ライフサイエンスコーパス: cryptophane

1 the aqueous behavior of the large, nonpolar cryptophane.

2 ed in aqueous solution using two enantiopure cryptophanes.

3 The known xenon-binding (+/-)-cryptophane-111 (1) has been functionalized with six [(e

4 ies of xenon and krypton clathrates of (+/-)-cryptophane-111 (111).

5 give, in 89% yield, the first water-soluble cryptophane-111 derivative, namely [(Cp*Ru)(6)1]Cl(6) ([

6 ion at pH 5.5 generated a 13.4 ppm downfield cryptophane-(129)Xe NMR chemical shift relative to pH 7.

7 We show that the cryptophane-223 skeleton can be modified to introduce a

8 ional affinity to tris-(triazole ethylamine) cryptophane, a previously unsynthesized water-soluble or

9 figuration was thus established for the anti-cryptophane-A (1) and its congeners 2 and 4.

10 D) experiments and were compared to those of cryptophane-A (1) derivative.

11 e report high-resolution X-ray structures of cryptophane-A and trifunctionalized derivatives in crown

12 In the preparation of a tethered cryptophane-A cage for biosensor applications, some achi

13 m at the same strategic position within an L cryptophane-A cage, under the influence of chiral potent

14 In contrast to what is observed for the cryptophane-A congener, the synthesis of these highly su

15 Following this scheme, a triacetic acid cryptophane-A derivative (TAAC) was indirectly detected

16 A water-soluble triacetic acid cryptophane-A derivative (TAAC) was synthesized and dete

17 ly synthesized tris(triazole propionic acid) cryptophane-A derivative (TTPC) showed how solvation of

18 Of note are trifunctionalized, water-soluble cryptophane-A derivatives, which exhibit exceptional aff

19 Functionalization of cryptophane-A has permitted the development of Xe as a b

20 according to the amount of CH4 bound to the cryptophane-A in the film and is determined using surfac

21 Cryptophane-A serves as a chemical host for hyperpolariz

22 direct detection of Xe host molecules (e.g., cryptophane-A).

23 Cryptophane-A, comprised of two cyclotriguaiacylenes joi

24 spin-hyperpolarized xenon ((129)Xe) atoms in cryptophane-A-monoacid (CrAma) and their indirect detect

25 ttle as 20 nM of the xenon MRI readout unit, cryptophane-A.

26 xane (PDMS) layer incorporating molecules of cryptophane-A.

27 cancers, to the xenon-binding organic cage, cryptophane-A.

28 axation rate induced by slowed tumbling of a cryptophane-based sensor upon target binding.

29 On a per cryptophane basis, this equates to 1.2 x 10(4)(129)Xe at

30 rms binding measurements indicating that the cryptophane cage does not strongly interact with the sur

31 Xenon associated with the target-bound cryptophane cage is rapidly relaxed and then detected af

32 The sensor comprises a xenon-binding cryptophane cage, a target interaction element, and a me

33 Cryptophane cages serve as host molecules to a Xe atom.

34 Pd3L2 metallo-cryptophane cages with cyclotriveratrylene-type L ligand

35 We report the synthesis of new cryptophane derivatives 1-4 bearing nine (1, 2) and twel

36 se compounds represent the first examples of cryptophane derivatives bearing more than six substituen

37 Enantiopure cryptophane derivatives bearing nine (2, 3) and 12 (4) m

38 determine the absolute configuration (AC) of cryptophane derivatives.

39 o ascertain the stereochemistry of these new cryptophane derivatives.

40 The 1.70 A resolution crystal structure of a cryptophane-derivatized benezenesulfonamide complexed wi

41 The cryptophane effectively "catalyzes" this process by prov

42 r, the synthesis of these highly substituted cryptophanes gives rise to the two anti- and syn-diaster

43 nocyclohexane (R)-5, which leads to a chiral cryptophane (>90% yield) that is built-up from two (P)-2

44 To a cryptophane host molecule with high Xe affinity, we conj

45 We report the synthesis of new water-soluble cryptophane host molecules that can be used for the prep

46 lta = 67.6 ppm at pH 5.5, where Trp(peptide)-cryptophane interactions were evidenced by Trp fluoresce

47 Cryptophane internal volume varied by more than 20% acro

48 consider multiple Xe exchange processes for cryptophane-mediated bulk (129)Xe depolarization, which

49 Hydrolysis of this cryptophane provides (P)-2 with >99% ee.

50 n was determined radiometrically to give the cryptophane-radon association constant K(a)=49,000 +/- 1

51 Cryptophanes represent an exciting class of xenon-encaps

52 Irradiation at the appropriate Xe-cryptophane resonant radio frequency results in relaxati

53 Synthetic routes used to prepare cryptophanes result in racemic mixtures of the chiral ca

54 artitioning of radon between air and aqueous cryptophane solutions of varying concentration was deter

55 the efficient large-scale production of new cryptophanes that can be used as chemical platforms read

56 A xenon-binding cryptophane was substituted with linkers of varying leng

57 The preparation of these highly substituted cryptophanes was achieved due to the synthesis of a new

58 The cryptophane-xenon association constant, K(a)=42,000 +/-