ライフサイエンスコーパス: cryoglobulin

1 actosylation and sialylation, in relation to cryoglobulin activity, to the nephritogenic potential of

2 genic potential of 6-19 IgG3 by limiting its cryoglobulin activity.

3 leads to formation of large amounts of mixed cryoglobulins and a systemic inflammatory injury that re

4 HCV is specifically concentrated in type II cryoglobulins and has been implicated in the cutaneous v

5 HCV load, cryoglobulins, and cytokines were quantified by flow cyt

6 sera, HCV, but not HGV, was concentrated in cryoglobulins, and HCV, but not HGV, correlated with cry

7 in rashes, renal abnormalities, and elevated cryoglobulins, and was receiving interferon-alpha at the

8 Cryoglobulins are cold-precipitating immunoglobulins tha

9 Mixed cryoglobulins are complexes of immunoglobulins that reve

10 Circulating mixed cryoglobulins are detected in 40%-60% of patients with h

11 HCV-MCS was defined by circulating cryoglobulin associated with systemic vasculitis symptom

12 Here, we used the 6-19 model of cryoglobulin-associated GN to define the relative contri

13 the role of FcgammaRIIb in a mouse model of cryoglobulin-associated membranoproliferative glomerulon

14 eginning at weaning suppressed production of cryoglobulin, attenuating both the renal injury and syst

15 Because serum cryoglobulins (CG) are known to be associated with an in

16 In only one case were cryoglobulins detected (at low titer and on only one of

17 Cryoglobulins differ in their composition, which has an

18 These cryoglobulins form crystals, and we measured their solub

19 ion and the underlying disease that triggers cryoglobulin formation.

20 ts for more than 97% of the mouse Ig in this cryoglobulin; furthermore, glomerular disease develops w

21 lpha-fetoprotein >10 ng/ml in 2/8 (25%), and cryoglobulins >50 microg/ml in 3/6 (50%) infected with H

22 liferative glomerulonephritis); hematologic (cryoglobulin, Hodgkin's and non-Hodgkin's lymphoma [NHL]

23 ex deposits and higher levels of circulating cryoglobulins, IgG2a, IgG2b, and IgM, compared with TSLP

24 s such as anti-double stranded DNA titers or cryoglobulin IgG3 levels, circulating immune complex lev

25 HCV is selectively precipitated by type II cryoglobulins in coinfected sera.

26 No patient had cryoglobulins in the blood or kidney.

27 inct entity characterized by the presence of cryoglobulins in the serum.

28 Our results suggest that in this model of cryoglobulin-induced glomerulonephritis the neutrophil i

29 d the role of complement in a mouse model of cryoglobulin-induced immune complex glomerulonephritis.

30 Patients' mean cryoglobulin level decreased from 0.56 +/- 0.18 at basel

31 Cryoglobulin levels correlated with in vivo proliferatio

32 Cryoglobulin levels decreased in 89% of patients, with m

33 In conclusion, cryoglobulins may be a useful prognostic indicator for i

34 y disappearing in four of nine cases who had cryoglobulins measured after treatment.

35 f IgG sialylation against the development of cryoglobulin-mediated GN, highlighting the anti-inflamma

36 pitate in C57BL/6 mice consisted of the IgG3 cryoglobulin only (type I cryoglobulinemia) compared wit

37 rus (HCV) infection develop detectable serum cryoglobulins or cryoprecipitates (CP), although most do

38 Seven patients cleared cryoglobulins out of 15 who were initially positive.

39 We report a study of monoclonal IgG cryoglobulins overexpressed by two patients with multipl

40 s of Tfh cells (P = .03) and serum levels of cryoglobulin (P = .01).

41 tor activity, C4 fraction of complement, and cryoglobulin; peripheral blood mononuclear cells were is

42 These changes promoted cryoglobulin production and immune complex-mediated rena

43 c mice with established MPGN also diminished cryoglobulin production and reversed the renal and syste

44 decreased renal scores as well as lower IgG3 cryoglobulin production and vasculitis.

45 e bone marrow likely caused the reduction in cryoglobulin production.

46 Cryoglobulins showed HCV, monomeric IgM, and monomeric I

47 line to 0.21 +/- 0.14 g/L at week 36, and no cryoglobulin was detected in 50% of patients at this tim

48 Serum HCV was quantitated, cryoglobulins were analyzed by column chromatography at

49 Type II cryoglobulins were detected in the sera of all 3 patient

50 on of 6-19 hybridoma cells producing an IgG3 cryoglobulin with rheumatoid factor activity against IgG

51 in mice results in the development of mixed cryoglobulins, with renal involvement closely resembling