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1 acids was synthesized and incorporated into cryptophycins.
2 ecame the C16 hydroxyl and C1' methyl of the cryptophycins.
4 of about 40 nm, while the morphology of the cryptophycin 1 aggregate consisted primarily of smaller
6 crotubules, perhaps in the form of a tubulin-cryptophycin 1 complex, resulting in the most potent sup
10 video microscopy, we examined the effects of cryptophycin 1 on the dynamics of individual microtubule
11 absence of net microtubule depolymerization, cryptophycin 1 potently stabilized microtubule dynamics.
12 grees C and stimulated at 0 degrees C, while cryptophycin 1 was inhibitory at both reaction temperatu
14 Cryptophycin 52 is a synthetic derivative of Cryptophycin 1, a potent antimicrotubule agent isolated
15 r docking studies, a common binding site for cryptophycin 1, cryptophycin 52, dolastatin 10, hemiaste
20 group into cryptophycin-4 (Cr-4) to produce cryptophycin-2 (Cr-2) in a regio- and stereospecific man
22 esults demonstrated that the 4'-MeO group in cryptophycin-24 is not essential and can be replaced wit
23 '-Cl, 4'-C1, and 3',4'-diCl C10 analogues of cryptophycin-24 were prepared via total synthesis and te
25 pi-C3-cryptophycin-24, epi-C3-m-chlorobenzyl-cryptophycin-24, and the corresponding styrenes were syn
29 wn to install this key functional group into cryptophycin-4 (Cr-4) to produce cryptophycin-2 (Cr-2) i
31 enantioselective and convergent synthesis of cryptophycin 52 (2), an exceedingly potent cytotoxic age
34 e analogues were equally or more potent than Cryptophycin 52 when evaluated in vitro in the CCRF-CEM
36 s, a common binding site for cryptophycin 1, cryptophycin 52, dolastatin 10, hemiasterlin, and phomop
43 high concentrations (>/=10 times the IC50), cryptophycin-52 blocked HeLa cell proliferation at mitos
44 termined that approximately 5-6 molecules of cryptophycin-52 bound to a microtubule were sufficient t
45 ls 730-fold, and the resulting intracellular cryptophycin-52 concentration was similar to that requir
53 e binding data indicated that the binding of cryptophycin-52 to tubulin is primarily entropy-driven w
57 ould remove [(3)H]cryptophycin-52 from [(3)H]cryptophycin-52-tubulin complex by denaturing the comple
58 sis and that it acts by forming a reversible cryptophycin-52-tubulin stabilizing cap at microtubule e
62 igated with a series of structurally related cryptophycin analogues generated by chemoenzymatic synth
65 d tubulin rings of 23.8 nm mean diameter for cryptophycin and 44.6 nm mean diameter for hemiasterlin
70 this study, the thioesterase domain from the cryptophycin biosynthetic pathway was isolated and its f
75 peptides and depsipeptides which include the cryptophycins, dolastatin 10, hemiasterlin, and phomopsi
76 (LY355703) is a new synthetic member of the cryptophycin family of antimitotic antitumor agents that
77 Cryptophycin 52, a synthetic variant of the cryptophycin family, is currently undergoing clinical tr
78 ncoded by c rpE recently identified from the cryptophycin gene cluster was shown to install this key
89 ntrast to the standard direct epoxidation of cryptophycin substrates, which proceeds with poor diaste
91 with its persistent effects on intact cells, cryptophycin-treated microtubule protein remained polyme
93 nce for structural variation within the seco-cryptophycin unit C beta-alanine residue, but strict str
96 remained polymerization-defective even after cryptophycin was reduced to sub-inhibitory concentration
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