ライフサイエンスコーパス: cryo-electron microscopy

1 X-ray crystallography, NMR spectroscopy, and cryo electron microscopy.

2 NA to 3.8 A resolution using single-particle cryo-electron microscopy.

3 s complex at 3.6-A resolution, determined by cryo-electron microscopy.

4 ORC determined by X-ray crystallography and cryo-electron microscopy.

5 -220 A diameter mini-rings, here observed by cryo-electron microscopy.

6 molecules was determined by single-particle cryo-electron microscopy.

7 mmalian (ovine) supercomplexes determined by cryo-electron microscopy.

8 o 3.9-angstrom resolution by single-particle cryo-electron microscopy.

9 gth TRPV2 at approximately 5 A resolution by cryo-electron microscopy.

10 sions to be high fidelity by single-particle cryo-electron microscopy.

11 coli F-ATP synthase has been generated using cryo-electron microscopy.

12 1 S protein determined using single-particle cryo-electron microscopy.

13 rtaker in the blooming of a technique I love-cryo-electron microscopy.

14 mined at 4.0 A resolution by single particle cryo-electron microscopy.

15 resolution, as determined by single-particle cryo-electron microscopy.

16 of the active human apoptosome determined by cryo-electron microscopy.

17 odel of the CVB3-DAF interaction obtained by cryo-electron microscopy.

18 tracted Vibrio cholerae sheath determined by cryo-electron microscopy.

19 sents a significant technical advance for 3D cryo-electron microscopy.

20 of Pvr at a 4-A resolution, as determined by cryo-electron microscopy.

21 OS-1 antibody Fab fragment was determined by cryo-electron microscopy.

22 n bound to lipid nanotubes, as determined by cryo-electron microscopy.

23 S. cerevisiae Pol II-Rad26 complex solved by cryo-electron microscopy.

24 and the complete Mtb 70S ribosome, solved by cryo-electron microscopy.

25 employing time-resolved x-ray scattering and cryo-electron microscopy.

26 ermined by Volta phase-plate single-particle cryo-electron microscopy.

27 recipitation experiments and single particle cryo-electron microscopy.

28 e molecular structure of hERG to 3.8 A using cryo-electron microscopy.

29 tructure of a WRC-Rac1 complex determined by cryo-electron microscopy.

30 d two tissue culture adapted FMDV strains by cryo-electron microscopy.

31 ECs) with and without Nun by single-particle cryo-electron microscopy.

32 ucture of a bovine CLC channel (CLC-K) using cryo-electron microscopy.

33 ffraction or NMR data), and 3D reconstructed cryo-electron microscopy (3D EM) maps (albeit at coarser

34 with stem-specific monoclonal antibodies and cryo-electron microscopy analysis of HA-SS on ferritin n

35 Cryo-electron microscopy analysis reveals that Hel2-boun

36 WV determined to a resolution of 3.1 A using cryo-electron microscopy and 3.8 A by X-ray crystallogra

37 structure determination of mouse TMEM16A by cryo-electron microscopy and a complementary functional

38 The CSN conformers defined by cryo-electron microscopy and a novel apo-CSN crystal str

39 Using three-dimensional cryo-electron microscopy and analytical ultracentrifugat

40 Here, using cryo-electron microscopy and biochemical analysis, we de

41 Using cryo-electron microscopy and biophysical assays, we have

42 plex (Med-PIC) was assembled and analyzed by cryo-electron microscopy and by chemical cross-linking a

43 Both single particle cryo-electron microscopy and cryotomography reconstructi

44 With cryo-electron microscopy and helical reconstruction we s

45 b, AAV5-ADK5a, and AAV5-ADK5b, determined by cryo-electron microscopy and image reconstruction to a r

46 f capsid-antibody complexes determined using cryo-electron microscopy and image reconstruction.

47 A template for cryo-electron microscopy and multimodal cryo-imaging app

48 Here we report cryo-electron microscopy and negative-staining electron

49 Using cryo-electron microscopy and new direct electron detecto

50 We used cryo-electron microscopy and scanning transmission elect

51 20S proteasome bound to the inhibitor using cryo-electron microscopy and single-particle analysis, t

52 the stabilized mutant at 3.6 A resolution by cryo-electron microscopy and single-particle reconstruct

53 o motility assays, single-molecule tracking, cryo-electron microscopy and structural probing (16) .

54 etermined to a resolution of 2.8 to 3.0 A by cryo-electron microscopy and three-dimensional image rec

55 ent variant, AAV2-R432A, were examined using cryo-electron microscopy and three-dimensional image rec

56 2, HBoV1-9G12, and HBoV1-12C1, determined by cryo-electron microscopy and three-dimensional image rec

57 mined using X-ray crystallography as well as cryo-electron microscopy and three-dimensional image rec

58 Using cryo-electron microscopy and time-resolved small-angle X

59 ly analyze their subcellular water states by cryo-electron microscopy and tomography, cryoelectron di

60 and Esigma(70) determined by single-particle cryo-electron microscopy and validation of the structure

61 ding motif (MBM) assembling around MTs using cryo-electron microscopy and verified it with chemical c

62 Cryo-electron microscopy and X-ray crystallography have

63 Here, using single-particle cryo-electron microscopy and X-ray crystallography, we d

64 gments (8B10 and 5F10) were determined using cryo-electron microscopy and X-ray crystallography.

65 e results of others that were obtained using cryo-electron microscopy (and single particle analysis),

66 ule fluorescence microscopy, single-particle cryo-electron microscopy, and biochemistry.

67 0 approximately Ub-substrate intermediate by cryo-electron microscopy, and in isolation by X-ray crys

68 type CHIKV, as determined by single-particle cryo-electron microscopy, and it mimicked the early stag

69 methods, including atomic force microscopy, cryo-electron microscopy, and neutron scattering, to inv

70 aPI1 procapsids to near-atomic resolution by cryo-electron microscopy, and show that CpmB competes wi

71 molecular fiducial marks for single particle cryo-electron microscopy approaches.

72 ctron microscopy of frozen hydrated samples (cryo-electron microscopy) are providing unprecedented op

73 e isolated lid sub-complex, as determined by cryo-electron microscopy at 3.5 A resolution, revealing

74 lizer, was constructed, and its structure by cryo-electron microscopy at 6.2 A resolution reveals a c

75 o2.2, in the Na(+)-free state, determined by cryo-electron microscopy at a nominal resolution of 4.5

76 report the structure of APBV1, determined by cryo-electron microscopy at near-atomic resolution.

77 promoter DNA, determined by single-particle cryo-electron microscopy at sub-nanometre resolution.

78 Herein, we report a cryo-electron microscopy-based model of a large rHDL for

79 At the concentrations used in cryo-electron microscopy, Bim1 causes the compaction of

80 -ray crystallography, homology modeling, and cryo-electron microscopy by an integrative modeling appr

81 alyzed by a hybrid structural approach using cryo-electron microscopy, chemical cross-linking coupled

82 We used three-dimensional cryo-electron microscopy combined with complementary bio

83 Here, we report high resolution cryo electron microscopy (cryo-EM) maps of wild type CPM

84 tide transporter PeptTSo2 by single-particle cryo-electron microscopy (cryo-EM) and allowed us to sta

85 Based on cryo-electron microscopy (cryo-EM) and dynamic light sca

86 Applying single-particle cryo-electron microscopy (cryo-EM) and image classificat

87 ation of the phage tail after ejection using cryo-electron microscopy (cryo-EM) and single particle r

88 derived independently from photographic film cryo-electron microscopy (cryo-EM) and X-ray crystallogr

89 as realized the potential of single particle cryo-electron microscopy (cryo-EM) as a technique to gen

90 r GluK2 subtype in its desensitized state by cryo-electron microscopy (cryo-EM) at 3.8 A resolution,

91 In this work, we demonstrate that cryo-electron microscopy (cryo-EM) can be used to image

92 Cryo-electron microscopy (cryo-EM) had played a central

93 Single-particle cryo-electron microscopy (cryo-EM) has become a mainstre

94 The suddenness with which single-particle cryo-electron microscopy (cryo-EM) has emerged as a meth

95 In the last few years, however, progress in cryo-electron microscopy (cryo-EM) has made possible the

96 U4 fragments of antibody (Fab) was solved by cryo-electron microscopy (cryo-EM) image reconstruction.

97 Cryo-electron microscopy (cryo-EM) is a powerful techniq

98 3D cryo-electron microscopy (cryo-EM) is an expanding struc

99 Here we present cryo-electron microscopy (cryo-EM) maps at 3.4-3.5 A res

100 c modeling of macromolecular structures into cryo-electron microscopy (cryo-EM) maps is a major chall

101 re determination from near-atomic-resolution cryo-electron microscopy (cryo-EM) maps.

102 Cryo-electron microscopy (cryo-EM) methods are now being

103 orkflow enabled by these grids, we performed cryo-electron microscopy (cryo-EM) of His6-GroEL obtaine

104 Cryo-electron microscopy (cryo-EM) of single-particle sp

105 We have obtained high-resolution (3.9-4.2A) cryo-electron microscopy (cryo-EM) reconstructions of MT

106 Here, we present five cryo-electron microscopy (cryo-EM) reconstructions of ri

107 Advances in high-resolution cryo-electron microscopy (cryo-EM) require the developme

108 ly reported as a pentameric configuration by cryo-electron microscopy (cryo-EM) since the contact by

109 Combining cryo-electron microscopy (cryo-EM) structure analysis an

110 Here we report the 4.2-A cryo-electron microscopy (cryo-EM) structure and in vitr

111 etermined an intermediate-resolution (8.5-A) cryo-electron microscopy (cryo-EM) structure of a chimer

112 Here we present the cryo-electron microscopy (cryo-EM) structure of a full-l

113 , through which we present a high-resolution cryo-electron microscopy (cryo-EM) structure of the core

114 Here, we report the cryo-electron microscopy (cryo-EM) structure of the Csy

115 Here we present cryo-electron microscopy (cryo-EM) structures at 3.5-3.8

116 We report cryo-electron microscopy (cryo-EM) structures for adenos

117 The cryo-electron microscopy (cryo-EM) structures of a matur

118 We determined the cryo-electron microscopy (cryo-EM) structures of HMAb 2D

119 We report six cryo-electron microscopy (cryo-EM) structures of MTs, at

120 Here, we report the cryo-electron microscopy (cryo-EM) structures of Qbeta w

121 lidations by both negative staining (NS) and cryo-electron microscopy (cryo-EM) suggest that this met

122 roV), one of the largest viruses analyzed by cryo-electron microscopy (cryo-EM) to date.

123 To resolve aspects of the mechanism, we used cryo-electron microscopy (cryo-EM) to visualize Bax-indu

124 scribe our protocol for correlated cryo-fLM, cryo-electron microscopy (cryo-EM), and cryo-ET (i.e., c

125 We report cryo-electron microscopy (cryo-EM), biophysical, biochem

126 In single-particle cryo-electron microscopy (cryo-EM), molecules suspended

127 such as data from antibody binding studies, cryo-electron microscopy (cryo-EM), mutational analyses,

128 d CFTR), determined by using single-particle cryo-electron microscopy (cryo-EM), reveal structural de

129 Despite the recent rapid progress in cryo-electron microscopy (cryo-EM), there still exist am

130 l proteins in C capsids has been moot as, in cryo-electron microscopy (cryo-EM), they would be camouf

131 Using recent advances in cryo-electron microscopy (cryo-EM), we determined the st

132 Combining constraints from ssNMR and cryo-electron microscopy (cryo-EM), we establish an atom

133 Previously, using cryo-electron microscopy (cryo-EM), we showed that activ

134 tructure of mature Zika virus, determined by cryo-electron microscopy (cryo-EM).

135 ere only resolved at moderate resolutions by cryo-electron microscopy (cryo-EM).

136 Cryo-electron-microscopy (cryo-EM) structures of flavivi

137 atomic model of the archaella, based on the cryo electron microscopy (cryoEM) structure of the Metha

138 ly confirm the identity of this T6SS and, by cryo electron microscopy (cryoEM), show the structure of

139 resolution, determined by electron-counting cryo-electron microscopy (cryoEM) and asymmetric reconst

140 software have revolutionized single particle cryo-electron microscopy (cryoEM) and led to a wave of n

141 probe their molecular architectures by using cryo-electron microscopy (cryoEM) image reconstruction t

142 Here, we report 11 single-particle cryo-electron microscopy (cryoEM) reconstructions of the

143 present a 6.2 A resolution three-dimensional cryo-electron microscopy (cryoEM) structure of an infect

144 ucture of the CVB3-DAF complex determined by cryo-electron microscopy, DAF S104 is in close contact w

145 h as several NMR observables, FRET, SAXS and cryo-electron microscopy data, and enables modelling str

146 litated 3D helical image reconstruction from cryo-electron microscopy data, revealing the basic tube

147 Coarse-grained models are compared with 3D cryo-electron microscopy density maps for these five DNA

148 Given that cryo-electron microscopy directly observes projections o

149 s, characterized by atomic force microscopy, cryo-electron microscopy, dynamic light scattering, and

150 n NMR, these nanodiscs can also be used for (cryo-) electron microscopy (EM) and small-angle X-ray an

151 tting of the VP90(71-415) structure into the cryo-electron microscopy (EM) maps of HAstV produced an

152 paradigm, are presented that resolve sub-5 A cryo-electron microscopy (EM) maps with either single st

153 We have determined the cryo-electron microscopy (EM) structure of Tor bound to

154 By using cryo-electron microscopy, expanded 80S-like poliovirus v

155 Finally, cryo-electron microscopy experiments indicate that tau a

156 Structure determination by cryo-electron microscopy has approached atomic resolutio

157 Recent high-resolution cryo-electron microscopy has revealed the effect of coev

158 Technical advances in cryo-electron microscopy have resulted in a series of at

159 By cryo-electron microscopy, here we determine the near-ato

160 Cryo-electron microscopy, high-resolution transmission e

161 Three-dimensional reconstruction based on cryo-electron microscopy images and single-particle imag

162 Major developments in cryo-electron microscopy in the past three or four years

163 re collected for each selected crystal using cryo-electron microscopy, in which the crystal is diffra

164 sional reconstruction of images generated by cryo-electron microscopy indicates that the SpoIIIAG rin

165 Cryo-electron microscopy is used to uncover the structur

166 Single-particle cryo-electron microscopy is widely used to study the str

167 , elucidated at near-atomic resolution using cryo-electron microscopy, is strikingly similar to that

168 ) was recently modeled in our 9 A resolution cryo-electron microscopy map by fitting protein and TER

169 Comparison with a 7.8 A resolution cryo-electron microscopy map of a Mediator-RNA polymeras

170 Here we present a 4.4 A resolution cryo-electron microscopy map of Schizosaccharomyces pomb

171 A recently reported 9-A cryo-electron microscopy map of the Tetrahymena telomera

172 Modelling of Tsr1 into cryo-electron microscopy maps of pre-40S particles shows

173 ing protein structure models on the basis of cryo-electron microscopy maps with near-atomic resolutio

174 structures of this segment determined by the cryo-electron microscopy method micro-electron diffracti

175 edge, the highest resolution achieved by any cryo-electron microscopy method to date.

176 equilibrium constant measurements as well as cryo-electron microscopy methodologies to investigate th

177 Using cryo-electron microscopy, multireference single-particle

178 ray scattering, free-electron laser imaging, cryo-electron microscopy, nuclear magnetic resonance, el

179 ents give rise to large vesicles, as seen by cryo-electron microscopy observations.

180 erized, RNA-encapsidating nucleoprotein, and cryo-electron microscopy of nucleocapsid or nucleocapsid

181 Cryo-electron microscopy permits 3-D structures of viral

182 Cryo-electron microscopy provides evidence of elongated

183 Here we present an 8.5-A-resolution cryo-electron microscopy reconstruction and pseudo-atomi

184 We also present the cryo-electron microscopy reconstruction of a fully assem

185 -bound subunit PulG into the 5-A-resolution cryo-electron microscopy reconstruction of assembled fib

186 A cryo-electron microscopy reconstruction of prohead I inc

187 dis major pilin PilE and a approximately 6 A cryo-electron microscopy reconstruction of the intact pi

188 Here we present a cryo-electron microscopy reconstruction of the RPP TetM

189 Asymmetric cryo-electron microscopy reconstruction of the T = 4 VLP

190 This conclusion was supported by cryo-electron microscopy reconstruction of the virus par

191 Cryo-electron microscopy reconstruction revealed dramati

192 he P pilus generated from a 3.8 A resolution cryo-electron microscopy reconstruction.

193 Here we have determined cryo-electron microscopy reconstructions for the wild-ty

194 We compare these to cryo-electron microscopy reconstructions of B41 SOSIP En

195 Near-atomic resolution cryo-electron microscopy reconstructions of native type

196 In this study, we present high-resolution cryo-electron microscopy reconstructions of poliovirus w

197 s spectrometric analysis and single-particle cryo-electron microscopy reconstructions of the BtAdV 25

198 xes to microtubules at high resolution using cryo-electron microscopy reconstructions.

199 tative mass spectrometry and single-particle cryo-electron microscopy reveal 13 distinct intermediate

200 Biochemical analyses and cryo-electron microscopy reveal that one design, EPN-01,

201 Cryo-electron microscopy revealed that Rca docks onto Ru

202 olysaccharide profiles, protein profiles and cryo-electron microscopy revealed that there were no sig

203 Single-particle cryo-electron microscopy reveals a multivalent intasome-

204 Cryo-electron microscopy reveals the structure of a chlo

205 NMR and cryo-electron microscopy show its binding to an exposed

206 Light and cryo-electron microscopy show that synthetic seeds nucle

207 Here we use cryo-electron microscopy single-particle reconstruction

208 n p53/Pol II interaction via single-particle cryo-electron microscopy, structural docking, and bioche

209 etermination of intact human gamma-secretase cryo-electron microscopy structure has opened the way fo

210 oreover, comparison with a recently reported cryo-electron microscopy structure indicates that dramat

211 Here, we present an 8.9-A cryo-electron microscopy structure of a BG505 Env-sCD4-1

212 Here, we determine the cryo-electron microscopy structure of a central region o

213 Here we present the cryo-electron microscopy structure of a full-length Slo1

214 Here, we report the cryo-electron microscopy structure of a quaternary compl

215 Here, we present a 2.9 A cryo-electron microscopy structure of a ribosome stalled

216 Here we present, at 3.8 A resolution, the cryo-electron microscopy structure of a Saccharomyces ce

217 Here we report a high-resolution cryo-electron microscopy structure of an intact Escheric

218 In a recent cryo-electron microscopy structure of chicken Slo2.2, th

219 Here, we report the cryo-electron microscopy structure of full-length ZntB f

220 Here we describe the cryo-electron microscopy structure of human TAP in compl

221 Here we present the cryo-electron microscopy structure of human TFIIH at 4.4

222 We determined the single-particle cryo-electron microscopy structure of mammalian K(v)10.1

223 Here, we report the cryo-electron microscopy structure of mature Japanese en

224 Here we present the 3.0 angstrom cryo-electron microscopy structure of mTORC1 and the 3.4

225 Here we present the cryo-electron microscopy structure of RelA bound to the

226 Here we present a cryo-electron microscopy structure of S. cerevisiae Hrd1

227 A cryo-electron microscopy structure of Saccharomyces cere

228 A cryo-electron microscopy structure of Slo2.2 suggests th

229 We report the cryo-electron microscopy structure of Tetrahymena telome

230 Here we report the cryo-electron microscopy structure of the assembled 1.4

231 product integration complexes, as well as a cryo-electron microscopy structure of the full CRISPR lo

232 We determined the cryo-electron microscopy structure of the full-length TR

233 Here we report a 3.9 angstrom cryo-electron microscopy structure of the Hsp90-Cdc37-Cd

234 Here we report a high-resolution cryo-electron microscopy structure of the mouse Piezo1 t

235 Here we report the cryo-electron microscopy structure of the native 100S ri

236 Here we report the cryo-electron microscopy structure of the peptide-activa

237 We solved a 3.2 A cryo-electron microscopy structure of the Plasmodium fal

238 Here we report a cryo-electron microscopy structure of the postcatalytic

239 Here we report the crystal and cryo-electron microscopy structure of the pro-form of Mo

240 Here we report the genome and cryo-electron microscopy structure of the Sinorhizobium

241 Here we present the 3.8 A cryo-electron microscopy structure of the spliceosome im

242 A comparison with the recently determined cryo-electron microscopy structure of the U4/U6.U5 tri-s

243 Here we present the 3.7-angstrom cryo-electron microscopy structure of the yeast P-comple

244 Here we report the cryo-electron microscopy structure of the yeast Saccharo

245 Here, we present the cryo-electron microscopy structure of the yeast SSU proc

246 The recent cryo-electron microscopy structure of TRPV1 only provide

247 -molecule biochemistry, our hybrid X-ray and cryo-electron microscopy structure of TTLL7 bound to the

248 ffect vector transmission, we determined the cryo-electron microscopy structure of wild-type CNV in t

249 Our 3.4-angstrom cryo-electron microscopy structure reveals how the adeno

250 Using a model substrate (casein), we report cryo-electron microscopy structures at near-atomic resol

251 Here we present cryo-electron microscopy structures for CSN in complex w

252 croscopy have resulted in a series of atomic cryo-electron microscopy structures of both human and ye

253 We describe the cryo-electron microscopy structures of complexes of five

254 mparisons of six high-resolution (2.9-3.1 A) cryo-electron microscopy structures of cytoplasmic polyh

255 In this study, we present cryo-electron microscopy structures of GP and sGP in com

256 Here we present cryo-electron microscopy structures of human TRPV6 in th

257 Here we present high-resolution cryo-electron microscopy structures of subtype B B41 SOS

258 We report cryo-electron microscopy structures of synaptic RAG comp

259 Here, we present two cryo-electron microscopy structures of TF bound to ribos

260 de inserts into the channel is uncertain, as cryo-electron microscopy structures of the active channe

261 We present cryo-electron microscopy structures of the human HCN cha

262 Here we report the cryo-electron microscopy structures of the Nef- and Arf1

263 he major capsid protein, in combination with cryo-electron microscopy structures of two different mat

264 Here we report cryo-electron microscopy structures revealing that the R

265 Cryo-electron microscopy suggests that the samples are a

266 the structure of one of these conformers by cryo electron microscopy to near-atomic resolution, eluc

267 ucture of the 23-subunit dynactin complex by cryo-electron microscopy to 4.0 angstroms.

268 Here we use cryo-electron microscopy to characterize the structures

269 Here we use cryo-electron microscopy to describe two subnanometre re

270 Here we use cryo-electron microscopy to determine atomic structures

271 Here, we used cryo-electron microscopy to determine the structure of a

272 Here, we have used cryo-electron microscopy to determine the structure of t

273 Here, we used cryo-electron microscopy to elucidate the structural bas

274 Here we use single-particle cryo-electron microscopy to elucidate the structures of

275 We have used cryo-electron microscopy to generate a three-dimensional

276 oquine and demonstrate the vast potential of cryo-electron microscopy to guide the development of mef

277 Here, we have used cryo-electron microscopy to image ex-vivo-derived human

278 We use X-ray crystallography and cryo-electron microscopy to show that the ATPase subunit

279 We used cryo-electron microscopy to show that the binding of the

280 To understand this discrimination, we used cryo-electron microscopy to solve structures of Drosophi

281 Our previous paper used high-resolution cryo-electron microscopy to solve the structure of the E

282 Here we use cryo-electron microscopy to solve the structures of AMPA

283 in the transmembrane region of the original cryo-electron microscopy Torpedo model; the only pentame

284 Here using cryo-electron microscopy we directly observe the structu

285 Using cryo-electron microscopy, we characterize the architectu

286 hrough direct comparison with the results of cryo-electron microscopy, we demonstrate de novo reconst

287 Using single-particle cryo-electron microscopy, we demonstrate here that a fol

288 Using single-particle cryo-electron microscopy, we have reconstructed the RdRP

289 Using cryo-electron microscopy, we now visualize the functiona

290 Here, using cryo-electron microscopy, we report a near-atomic struct

291 Using cryo-electron microscopy, we report the structure at 4.1

292 Using single-particle cryo-electron microscopy, we report the surprising disco

293 Using cryo-electron microscopy, we show that in this intermedi

294 Using cryo-electron microscopy, we show that the GroEL C-termi

295 Using cryo-electron microscopy, we solved the atomic structure

296 d on these findings and structural data from cryo-electron microscopy, we suggest a refined disassemb

297 rAB from Vibrio alginolyticus, determined by cryo-electron microscopy, which, combined with EPR spect

298 ial complex I at 3.9 A resolution, solved by cryo-electron microscopy with cross-linking and mass-spe

299 Here, by cryo-electron microscopy with direct electron counting,

300 basal body, determined using single-particle cryo-electron microscopy, with the inner-membrane-ring a