ライフサイエンスコーパス: cryptic

1 city of the environment, making these cycles cryptic.

2 half of RBM17-dependent splicing changes are cryptic.

3 s indicate that 1-2% of species may be truly cryptic.

4 t asymmetries in brains are usually minor or cryptic.

5 omic studies, the metabolite itself has been cryptic.

6 ograft endothelium, autoantigens are usually cryptic.

7 noma tumor samples, we show that hundreds of cryptic 3' splice sites (3'SSs) are used in cancers with

8 ciated with aberrant pre-mRNA splicing using cryptic 3' splice sites (3'SSs), but the mechanism of th

9 necessary sequence context for the observed cryptic 3' SSs and propose that cryptic 3'SS selection i

10 We hypothesized that these cryptic 3'SS are inaccessible during normal splicing cat

11 the observed cryptic 3' SSs and propose that cryptic 3'SS selection is a result of SF3B1 mutations ca

12 f secondary structure-dependent selection of cryptic 3'SS was found across multiple clonal processes

13 Hundreds of cryptic 3'SS were detectable across the genome in cells

14 While most cryptic 3'SSs are present at low frequency (<10%) relati

15 To understand how cryptic 3'SSs are selected, we performed comprehensive a

16 mutations in the SF3B1 HEAT 5-9 repeats use cryptic 3'SSs downstream of the branch point and provide

17 tified ten genes that preferred out-of-frame cryptic 3'SSs.

18 splicing modulation through activation of a cryptic 5'ss (Cr1).

19 avirulent parent, suggesting a reservoir of cryptic alleles.

20 arts, providing a new metric for identifying cryptic and alternative sites of initiation.

21 Both cryptic and conspicuous species in this group presented

22 ium/long wavelength sensitive opsins both in cryptic and conspicuous species of this primate family.

23 pulation change can be challenging for rare, cryptic and elusive species.

24 ment associations, thereby creating a fairly cryptic and fine-scale dimension of niche differentiatio

25 This binding to CD4 reveals cryptic and highly conserved epitopes, the molecular nat

26 ng; yet most of these splicing variants were cryptic and increased in nuclear degradation mutants.

27 Transcription of four so far cryptic and otherwise silent putative SM gene clusters w

28 been utilized to collect fecal samples from cryptic and rare mammals.

29 ting an important role for autoantibodies to cryptic antigens as novel accelerators of kidney dysfunc

30 placental mammals remains as evolutionarily cryptic as the approximately 280 genera grouped as 'Sout

31 nucleoporin complex, functions as part of a cryptic aspect of the ethylene signaling pathway that is

32 permissive conditions for the expression of cryptic autoantigens, allowing these autoantibodies to b

33 a small form, suggesting the existence of a cryptic bat species.

34 natively, allonursing may confer other, more cryptic, benefits to pups or allonurses, such as immunol

35 and a thiophene-carboxamide, ML402-define a cryptic binding pocket unlike other ion channel small-mo

36 amic network of atomic communication linking cryptic binding site occupancy and allosteric inactivati

37 The number and location of cryptic binding sites have been debated, but experimenta

38 Targeting of cryptic binding sites represents an attractive but under

39 ee-dimensional (3D) genome organizer CTCF at cryptic binding sites, in conjunction with DNA cytosine

40 ry significant units (ESUs), suggesting that cryptic biodiversity may be higher than expected for one

41 Significantly, Cripto-1 and Cryptic blocked binding of their cognate ligands to type

42 -length VWF, this macrophage-binding site is cryptic but becomes exposed following exposure to shear

43 The combined data show anillin contains a cryptic C2 domain and a Rho-binding domain.

44 y, Mid1 also binds to the membrane through a cryptic C2 domain.

45 es on the differentiation of lamellocytes, a cryptic cell type, dedicated to pathogen encapsulation a

46 ies compatible with proteolytic unmasking of cryptic CendR motifs, the strategy described here may pr

47 Metabolomic analysis thereby revealed cryptic changes to seagrass condition that could not be

48 nfection with trachoma organisms lacking the cryptic chlamydial plasmid is highly attenuated in macaq

49 stulate that the mutations identified create cryptic cis-acting regulatory sequence binding sites tha

50 m response transcription factor binding to a cryptic cis-element.

51 l studies uncovered conserved roles for such cryptic CNEs, facilitating annotation of sequences ident

52 al cell mechano-signaling pathway in which a cryptic collagen epitope activates alphavbeta3 leading t

53 We provide evidence that the HU177 cryptic collagen epitope is selectively generated within

54 Here, we identified an RGD-containing cryptic collagen epitope that is generated in vivo.

55 ases of 17 independent instances of the same cryptic colony phenotype in a yeast cross.

56 uce the direct costs of predation, including cryptic coloration and behavior, chemical defenses, mimi

57 idirectional transitions between mimetic and cryptic coloration are unexpectedly frequent over both l

58 mental analyses suggest that the overlapping cryptic columns have a width of 100 mum, in agreement wi

59 vity suggests that DL is also organized into cryptic columns; these connections are highly asymmetric

60 ociated contact between patients, indicating cryptic community transmission.

61 beta receptors, indicating that Cripto-1 and Cryptic contact ligands at their receptor interaction su

62 ould help to constrain the antiquity of this cryptic crab family.

63 and determine the population structure of a cryptic deep ocean cetacean, the Gray's beaked whale (Me

64 The resulting naivety has made this cryptic, deep-diving cetacean highly susceptible to dist

65 precursor protein in the brain, exhibit two cryptic deficits that are normally undetected using stan

66 Radiocarbon analysis allowed us to elucidate cryptic dietary change associated with invasion success.

67 Whereas the three species are cryptic, differing but slightly in appearance, their com

68 d Yule-Coalescent model to explore potential cryptic diversity at a continental scale.

69 on and ZetaOtu classification to demonstrate cryptic diversity between closely related Zetaproteobact

70 The consideration of cryptic diversity helps to accurately describe the compl

71 n ecological studies, reveals a key role for cryptic diversity in structuring communities of mutualis

72 An accurate assessment of cryptic diversity in this emblematic group requires meti

73 logical species as well as to confirm hidden cryptic diversity under a single taxonomic name.

74 rubra sampled in England and Spain indicates cryptic diversity.

75 putative regulator, which is encoded in the cryptic E. coli type three secretion system 2 (ETT2) loc

76 CD68(+) cells (macrophages/monocytes) as the cryptic EBOV reservoir cells in the vitreous humour and

77 soforms emerging from long genes by coupling cryptic elements with inclusion of RS-exons.

78 ialine) thrive in this globally distributed, cryptic environment is poorly understood.

79 e nanchangmycin synthase, were shown to have cryptic epimerase activity.

80 y guides Env to metastable forms that expose cryptic epitopes and that are highly sensitive to neutra

81 induced shifts in protein structure generate cryptic epitopes capable of bypassing B cell tolerance i

82 t, following proteolytic cleavage, recognize cryptic epitopes exposed in the hinge regions of immunog

83 versible inactivation; and (iii) exposure of cryptic epitopes to antibodies, allowing virus neutraliz

84 le characteristic, allowing the targeting of cryptic epitopes.

85 This includes cryptic events located far from the currently annotated

86 -active AR-V7 splice variant generated by AR cryptic exon 3b inclusion.

87 as it was demonstrated that TDP-43 represses cryptic exon splicing to promote cell survival.

88 that repressive motifs are strongest next to cryptic exons and that gradual weakening of these motifs

89 Furthermore, repression of cryptic exons was impaired in ALS-FTD cases, suggesting

90 leted from mouse embryonic stem cells, these cryptic exons were spliced into messenger RNAs, often di

91 DP-43 repressed the splicing of nonconserved cryptic exons, maintaining intron integrity.

92 f the epidermal growth factor-Cripto-1/FRL-1/Cryptic family, is critical for early embryonic developm

93 tive significance of sperm ornaments and the cryptic female preferences driving their evolution is ex

94 ether such directional post-mating (that is, cryptic) female mate choice can also occur in species wi

95 habitat limitation), but densities of other cryptic fishes decreased as habitat availability increas

96 ng hypotheses for the location and number of cryptic FN-FN binding sites and quantify the effect of t

97 requires cell-generated forces, which expose cryptic FN-FN binding sites buried in FN Type III domain

98 um life history is inherently tied to a more cryptic free-living (ex hospite) phase that remains larg

99 Dehydratase (DH) domains of cryptic function are often found in polyketide synthase

100 These results are consistent with a cryptic function for the similarly structured oxydianion

101 ducts are thus useful tools in unmasking the cryptic functions of conventional enzymes in the regulat

102 obustness properties, due the persistence of cryptic gene and pathway functions, to generate variatio

103 These so-called silent or cryptic gene clusters are sources of new natural product

104 ediation effects suggests a critical role of cryptic gene regulation underlying many disease traits.

105 Cryptic genetic variants that do not typically influence

106 s essentiality may favor the accumulation of cryptic genetic variation (CGV) that has no effect in th

107 Epistasis for aggressive behavior causes cryptic genetic variation in the DGRP that is revealed b

108 e expression of plasticity or the release of cryptic genetic variation.

109 lls by tracing cell lineages and discovering cryptic genetic variations that would otherwise be obscu

110 is a CD4-gp120 fusion immunogen that exposes cryptic gp120 epitopes to the immune system.

111 ealand and southern South America, are tiny, cryptic, ground-dwelling spiders that rely on hunting ra

112 Phylogenetic analyses revealed several cryptic Hepatocystis parasite species and, in contrast t

113 However, despite extensive cryptic (i.e., presymptomatic) infection and frequent lo

114 ng site in the C-terminal CCPs 19-20 that is cryptic in full-length native FH.

115 ing to irreversible protein misfolding; when cryptic in the protein's microenvironment, it readily co

116 o identify a set of genes that may represent cryptic information that is silenced by DNA methylation

117 Indeed, soluble Cripto-1 and Cryptic inhibited ligand signaling in various cell-based

118 The principle of the cryptic inhibitor envelope approach may be broadly appli

119 By analogy with the three cryptic inscriptions of the classical Rosetta Stone, the

120 eld is using molecular information to detect cryptic interactions between species and to increase our

121 addition to its known partner Nodal, whereas Cryptic interacts only with Activin B.

122 We identify a pPA event at a cryptic intronic poly(A) signal in MAGI3, occurring in t

123 lete CFTR sequencing, the method found three cryptic intronic splice variants (one known and two expe

124 rotransposons and regulated genes containing cryptic introns.

125 rcellate DL into narrow (60 mum) overlapping cryptic layers.

126 Our analyses revealed the presence of two cryptic lineages within Q. chrysolepis.

127 of the five kiwi species, we discovered many cryptic lineages, bringing the total number of kiwi taxa

128 The silencing defect was not limited to cryptic mating type loci and was associated with broad c

129 the apicoplast depends on novel, but largely cryptic, mechanisms for protein/lipid import and organel

130 families and the biological significance of cryptic metabolic pathways, such as pectinolysis within

131 Cryptic minor variant mycobacterial subpopulations exist

132 t alter the ACD building blocks to unleash a cryptic mode of chaperone action.

133 y be maintained at low frequencies alongside cryptic morphs.

134 e IMD pathway form functional amyloids via a cryptic motif resembling the RHIM motif found in mammali

135 ysis also reveals many previously unreported cryptic ncRNAs induced by specific carbon sources, showi

136 enotypes because melanistic T. cristinae are cryptic on the stems of both host species, are resistant

137 Mus81-deficient cells does not initiate from cryptic or latent origins not used during normal growth.

138 tool to bind efficiently to viral epitopes, cryptic or not accessible to conventional antibodies.

139 es of eDNA analysis include the detection of cryptic or otherwise elusive organisms, large-scale samp

140 Native SpyCEP may be poorly immunogenic (cryptic or subdominant), and it would be to the organism

141 um compression is determined by the process' cryptic order--a classical, topological property closely

142 is the first viral protein shown to activate cryptic PASs in introns, we suspect that other viruses a

143 We present the epidemiology of a cryptic pathogen and show that its presence has importan

144 ve amplification strategy for characterizing cryptic pathogen species, and reveal evolutionary events

145 these cytokines abrogated the enhancement of cryptic peptide presentation in response to infection.

146 -reading frames of mRNA transcripts but also cryptic peptides encoded in apparently 'untranslated' re

147 novel translational mechanisms that generate cryptic peptides from unusual sources.

148 that presentation of endogenously translated cryptic peptides is enhanced by TLR signaling pathways i

149 Thus, presentation of cryptic peptides is selectively enhanced during inflamma

150 This enhancement of cryptic peptides was caused by proinflammatory cytokines

151 es the MHC-II-presented peptidome, including cryptic peptides, modified peptides, and other peptides

152 trand-swapped regions (TolR(60-133)) exposes cryptic PG binding activity that is absent in the full-l

153 ble-headed to normal morphology, revealing a cryptic phenotype that is not apparent unless the animal

154 a tractable control point for investigating cryptic phenotypes and the stochasticity of large-scale

155 Surprisingly, we identified a cryptic phosphate-independent core metabolism producible

156 The cryptic plasmid is essential for Chlamydia muridarum dis

157 Noctiluca, Oxyrrhis, and Dinophysis, contain cryptic plastidial metabolisms and lack alternative cyto

158 tricopeptide repeat (TPR) region capped by a cryptic pleckstrin homology domain.

159 we review studies on the composition of the cryptic pMHC I repertoire, the immunological significanc

160 Cryptic pockets, that is, sites on protein targets that

161 approach to distinguish them from druggable cryptic pockets.

162 prematurely cleaved and polyadenylated from cryptic polyadenylation signals (PAS) located in intron

163 Cryptic polyadenylation within coding sequences (CDS) tr

164 ht into recent population history and reveal cryptic population structure in European Americans.

165 The detection of bias due to cryptic population structure is an important step in the

166 However, we remain cautious that cryptic population structure, assortative mating, and dy

167 This ratio is inflated in the presence of cryptic population structure.

168 ller animals may expose movements harbouring cryptic power amplification mechanisms and illustrate ho

169 remodel the tertiary organization and unmask cryptic primary microRNA domains to facilitate their pro

170 y hydrologic processes, including frequently cryptic processes such as groundwater flow.

171 ere we use purified human Cripto-1 and mouse Cryptic produced in mammalian cells to show that these t

172 The Set2-Rpd3 regulatory system prevents cryptic promoter function within expressed genes.

173 Pervasive transcription initiates from cryptic promoters and is observed in eukaryotes ranging

174 d regions of mRNA genes, repressing internal cryptic promoters and slowing elongation.

175 ced by specific carbon sources, showing that cryptic promoters can be environmentally regulated.

176 mechanisms exist to both suppress intragenic cryptic promoters during genic transcription and to repr

177 ing the action of a promiscuous activator on cryptic promoters is a critical mechanism for specifying

178 ly, the RS-exon is included when preceded by cryptic promoters or exons that fail to reconstitute an

179 limit aberrant transcription initiation from cryptic promoters present in gene bodies.

180 By blocking transcription from normally cryptic promoters, Kmg restricts activation by Aly, a co

181 DC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC, which ill

182 ccamycin and tetarimycin) and to the silent, cryptic pseudogene-containing, environmental DNA-derived

183 Tumor penetrating peptides contain a cryptic (R/K)XX(R/K) CendR element that must be C-termin

184 ibility gene for PthXo2 and the existence of cryptic recessive resistance to PthXo2-dependent X. oryz

185 ding how the mammalian homologs Cripto-1 and Cryptic recognize and regulate TGF-beta family ligands,

186 have responded by reducing the abundance of "cryptic" recombination signals near RAG1 binding sites.

187 count for both population stratification and cryptic relatedness and achieve increased statistical po

188 tic effects) and confounding biases, such as cryptic relatedness and population stratification, can y

189 association studies of admixed individuals, cryptic relatedness and population structure are known t

190 ifying pleiotropic genes while adjusting for cryptic relatedness and population structure between sub

191 zygosity can occur to varying degrees due to cryptic relatedness between parents.

192 Population structure and cryptic relatedness can also be controlled.

193 They jointly adjust for cryptic relatedness, population structure and other conf

194 ogeography provides essential clues to their cryptic relationship with hosts and the environment in w

195 RE to the HapMap3 CEU samples and report new cryptic relationships and validation of previously descr

196 jects that are genetically too similar, e.g. cryptic relationships, or that are genetically too diffe

197 espite sequence divergence, these Drosophila cryptic RHIMs formed amyloid fibrils in vitro and in cel

198 lting in non-coding RNA hyperproduction from cryptic RNA polymerase II promoters; (ii) alterations in

199 common during morphogenesis, and that their cryptic roles can be revealed when tissues are challenge

200 ment in RAG1 binding, and correspondingly, a cryptic RSS consisting of a repeat of CA dinucleotides,

201 The rearrangement occurs between the cryptic RSS of the original VH element and the conventio

202 ve folded to an unfolded state, in which the cryptic scissile bond (Y1605-M1606) is exposed and can t

203 ncement arises from exposure of a C-terminal cryptic second binding site in FH for C3b, the activatio

204 e of microscale systems to unlock unknown or cryptic secondary metabolites for natural products disco

205 Importantly, our findings suggest that the cryptic sequence features of the WT p27 IDR negatively r

206 Through functional studies, we uncover cryptic sequence features within the p27 IDR that influe

207 This makes it unlikely that numerous "cryptic, sequence-degenerate, dispersed RNA packaging si

208 The genome has been shown to contain a cryptic set of dispersed assembly signals in the form of

209 This suggests the existence of multiple cryptic sexually dichromatic traits within this species.

210 Random oxidative modification of cryptic side chains exposed by mechanical unfolding can

211 gnal of spatial genetic structure and, (b) a cryptic signal of host differentiation.

212 the canonical E2 site, demonstrate that the cryptic Site 1 is associated with thioester formation, w

213 sect a putative allosteric network linking a cryptic site at the dimerization interface to enzyme fun

214 conformational change to become apparent; a cryptic site can therefore be defined as a site that for

215 resulted in a promising general approach for cryptic site discovery.

216 ggers a conformational change that exposes a cryptic site for the actin-binding protein vinculin.

217 Our observed mechanism of cryptic site formation is suggestive of an interplay bet

218 ch in practice, we experimentally validate a cryptic site in protein tyrosine phosphatase 1B using a

219 ng Drosophila melanogaster introns contain a cryptic site, known as a recursive splice site (RS-site)

220 ts, understanding and accurately identifying cryptic sites could expand the set of drug targets.

221 We find that the studied cryptic sites do not correspond to local minima in the c

222 mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leadin

223 igate the nature and dynamical properties of cryptic sites in four pharmacologically relevant targets

224 Next, we comprehensively characterize the cryptic sites in terms of their sequence, structure, and

225 We then predict cryptic sites in the entire structurally characterized h

226 These cryptic sites require a conformational change to become

227 We find that cryptic sites tend to be as conserved in evolution as tr

228 Previously, cryptic sites were identified experimentally by fragment

229 rization, we use machine learning to predict cryptic sites with relatively high accuracy (for our ben

230 of structurally defined apo-holo pairs with cryptic sites.

231 y it leads to the opening and binding to the cryptic sites.

232 of conspecifics, locusts occur in a shy and cryptic solitarious phase.

233 (Monotropa, Hypopitys), which indicates that cryptic speciation may be occurring in several lineages.

234 (cytochrome oxidase I) revealed significant cryptic species diversity.

235 sive inventory suggests that the presence of cryptic species is a widespread phenomenon and that furt

236 Identification of cryptic species is an essential aim for conservation bio

237 ntracaecum ogmorhini represents a complex of cryptic species is not supported by mt genome data.

238 transmission of CCYV by Mediterranean (MED) cryptic species of B. tabaci complex.

239 ns attributed to Bd have been reported among cryptic species undergoing direct development away from

240 ss there is high initial occupancy, rare and cryptic species will be particularly challenging when it

241 How common are cryptic species--those overlooked because of their morph

242 a decipiens complex consists of at least six cryptic species.

243 pulation-level structure or the evolution of cryptic species.

244 p lineages of T. submersa that may represent cryptic species.

245 uld be interpreted as indicative of multiple cryptic species.

246 events preceded secondary sympatry of these cryptic species.

247 e I barcoding has exposed many potential new cryptic species.

248 as enormous potential for assessing rare and cryptic species.

249 oform L, and morphoform 'a' contain possible cryptic species; and suggested that cytoform B is in the

250 indicate each lineage represents a distinct (cryptic) species, contradicting current morphospecies de

251 RT-PCR confirmed that this change creates a cryptic splice donor and thus causes retention of the in

252 n CEP290 (c.2991 + 1655A > G) that creates a cryptic splice donor site resulting in the insertion of

253 c mutation (c.1909+22G>A), which activates a cryptic splice site in a tissue and stage of development

254 d a maternal deletion due to activation of a cryptic splice site in exon 9 of the gene (c.1090_1129de

255 nscript in patients revealed activation of a cryptic splice site in intron 4 resulting in a frame shi

256 The del12 mutation activates a cryptic splice site, leading to a frameshift mutation an

257 ading to exon skipping, or by creating a new cryptic splice site.

258 Private exons often arise from cryptic splice sites providing an important clue for var

259 ent within SMOC2 promotes the utilization of cryptic splice sites, causing its incorporation into tra

260 s, the method identified 32 potential exonic cryptic splice variants, two of which were experimentall

261 Our findings suggest that cryptic splice-site activation is more common than previ

262 We propose that repression of cryptic splicing by RBPs is critical for neuronal health

263 Importantly, RBM17 represses cryptic splicing of genes that likely contribute to moto

264 hat undergo both RBM17- and TDP-43-dependent cryptic splicing repression, many of which are associate

265 h disease-associated variants might activate cryptic splicing, we selected 458 pathogenic variants an

266 revealing that TDP-43 extensively regulates cryptic splicing.

267 tudies promise to reveal rare cell types and cryptic states, but the high variability of single-cell

268 on, resulting in the emergence of previously cryptic structures that subsequently mediate reversible,

269 st molecular evidence for the existence of a cryptic subcoxal segment in developing legs.

270 early infection in vivo, including ASPRs, a cryptic subfamily of activation-associated secreted prot

271 evolution, taxonomy and conservation of the cryptic subterranean fauna.

272 Phylogenetic studies have suggested cryptic subtype B circulation in the United States (US)

273 oxic-anoxic interface is consistent with the cryptic sulfur cycling concept.

274 nts of taxonomic boundaries and discovery of cryptic taxa are of paramount importance in interpreting

275 ts can help identify and address some of the cryptic threats to natural populations that are likely t

276 CAP has a sequence previously proposed as a "cryptic" TIR domain.

277 This complex variant class is cryptic to CMA, but we observed it in 8.1% of all subjec

278 yotypes and demonstrated complexity that was cryptic to karyotyping in 21% of BCAs, highlighting the

279 common sources of genomic variation that is cryptic to population-based microarray and low-depth who

280 d a hypomethylation event that reactivates a cryptic transcript of the Rab GTPase activating protein

281 that this aging phenomenon is conserved, as cryptic transcription also increases in old worms.

282 Therefore, in addition to repression of cryptic transcription and modulation of elongation, H3K3

283 6 methylation is commensurate with increased cryptic transcription in a subset of genes in old cells

284 K36 per nucleosome was sufficient to silence cryptic transcription in vivo.

285 However, neither cryptic transcription initiation, nor alternative pre-mR

286 TSS) and chromatin dynamics, we observed the cryptic transcription of thousands of treatment-induced

287 moters that otherwise may license or promote cryptic transcription.

288 to maintain chromatin structure and prevent cryptic transcriptional initiation from within transcrib

289 Taken together, we have uncovered cryptic transcriptional programs used by the human embry

290 Previous studies have shown that cryptic translation can be initiated by distinct mechani

291 hesized proteins including those produced by cryptic translation mechanisms.

292 razil indicate the duration of pre-detection cryptic transmission in recipient regions.

293 unannotated transcripts) and unstable (CUTs, cryptic unstable transcripts) transcripts with protein-c

294 The HIV-1 isolate JRFL with its cryptic V3 is resistant to most V3-specific monoclonal a

295 The number and identities of detected cryptic variants depended on the mutated gene.

296 es and disease, as most of the mutations and cryptic variants identified in our study reside in compo

297 order genetic interactions that only involve cryptic variants.

298 n between a de novo mutation and one or more cryptic variants.

299 d that the silvery sides of certain fish are cryptic when viewed by animals with polarization sensiti

300 is not clear if these differences are due to cryptic wSuz polymorphism, host background, geographical