial for evaluation of its authenticity and attributi

58 Visuomotor ability is quite crucial for everyday functioning, particularly in drivin

59 Proper division plane positioning is crucial for faithful chromosome segregation but also inf

60 Position detection with high accuracy is crucial for force calibration of optical trapping system

61 monitoring of the clinical status, which is crucial for further management.

62 ved from the first tetrapods to man, that is crucial for higher order structure self-assembly of the

63 Cs with proregenerative molecules ex vivo is crucial for improving the therapeutic outcome in patient

64 ecifically whether systemic drug exposure is crucial for in vivo efficacy.

65 ticides and pesticide residues (PRs) remains crucial for informing public health policies, despite st

66 bly regulating activation of SFKs, which are crucial for initiation of CLEC-2 signaling.

67 The phagocyte respiratory burst is crucial for innate immunity.

68 at have structural similarities to a protein crucial for invasion of red blood cells.

69 de with a controlled redox state and rate is crucial for its pharmaceutical/medicinal applications.

70 n as integrin alphaMbeta2, or CD11b/CD18) is crucial for leukocyte recruitment to the endothelium, an

71 trate that the co-repressor protein Sin3a is crucial for lung endoderm development.

72 Microbial water quality monitoring is crucial for managing water resources and protecting publ

73 Midbrain dopamine neurons are crucial for many behavioral and cognitive functions.

74 on of plant genomes and genetic diversity is crucial for meeting these challenges.

75 ate meiotic DSB formation to form crossovers crucial for meiosis.

76 To identify key residues crucial for MjAgo function, we analysed the effect of se

77 of histone H4 at lysine 16 (H4K16ac) and is crucial for murine embryogenesis.

78 are ionotropic glutamate receptors that are crucial for neuronal development and higher cognitive pr

79 somal rearrangements and contains many genes crucial for neuronal development and migration.

80 UreG is crucial for nickel delivery because UreG-dependent ureas

81 sthma, and thorough assessment of allergy is crucial for optimal care of these children.

82 , indicating the presence of active O atoms, crucial for oxidation catalysts.Improving platinum as an

83 endent endothelial cell glycolysis, which is crucial for pathological angiogenesis in proliferative r

84 -relevant-here, formant frequencies that are crucial for phoneme discrimination.

85 of the situation-the self in context-that is crucial for placebo effects.

86 factors such as aridity and soil N status is crucial for predicting plant and ecosystem-scale respons

87 Protein N-glycosylation (PNG) is crucial for protein folding and enzymatic activities, an

88 In living cells intracellular proteolysis is crucial for protein homeostasis, and ClpP proteases are

89 rotection of the stalled replication fork is crucial for responding to replication stress and minimiz

90 Appropriateness of reference genes is crucial for RT-qPCR.

91 o-stored/co-secreted with catecholamines and crucial for secretory vesicle biogenesis in neuronal/neu

92 h ubiquitin/ubiquitin-like (Ubl) proteins is crucial for several physiological processes and in the o

93 This indicates that IKKepsilon is crucial for SPL-mediated inhibition of influenza virus r

94 aused by deficiency of SMN protein, which is crucial for spliceosome subunits biogenesis.

95 wo landscapes complement each other with one crucial for stabilities of states on the cycle and the o

96 bunit, we demonstrate that Arg116/Arg117 are crucial for stabilizing PIC-mRNA contacts at the entry c

97 These data suggest that 11beta-HSD1 is not crucial for survival of experimental malaria, but alters

98 ideration of cellular context will likely be crucial for targeting signalling networks.

99 miR-430 is crucial for the clearance of maternal mRNA during matern

100 Progesterone (P4) signaling is crucial for the decidualization of the endometrial strom

101 nowledge of these photophysical processes is crucial for the development of efficient light-harvestin

102 termination of intraocular pressure (IOP) is crucial for the diagnosis and management of glaucoma.

103 ion channel gate by environmental stimuli is crucial for the fulfilment of its biological role.

104 3 released from breast tumor cells, which is crucial for the induction of IL-13(+) Th2 cells, but it

105 Their biological fidelity is therefore crucial for the interpretation of simulations.

106 for damaged or superfluous mitochondria are crucial for the maintenance of cellular and organismal h

107 us to conclude that the imidazolium salts is crucial for the oxidation.

108 ggest that OXTR signaling in the CA2/CA3a is crucial for the persistence of long-term SRM.SIGNIFICANC

109 and development in oligodendrocytes which is crucial for the powerful brain functions.

110 eriment, highlighting that the time frame is crucial for the quantification and interpretation of sex

111 lar basis for learning and memory, and it is crucial for the refinement of neuronal circuits during d

112 Olfaction is crucial for the reproductive success of parasitoid wasps

113 of a crystalline material on a substrate-is crucial for the semiconductor industry, but is often lim

114 ilities of states on the cycle and the other crucial for the stability of the flow along the cycle.

115 This is especially crucial for the tasks, in which the performance is heavi

116 tion in the biosynthesis of mycocyclosin, is crucial for the viability of this pathogen.

117 Understanding biological invasions is crucial for their control and prevention.

118 lls to reach environment-dependent decisions crucial for their survival or reproduction.

119 Working towards achieving 120 x 20 is crucial for ultimately achieving the Sustainable Develop

120 Reconstructing ancient mobility is crucial for understanding human strategy at exploiting t

121 Unraveling the complexity of aging is crucial for understanding its mechanisms and its role as

122 , and is defective in transcription of genes crucial for utilization of carbohydrate stores at night.

123 For example, the TRPP2-PKD1 complex has a crucial function in renal physiology, with mutations in

124 jects through vision, or visual search, is a crucial function that has received considerable attentio

125 As such, connexins regulate one of the most crucial functional refinements in the mammalian cochlea,

126 vivo Taken together, these results identify crucial functions for RB in the cerebral organoid model

127 MYST histone acetyltransferases have crucial functions in transcription, replication and DNA

128 Here, we review the crucial functions of KLFs in mammalian embryogenesis, st

129 beta-catenin signaling components, which are crucial gatekeepers in common forms of intestinal cancer

130 PDZ1i inhibited crucial GBM signaling involving FAK and mutant EGFR, EGF

131 This crucial Hsp70 function relies on allosteric communicatio

132 One of the crucial IFN-gamma target genes required for control of M

133 tanding of physiological processes and has a crucial impact in developing novel therapeutic strategie

134 sus metastatic disease and thus might have a crucial impact on further clinical management.

135 arker genes for plastid transformation is of crucial importance to all efforts towards extending the

136 rmation on aerosol particles is a process of crucial importance to Earth's climate and the environmen

137 Dynamic ultrasound is crucial in confirming the diagnosis and should be done o

138 ue anatomy and accurate surgical planning is crucial in conjoined twin separation surgery.

139 An appropriately balanced immune response is crucial in determining the outcome of malarial infection

140 ide polymorphism-independent method could be crucial in dominant diseases that feature both gain- and

141 It has become crucial in drug trials and to follow individual clones i

142 e advent of single-cell technologies will be crucial in enabling the diagnosis and stratification of

143 ng of the quality of survival of patients is crucial in evaluating trauma care, understanding recover

144 Asparagine further proved crucial in glutamine-deprived ECs to restore protein syn

145 Random number generation is crucial in many aspects of everyday life, as online secu

146 cal characterization of the nanointerface is crucial in order to select suitable nanomaterials for fu

147 sis and injury repair, which is likely to be crucial in prevention of disease.

148 FA signaling is crucial in the DNA damage response (DDR) to mediate the

149 egulation of PlexA1 expression may have been crucial in the evolution of mammalian CS systems that im

150 t integrity of the respiratory epithelium is crucial in the host's innate defence against primary alp

151 Efficient DNA repair pathways are crucial in these organelles to fix damage resulting from

152 d anti-HIV serum neutralizing responses were crucial in this effort.

153 stacking interactions have been shown to be crucial in urea-assisted RNA unfolding.

154 Moreover, this regulation is particularly crucial in yeast for the stress-induced transient elevat

155 Here, we reveal crucial information from the wing pad joints of Carbonif

156 have too many confounding effects, and lack crucial information.

157 hes of artificial intelligence have designed crucial ingredients towards autonomous learning: curiosi

158 Dendritic cells (DCs) are crucial initiators of immune responses, but little is kn

159 trol disorders and dyskinesias could provide crucial insights into other behavioural symptoms in Park

160 Our study provides crucial insights into RIBEs, and will facilitate the ide

161 med a modeling study that sheds light on the crucial interactions for both the affinity and dissociat

162 Of crucial interest is the effect of spin state of the Fe(I

163 autocrine/paracrine C3ar1/C5ar1 signaling as crucial intermediary processes that link TLR stimulation

164 The tripeptide glutathione (GSH) is a crucial intracellular reductant and radical scavenger, b

165 To clarify this crucial issue, we studied 87 human participants of both

166 IM5 for proper kAE1 membrane residency, as a crucial linker between kAE1 and actin cytoskeleton-assoc

167 Neomorphic missense mutations affecting crucial lysine residues in histone H3 genes significantl

168 can control an entire process by acting on a crucial mediator; however, this is a quite exceptional m

169 including regulated splicing of a number of crucial meiosis-specific RNAs.

170 effectiveness in the target population is a crucial milestone in developing IPV-Al.

171 Cyclin A2 is a crucial mitotic Cdk regulatory partner that coordinates

172 HIR operates as a crucial modulator of hyphal development, since genetic a

173 ic syndromes and that the STAT1 pathway is a crucial modulator of this phenotypic spectrum.

174 tor (BDNF) and nerve growth factor (NGF) are crucial modulators in the neurodevelopment and maintenan

175 trast, the hexapeptide motif in repeat R3, a crucial motif for fibril formation, shows strikingly low

176 ere is evidence that few mutations including crucial mutations in VP24 enable Ebola virus adaptation

177 eins failed to regulate a promoter lacking a crucial NACbs.

178 ings show that the temporal pathways are the crucial neural substrate supporting one of the most stri

179 lls derived from its natural host and may be crucial not only to better understand ChHV5 circulation

180 tigations implied ceRNA interaction performs crucial oncogenic/tumor suppressive functions in gliobla

181 detected count rate per molecule, which is a crucial parameter for localization microscopy.

182 ent on the reaction conditions, and H2O is a crucial parameter in the control of selectivity.

183 results indicate that the cerebellum forms a crucial part of the feedforward control system for speec

184 ulation of BCL-2 has long been known to be a crucial part of the pathophysiology of B-cell lymphomas;

185 nvolved in full methane oxidation, but their crucial participation, likely being mediators in electro

186 en preclude genetic characterization of that crucial phase.

187 t mitochondrial pyruvate carrier 1 (MPC1), a crucial player in pyruvate metabolism, is downregulated

188 iation; moreover, they highlight HOTAIR as a crucial player in the Snail-mediated EMT.

189 Ubiquitination, the crucial posttranslational modification that regulates th

190 ized fibrous extracellular matrix (ECM) is a crucial precursor to collective cell migration in wound

191 mental stewardship and public participation, crucial prerequisites of effective management.

192 urification of MPs from organic materials is crucial prior to conducting an identification via spectr

193 aling up of interventions for PWID remains a crucial priority for halting the HIV and HCV epidemics.

194 Steady dissipation of energy is a crucial property that distinguishes active particles fro

195 We address the crucial question of whether the seven Earth-sized planet

196 n factor R1 and hexokinase HEX9 might act as crucial regulators for flavonoid biosynthesis and glycol

197 udies indicated that lncRNAs are emerging as crucial regulators in cancer processes and potentially u

198 ole that key transcription factors and other crucial regulatory genes play in these events.

199 rients are necessary for life, as they are a crucial requirement for biological processes including r

200 severe intestinal inflammation, indicating a crucial role for Blimp1 in T cell homeostasis regulation

201 d into the periglomerular layer, revealing a crucial role for EphA4 in facilitating efficient neurobl

202 gulation of SREBP-1 in cancer and suggests a crucial role for O-GlcNAc signaling in transducing nutri

203 e GLP-1 secretion in the model, suggesting a crucial role for SGLT1 in triggering GLP-1 release in ag

204 reveal such a function, supporting instead a crucial role for SHH in promoting proliferation of these

205 ndromatosis in humans and mice, suggesting a crucial role for SHP2 in the skeleton.

206 he defensive peripersonal space (DPPS) has a crucial role for survival, and its modulation is fundame

207 and rescued by deleting upd3, highlighting a crucial role for this cytokine.

208 Recent studies identified a crucial role for this pathway in activity-dependent long

209 d with its potency to resolve AAI supports a crucial role for transcriptional regulation by the GR in

210 ted with these pathways were found to have a crucial role in AD pathogenesis.

211 agating in a disordered potential and play a crucial role in Anderson localization, which is the abse

212 These play a crucial role in auditory perception as well as attention

213 Cav1.2 channels play a crucial role in calcium-mediated processes involved in b

214 Chronic inflammation is believed to have a crucial role in colon cancer development.

215 he International Monetary Fund (IMF) plays a crucial role in determining how governments allocate sca

216 est that top-down sensory prediction plays a crucial role in development and that deficits in this ab

217 activation of the Hh pathway, which plays a crucial role in development and tumorigenesis.

218 he E-cadherin/AmotL2/actin filaments plays a crucial role in developmental processes such as epitheli

219 tochondrial dysfunction is thought to play a crucial role in disease pathogenesis.

220 Neutrophils play a crucial role in host defense.

221 (MC1R), a G-protein-coupled receptor, has a crucial role in human and mouse pigmentation.

222 Nematode effectors play a crucial role in initializing and sustaining successful p

223 meobox 1 gene (PBX1), a gene known to have a crucial role in kidney development.

224 pal replays have been demonstrated to play a crucial role in memory.

225 hin WRDPLVDID indicated that Trp-637 plays a crucial role in Pah1 function.

226 netic behaviours, have been proven to play a crucial role in photovoltaic properties of ferroelectric

227 expression in CD4(+)CD8(+) thymocytes, has a crucial role in positive selection and T cell developmen

228 outcome of another's decisions-might play a crucial role in processing social information.

229 F to regulate their stability, thus having a crucial role in proper centrosome positioning, chromosom

230 IgE production plays a crucial role in protective as well as pathogenic type 2

231 nucleosome interactions is thought to play a crucial role in regulating transcription and access to D

232 Interfaces play a crucial role in semiconductor devices, but in many devic

233 These results indicate that SP110b plays a crucial role in shaping the inflammatory milieu that sup

234 rt, laminin alpha2 in the BM seems to play a crucial role in the BTB-BM axis by modulating BTB dynami

235 These results suggest that Gpr64 has a crucial role in the decidualization of endometrial strom

236 FPP plays a crucial role in the post-translational prenylation of sm

237 rials with enzymatic properties could play a crucial role in the treatment of such pathologies.

238 ers than from HIV-1 progressors supports the crucial role of effective HIV-specific CD8(+) T cells in

239 Increasing evidence suggests a crucial role of inflammation in cytokine-mediated beta-c

240 study thus provides direct evidence for the crucial role of Nrf2 in protecting human organ function

241 Our data underline the crucial role of the actin cortex in maintaining hindered

242 on of stiffened RBCs in vivo, and reveal the crucial role of the vessel geometry in the margination b

243 The results identify crucial roles for the active site amino acid trio in det

244 Condensin plays crucial roles in chromosome organization and compaction,

245 , emerging evidence suggest that miRNAs have crucial roles in control of EMT and EMT-associated trait

246 tes that long non-coding RNAs (lncRNAs) play crucial roles in epigenetic and transcriptional regulati

247 Voltage-gated sodium channels (Navs) play crucial roles in excitable cells.

248 hogen-associated molecular patterns and play crucial roles in innate immune responses to invading pat

249 Secreted proteins play crucial roles in mediating tumor-stroma interactions dur

250 which regulate neuronal plasticity and have crucial roles in myriad brain functions, this study reve

251 ning, calcium (Ca(2+))-binding proteins with crucial roles in plant development and in coordinating p

252 conserved from bacteria to humans, performs crucial roles in protein homeostasis, and is implicated

253 t LUBAC-mediated linear ubiquitination plays crucial roles in regulating LMP1 signaling and functions

254 work has led to advancements in a number of crucial sensing domains, including biomolecules, environ

255 first time that the primary cilium acts as a crucial sensor for electrical field stimulation (EFS)-en

256 that have recently been implicated to play a crucial sensor role for many mechanical and chemical sti

257 onstrate the existence of cross-seeding as a crucial step in the formation of the yeast prion [PSI (+

258 One of the most crucial steps in high-throughput sequence-based microbio

259 Oligomeric Amyloid beta1-42 (Abeta) plays a crucial synaptotoxic role in Alzheimer's disease, and hy

260 do45 (LD organization protein of 45 kD) as a crucial targeting determinant.

261 e harm free environments for patients, it is crucial that nursing students develop confidence communi

262 ew ways of sharing knowledge globally, it is crucial that the high quality of medical congresses be m

263 hich chemical denaturants unfold proteins is crucial; this study explores the nature of urea-aromatic

264 x regulatory network within the cell that is crucial to cell functioning and human health.

265 ess to safe drinking water is a human right, crucial to combat inequalities, reduce poverty and allow

266 appropriate level of process description is crucial to constructing the best possible model, given t

267 ade-offs involved in mate search may thus be crucial to determining how density influences the evolut

268 Therefore, it is crucial to develop a fast and effective filter that can

269 antation, appropriate vascular remodeling is crucial to ensure the survival and function of engrafted

270 long-term follow-up of patients with TTP is crucial to identify the occurrence of other autoimmune d

271 mplex in these sensitive alpine areas, it is crucial to identify their long-term natural trends, ecol

272 istics of latently infected cells in vivo is crucial to identifying and developing effective latency-

273 t lipid components of the immune response is crucial to identifying novel strategies to effectively a

274 Refinement of this T-cell therapy is crucial to improve the frequency of clinical responses a

275 Rapid recognition of TTP is crucial to initiate appropriate treatment.

276 ing how selection acts on risk preference is crucial to interpreting and predicting behavior.

277 nteractions between capsid subunits that are crucial to maintain stability in the absence of cementin

278 Leaf hydraulic supply is crucial to maintaining open stomata for CO2 capture and

279 ive genomic context is becoming increasingly crucial to make full use of the data.

280 -amino acid containing peptides (DAACPs) are crucial to many life processes.

281 of molecular structure-property relations is crucial to optimize gamma but requires state of the art

282 ng boys who have not yet been exposed may be crucial to reduce prevalence, but our results suggest th

283 oligomerization in a membrane-bound state is crucial to restrict caveolae dynamics in cells.

284 akdown behavior of polymer nanocomposites is crucial to the design of high-energy-density dielectric

285 rging cooperative-communicative abilities as crucial to the evolution of all forms of human cultural

286 If correct, orofacial stereotypies are crucial to the maturation of aerodigestion in the neonat

287 giectasia), and DNA double-strand breaks are crucial to the modulation of early gene expression, whic

288 Suitable membrane mimetics are crucial to the performance of structural and functional

289 cificities of transcription factors (TFs) is crucial to the study of gene expression regulation.

290 ing ligands to gold nanoparticles (AuNPs) is crucial to understand their stabilizing role.

291 phases under extreme conditions is not only crucial to understanding and manipulating materials but

292 bution of phylogenetically older pathways is crucial to understanding its origin.

293 ding how the human visual system develops is crucial to understanding the nature and organization of

294 detection of prions in saliva-a distinction crucial to understanding the role of prion shedding in d

295 sequence to a specified designed sequence is crucial to verify design principles in genome synthesis.

296 The pheromone will also be a crucial tool in ongoing efforts to eradicate the beetle

297 e-based blood-brain barrier (BBB) models are crucial tools to enable rapid screening of brain-penetra

298 xtraction solvent recovery was found to be a crucial uncertainty that may have a substantial influenc

299 ntiation-associated gene 5 (MDA5), which are crucial viral sensors in the host innate immune system.

300 A crucial, yet open, question regards how babies deal with